PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26557094-6 2015 In parallel, resveratrol augmented the expression level and activity of SIRT1 and phosphorylation levels of Foxo3a and Akt while suppressed the increases in protein abundances of p53, Bax, MAFbx, and ubiquitin, enzymatic activities of caspase 3 and 20S proteasome, and apoptotic DNA fragmentation in the compressed muscle. Resveratrol 13-24 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 179-182 30055545-0 2018 Modulatory Potential of Curcumin and Resveratrol on p53 Post-Translational Modifications during Gastric Cancer. Resveratrol 37-48 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 52-55 30055545-2 2018 The present study evaluated the potential of curcumin and resveratrol on p53 post-translational modifications during gastric cancer. Resveratrol 58-69 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 73-76 30055545-13 2018 Therefore, we conclude that curcumin and resveratrol significantly modulated p53 post-translational modifications during gastric cancer. Resveratrol 41-52 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 77-80 26675978-0 2016 Resveratrol protects cardiomyocytes from doxorubicin-induced apoptosis through the AMPK/P53 pathway. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 88-91 26675978-2 2016 The aim of the present study was to investigate the effects of resveratrol on the adenosine monophosphate-activated protein kinase (AMPK)/P53 pathway in mediating DOX-induced cytotoxicity. Resveratrol 63-74 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 138-141 26675978-7 2016 Of note, resveratrol protected against DOX-induced increases of P53 and Bax and also prevented the downregulation of Bcl-2 in H9c2 cells. Resveratrol 9-20 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 64-67 26675978-9 2016 The results of the present study therefore indicated that resveratrol protected H9c2 cells from DOX-induced apoptosis via the AMPK/P53 pathway. Resveratrol 58-69 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 131-134 26819684-11 2015 Depending on the dose of resveratrol, Bcl2 levels increased, p53 levels decreased but Annexin V did not effected. Resveratrol 25-36 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 61-64 28847722-8 2017 Furthermore, exercise, resveratrol or their combination significantly increased the expression of p-AMPK and SIRT1, decreased the expression of acetyl P53 and Bax/Bcl-2 ratio in aged rats (P<0.05). Resveratrol 23-34 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 151-154 27160820-7 2016 In contrast, inhibiting this transcriptional activity via p53 interference greatly protected beta cells from the damage provoked by GS, as well as damage strengthened by RSV. Resveratrol 170-173 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 58-61 27551266-0 2016 Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol. Resveratrol 109-120 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 23-26 27551266-4 2016 Our present study in isolated testicular germ cell population from adult male Wistar rats, highlighted the synergistic protective effect of curcumin and resveratrol against B(a)P induced p53 mediated germ cell apoptosis. Resveratrol 153-164 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 187-190 27551266-9 2016 Curcumin-resveratrol decreased the expression of p53 dependent apoptotic genes like Fas, FasL, Bax, Bcl2, and Apaf1. Resveratrol 9-20 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 49-52 27551266-14 2016 Curcumin-resveratrol co-treatment significantly decreased p53 level and its phosphorylation (p53 ser 15). Resveratrol 9-20 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 58-61 27551266-14 2016 Curcumin-resveratrol co-treatment significantly decreased p53 level and its phosphorylation (p53 ser 15). Resveratrol 9-20 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 93-96 27551266-15 2016 The study concludes that curcumin-resveratrol synergistically modulated MAPKs and p53, prevented oxidative stress, regulated the expression of pro and anti-apoptotic proteins as well as the proteins involved in B(a)P metabolism thus protected germ cells from B(a)P induced apoptosis. Resveratrol 34-45 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 82-85 26819684-0 2015 Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats. Resveratrol 26-37 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 105-108 25483559-0 2015 Resveratrol inhibits beta-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 79-82 25483559-5 2015 It was demonstrated that resveratrol exerted neuronal protection through inhibition of cell apoptosis, which was associated with an increased acetylation level of p53. Resveratrol 25-36 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 163-166 25483559-6 2015 In accordance with this effect, when the acetylation level of p53 was decreased by p53 acetylation inhibitor pifithrin-alpha, the protective effects of resveratrol were abrogated. Resveratrol 152-163 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 62-65 25483559-6 2015 In accordance with this effect, when the acetylation level of p53 was decreased by p53 acetylation inhibitor pifithrin-alpha, the protective effects of resveratrol were abrogated. Resveratrol 152-163 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 83-86 25483559-7 2015 In conclusion, it was revealed that resveratrol inhibited Abeta(25-35)-induced cell apoptosis via the acetylation of p53 in PC12 cells. Resveratrol 36-47 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 117-120 24492640-0 2014 Resveratrol reverses cadmium chloride-induced testicular damage and subfertility by downregulating p53 and Bax and upregulating gonadotropins and Bcl-2 gene expression. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 99-102 25501918-2 2014 Resveratrol can prevent cells from p53- and reactive oxygen species-dependent apoptosis induced by interleukin-1b. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 35-38 24492640-9 2014 Resveratrol protected against and partially reversed cadmium chloride testicular toxicity via upregulation of Bcl2 and downregulation of p53 and Bax gene expression. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 137-140 24458046-13 2014 CONCLUSION: Resveratrol prevents cell death in HSR and exerts a protective effect on the mitochondria in a hepatocyte model of hypoxic injury-reoxygenation possibly via Sirt-1 modulation of p53 and NF-kappaB activity. Resveratrol 12-23 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 190-193 23792339-7 2013 In contrast, resveratrol downregulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Resveratrol 13-24 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 57-60 24218232-0 2014 Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 108-111 22995369-8 2012 Resveratrol significantly decreased serum levels of homocysteine, reversed Hcy induced LPO increase, decreased DNA fragmentation and p53 mRNA expression in the rat brains, and improved homocysteine induced impairment of long term spatial memory. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 133-136 18404539-0 2008 Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy. Resveratrol 82-93 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 64-67 21850372-9 2011 Immunoblot analysis revealed that resveratrol intervention at both the early and advanced stages of DEN-induced HCC activated the apoptotic markers, such as PARP cleavage, caspase-3 activation, p53 up-regulation and cytochrome-c release. Resveratrol 34-45 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 194-197 18404539-9 2008 This is the first report which suggests that protection against development of diabetic nephropathy by resveratrol treatment involves change in phosphorylation of histone H3, expression of Sir-2, p53 and p38 in diabetic kidney. Resveratrol 103-114 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 196-199 34968465-0 2022 Resveratrol alleviates cardiac apoptosis following exposure to fenitrothion by modulating the sirtuin1/c-Jun N-terminal kinases/p53 pathway through pro-oxidant and inflammatory response improvements: In vivo and in silico studies. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 128-131 34968465-8 2022 Moreover, RSV alleviated the histopathological changes promoted by FNT and repaired the transcript levels of SIRT1, c-JNK, and caspase-9/3 along with p53 immunoreactivity. Resveratrol 10-13 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 150-153 34968465-10 2022 Therefore, RSV reserved myocardial injury-induced apoptosis following exposure to FNT by modulating the SIRT1/c-JNK/p53 pathway through cellular redox status and inflammatory response improvements. Resveratrol 11-14 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 116-119 34968465-3 2022 Here, we have evaluated the possible ameliorative roles of resveratrol (RSV) against FNT-induced cardiac apoptosis in male rats through the sirtuin1 (SIRT1)/c-Jun N-terminal kinase (c-JNK)/p53 pathway concerning pro-oxidant and inflammatory cytokines. Resveratrol 59-70 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 189-192 34968465-3 2022 Here, we have evaluated the possible ameliorative roles of resveratrol (RSV) against FNT-induced cardiac apoptosis in male rats through the sirtuin1 (SIRT1)/c-Jun N-terminal kinase (c-JNK)/p53 pathway concerning pro-oxidant and inflammatory cytokines. Resveratrol 72-75 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 189-192 30890012-7 2020 RESULTS: Hyperoxia-induced alveolar simplification and apoptosis were alleviated by resveratrol; resveratrol reduced ROS production, up-regulated SIRT1, decreased the expressing of p53, and acetyl-p53 in the lung of hyperoxia-exposed neonatal rats. Resveratrol 97-108 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 181-184 30890012-8 2020 CONCLUSIONS: This study showed that resveratrol alleviated hyperoxia-induced apoptosis in neonatal rats lung tissue via reducing ROS and p53. Resveratrol 36-47 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 137-140 30890012-9 2020 Resveratrol-induced SIRT1 upregulation and acetyl-p53 reduction may also be involved in lung protection. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 50-53 34563044-9 2021 Additionally, the senescence markers (p53, p16 and p21) which were also reported to play a role in the pathogenesis of vascular calcification, were reduced upon treatment with resveratrol and estrogen. Resveratrol 176-187 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 38-41 33912959-8 2021 Resveratrol increased SIRT1 expression after irradiation and inhibited ionizing radiation-induced p53 acetylation and pro-apoptotic protein, Bax, expression. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 98-101 30890012-7 2020 RESULTS: Hyperoxia-induced alveolar simplification and apoptosis were alleviated by resveratrol; resveratrol reduced ROS production, up-regulated SIRT1, decreased the expressing of p53, and acetyl-p53 in the lung of hyperoxia-exposed neonatal rats. Resveratrol 97-108 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 197-200 32908628-7 2020 RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF-kappaB, hence alleviating infarction area, fibrosis, and cell apoptosis. Resveratrol 0-3 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 52-55 32357375-7 2021 Real time-polymerase chain reaction and western blotting identified increases in Sirt1 expression and decreases in p53 expression in the resveratrol intervened group. Resveratrol 137-148 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 115-118 31046448-0 2019 Resveratrol Attenuates Cardiomyocyte Apoptosis in Rats Induced by Coronary Microembolization Through SIRT1-Mediated Deacetylation of p53. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 133-136 32405350-8 2020 Bax/Bcl-2 and p53 analysis showed a statistically significant increase in apoptotic cells in DEN+RSV 100 group. Resveratrol 97-100 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 14-17 31046448-10 2019 CONCLUSIONS: Resveratrol can improve cardiac function, in the sense that it attenuates CME-induced cardiomyocyte apoptosis, which is perhaps associated with its inhibition pro-apoptotic pathway of p53 which is transcription-independent. Resveratrol 13-24 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 197-200 31053297-0 2019 Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway. Resveratrol 0-11 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 107-110 31053297-6 2019 Moreover, Resveratrol increased DJ-1 expression and promoted the interaction of DJ-1 with SIRT1, which further contributed to subsequent restoration of SIRT1 activity and decrease of acetylation level of p53. Resveratrol 10-21 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 204-207 31053297-8 2019 In conclusion, the current study demonstrated that Resveratrol suppressed H/R-induced cell apoptosis, which may be conducted by up-regulating DJ-1, and later activating SIRT1 activity and subsequently inhibiting p53 acetylation level in the H9c2 cells. Resveratrol 51-62 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 212-215