PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33244652-0	2021	Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation.	Resveratrol	49-60	tyrosyl-tRNA synthetase 1	Homo sapiens	114-119	
33244652-6	2021	RSV acts as a tyrosine antagonist and competes with it to bind to human tyrosyl-tRNA synthetase (TyrRS).	Resveratrol	0-3	tyrosyl-tRNA synthetase 1	Homo sapiens	72-95	
33244652-6	2021	RSV acts as a tyrosine antagonist and competes with it to bind to human tyrosyl-tRNA synthetase (TyrRS).	Resveratrol	0-3	tyrosyl-tRNA synthetase 1	Homo sapiens	97-102	
33244652-7	2021	Interestingly, although both isomers of RSV bind to TyrRS, only the cis-isomer evokes a unique structural change at the active site to promote its interaction with poly-ADP-ribose polymerase 1 (PARP1), a major determinant of cellular NAD+-dependent stress response.	Resveratrol	40-43	tyrosyl-tRNA synthetase 1	Homo sapiens	52-57	
33244652-8	2021	However, retention of trans-RSV in the active site of TyrRS mimics its tyrosine-bound conformation that inhibits the auto-poly-ADP-ribos(PAR)ylation of PARP1.	Resveratrol	22-31	tyrosyl-tRNA synthetase 1	Homo sapiens	54-59	
33244652-9	2021	Therefore, we proposed that cis-RSV-induced TyrRS-regulated auto-PARylation of PARP1 would contribute, at least in part, to the reported health benefits of RSV through the induction of protective stress response.	Resveratrol	28-35	tyrosyl-tRNA synthetase 1	Homo sapiens	44-49	
33244652-9	2021	Therefore, we proposed that cis-RSV-induced TyrRS-regulated auto-PARylation of PARP1 would contribute, at least in part, to the reported health benefits of RSV through the induction of protective stress response.	Resveratrol	32-35	tyrosyl-tRNA synthetase 1	Homo sapiens	44-49	
33244652-10	2021	This observation suggested that trans-RSV would inhibit TyrRS/PARP1-mediated protective stress response and would instead elicit an opposite effect compared to cis-RSV.	Resveratrol	32-41	tyrosyl-tRNA synthetase 1	Homo sapiens	56-61	
33244652-12	2021	Therefore, the finding that cis-RSV and trans-RSV induce two distinct conformations of TyrRS with opposite effects on the auto-PARylation of PARP1 provides a potential molecular basis for the observed dichotomic effects of RSV under different experimental paradigms.	Resveratrol	28-35	tyrosyl-tRNA synthetase 1	Homo sapiens	87-92	
33244652-12	2021	Therefore, the finding that cis-RSV and trans-RSV induce two distinct conformations of TyrRS with opposite effects on the auto-PARylation of PARP1 provides a potential molecular basis for the observed dichotomic effects of RSV under different experimental paradigms.	Resveratrol	40-49	tyrosyl-tRNA synthetase 1	Homo sapiens	87-92	
33244652-12	2021	Therefore, the finding that cis-RSV and trans-RSV induce two distinct conformations of TyrRS with opposite effects on the auto-PARylation of PARP1 provides a potential molecular basis for the observed dichotomic effects of RSV under different experimental paradigms.	Resveratrol	32-35	tyrosyl-tRNA synthetase 1	Homo sapiens	87-92	
30939244-0	2019	Resveratrol targets TyrRS acetylation to protect against radiation-induced damage.	Resveratrol	0-11	tyrosyl-tRNA synthetase 1	Homo sapiens	20-25	
31308445-4	2019	Recent work demonstrated that RSV facilitates tyrosyl-tRNA synthetase (TyrRS)-dependent activation of PARP1.	Resveratrol	30-33	tyrosyl-tRNA synthetase 1	Homo sapiens	46-69	
31308445-4	2019	Recent work demonstrated that RSV facilitates tyrosyl-tRNA synthetase (TyrRS)-dependent activation of PARP1.	Resveratrol	30-33	tyrosyl-tRNA synthetase 1	Homo sapiens	71-76	
30939244-6	2019	RSV can promote TyrRS acetylation, thus promoting TyrRS to enter the nucleus, where it regulates the relevant signaling proteins and reduces apoptosis and DNA damage.	Resveratrol	0-3	tyrosyl-tRNA synthetase 1	Homo sapiens	16-21	
30939244-6	2019	RSV can promote TyrRS acetylation, thus promoting TyrRS to enter the nucleus, where it regulates the relevant signaling proteins and reduces apoptosis and DNA damage.	Resveratrol	0-3	tyrosyl-tRNA synthetase 1	Homo sapiens	50-55	
30939244-7	2019	SIRT1 is a deacetylase, and SIRT1 knockdown or inhibition can increase TyrRS acetylation levels, further reducing radiation-induced apoptosis after RSV treatment.	Resveratrol	148-151	tyrosyl-tRNA synthetase 1	Homo sapiens	71-76