PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33718067-6	2021	Smad2/Smad3/Smad4 complex could bind to the DIO3OS promotor region and thereby enhanced its transcription which was responsible for the regulation of TGF-beta1 and resveratrol on DIO3OS expression.	Resveratrol	164-175	SMAD family member 4	Homo sapiens	12-17	
27008654-0	2016	Inhibitory Effects of Resveratrol on the Human Alveolar Rhabdomyosarcoma Cell Line PLA-802 through Inhibition of the TGF-beta1/Smad Signaling Pathway.	Resveratrol	22-33	SMAD family member 4	Homo sapiens	127-131	
26316584-11	2016	SIRT1 was up-regulated by RSV inhibited TGF-beta pathway on MMP7 via deacetylating Smad4.	Resveratrol	26-29	SMAD family member 4	Homo sapiens	83-88	
26316584-12	2016	In conclusion, RSV attenuated renal injury and fibrosis by inhibiting EMT process which was attributed to the fact that the up-regulated SIRT1 by RSV deacetylated Smad4 and inhibited MMP7 expression.	Resveratrol	15-18	SMAD family member 4	Homo sapiens	163-168	
27008654-7	2016	Furthermore, expression of TGF-beta1 and its downstream factor Smad4 mRNA and protein, assessed by RT-PCR and Western blot, were inhibited by resveratrol in a concentration- and time-dependent manner.	Resveratrol	142-153	SMAD family member 4	Homo sapiens	63-68	
27008654-8	2016	Immunofluorescent staining results confirmed these changes in expression and showed that co-localization of TGF-beta1 with Smad4 was gradually decreased by resveratrol.	Resveratrol	156-167	SMAD family member 4	Homo sapiens	123-128	
25234611-8	2015	In contrast, resveratrol treatment attenuated LPS-induced EMT and pulmonary fibrosis, meanwhile it suppressed LPS-induced oxidative stress, TGF-beta1 production and activation of Smad signaling pathway.	Resveratrol	13-24	SMAD family member 4	Homo sapiens	179-183	
25234611-9	2015	CONCLUSIONS: Resveratrol may ameliorate LPS-induced EMT and pulmonary fibrosis through suppression of oxidative stress and TGF-beta1/Smad signaling pathway.	Resveratrol	13-24	SMAD family member 4	Homo sapiens	133-137	
21705453-2	2011	EXPERIMENTAL DESIGN: Resveratrol efficacy was evaluated against the HNSCC cells FaDu, Cal27, Det562, and Cal27-Smad4 for viability, DNA damage, cell-cycle progression, and apoptosis, as well as gamma-H2AX expression, and focus formation (gamma-H2AX and Brca1).	Resveratrol	21-32	SMAD family member 4	Homo sapiens	111-116