PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34649540-10 2021 The results of reverse molecular docking suggest that in addition to triptolide, (-)-Epigallocatechin-3-gallate and resveratrol, the other 5 compounds (flavonoids) with similar structures may bind to the same position of STAT1 protein with different docking score. Resveratrol 116-127 signal transducer and activator of transcription 1 Homo sapiens 221-226 29762078-0 2018 Resveratrol Promoted Interferon-alpha-Induced Growth Inhibition and Apoptosis of SMMC7721 Cells by Activating the SIRT/STAT1. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 119-124 29762078-3 2018 In this study, we aimed to investigate whether resveratrol can promote IFN-alpha-induced growth inhibition and the apoptosis on HCC cells through the SIRT/STAT1 pathway. Resveratrol 47-58 signal transducer and activator of transcription 1 Homo sapiens 155-160 29762078-5 2018 Resveratrol not only activated SIRT1 but also induced phosphorylation of STAT1. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 73-78 29762078-6 2018 Further study revealed that ablation of STAT1 reduced the combined antitumor effects of IFN-alpha and resveratrol, lowered the rate of apoptosis, and improved the viability of SMMC7721 cells. Resveratrol 102-113 signal transducer and activator of transcription 1 Homo sapiens 40-45 29762078-7 2018 Whereas STAT1 overexpression strengthened the combined antitumor effects of resveratrol and IFN-alpha. Resveratrol 76-87 signal transducer and activator of transcription 1 Homo sapiens 8-13 29762078-8 2018 Our findings suggest a novel strategy of using resveratrol to enhance the response of HCC to IFN-alpha treatment through the SIRT/STAT1 pathway. Resveratrol 47-58 signal transducer and activator of transcription 1 Homo sapiens 130-135 21189227-7 2011 To understand a mechanism of the action, we tested resveratrol could affect the signal transducers and activation of transcription-1 (STAT-1), a pivotal transcription factor in IFN-gamma-induced expression of inflammatory genes. Resveratrol 51-62 signal transducer and activator of transcription 1 Homo sapiens 80-132 21189227-7 2011 To understand a mechanism of the action, we tested resveratrol could affect the signal transducers and activation of transcription-1 (STAT-1), a pivotal transcription factor in IFN-gamma-induced expression of inflammatory genes. Resveratrol 51-62 signal transducer and activator of transcription 1 Homo sapiens 134-140 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 68-74 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 157-163 21189227-11 2011 Taken together, this study proposes a new mechanism of resveratrol, blocking JAK/STAT-1 pathway that controls inflammatory responses in IFN-gamma-activated macrophages. Resveratrol 55-66 signal transducer and activator of transcription 1 Homo sapiens 81-87 19397895-7 2009 Resveratrol and UVB treatment also decreased the phosphorylation of tyrosine 701 of the important transcription factor signal transducer activator of transcription (STAT1), which in turn inhibited translocation of phospho-STAT1 to the nucleus. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 165-170 19397895-7 2009 Resveratrol and UVB treatment also decreased the phosphorylation of tyrosine 701 of the important transcription factor signal transducer activator of transcription (STAT1), which in turn inhibited translocation of phospho-STAT1 to the nucleus. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 222-227 25271420-6 2014 However, as already verified with 5-aminosalicylic acid, in spite of not exhibiting any effect on IkB-alpha degradation, resveratrol down-regulated JAK-STAT pathway, decreasing the levels of activated STAT1 in the nucleus. Resveratrol 121-132 signal transducer and activator of transcription 1 Homo sapiens 201-206 22118570-6 2012 Consequently, downstream phosphorylation of signal transducer and activator of transcription (STAT)1 and STAT3 upon LPS stimulation was also inhibited by resveratrol. Resveratrol 154-165 signal transducer and activator of transcription 1 Homo sapiens 44-100 22118570-8 2012 Resveratrol treatment also prevented the pro-inflammatory effect of fibrillar Abeta on macrophages by potently inhibiting the effect of Abeta on IkappaB phosphorylation, activation of STAT1 and STAT3, and on tumor necrosis factor-alpha and interleukin-6 secretion. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 184-189 21189227-0 2011 Resveratrol down-regulates interferon-gamma-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation. Resveratrol 0-11 signal transducer and activator of transcription 1 Homo sapiens 123-129 18996091-4 2008 Results revealed that inhibition of proliferation is associated with regulation of the JAK/STAT pathway, where resveratrol prevents phosphorylation of JAK, thereby inhibiting STAT1 phosphorylation. Resveratrol 111-122 signal transducer and activator of transcription 1 Homo sapiens 175-180 18025278-8 2007 Further analysis indicated that resveratrol functions as an effective tyrosine kinase inhibitor, similar to its analogue, piceatannol, and could inhibit Src and Jak kinases, thus resulting in loss of Stat1 activation. Resveratrol 32-43 signal transducer and activator of transcription 1 Homo sapiens 200-205