PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32334435-12	2020	Resveratrol in combination with HQ upregulated C/EBP homologous protein and spliced X-box binding protein 1.	Resveratrol	0-11	X-box binding protein 1	Homo sapiens	84-107	
31483910-9	2020	In addition, gene expression results showed that the expression levels of ATF4 (p<0.05) and ATF6 (p<0.001) significantly increased in resveratrol treatment group, while the expression levels of CHOP, GRP78, and XBP1 (p<0.001 for all) significantly decreased.	Resveratrol	140-151	X-box binding protein 1	Homo sapiens	217-221	
25436452-7	2014	Additionally, RSV decreases radical oxygen species (ROS) generation in palmitate-treated cells but leads to enhanced X-box binding protein-1 (XBP1) splicing and C/EBP homologous protein (CHOP) expression.	Resveratrol	14-17	X-box binding protein 1	Homo sapiens	117-140	
25436452-7	2014	Additionally, RSV decreases radical oxygen species (ROS) generation in palmitate-treated cells but leads to enhanced X-box binding protein-1 (XBP1) splicing and C/EBP homologous protein (CHOP) expression.	Resveratrol	14-17	X-box binding protein 1	Homo sapiens	142-146	
21723843-0	2011	Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.	Resveratrol	0-11	X-box binding protein 1	Homo sapiens	104-108	
21723843-3	2011	We investigated the molecular action of resveratrol on IRE1alpha/XBP1 axis in human MM cells.	Resveratrol	40-51	X-box binding protein 1	Homo sapiens	65-69	
21723843-6	2011	The effect of resveratrol on the transcriptional activity of spliced XBP1 was assessed by luciferase assays.	Resveratrol	14-25	X-box binding protein 1	Homo sapiens	69-73	
21723843-7	2011	Chromatin immunoprecipitation was performed to determine the effects of resveratrol on the DNA binding activity of XBP1 in MM cells.	Resveratrol	72-83	X-box binding protein 1	Homo sapiens	115-119	
21723843-8	2011	RESULTS: Resveratrol activated IRE1alpha as evidenced by XBP1 messenger RNA splicing and phosphorylation of both IRE1alpha and its downstream kinase c-Jun N-terminal kinase in MM cells.	Resveratrol	9-20	X-box binding protein 1	Homo sapiens	57-61	
21723843-10	2011	Resveratrol selectively suppressed the transcriptional activity of XBP1s while it stimulated gene expression of the molecules that are regulated by the non-IRE1/XBP1 axis of the ER stress response.	Resveratrol	0-11	X-box binding protein 1	Homo sapiens	67-71	
21723843-10	2011	Resveratrol selectively suppressed the transcriptional activity of XBP1s while it stimulated gene expression of the molecules that are regulated by the non-IRE1/XBP1 axis of the ER stress response.	Resveratrol	0-11	X-box binding protein 1	Homo sapiens	161-165	
21723843-11	2011	Luciferase assays indicated that resveratrol suppressed the transcriptional activity of XBP1s through sirtuin 1, a downstream molecular target of resveratrol.	Resveratrol	33-44	X-box binding protein 1	Homo sapiens	88-92	
21723843-11	2011	Luciferase assays indicated that resveratrol suppressed the transcriptional activity of XBP1s through sirtuin 1, a downstream molecular target of resveratrol.	Resveratrol	146-157	X-box binding protein 1	Homo sapiens	88-92	
21723843-12	2011	Chromatin immunoprecipitation studies revealed that resveratrol decreased the DNA binding capacity of XBP1 and increased the enrichment of sirtuin 1 at the XBP1 binding region in the XBP1 promoter.	Resveratrol	52-63	X-box binding protein 1	Homo sapiens	102-106	
21723843-12	2011	Chromatin immunoprecipitation studies revealed that resveratrol decreased the DNA binding capacity of XBP1 and increased the enrichment of sirtuin 1 at the XBP1 binding region in the XBP1 promoter.	Resveratrol	52-63	X-box binding protein 1	Homo sapiens	156-160	
21723843-12	2011	Chromatin immunoprecipitation studies revealed that resveratrol decreased the DNA binding capacity of XBP1 and increased the enrichment of sirtuin 1 at the XBP1 binding region in the XBP1 promoter.	Resveratrol	52-63	X-box binding protein 1	Homo sapiens	156-160	
21723843-13	2011	CONCLUSIONS: Resveratrol exerts its chemotherapeutic effect on human MM cells through mechanisms involving the impairment of the pro-survival XBP1 signaling and the activation of pro-apoptotic ER stress response.	Resveratrol	13-24	X-box binding protein 1	Homo sapiens	142-146	
17914584-3	2007	Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2alpha (eIF-2alpha), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP).	Resveratrol	51-62	X-box binding protein 1	Homo sapiens	212-216