PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34512368-3 2021 In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53. Resveratrol 113-124 autophagy related 5 Homo sapiens 338-342 34966970-3 2021 The viability of HuH7 and hep3B cells was suppressed to 23 and 18%, respectively on exposure to 2 microM triethylsilyl resveratrol for 72 h. Triethylsilyl resveratrol treatment of HuH7 cells led to a prominent increase in expression of Atg-5, LC3B-II and Beclin proteins. Resveratrol 119-130 autophagy related 5 Homo sapiens 236-241 34966970-3 2021 The viability of HuH7 and hep3B cells was suppressed to 23 and 18%, respectively on exposure to 2 microM triethylsilyl resveratrol for 72 h. Triethylsilyl resveratrol treatment of HuH7 cells led to a prominent increase in expression of Atg-5, LC3B-II and Beclin proteins. Resveratrol 155-166 autophagy related 5 Homo sapiens 236-241 32544275-6 2021 Further study showed that resveratrol promoted the mRNA expressions of genes involved in mitophagy, such as transcription factor Ebeta (Tfebeta), Bcl1lc3beta, homo sapiens microtubule-associated protein 1 light chain 3 beta (Map1lc3beta), Parkin, sequestosome1 (p62), autophagy related protein (Atg5) and Beclin-1 (Becn1) in the mammary gland. Resveratrol 26-37 autophagy related 5 Homo sapiens 295-299 29461680-6 2018 Furthermore, the expression level of autophagy-related proteins (LC3A/B, ATG-5) decreased with the increased concentration of resveratrol, as determined by immunofluorescence and western blot analysis. Resveratrol 126-137 autophagy related 5 Homo sapiens 73-78 29263464-7 2017 In the meanwhile, resveratrol (RSV) was used to induce autophagy, 3-methyladenine (3-MA) and siRNA against Beclin 1 or ATG5 were used to block auto-phagy, flow cytometric was used to analyze the respiring (mitotracker deep red), total (mitotracker green) and reactive oxygen species (ROS)-generating mitochondria (mitoSOX); Western blot was used to evaluate the expression of IL-1beta. Resveratrol 18-29 autophagy related 5 Homo sapiens 119-123 29263464-7 2017 In the meanwhile, resveratrol (RSV) was used to induce autophagy, 3-methyladenine (3-MA) and siRNA against Beclin 1 or ATG5 were used to block auto-phagy, flow cytometric was used to analyze the respiring (mitotracker deep red), total (mitotracker green) and reactive oxygen species (ROS)-generating mitochondria (mitoSOX); Western blot was used to evaluate the expression of IL-1beta. Resveratrol 31-34 autophagy related 5 Homo sapiens 119-123 24499351-5 2014 However, the depletion of ATG5 significantly suppressed RSV-mediated antimelanogenesis as well as RSV-induced autophagy in melanocytes. Resveratrol 56-59 autophagy related 5 Homo sapiens 26-30 28197628-9 2017 Importantly, resveratrol also stimulated the autophagic mRNA gene expression, including Atg5, Atg12, Beclin-1 and LC3-II in CAR cells. Resveratrol 13-24 autophagy related 5 Homo sapiens 88-92 27698828-12 2016 Knocking down ATG5 or ATG7 expression significantly augmented RSV-induced apoptosis. Resveratrol 62-65 autophagy related 5 Homo sapiens 14-18 26067645-6 2015 Resveratrol induced ATG5 expression and promoted LC3 cleavage. Resveratrol 0-11 autophagy related 5 Homo sapiens 20-24 26067645-9 2015 We also demonstrated that targeting ATG5 by siRNA also suppressed resveratrol-induced apoptotic cell death. Resveratrol 66-77 autophagy related 5 Homo sapiens 36-40 24499351-5 2014 However, the depletion of ATG5 significantly suppressed RSV-mediated antimelanogenesis as well as RSV-induced autophagy in melanocytes. Resveratrol 98-101 autophagy related 5 Homo sapiens 26-30 24499351-6 2014 Moreover, suppression of ATG5 retrieved the RSV-mediated downregulation of tyrosinase and TRP1 in alpha-MSH-treated cells. Resveratrol 44-47 autophagy related 5 Homo sapiens 25-29 23088850-7 2013 Inhibition of autophagy by silencing key autophagy regulators such as ATG5 and Beclin-1 enhanced resveratrol-induced caspase activation. Resveratrol 97-108 autophagy related 5 Homo sapiens 70-74 24145604-10 2013 Furthermore, autophagy inhibitors 3-methyladenine (3-MA), chloroquine as well as ATG5 and BECN1 siRNA significantly attenuated RSV-induced autophagy, which, subsequently, suppressed the downregulation of RSV-induced inflammatory factors expression. Resveratrol 127-130 autophagy related 5 Homo sapiens 81-85 24145604-10 2013 Furthermore, autophagy inhibitors 3-methyladenine (3-MA), chloroquine as well as ATG5 and BECN1 siRNA significantly attenuated RSV-induced autophagy, which, subsequently, suppressed the downregulation of RSV-induced inflammatory factors expression. Resveratrol 204-207 autophagy related 5 Homo sapiens 81-85 22082875-4 2011 Resveratrol-mediated autophagy was shown to enter autophagic degradation in a noncanonical manner, independent of Beclin 1 but dependent on Atg7 and Atg5. Resveratrol 0-11 autophagy related 5 Homo sapiens 149-153 22082875-9 2011 From this it is tempting to speculate that resveratrol promotes noncanonical autophagic degradation downstream of the PtdIns(3)P-WIPI-Atg7-Atg5 pathway, by engaging a distinct subset of LC3-II that might be generated at membrane origins apart from canonical phagophore structures. Resveratrol 43-54 autophagy related 5 Homo sapiens 139-143 20946021-7 2010 In addition, resveratrol was noted to trigger autophagic cell death through the increased expression of autophagy-related Atg5, Atg7, Atg9, and Atg12 proteins. Resveratrol 13-24 autophagy related 5 Homo sapiens 122-126 21695150-6 2011 Rsv induced the formation of autophagosomes in three human GBM cell lines, accompanied by an upregulation of autophagy proteins Atg5, beclin-1 and LC3-II. Resveratrol 0-3 autophagy related 5 Homo sapiens 128-132