PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26706021-4 2016 In addition, resveratrol inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, explaining its effective action against cancer. Resveratrol 13-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 48-79 30535465-5 2019 Moreover, resveratrol was found to inhibit tumor cells under chronic stress by decreasing the expression of the beta2-adrenergic receptor (ADRB-2); in addition, the protein expression of hypoxia-inducible factor (HIF)-1alpha was suppressed by resveratrol in a dose-dependent manner. Resveratrol 10-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 187-224 30535465-5 2019 Moreover, resveratrol was found to inhibit tumor cells under chronic stress by decreasing the expression of the beta2-adrenergic receptor (ADRB-2); in addition, the protein expression of hypoxia-inducible factor (HIF)-1alpha was suppressed by resveratrol in a dose-dependent manner. Resveratrol 243-254 hypoxia inducible factor 1 subunit alpha Homo sapiens 187-224 28456938-7 2018 Resveratrol also prevented the increase of the transcriptional activities of nuclear factor kappaB (NFkappaB) and hypoxia-inducible factor 1 alpha (HIF-1alpha) after LPS challenge. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 114-146 28456938-7 2018 Resveratrol also prevented the increase of the transcriptional activities of nuclear factor kappaB (NFkappaB) and hypoxia-inducible factor 1 alpha (HIF-1alpha) after LPS challenge. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 148-158 28656256-11 2017 Overall, the present study suggests that the synthetic resveratrol analogue HS-1793 is a potent antitumor agent that inhibits tumor growth via the regulation of HIF-1, and demonstrates significant therapeutic potential for solid cancers. Resveratrol 55-66 hypoxia inducible factor 1 subunit alpha Homo sapiens 161-166 26748400-5 2016 Therefore, methoxyamine as base excision repair inhibitor and resveratrol as hypoxia inducible factor 1-alpha inhibitor in combination with iododeoxyuridine as radiosensitizer enhanced the radiosensitization of glioblastoma spheroid cells. Resveratrol 62-73 hypoxia inducible factor 1 subunit alpha Homo sapiens 77-109 30409902-9 2019 Chemical SIRT1 activators (SIRT1720 and resveratrol) suppressed the PGE2-mediated induction of acetyl-HIF-1alpha, HIF-1alpha, and aromatase. Resveratrol 40-51 hypoxia inducible factor 1 subunit alpha Homo sapiens 102-112 30409902-9 2019 Chemical SIRT1 activators (SIRT1720 and resveratrol) suppressed the PGE2-mediated induction of acetyl-HIF-1alpha, HIF-1alpha, and aromatase. Resveratrol 40-51 hypoxia inducible factor 1 subunit alpha Homo sapiens 114-124 26174951-3 2015 Western blot and ELISA assay showed that RSV inhibited hypoxia-inducible factor (HIF)-1alpha accumulation and VEGF secretion induced by cobalt chloride (CoCl2) through SIRT1 in human retinal pigment epithelial (hRPE) cells. Resveratrol 41-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 55-92 24975222-8 2014 Resveratrol repressed the expression of HIF-1alpha protein, but not HIF-1alpha mRNA, and decreased hypoxia-activated HIF-1 activity. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 40-50 26446654-1 2015 PURPOSE: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and on experimental choroidal neovascularization (CNV) in mice. Resveratrol 39-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 72-103 26446654-1 2015 PURPOSE: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and on experimental choroidal neovascularization (CNV) in mice. Resveratrol 39-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 105-115 26446654-6 2015 RESULTS: In ARPE-19 cells, resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation. Resveratrol 27-38 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-73 26446654-6 2015 RESULTS: In ARPE-19 cells, resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation. Resveratrol 27-38 hypoxia inducible factor 1 subunit alpha Homo sapiens 188-198 26074695-6 2015 The expressions of hypoxia inducible factor (HIF)-1alpha, mammalian target of rapamycin (mTOR), and signal transducer and activator of transcription 3 were significantly decreased in the intestinal tissues of mice treated with resveratrol. Resveratrol 227-238 hypoxia inducible factor 1 subunit alpha Homo sapiens 19-56 25367760-5 2015 That results indicated that resveratrol as an inhibitor of hypoxia inducible factor 1 alpha (HIF-1alpha) protein in combination with IUdR as a radiosensitizer enhanced the radiosensitization of glioblastoma spheroid cells. Resveratrol 28-39 hypoxia inducible factor 1 subunit alpha Homo sapiens 59-91 25367760-5 2015 That results indicated that resveratrol as an inhibitor of hypoxia inducible factor 1 alpha (HIF-1alpha) protein in combination with IUdR as a radiosensitizer enhanced the radiosensitization of glioblastoma spheroid cells. Resveratrol 28-39 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-103 26174951-5 2015 Thus, the inhibitory effect of RSV on the HIF-1alpha/VEGF/VEGFR2 signaling axis is mediated, at least in part, through SIRT1. Resveratrol 31-34 hypoxia inducible factor 1 subunit alpha Homo sapiens 42-52 25384583-0 2015 Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1alpha protein. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 137-147 25384583-13 2015 Moreover, resveratrol inhibited HIF-1alpha protein accumulation without affecting the HIF-1alpha mRNA level. Resveratrol 10-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 32-42 25384583-14 2015 These data suggest that resveratrol can inhibit the hypoxia-enhanced proliferation, invasion and epithelial to mesenchymal transition process in osteosarcoma via downregulation of the HIF-1alpha protein. Resveratrol 24-35 hypoxia inducible factor 1 subunit alpha Homo sapiens 184-194 25384583-15 2015 Thus, HIF-1alpha may be a promising drug target of resveratrol in the context of development of anticancer therapy for human osteosarcoma. Resveratrol 51-62 hypoxia inducible factor 1 subunit alpha Homo sapiens 6-16 25297617-5 2014 In LNCaP xenografts, dietary resveratrol decreased the protein level of HIF-1alpha, but not the AR coactivator beta-catenin, and reduced the mRNA levels of androgen-responsive genes. Resveratrol 29-40 hypoxia inducible factor 1 subunit alpha Homo sapiens 72-82 25297617-8 2014 Furthermore, resveratrol repressed the expression level of HIF-1alpha even in the presence of a proteasome inhibitor and suppressed hypoxia-enhanced AR transactivation. Resveratrol 13-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 59-69 25297617-9 2014 These results indicate that dietary resveratrol represses nuclear localization of beta-catenin by decreasing the HIF-1alpha expression, perhaps in a proteasome-independent manner, and inhibits beta-catenin-mediated AR signaling; this contributes to suppression of tumor growth of CRPC. Resveratrol 36-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 113-123 24100602-3 2013 This study investigated the effects of a novel analogue of resveratrol, HS-1793, on the expression of HIF-1alpha and vascular endothelial growth factor (VEGF) in PC-3 human prostate cancer cells. Resveratrol 59-70 hypoxia inducible factor 1 subunit alpha Homo sapiens 102-112 24975222-8 2014 Resveratrol repressed the expression of HIF-1alpha protein, but not HIF-1alpha mRNA, and decreased hypoxia-activated HIF-1 activity. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 40-45 24975222-11 2014 Furthermore, resveratrol decreased the expression of HIF-1alpha protein even in the presence of the proteasome inhibitor MG132 in hypoxia. Resveratrol 13-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 53-63 24975222-12 2014 Theses results indicate that in MCF-7 cells, HIF-1alpha-increased CBR1 expression plays an important role in hypoxia-induced resistance to doxorubicin and that resveratrol and 3,5-dihydroxy-4"-methoxy-trans-stilbene decrease CBR1 expression by decreasing HIF-1alpha protein expression, perhaps through a proteasome-independent pathway, and consequently repress hypoxia-induced resistance to doxorubicin. Resveratrol 160-171 hypoxia inducible factor 1 subunit alpha Homo sapiens 45-55 22245592-6 2012 We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning. Resveratrol 57-68 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-92 23314035-7 2013 Mechanistically, resveratrol treatment downregulated the expression of Bcl-2 and hypoxia-inducible factor-1alpha (HIF-1alpha) proteins and upregulated the expression of caspase-3 protein. Resveratrol 17-28 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-124 23314035-7 2013 Mechanistically, resveratrol treatment downregulated the expression of Bcl-2 and hypoxia-inducible factor-1alpha (HIF-1alpha) proteins and upregulated the expression of caspase-3 protein. Resveratrol 17-28 hypoxia inducible factor 1 subunit alpha Homo sapiens 138-148 24221993-0 2013 Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1alpha activation. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-127 24221993-13 2013 HIF-1alpha protein was markedly reduced by resveratrol, and inhibiting HIF-1alpha expression with cycloheximide or specific small interfering RNAs suppressed (18)F-FDG uptake. Resveratrol 43-54 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 24221993-17 2013 CONCLUSION: Resveratrol suppresses cancer cell (18)F-FDG uptake and glycolytic metabolism in a manner that depends on the capacity of resveratrol to inhibit intracellular ROS, which downregulates HIF-1alpha accumulation. Resveratrol 12-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 196-206 24221993-17 2013 CONCLUSION: Resveratrol suppresses cancer cell (18)F-FDG uptake and glycolytic metabolism in a manner that depends on the capacity of resveratrol to inhibit intracellular ROS, which downregulates HIF-1alpha accumulation. Resveratrol 134-145 hypoxia inducible factor 1 subunit alpha Homo sapiens 196-206 21914476-9 2011 Resveratrol also inhibited HIF-1alpha mRNA expression. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 27-37 21914476-10 2011 CONCLUSIONS: These results suggested that resveratrol attenuates acute hypoxic injury in cardiomyocytes, and the mechanism might be associated with inhibition of iNOS-NO signaling pathway via HIF-1alpha. Resveratrol 42-53 hypoxia inducible factor 1 subunit alpha Homo sapiens 192-202 17473185-2 2007 The purpose of this study was (a) to investigate whether expression of HPV-16 E6 and E7 oncoproteins induces hypoxia-inducible factor 1 alpha (HIF-1 alpha) and vascular endothelial growth factor expression in cervical cancer cells; and (b) to assess the effect of resveratrol on 16 E6- and E7-induced HIF-1 alpha and VEGF gene expression. Resveratrol 264-275 hypoxia inducible factor 1 subunit alpha Homo sapiens 143-154 19828106-9 2009 Resveratrol could down-regulate the expressions of HIF-1alpha, mdr1 and MRP1 significantly. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 51-61 19828106-10 2009 After being treated with resveratrol at different concentrations separately, the expressions of HIF-1alpha, mdr1 and MRP1 in CNE2 cells decreased significantly as compared with paclitaxel alone or paclitaxel plus verapamil (P<0.01). Resveratrol 25-36 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-106 18674879-5 2008 Hypoxia and iron chelator 2,2"-dipyridyl treatment can stimulate the invasion and migration enhancement of Lovo cells, while resveratrol exhibited substantial resistance on the metastasis potential stimulation by inhibiting the mRNA expression of VEGF and MMP-9 in colon carcinoma cells under normoxia and hypoxia, reducing HIF-1 alpha protein expression under hypoxia. Resveratrol 125-136 hypoxia inducible factor 1 subunit alpha Homo sapiens 324-335 18674879-7 2008 These data demonstrated that, the antimetastatic effect of resveratrol under hypoxia were associated with the restriction of HIF-1 alpha protein expression and stabilization, which could be a promising drug target for resveratrol in the development of an effective chemopreventive and anticancer therapy in human tumors. Resveratrol 59-70 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-136 18674879-7 2008 These data demonstrated that, the antimetastatic effect of resveratrol under hypoxia were associated with the restriction of HIF-1 alpha protein expression and stabilization, which could be a promising drug target for resveratrol in the development of an effective chemopreventive and anticancer therapy in human tumors. Resveratrol 218-229 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-136 17919812-0 2007 Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol. Resveratrol 81-92 hypoxia inducible factor 1 subunit alpha Homo sapiens 29-39 17919812-4 2007 These increases in HIF-1alpha and VEGF expression are dramatically attenuated by resveratrol. Resveratrol 81-92 hypoxia inducible factor 1 subunit alpha Homo sapiens 19-29 17919812-5 2007 The underlying mechanism of inhibition of HIF-1alpha expression by resveratrol seems to be associated with both inactivation of p42/p44 MAPK and p70S6K, as well as enhanced degradation of HIF-1alpha protein, resulting in profound decrease in VEGF expression and cell migration. Resveratrol 67-78 hypoxia inducible factor 1 subunit alpha Homo sapiens 42-52 17919812-5 2007 The underlying mechanism of inhibition of HIF-1alpha expression by resveratrol seems to be associated with both inactivation of p42/p44 MAPK and p70S6K, as well as enhanced degradation of HIF-1alpha protein, resulting in profound decrease in VEGF expression and cell migration. Resveratrol 67-78 hypoxia inducible factor 1 subunit alpha Homo sapiens 188-198 17919812-6 2007 Collectively, these results show that LPA under hypoxic condition enhances cell migration through the sequential induction of HIF-1alpha and VEGF, and that this enhancement is efficiently blocked by resveratrol. Resveratrol 199-210 hypoxia inducible factor 1 subunit alpha Homo sapiens 126-136 17473185-6 2007 The effect of resveratrol on oncoprotein-induced HIF-1 alpha/VEGF expression and in vitro angiogenesis was investigated. Resveratrol 14-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 49-60 17473185-10 2007 Functionally, we showed that HPV-16 E6- and E7-transfected cervical cancer cells stimulated in vitro capillary or tubule formation, and these angiogenic effects could be abolished either by cotransfection with HIF-1 alpha siRNA or by treatment with resveratrol. Resveratrol 249-260 hypoxia inducible factor 1 subunit alpha Homo sapiens 210-221 17473185-12 2007 Resveratrol suppresses 16 E6- and E7-induced HIF-1 alpha-mediated angiogenic activity and, thus, is a promising chemotherapeutic agent for human cervical cancer. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 45-56 16227395-0 2005 Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 53-84 16227395-3 2005 Our results showed that resveratrol significantly inhibited both basal level and hypoxia-induced HIF-1alpha protein accumulation in cancer cells, but did not affect HIF-1alpha mRNA levels. Resveratrol 24-35 hypoxia inducible factor 1 subunit alpha Homo sapiens 97-107 16227395-8 2005 These data suggested that HIF-1alpha/VEGF could be a promising drug target for resveratrol in the development of an effective chemopreventive and anticancer therapy in human cancers. Resveratrol 79-90 hypoxia inducible factor 1 subunit alpha Homo sapiens 26-36 35415913-0 2022 Resveratrol may ameliorate rheumatoid arthritis via the STAT3/HIF-1/VEGF molecular pathway. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 62-67 15297429-3 2004 In this study, we investigated the effect of resveratrol on hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells A2780/CP70 and OVCAR-3. Resveratrol 45-56 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-103 15297429-4 2004 We found that although resveratrol did not affect HIF-1alpha mRNA levels, it did dramatically inhibit both basal-level and growth factor-induced HIF-1alpha protein expression in the cells. Resveratrol 23-34 hypoxia inducible factor 1 subunit alpha Homo sapiens 145-155 15297429-6 2004 Mechanistically, we demonstrated that resveratrol inhibited HIF-1alpha and VEGF expression through multiple mechanisms. Resveratrol 38-49 hypoxia inducible factor 1 subunit alpha Homo sapiens 60-70 15297429-7 2004 First, resveratrol inhibited AKT and mitogen-activated protein kinase activation, which played a partial role in the down-regulation of HIF-1alpha expression. Resveratrol 7-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 136-146 15297429-8 2004 Second, resveratrol inhibited insulin-like growth factor 1-induced HIF-1alpha expression through the inhibition of protein translational regulators, including M(r) 70,000 ribosomal protein S6 kinase 1, S6 ribosomal protein, eukaryotic initiation factor 4E-binding protein 1, and eukaryotic initiation factor 4E. Resveratrol 8-19 hypoxia inducible factor 1 subunit alpha Homo sapiens 67-77 15297429-9 2004 Finally, we showed that resveratrol substantially induced HIF-1alpha protein degradation through the proteasome pathway. Resveratrol 24-35 hypoxia inducible factor 1 subunit alpha Homo sapiens 58-68 15297429-10 2004 Our data suggested that resveratrol may inhibit human ovarian cancer progression and angiogenesis by inhibiting HIF-1alpha and VEGF expression and thus provide a novel potential mechanism for the anticancer action of resveratrol. Resveratrol 24-35 hypoxia inducible factor 1 subunit alpha Homo sapiens 112-122 15297429-10 2004 Our data suggested that resveratrol may inhibit human ovarian cancer progression and angiogenesis by inhibiting HIF-1alpha and VEGF expression and thus provide a novel potential mechanism for the anticancer action of resveratrol. Resveratrol 217-228 hypoxia inducible factor 1 subunit alpha Homo sapiens 112-122 34903412-4 2021 Our in vitro experiments in human umbilical vein endothelial cells showed that long term exposure of hyperglycemia induces oxidative stress and suppression of hypoxia inducible factor1alpha (HIF1alpha) signaling pathway, and pterostilbene treatment completely, while resveratrol treatment partly, reversed this effect. Resveratrol 267-278 hypoxia inducible factor 1 subunit alpha Homo sapiens 159-189 34917160-8 2021 Finally, six genes, namely, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2, were selected to validate the treatment effects of the resveratrol. Resveratrol 126-137 hypoxia inducible factor 1 subunit alpha Homo sapiens 35-40 34917160-10 2021 In addition, in these chondrocytes, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 were reduced considerably, but HIF1A was significantly increased after resveratrol treatment. Resveratrol 149-160 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-48 34917160-10 2021 In addition, in these chondrocytes, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 were reduced considerably, but HIF1A was significantly increased after resveratrol treatment. Resveratrol 149-160 hypoxia inducible factor 1 subunit alpha Homo sapiens 109-114 34917160-11 2021 Conclusions: Our data indicates that CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 are all targets of resveratrol therapy. Resveratrol 98-109 hypoxia inducible factor 1 subunit alpha Homo sapiens 44-49 34934403-7 2022 Resveratrol suppresses the production of hypoxia-inducible factor-1alpha and vascular endothelial growth factor proteins. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 41-72 35415913-5 2022 We suggest this hypothesis that Resveratrol (RSV) may act its anti-rheumatoid arthritis effects by STAT3/HIF-1/VEGF pathway for these reasons: (A) RSV exhibits anti-inflammatory properties, which can reduce inflammation of joints, (B) RSV reduces the level of pro-inflammatory cytokines accumulation, (C) RSV can suppress the expression of HIF-1 and VEGF genes and also inhibits STAT3 function. Resveratrol 32-43 hypoxia inducible factor 1 subunit alpha Homo sapiens 105-110 35415913-5 2022 We suggest this hypothesis that Resveratrol (RSV) may act its anti-rheumatoid arthritis effects by STAT3/HIF-1/VEGF pathway for these reasons: (A) RSV exhibits anti-inflammatory properties, which can reduce inflammation of joints, (B) RSV reduces the level of pro-inflammatory cytokines accumulation, (C) RSV can suppress the expression of HIF-1 and VEGF genes and also inhibits STAT3 function. Resveratrol 32-43 hypoxia inducible factor 1 subunit alpha Homo sapiens 340-345 35415913-5 2022 We suggest this hypothesis that Resveratrol (RSV) may act its anti-rheumatoid arthritis effects by STAT3/HIF-1/VEGF pathway for these reasons: (A) RSV exhibits anti-inflammatory properties, which can reduce inflammation of joints, (B) RSV reduces the level of pro-inflammatory cytokines accumulation, (C) RSV can suppress the expression of HIF-1 and VEGF genes and also inhibits STAT3 function. Resveratrol 45-48 hypoxia inducible factor 1 subunit alpha Homo sapiens 105-110 35415913-5 2022 We suggest this hypothesis that Resveratrol (RSV) may act its anti-rheumatoid arthritis effects by STAT3/HIF-1/VEGF pathway for these reasons: (A) RSV exhibits anti-inflammatory properties, which can reduce inflammation of joints, (B) RSV reduces the level of pro-inflammatory cytokines accumulation, (C) RSV can suppress the expression of HIF-1 and VEGF genes and also inhibits STAT3 function. Resveratrol 147-150 hypoxia inducible factor 1 subunit alpha Homo sapiens 105-110 35415913-7 2022 Thus RSV can act as an anti-RA drug in this way, (D) According to previous findings, angiogenesis plays one of the main roles in RA and RSV inhibits angiogenesis via STAT3/HIF-1/VEGF pathway. Resveratrol 5-8 hypoxia inducible factor 1 subunit alpha Homo sapiens 172-177 35415913-7 2022 Thus RSV can act as an anti-RA drug in this way, (D) According to previous findings, angiogenesis plays one of the main roles in RA and RSV inhibits angiogenesis via STAT3/HIF-1/VEGF pathway. Resveratrol 136-139 hypoxia inducible factor 1 subunit alpha Homo sapiens 172-177 35415913-14 2022 We recommend the theory that RSV has therapeutic effects on RA via STAT3/HIF-1/VEGF molecular pathway and we investigate more information about it in this article. Resveratrol 29-32 hypoxia inducible factor 1 subunit alpha Homo sapiens 73-78 35415913-15 2022 As this paper shows pharmacological and clinical documents about RSV in RA, it considers that RSV can ameliorate RA in STAT3/HIF-1/VEGF molecular pathway. Resveratrol 65-68 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-130 35415913-15 2022 As this paper shows pharmacological and clinical documents about RSV in RA, it considers that RSV can ameliorate RA in STAT3/HIF-1/VEGF molecular pathway. Resveratrol 94-97 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-130 33112382-3 2021 We found that HIF1A was markedly suppressed in the presence of resveratrol or a specific SIRT1 activator, SRT2104. Resveratrol 63-74 hypoxia inducible factor 1 subunit alpha Homo sapiens 14-19 33521378-18 2021 In view of this, inhibiting HIF-1alpha release or switching its production to HIF-2alpha by natural products such as resveratrol or by synthetic drugs, offer a good therapeutic strategy that can prevent COVID-19 worst outcome in infected patients. Resveratrol 117-128 hypoxia inducible factor 1 subunit alpha Homo sapiens 28-38 32485183-0 2020 Resveratrol binds and inhibits transcription factor HIF-1alpha in pancreatic cancer. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 52-62 32493094-0 2020 Resveratrol inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting HIF-1alpha. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-103 32493094-10 2020 Furthermore, we demonstrated that resveratrol could reverse the effect of hypoxia on keloids through down-regulation of HIF-1alpha. Resveratrol 34-45 hypoxia inducible factor 1 subunit alpha Homo sapiens 120-130 32493094-11 2020 Moreover, collagen synthesis in keloid fibroblasts was also inhibited by resveratrol, which corresponded with HIF-1alpha suppression. Resveratrol 73-84 hypoxia inducible factor 1 subunit alpha Homo sapiens 110-120 32493094-12 2020 These results provide evidence for resveratrol"s treatment effect against keloids through inhibiting cell proliferation and promoting cell apoptosis, while, HIF-1alpha may play the key role in this process. Resveratrol 35-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 157-167 32485183-2 2020 Resveratrol was identified as a natural compound with many biological functions, with anti-inflammatory, antioxidant, and anticancer effects that inhibit the proliferation and progression of PC cells caused by HIF-1alpha. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 210-220 32485183-3 2020 The current investigation explored the binding affinity and ligand efficacy of resveratrol against HIF-1alpha using an in silico approach, and the execution of molecular dynamics simulation (MDS) increased the prediction precision of these outcomes. Resveratrol 79-90 hypoxia inducible factor 1 subunit alpha Homo sapiens 99-109 32485183-4 2020 This is the first study that provides an in silico characterization of the interaction between resveratrol and HIF-1alpha and its spatial structural arrangements in pancreatic cancer therapy, providing an in-depth analysis of their drug target interactions. Resveratrol 95-106 hypoxia inducible factor 1 subunit alpha Homo sapiens 111-121 32923443-9 2020 We found that resveratrol enhanced Bnip3 transcription through hypoxia-inducible factor 1 (HIF1) and 5" AMP-activated protein kinase (AMPK). Resveratrol 14-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-89 32923443-9 2020 We found that resveratrol enhanced Bnip3 transcription through hypoxia-inducible factor 1 (HIF1) and 5" AMP-activated protein kinase (AMPK). Resveratrol 14-25 hypoxia inducible factor 1 subunit alpha Homo sapiens 91-95 32923443-10 2020 Inhibition of AMPK and HIF1 abolished resveratrol-mediated protection of mitochondrial redox balance and endothelial viability. Resveratrol 38-49 hypoxia inducible factor 1 subunit alpha Homo sapiens 23-27 32273826-10 2020 Resveratrol significantly suppressed the production of the CoCl2-induced HIF-1alpha and VEGF proteins. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 73-83 32482454-6 2020 This insult induced apoptosis and decreased viability during 72 h. The presence of resveratrol significantly attenuated HIF-1alpha and ROS production, reduced apoptosis, promoted the VEGF secretion, and increased the insulin and C-peptide secretion. Resveratrol 83-94 hypoxia inducible factor 1 subunit alpha Homo sapiens 120-130 31960447-0 2020 A combination of pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia-inducible factor 1-alpha and improves hair density in female volunteers. Resveratrol 67-78 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-122 31960447-2 2020 METHODS: The effects of pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol directly on the hypoxic inducible factor-1alpha protein (HIF-1alpha) and related genes expression were demonstrated on keratinocytes in culture in vitro using western-blot analysis and real time quantitative polymerase chain reaction analysis. Resveratrol 74-85 hypoxia inducible factor 1 subunit alpha Homo sapiens 143-153 31960447-5 2020 RESULTS: Pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol stabilized HIF-1a protein and increased the expression of HIF-1alpha target genes. Resveratrol 59-70 hypoxia inducible factor 1 subunit alpha Homo sapiens 82-88 31960447-5 2020 RESULTS: Pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol stabilized HIF-1a protein and increased the expression of HIF-1alpha target genes. Resveratrol 59-70 hypoxia inducible factor 1 subunit alpha Homo sapiens 129-139 31960447-8 2020 CONCLUSION: In addition to the antioxidant properties of resveratrol, the association of pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol revealed a synergistic effect on the HIF-1alpha pathway. Resveratrol 139-150 hypoxia inducible factor 1 subunit alpha Homo sapiens 188-198 32273826-11 2020 Conclusion: These results suggest that resveratrol improves mitochondrial quantity by activating the SIRT1/PGC-1alpha pathway and inhibits VEGF induction through HIF-1alpha under hypoxic conditions. Resveratrol 39-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 162-172 32111491-3 2020 Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-alpha (TNF-alpha), interleukin-17 (IL-17) and other pro-inflammatory molecules and inhibits expression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) that may explain its anti-inflammatory actions. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 195-226 32111491-3 2020 Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-alpha (TNF-alpha), interleukin-17 (IL-17) and other pro-inflammatory molecules and inhibits expression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) that may explain its anti-inflammatory actions. Resveratrol 0-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 228-238 31327131-0 2019 Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial. Resveratrol 11-22 hypoxia inducible factor 1 subunit alpha Homo sapiens 37-41 31327131-8 2019 The results showed a reduction in the expression of VEGF & HIF1 genes under the effect of resveratrol in the granulosa cells (P = 0.0001). Resveratrol 94-105 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-67 31327131-10 2019 CONCLUSIONS: Based on the results, resveratrol may improve some outcomes of PCOS patients, probably through changing the serum levels of some sex hormones and expression of VEGF & HIF1 genes in the angiogenesis pathway of granulosa cells. Resveratrol 35-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 184-188 32238142-11 2020 RESULTS: Resveratrol was found to significantly decrease HIF-1alpha protein levels induced by hypoxia in SGC-7901 cells. Resveratrol 9-20 hypoxia inducible factor 1 subunit alpha Homo sapiens 57-67