PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32414118-7 2020 Consequentially, resveratrol reduced PM-induced cyclooxygenase-2/prostaglandin E2 and proinflammatory cytokine expression, including that of matrix metalloproteinase (MMP)-1, MMP-9, and interleukin-8, all of which are known to be central mediators of various inflammatory conditions and aging. Resveratrol 17-28 prostaglandin-endoperoxide synthase 2 Homo sapiens 48-64 33081687-11 2021 On the other hand, resveratrol has an inhibitory effect on anti-apoptotic mediators such as nuclear factor kappa B (NFkappaB), cyclooxygenase-2 (COX-2), phosphatidylinositol 3-kinase (PI3K) and mTOR. Resveratrol 19-30 prostaglandin-endoperoxide synthase 2 Homo sapiens 127-143 33081687-11 2021 On the other hand, resveratrol has an inhibitory effect on anti-apoptotic mediators such as nuclear factor kappa B (NFkappaB), cyclooxygenase-2 (COX-2), phosphatidylinositol 3-kinase (PI3K) and mTOR. Resveratrol 19-30 prostaglandin-endoperoxide synthase 2 Homo sapiens 145-150 32948212-17 2020 On the other hand, RSV inhibited cyclooxygenase-2 (COX-2), matrix metalloproteinase-1 (MMP-1), MMP-3, MMP-13, and inducible nitric oxide synthase (iNOs) expression (P < 0.05), while increased collagen-II and aggrecan levels (P < 0.05). Resveratrol 19-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 33-49 32948212-17 2020 On the other hand, RSV inhibited cyclooxygenase-2 (COX-2), matrix metalloproteinase-1 (MMP-1), MMP-3, MMP-13, and inducible nitric oxide synthase (iNOs) expression (P < 0.05), while increased collagen-II and aggrecan levels (P < 0.05). Resveratrol 19-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 51-56 28356937-3 2017 The effects of AngII, AT1R, VEGF and COX-2 on resveratrol-induced cell growth inhibition and apoptosis were also examined. Resveratrol 46-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-42 29255096-2 2018 Resveratrol - the polyphenolic phytoalexin - binds to integrin alphavbeta3 to induce apoptosis in cancer cells via cyclooxygenase 2 (COX-2) nuclear accumulation and p53-dependent apoptosis. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 115-131 29255096-2 2018 Resveratrol - the polyphenolic phytoalexin - binds to integrin alphavbeta3 to induce apoptosis in cancer cells via cyclooxygenase 2 (COX-2) nuclear accumulation and p53-dependent apoptosis. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 133-138 29255096-4 2018 In the current study, we found that tetrac promoted resveratrol-induced anti-proliferation in colon cancer cell lines, in primary cultures of colon cancer cells, and in vivo The mechanisms implicated in this action involved the downregulation of nuclear beta-catenin and HMGA2, which are capable of compromising resveratrol-induced COX-2 nuclear translocation. Resveratrol 52-63 prostaglandin-endoperoxide synthase 2 Homo sapiens 332-337 29255096-5 2018 Silencing of either beta-catenin or HMGA2 promoted resveratrol-induced anti-proliferation and COX-2 nuclear accumulation which is essential for integrin alphavbeta3-mediated-resveratrol-induced apoptosis in cancer cells. Resveratrol 174-185 prostaglandin-endoperoxide synthase 2 Homo sapiens 94-99 28435473-6 2017 The present study also found that inhibition of mitochondrial COX-2 with resveratrol (RSV), a natural phytochemical, increased the sensitivity of NPC to 5-fluorouracil (5-FU), a classical chemotherapy drug for NPC. Resveratrol 73-84 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-67 28435473-6 2017 The present study also found that inhibition of mitochondrial COX-2 with resveratrol (RSV), a natural phytochemical, increased the sensitivity of NPC to 5-fluorouracil (5-FU), a classical chemotherapy drug for NPC. Resveratrol 86-89 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-67 28435473-7 2017 The underlying mechanism is that RSV suppresses mitochondrial COX-2, thereby reducing NPC stemness by inhibiting Drp1 activity as demonstrated in both the in vitro and the in vivo studies. Resveratrol 33-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-67 28356937-4 2017 The results indicated that resveratrol treatment may suppress growth, induce apoptosis, and decrease AngII, AT1R, VEGF and COX-2 levels in renal carcinoma ACHN and A498 cells. Resveratrol 27-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 123-128 27980581-0 2016 Developing a CoMSIA Model for Inhibition of COX-2 by Resveratrol Derivatives. Resveratrol 53-64 prostaglandin-endoperoxide synthase 2 Homo sapiens 44-49 27980581-3 2016 Compounds in a series of resveratrol derivatives inhibitors with reported biological activity against COX-2 were used to construct a predictive comparative molecular similarity indices (CoMSIA) model. Resveratrol 25-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 102-107 27323060-9 2016 In summary, we conclude that resveratrol inhibits the proliferation of MCF-7 cells by TTP upregulation, which is associated with downregulation of COX-2 and VEGF and upregulation of iNOS. Resveratrol 29-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 147-152 27035791-0 2016 Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells. Resveratrol 16-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 79-84 27323060-7 2016 In addition, the expression of COX-2 and VEGF were significantly suppressed by resveratrol while that of inducible nitric oxide synthase (iNOS) was upregulated. Resveratrol 79-90 prostaglandin-endoperoxide synthase 2 Homo sapiens 31-36 27323060-8 2016 Lastly, the effects of resveratrol on both MCF-7 proliferation and expression of COX-2, VEGF, and iNOS were significantly inhibited by TTP knockdown, indicating that TTP mediates the anticancer properties of resveratrol. Resveratrol 23-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 27040803-13 2016 The colon cancer cells exposed to resveratrol showed significantly lower cyclooxygenase-2 and prostaglandin receptor expression. Resveratrol 34-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 73-89 25775159-8 2015 In addition, there was also a reduction in UVA-induced cyclooxygenase-2 (COX-2) expression in RPE cells pretreated with resveratrol. Resveratrol 120-131 prostaglandin-endoperoxide synthase 2 Homo sapiens 55-71 25701505-5 2015 70kGy gamma-irradiated resveratrol significantly inhibited cyclooxygenase-2 levels, as well as the expression of cell surface molecules, such as CD80 and CD86, in LPS-induced macrophages. Resveratrol 23-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 59-75 25775159-8 2015 In addition, there was also a reduction in UVA-induced cyclooxygenase-2 (COX-2) expression in RPE cells pretreated with resveratrol. Resveratrol 120-131 prostaglandin-endoperoxide synthase 2 Homo sapiens 73-78 24149798-8 2014 Moreover, cis-resveratrol attenuates cyclooxygenase-2 expression and prostaglandin E2 production. Resveratrol 10-25 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-53 24836925-3 2014 We intend to clarify whether resveratrol and other polyphenols effectively inhibit COX-2 activity and induce apoptosis in hormone-resistant PC-3 cell line. Resveratrol 29-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 83-88 24836925-10 2014 However, under PMA induction tannic acid (2.08 +-.21), gallic acid (2.46 +-.16), quercetin (1.78 +-.14) and resveratrol (1.15 +-.16) significantly inhibited COX-2 mRNA with respect to control (3.14 +-.07), what means a 34%, 23%, 46% and 61% reduction, respectively. Resveratrol 108-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 157-162 22571807-7 2012 Resveratrol treatment suppressed the 4-OHE2-induced activation of IkappaB kinasebeta (IKKbeta) and phosphorylation of IkappaBalpha, and consequently NF-kappaB DNA binding activity and cyclooxygenase-2 (COX-2) expression. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 184-200 23199342-7 2013 Resveratrol and Ad-SIRT1 decreased LPS and nicotine-induced cytotoxicity, ROS and PGE2 production, and expression of cyclooxygenase-2 in HGFs. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 117-133 23257246-5 2013 RESULTS: Resveratrol dose-dependently inhibited TNF-alpha-induced cyclooxygenase-2 (COX-2), MMP-1, MMP-3, MMP-13 and PGE(2) production in human chondrocytes. Resveratrol 9-20 prostaglandin-endoperoxide synthase 2 Homo sapiens 66-82 23257246-5 2013 RESULTS: Resveratrol dose-dependently inhibited TNF-alpha-induced cyclooxygenase-2 (COX-2), MMP-1, MMP-3, MMP-13 and PGE(2) production in human chondrocytes. Resveratrol 9-20 prostaglandin-endoperoxide synthase 2 Homo sapiens 84-89 22571807-7 2012 Resveratrol treatment suppressed the 4-OHE2-induced activation of IkappaB kinasebeta (IKKbeta) and phosphorylation of IkappaBalpha, and consequently NF-kappaB DNA binding activity and cyclooxygenase-2 (COX-2) expression. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 202-207 22571807-9 2012 In conclusion, resveratrol blocks activation of IKKbeta-NF-kappaB signalling and induction of COX-2 expression in 4-OHE2-treated MCF-10A cells, thereby suppressing migration and transformation of these cells. Resveratrol 15-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 94-99 22689577-8 2012 Resveratrol also reversed the IL-1beta- or nicotinamide-induced up-regulation of various gene products that mediate inflammation (cyclooxygenase-2) and matrix degradation (matrix metalloproteinase-9) that are known to be regulated by NF-kappaB. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 130-146 19889203-8 2009 RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3. Resveratrol 37-48 prostaglandin-endoperoxide synthase 2 Homo sapiens 120-136 23091400-5 2012 Inhibition of both aromatase and cyclo-oxygenase-2 expression was significantly greater in the eutopic endometrium of patients using combined drospirenone + resveratrol therapy compared with the endometrium of patients using oral contraceptives alone. Resveratrol 157-168 prostaglandin-endoperoxide synthase 2 Homo sapiens 33-50 23091400-6 2012 CONCLUSION: These results suggest that resveratrol potentiates the effect of oral contraceptives in the management of endometriosis-associated dysmenorrhea by further decreasing aromatase and cyclo-oxygenase-2 expression in the endometrium. Resveratrol 39-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 192-209 21999735-11 2011 A number of studies demonstrated that RSV mediates the downregulation of various inflammatory biomarkers such as tumor necrosis factor, cyclooxygenase 2, inducible nitric oxide synthase and interleukins. Resveratrol 38-41 prostaglandin-endoperoxide synthase 2 Homo sapiens 136-185 20578705-9 2010 Incubation of ARPE-19 cells with 33 mM glucose in the presence of 0-10 microM trans-resveratrol dose-dependently inhibited VEGF, TGF-beta1, COX-2, IL-6, and IL-8 accumulation, PKCbeta activation, and Cx43 degradation and enhanced GJIC. Resveratrol 78-95 prostaglandin-endoperoxide synthase 2 Homo sapiens 140-145 18487053-1 2009 Resveratrol (4,3",5"-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 118-134 19440051-8 2009 Chronic pharmacologic inhibition of COX-2 may oppose the pro-apoptotic effect of resveratrol. Resveratrol 81-92 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-41 18776171-3 2009 RSV blocked 10,12 CLA induction of the inflammatory response by preventing activation of extracellular signal-related kinase and induction of inflammatory gene expression (i.e., IL-6, IL-8, IL-1beta) within 12 h. Similarly, RSV suppressed 10,12 CLA-mediated activation of the inflammatory prostaglandin pathway involving phospholipase A(2), cyclooxygenase-2, and PGF(2alpha). Resveratrol 0-3 prostaglandin-endoperoxide synthase 2 Homo sapiens 341-357 18776171-3 2009 RSV blocked 10,12 CLA induction of the inflammatory response by preventing activation of extracellular signal-related kinase and induction of inflammatory gene expression (i.e., IL-6, IL-8, IL-1beta) within 12 h. Similarly, RSV suppressed 10,12 CLA-mediated activation of the inflammatory prostaglandin pathway involving phospholipase A(2), cyclooxygenase-2, and PGF(2alpha). Resveratrol 224-227 prostaglandin-endoperoxide synthase 2 Homo sapiens 341-357 18446786-0 2008 Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 19-24 18381589-0 2008 Resveratrol directly targets COX-2 to inhibit carcinogenesis. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 29-34 18381589-4 2008 Research findings suggest that resveratrol (RSVL; 3,5,4"-trihydroxy-trans-stilbene) demonstrates nonselective COX-2 inhibition. Resveratrol 31-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 110-115 18381589-4 2008 Research findings suggest that resveratrol (RSVL; 3,5,4"-trihydroxy-trans-stilbene) demonstrates nonselective COX-2 inhibition. Resveratrol 44-48 prostaglandin-endoperoxide synthase 2 Homo sapiens 110-115 18381589-5 2008 We report herein that RSVL directly binds with COX-2 and this binding is absolutely required for RSVL"s inhibition of the ability of human colon adenocarcinoma HT-29 cells to form colonies in soft agar. Resveratrol 22-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-52 18381589-5 2008 We report herein that RSVL directly binds with COX-2 and this binding is absolutely required for RSVL"s inhibition of the ability of human colon adenocarcinoma HT-29 cells to form colonies in soft agar. Resveratrol 97-101 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-52 18381589-6 2008 Binding of COX-2 with RSVL was compared with two RSVL analogues, 3,3",4",5",5-pentahydroxy-trans-stilbene (RSVL-2) or 3,4",5-trimethoxy-trans-stilbene (RSVL-3). Resveratrol 22-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 11-16 18381589-7 2008 The results indicated that COX-2 binds with RSVL-2 more strongly than with RSVL, but does not bind with RSVL-3. Resveratrol 44-48 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-32 18381589-10 2008 RSVL or RSVL-2 (not RSVL-3) suppressed growth of COX-2(+/+) cells by 60% or 80%, respectively. Resveratrol 0-4 prostaglandin-endoperoxide synthase 2 Homo sapiens 49-54 18446786-7 2008 Resveratrol-induced nuclear COX-2 accumulation was dependent upon ERK1/2 activation, but not p53 activation. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 28-33 18446786-9 2008 In UMSCC-22B cells, resveratrol-induced apoptosis and induction of nuclear COX-2 accumulation share dependence on the ERK1/2 signal transduction pathway. Resveratrol 20-31 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-80 18446786-10 2008 Resveratrol-inducible nuclear accumulation of COX-2 is essential for p53 activation and p53-dependent apoptosis in these cancer cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 46-51 18446786-2 2008 We have investigated the mechanism by which resveratrol, a stilbene that is pro-apoptotic in many tumor cell lines, causes apoptosis in human head and neck squamous cell carcinoma UMSCC-22B cells by a mechanism involving cellular COX-2. Resveratrol 44-55 prostaglandin-endoperoxide synthase 2 Homo sapiens 230-235 18446786-6 2008 Resveratrol also caused p53 binding to the p21 promoter and increased abundance of COX-2 protein in UMSCC-22B cell nuclei. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 83-88 17604631-1 2007 Resveratrol ((E)-3,4",5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 134-150 17604631-1 2007 Resveratrol ((E)-3,4",5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. Resveratrol 13-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 134-150 16928824-7 2006 A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. Resveratrol 186-197 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-29 17569614-5 2007 Resveratrol has also been shown to reduce inflammation via inhibition of prostaglandin production, cyclooxygenase-2 activity, and nuclear factor-kappaB activity. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 99-115 18001219-6 2007 The TCDD-induced binding of the AhR to COX-2 and CYP1A1 oligonucleotides was repressed by cotreatment with CLA (t10,c12-CLA > c9,t11-CLA), and the AhR antagonists, 3-methoxy-4-naphthoflavone, and resveratrol. Resveratrol 199-210 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-44 16928824-0 2006 Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 20-36 16928824-7 2006 A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. Resveratrol 186-197 prostaglandin-endoperoxide synthase 2 Homo sapiens 77-82 16928824-3 2006 We show here for the first time that a stilbene, resveratrol, induces nuclear accumulation of COX-2 protein in human breast cancer MCF-7 and MDA-MB-231 cell cultures. Resveratrol 49-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 94-99 16928824-8 2006 We conclude that nuclear accumulation of COX-2 can be induced by resveratrol and that the COX has a novel intranuclear colocalization with Ser(15)-phosphorylated p53 and p300, which facilitates apoptosis in resveratrol-treated breast cancer cells. Resveratrol 65-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-46 16928824-4 2006 The induction of COX-2 accumulation by resveratrol is mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase 1/2)- and activator protein 1- dependent. Resveratrol 39-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-22 16928824-5 2006 Nuclear COX-2 in resveratrol-treated cells colocalizes with Ser(15)-phosphorylated p53 and with p300, a coactivator for p53-dependent gene expression. Resveratrol 17-28 prostaglandin-endoperoxide synthase 2 Homo sapiens 8-13 16928824-8 2006 We conclude that nuclear accumulation of COX-2 can be induced by resveratrol and that the COX has a novel intranuclear colocalization with Ser(15)-phosphorylated p53 and p300, which facilitates apoptosis in resveratrol-treated breast cancer cells. Resveratrol 207-218 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-46 16685418-0 2006 Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-73 14760624-5 2004 These results indicate that styrylquinazolines can be considered as potential resveratrol analogues in the modulation of prostaglandin production by COX-2. Resveratrol 78-89 prostaglandin-endoperoxide synthase 2 Homo sapiens 149-154 15180920-10 2004 Resveratrol also inhibited granulocyte-macrophage colony-stimulating factor release (IC50 = 0.44 +/- 0.17 microM), IL-8 release (IC50 = 4.7 +/- 3.3 microM), and cyclooxygenase-2 expression in these cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 161-177 11895924-10 2002 Seg-1 cells expressed basal levels of cyclooxygenase-2 (cox-2), which was further induced by resveratrol. Resveratrol 93-104 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-54 12942161-1 2003 Resveratrol, a phytoalexin found in red wine, has several pharmacological properties which include inhibition of arachidonate metabolism in leukocytes and platelets, modulation of lipid metabolism, inhibition of platelet aggregation and lipid peroxidation, reduction of expression and activity of cyclooxygenase-2. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 297-313 11895924-10 2002 Seg-1 cells expressed basal levels of cyclooxygenase-2 (cox-2), which was further induced by resveratrol. Resveratrol 93-104 prostaglandin-endoperoxide synthase 2 Homo sapiens 56-61 10668496-0 1999 Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 21-37 10837497-10 2000 This enhancement was dependent upon concurrent up-regulation of SMC cyclooxygenase-2 expression and activity and was blocked by the cyclooxygenase-2 inhibitors NS-398 and Resveratrol. Resveratrol 171-182 prostaglandin-endoperoxide synthase 2 Homo sapiens 68-84 10837497-10 2000 This enhancement was dependent upon concurrent up-regulation of SMC cyclooxygenase-2 expression and activity and was blocked by the cyclooxygenase-2 inhibitors NS-398 and Resveratrol. Resveratrol 171-182 prostaglandin-endoperoxide synthase 2 Homo sapiens 132-148 10668496-5 1999 Nuclear runoffs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by resveratrol. Resveratrol 122-133 prostaglandin-endoperoxide synthase 2 Homo sapiens 44-49 11567657-7 2001 These protective and hyperemic effects of standard preconditioning were significantly attenuated by pretreatment with cyclooxygenase-2 and cyclooxygenase-1 inhibitors, such as indomethacin, Vioxx, resveratrol and nitric oxide (NO)-synthase inhibitor, N(G)-nitro-L-arginine (L-NNA). Resveratrol 197-208 prostaglandin-endoperoxide synthase 2 Homo sapiens 118-134 11480663-0 2001 Resveratrol inhibits the expression of cyclooxygenase-2 in mammary epithelial cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-55 10871330-4 2000 A Western blot analysis demonstrated that cyclooxygenase-2 induction stimulated by fetal calf serum or platelet-derived growth factor was inhibited by resveratrol. Resveratrol 151-162 prostaglandin-endoperoxide synthase 2 Homo sapiens 42-58 10783318-7 2000 Chemopreventive agents such as quercetin, kaempferol, genistein, resveratrol and resorcinol, all having a common resorcin moiety, were found to effectively suppress the COX-2 promoter activity with and without TGFalpha-stimulation in DLD-1 cells. Resveratrol 65-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 169-174 10668496-6 1999 Resveratrol inhibited PMA-mediated activation of protein kinase C and the induction of COX-2 promoter activity by c-Jun. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 87-92 10668496-2 1999 In this study, we investigated whether resveratrol, a chemopreventive agent found in grapes, could suppress phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells. Resveratrol 39-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-155 35353606-8 2022 RSV can activate the human silent information regulator 2/sirtuin 1 (Sirt-1) and can inhibit the cyclooxygenase-2 (COX-2), 5-lipoxygenase, and nuclear factor-kappaB, resulting in the reduction of the proinflammation pathways. Resveratrol 0-3 prostaglandin-endoperoxide synthase 2 Homo sapiens 97-113 9705326-0 1998 Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 21-37 9785383-5 1998 In vitro experiments to resolve these seemingly paradoxical observations revealed that resveratrol is not only an inhibitor of PGHS-1 but also is an activator of PGHS-2. Resveratrol 87-98 prostaglandin-endoperoxide synthase 2 Homo sapiens 162-168 9785383-6 1998 Resveratrol non-competitively inhibited PGHS-1 with a K1 of 26 +/- 2 microM but enhanced the PGHS-2 activity nearly twofold. Resveratrol 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 93-99 34917160-8 2021 Finally, six genes, namely, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2, were selected to validate the treatment effects of the resveratrol. Resveratrol 126-137 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 34917160-10 2021 In addition, in these chondrocytes, CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 were reduced considerably, but HIF1A was significantly increased after resveratrol treatment. Resveratrol 149-160 prostaglandin-endoperoxide synthase 2 Homo sapiens 72-77 34917160-11 2021 Conclusions: Our data indicates that CXCL1, HIF1A, IL-6, MMP3, NOX4, and PTGS2 are all targets of resveratrol therapy. Resveratrol 98-109 prostaglandin-endoperoxide synthase 2 Homo sapiens 73-78 35353606-8 2022 RSV can activate the human silent information regulator 2/sirtuin 1 (Sirt-1) and can inhibit the cyclooxygenase-2 (COX-2), 5-lipoxygenase, and nuclear factor-kappaB, resulting in the reduction of the proinflammation pathways. Resveratrol 0-3 prostaglandin-endoperoxide synthase 2 Homo sapiens 115-120 35159089-12 2022 Moreover, inhibiting mito-COX-2 acetylation with the natural phytochemical resveratrol resulted in reducing cell proliferation and mitochondrial fission, occurring through upregulation of mitochondrial deacetylase sirtuin 3 (SIRT3), which, in turn, increased the chemosensitivity of HCC to platinum drugs in vitro and in vivo. Resveratrol 75-86 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-31