PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33974882-5 2021 In control rats, 5 mg/kg/d trans-resveratrol administration for 30 days increased gene expressions of tumor suppressor protein 53, Bcl2-associated X protein, B-cell lymphoma-2 (Bcl2), Caspase-3 (CASP3), CASP8 and CASP9, p38alphaMAPK, c-Jun N-terminal kinase-1 (JNK1), and extracellular signal-regulated kinase-1 (ERK1). Resveratrol 27-44 mitogen-activated protein kinase 8 Rattus norvegicus 234-259 33974882-5 2021 In control rats, 5 mg/kg/d trans-resveratrol administration for 30 days increased gene expressions of tumor suppressor protein 53, Bcl2-associated X protein, B-cell lymphoma-2 (Bcl2), Caspase-3 (CASP3), CASP8 and CASP9, p38alphaMAPK, c-Jun N-terminal kinase-1 (JNK1), and extracellular signal-regulated kinase-1 (ERK1). Resveratrol 27-44 mitogen-activated protein kinase 8 Rattus norvegicus 261-265 33974882-7 2021 Trans-resveratrol reversed the inhibited gene expressions of CASP8, p38alphaMAPK, JNK, and ERK1 to normal control levels in diabetic rats. Resveratrol 0-17 mitogen-activated protein kinase 8 Rattus norvegicus 82-85 32905656-0 2021 The deleterious effect of stress-induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway. Resveratrol 85-96 mitogen-activated protein kinase 8 Rattus norvegicus 147-150 32905656-5 2021 Molecular signaling of resveratrol and DMF was estimated by diminishing hepatic expression of phosphorylated p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK). Resveratrol 23-34 mitogen-activated protein kinase 8 Rattus norvegicus 209-232 32905656-5 2021 Molecular signaling of resveratrol and DMF was estimated by diminishing hepatic expression of phosphorylated p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK). Resveratrol 23-34 mitogen-activated protein kinase 8 Rattus norvegicus 234-237 32905656-8 2021 In conclusion, resveratrol and DMF purveyed a significant anti-depressant effect, which may be mediated, at least in part, via inhibiting the MAPK/ERK/JNK pathway in the CUMS rat model. Resveratrol 15-26 mitogen-activated protein kinase 8 Rattus norvegicus 151-154 35196531-11 2022 Resveratrol and exercise enhanced mRNA expression of caspase-3, bax, and bcl-2 involved in the apoptotic pathway, but attenuated phosphorylation of stress-related mitogenic proteins p38 and JNK induced by hypertension. Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 190-193 22709670-11 2012 JNK was also suggested to play a protective role through in neuroprotection of resveratrol, which may also be contributing to reduction in neuroinflammation. Resveratrol 79-90 mitogen-activated protein kinase 8 Rattus norvegicus 0-3 22012614-0 2012 Resveratrol mobilizes Ca2+ from intracellular stores and induces c-Jun N-terminal kinase activation in tumoral AR42J cells. Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 65-88 22012614-9 2012 Finally, incubation of AR42J cells in the presence of resveratrol led to activation of c-Jun N-terminal kinase (JNK), a mitogen-activated protein kinase responsive to stress stimuli. Resveratrol 54-65 mitogen-activated protein kinase 8 Rattus norvegicus 87-110 22012614-9 2012 Finally, incubation of AR42J cells in the presence of resveratrol led to activation of c-Jun N-terminal kinase (JNK), a mitogen-activated protein kinase responsive to stress stimuli. Resveratrol 54-65 mitogen-activated protein kinase 8 Rattus norvegicus 112-115 22012614-12 2012 Reorganization of cell"s survival/death processes in the presence of resveratrol may involve Ca(2+)-mediated JNK activation. Resveratrol 69-80 mitogen-activated protein kinase 8 Rattus norvegicus 109-112 31872196-4 2020 Resveratrol markedly inhibited the expression of endoplasmic reticulum chaperone GRP 78/94 and ERS-related apoptosis proteins CHOP, Caspase12, and JNK induced by 2-DG. Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 147-150 30507263-0 2019 Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 108-111 29306408-9 2018 The results indicated that RSV could alleviate cognitive impairment, reduce neuronal loss, downregulate p-JAK, p-ERK, p-STAT and p-JNK expression and inflammatory cytokines. Resveratrol 27-30 mitogen-activated protein kinase 8 Rattus norvegicus 131-134 29723857-10 2018 CONCLUSION: Resveratrol protects cardiac cells by regulating the switch between autophagy and apoptotic machinery under diabetic conditions, which is attributed by AMPK-mediated phosphorylation of mTORC1/p70S6K1/4EBP1 and JNK-mediated dissociation of Beclin1-Bcl-2. Resveratrol 12-23 mitogen-activated protein kinase 8 Rattus norvegicus 222-225 28322346-6 2017 RSV could inhibit the signaling cascades of NF-kappaBp65 and MAPKs through down-regulating the mRNA levels of IkappaBalpha, p38MAPK, JNK, ERK1, ERK2 and ERK5 in liver and lung, and suppressing the dynamic changes of proteins and phosphorylated proteins including IkappaBalpha, NF-kappaBp65, p38MAPK, JNK, ERK1/2 and ERK5 from tissue"s cytoplasm to nucleus. Resveratrol 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 133-136 28322346-6 2017 RSV could inhibit the signaling cascades of NF-kappaBp65 and MAPKs through down-regulating the mRNA levels of IkappaBalpha, p38MAPK, JNK, ERK1, ERK2 and ERK5 in liver and lung, and suppressing the dynamic changes of proteins and phosphorylated proteins including IkappaBalpha, NF-kappaBp65, p38MAPK, JNK, ERK1/2 and ERK5 from tissue"s cytoplasm to nucleus. Resveratrol 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 300-303 26499206-0 2015 Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 98-121 26499206-6 2015 Resveratrol also recovered diabetes-induced increases in JNK signaling pathway proteins, namely, ASK1 (apoptosis signal-regulating kinase 1), JNKs (46 and 54 kDa isoforms) and p-JNK to normal control levels (P<0.05). Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 57-60 26499206-6 2015 Resveratrol also recovered diabetes-induced increases in JNK signaling pathway proteins, namely, ASK1 (apoptosis signal-regulating kinase 1), JNKs (46 and 54 kDa isoforms) and p-JNK to normal control levels (P<0.05). Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 142-145 26499206-10 2015 In conclusion, Resveratrol alleviates diabetes-induced apoptosis in testis by modulating oxidative stress, JNK signaling pathway and caspase-3 activities, but not by inhibiting hyperglycemia, in rats. Resveratrol 15-26 mitogen-activated protein kinase 8 Rattus norvegicus 107-110 26283207-9 2015 Analysis of signaling pathways in this study demonstrated that RSV increased JNK phosphorylation but decreased Akt phosphorylation and increased NF-kappaB activation. Resveratrol 63-66 mitogen-activated protein kinase 8 Rattus norvegicus 77-80 26283207-10 2015 CONCLUSION: RSV decreases cytokine-induced hepatocyte iNOS expression, possibly through up-regulation of the JNK signaling pathway. Resveratrol 12-15 mitogen-activated protein kinase 8 Rattus norvegicus 109-112 22245600-0 2012 High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-kappaB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. Resveratrol 154-165 mitogen-activated protein kinase 8 Rattus norvegicus 91-94 22245600-9 2012 Resveratrol prevented HG-induced mesangial cell proliferation and fibronectin expression through inhibiting HG-induced JNK and NF-kappaB activation, NADPH oxidase activity elevation and ROS production. Resveratrol 0-11 mitogen-activated protein kinase 8 Rattus norvegicus 119-122 22245600-10 2012 These results demonstrate that HG enhances mesangial cell proliferation and fibronectin expression through JNK/NF-kappaB/NADPH oxidase/ROS pathway, which was inhibited by resveratrol. Resveratrol 171-182 mitogen-activated protein kinase 8 Rattus norvegicus 107-110 19723098-6 2009 Treatment of PC12 cells with resveratrol increased their viability in a dose-dependent manner by blocking the activation of JNK and the downregulation of Bcl-2. Resveratrol 29-40 mitogen-activated protein kinase 8 Rattus norvegicus 124-127