PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25352008-0 2015 Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 160-163 25352008-12 2015 Additionally, RSV activated the phosphorylation of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and AKT. Resveratrol 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 109-112 24602480-2 2014 The aim of this study was to evaluate the antiapoptotic function of resveratrol in EBI and its relationship with the PI3K/Akt survival pathway. Resveratrol 68-79 AKT serine/threonine kinase 1 Rattus norvegicus 122-125 25388341-0 2014 [Resveratrol attenuates hypoxia-reperfusion injury induced rat myocardium microvascular endothelial cell dysfunction through upregulating PI3K/Akt/SVV pathways]. Resveratrol 1-12 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 25388341-8 2014 CONCLUSION: Resveratrol could significantly reduce H/RI induced apoptosis and attenuate H/RI induced cardiac microvascular endothelial cells dysfunction through up-regulating PI3K/Akt/SVV pathways. Resveratrol 12-23 AKT serine/threonine kinase 1 Rattus norvegicus 180-183 24974003-6 2014 Examination of prefrontal cortex subregion protein samples following acute resveratrol treatment in a separate cohort revealed that while monoamine oxidase A (MAOA) enzymatic activity remained unaltered, nuclear AKT activation was selectively increased in the infralimbic cortex, but not in the prelimbic or anterior cingulate cortex. Resveratrol 75-86 AKT serine/threonine kinase 1 Rattus norvegicus 212-215 24602480-6 2014 RESULTS: High-concentration but not low-concentration resveratrol treatment in SAH rats led to a significant increase in phosphorylated Akt (p-Akt) protein levels compared with SAH rats without treatment. Resveratrol 54-65 AKT serine/threonine kinase 1 Rattus norvegicus 136-139 24602480-6 2014 RESULTS: High-concentration but not low-concentration resveratrol treatment in SAH rats led to a significant increase in phosphorylated Akt (p-Akt) protein levels compared with SAH rats without treatment. Resveratrol 54-65 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 24602480-9 2014 The antiapoptotic effect of resveratrol in SAH rats could be partially abrogated by the PI3K/Akt signaling inhibitor LY294002. Resveratrol 28-39 AKT serine/threonine kinase 1 Rattus norvegicus 93-96 24602480-10 2014 CONCLUSIONS: Our results show that resveratrol has an antiapoptotic effect in EBI and that resveratrol might act through the PI3K/Akt signaling pathway. Resveratrol 91-102 AKT serine/threonine kinase 1 Rattus norvegicus 130-133 22817531-0 2012 Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3beta and CREB through PI3-K/Akt pathways. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 121-124 24547812-11 2014 CONCLUSIONS AND IMPLICATIONS: Collectively, resveratrol decreased BP through the phosphorylation of AMPK, Akt and neuronal NOS in fructose-fed rats. Resveratrol 44-55 AKT serine/threonine kinase 1 Rattus norvegicus 106-109 24534837-10 2014 Moreover, resveratrol induced the activation of ERK1/2, as well as the downregulation of Akt and mTOR phosphorylation. Resveratrol 10-21 AKT serine/threonine kinase 1 Rattus norvegicus 89-92 24534837-12 2014 In addition, resveratrol-induced autophagy is regulated by the PI3K/Akt/mTOR and ERK1/2 pathways. Resveratrol 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 68-71 25158994-8 2014 Moreover, the exercise training plus resveratrol group benefited from SIRT1 and PI3K-Akt dual pathways and blocked FOXO3 accumulation. Resveratrol 37-48 AKT serine/threonine kinase 1 Rattus norvegicus 85-88 23786522-8 2014 In diabetic slow-twitch muscle, RSV treatment elevated manganese SOD (MnSOD) and phosphorylated Akt protein levels and reduced acetyl-CoA carboxylase (ACC) phosphorylation. Resveratrol 32-35 AKT serine/threonine kinase 1 Rattus norvegicus 96-99 24738020-5 2014 Although PDGF stimulation elicited strong and detectable Akt and mTOR phosphorylations lasting for several hours, Akt activation was much weaker when PDGF was used with resveratrol. Resveratrol 169-180 AKT serine/threonine kinase 1 Rattus norvegicus 114-117 24738020-7 2014 In conclusion, RAOSMC dedifferentiation, phenotype, and proliferation rate were inhibited by resveratrol via interruption of the balance of Akt, 42/44MAPK, and p38MAPK pathway activation stimulated by PDGF-bb. Resveratrol 93-104 AKT serine/threonine kinase 1 Rattus norvegicus 140-143 22817531-8 2012 Both GSK-3beta and CREB appear to play a critical role in resveratrol neuroprotection through the PI3-K/Akt pathway, as resveratrol pretreatment increased the phosphorylation of Akt, GSK-3beta and CREB in 1 h in the CA1 hippocampus after ischemia/reperfusion. Resveratrol 58-69 AKT serine/threonine kinase 1 Rattus norvegicus 104-107 22817531-8 2012 Both GSK-3beta and CREB appear to play a critical role in resveratrol neuroprotection through the PI3-K/Akt pathway, as resveratrol pretreatment increased the phosphorylation of Akt, GSK-3beta and CREB in 1 h in the CA1 hippocampus after ischemia/reperfusion. Resveratrol 58-69 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 22817531-8 2012 Both GSK-3beta and CREB appear to play a critical role in resveratrol neuroprotection through the PI3-K/Akt pathway, as resveratrol pretreatment increased the phosphorylation of Akt, GSK-3beta and CREB in 1 h in the CA1 hippocampus after ischemia/reperfusion. Resveratrol 120-131 AKT serine/threonine kinase 1 Rattus norvegicus 104-107 22817531-8 2012 Both GSK-3beta and CREB appear to play a critical role in resveratrol neuroprotection through the PI3-K/Akt pathway, as resveratrol pretreatment increased the phosphorylation of Akt, GSK-3beta and CREB in 1 h in the CA1 hippocampus after ischemia/reperfusion. Resveratrol 120-131 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 22817531-10 2012 Taken together, the results suggest that resveratrol protects against delayed neuronal death in the hippocampal CA1 by maintaining the pro-survival states of Akt, GSK-3beta and CREB pathways. Resveratrol 41-52 AKT serine/threonine kinase 1 Rattus norvegicus 158-161 22817531-11 2012 These data suggest that the neuroprotective effect of resveratrol may be mediated through activation of the PI3-K/Akt signaling pathway, subsequently downregulating expression of GSK-3beta and CREB, thereby leading to prevention of neuronal death after brain ischemia in rats. Resveratrol 54-65 AKT serine/threonine kinase 1 Rattus norvegicus 114-117 21764074-0 2012 Role of Akt-dependent pathway in resveratrol-mediated cardioprotection after trauma-hemorrhage. Resveratrol 33-44 AKT serine/threonine kinase 1 Rattus norvegicus 8-11 23189743-0 2012 [Inhibitory effect of resveratrol on ischemia reperfusion-induced cardiocyte apoptosis and its relationship with PI3K-Akt signaling pathway]. Resveratrol 22-33 AKT serine/threonine kinase 1 Rattus norvegicus 118-121 23189743-1 2012 OBJECTIVE: To study the effect of resveratol on ischemia reperfusion-induced cardiocyte apoptosis and its relationship with PI3K-Akt signaling pathway. Resveratrol 34-44 AKT serine/threonine kinase 1 Rattus norvegicus 129-132 23189743-10 2012 CONCLUSION: Resveratol can inhibit the ischemia reperfusion-induced cardiocyte apoptosis, in which PI3K-Akt signaling pathway gets involved. Resveratrol 12-22 AKT serine/threonine kinase 1 Rattus norvegicus 104-107 21764074-2 2012 The aim of this study is to determine whether resveratrol provides cardioprotection mediated via an Akt-dependent pathway in trauma-hemorrhaged animals. Resveratrol 46-57 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 21764074-14 2012 CONCLUSION: Resveratrol attenuates cardiac injury following trauma-hemorrhage, which is, at least in part, due to its anti-inflammatory effects via Akt-dependent pathways. Resveratrol 12-23 AKT serine/threonine kinase 1 Rattus norvegicus 148-151 21071431-0 2011 Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 19-22 21248286-0 2011 Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT-dependent manner. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 109-112 21248286-13 2011 These data support the hypothesis that resveratrol can act in a prosurvival or antiapoptotic way through AKT, XIAP, and PTGS2 regulation in the endometrium and could positively affect the outcome of pregnancy and favor fertility. Resveratrol 39-50 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 21071431-1 2011 AIMS: Resveratrol (RV), an antioxidant, inhibits angiotensin II (Ang II)-induced hypertrophy and Ang II- or epidermal growth factor (EGF)-induced Akt phosphorylation in rat vascular smooth muscle cells (VSMCs). Resveratrol 6-17 AKT serine/threonine kinase 1 Rattus norvegicus 146-149 21071431-1 2011 AIMS: Resveratrol (RV), an antioxidant, inhibits angiotensin II (Ang II)-induced hypertrophy and Ang II- or epidermal growth factor (EGF)-induced Akt phosphorylation in rat vascular smooth muscle cells (VSMCs). Resveratrol 19-21 AKT serine/threonine kinase 1 Rattus norvegicus 146-149 20398797-0 2010 Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway. Resveratrol 48-59 AKT serine/threonine kinase 1 Rattus norvegicus 135-138 20978231-7 2011 Injection (ip) of resveratrol in rats potently increased muscle microvascular blood volume (MBV; P = 0.007) and flow (MBF; P < 0.02) within 30 min, and this was sustained for at least 2 h. The phosphorylation of Akt in liver or muscle was unchanged. Resveratrol 18-29 AKT serine/threonine kinase 1 Rattus norvegicus 215-218 19799646-8 2010 Most importantly, resveratrol and gamma-tocotrienol acted synergistically providing greater degree of cardioprotection simultaneously generating greater amount of survival signal through the activation of Akt-Bcl-2 survival pathway. Resveratrol 18-29 AKT serine/threonine kinase 1 Rattus norvegicus 205-208 20117814-0 2010 Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Resveratrol 58-69 AKT serine/threonine kinase 1 Rattus norvegicus 8-11 20117814-3 2010 The aim of this study is to elucidate whether Akt/HO-1 plays any role in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Resveratrol 73-84 AKT serine/threonine kinase 1 Rattus norvegicus 46-49 20117814-9 2010 Resveratrol treatment also increased hepatic Akt activation and HO-1 expression as compared with vehicle-treated trauma hemorrhaged rats. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 45-48 20117814-11 2010 CONCLUSION: These findings collectively suggest that the salutary effects of resveratrol administration on attenuation of hepatic injury after trauma hemorrhage are likely mediated via up-regulation of Akt-dependent HO-1 expression. Resveratrol 77-88 AKT serine/threonine kinase 1 Rattus norvegicus 202-205 20828608-9 2010 These results indicate that insulin and RSV synergistically prevented cardiac dysfunction in diabetes and this may be in parallel with activation of the insulin-mediated Akt/GLUT4 signaling pathway. Resveratrol 40-43 AKT serine/threonine kinase 1 Rattus norvegicus 170-173 19959541-8 2010 Although resveratrol attenuated the activation of mTOR complex 1, low-dose resveratrol significantly induced the expression of Rictor, a component of mTOR complex 2, and activated its downstream survival kinase Akt (Ser 473). Resveratrol 75-86 AKT serine/threonine kinase 1 Rattus norvegicus 211-214 19496785-5 2009 Western blot analyses showed that resveratrol (10 microM) and quercetin (25 microM) caused a reduction in phosphorylation of Akt, but this reduction was not sufficient by itself to mediate the effects of these polyphenols. Resveratrol 34-45 AKT serine/threonine kinase 1 Rattus norvegicus 125-128 19355928-6 2009 One hypothesis is that by activating Sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and nuclear factor-kappabeta (NFkappabeta). Resveratrol 48-59 AKT serine/threonine kinase 1 Rattus norvegicus 209-212 18789672-9 2009 The results thus indicate that at lower doses (2.5 or 5 mg/kg), resveratrol exerts survival signal by up-regulating anti-apoptotic and redox proteins Akt and Bcl-2, while at higher doses (>25 mg/kg), it potentiates a death signal by down-regulating redox proteins and up-regulating pro-apoptotic proteins. Resveratrol 64-75 AKT serine/threonine kinase 1 Rattus norvegicus 150-153 18266981-0 2008 Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 92-95 18266981-12 2008 Increased phosphorylation of endothelial Nitric Oxide Synthase (eNOS) & Akt was also observed in RSV compared to DM (P<0.05). Resveratrol 101-104 AKT serine/threonine kinase 1 Rattus norvegicus 76-79 18266981-14 2008 Our results suggests that the effect of RSV is non-insulin dependent and triggers some of the similar intracellular insulin signalling components in myocardium such as eNOS, Akt through AMPK pathway and also by regulating the caveolin-1 and caveolin-3 status that might play an essential role in Glut-4 translocation and glucose uptake in STZ- induced type-1 diabetic myocardium. Resveratrol 40-43 AKT serine/threonine kinase 1 Rattus norvegicus 174-177 17015251-10 2006 Resveratrol induced the activation of nuclear factor kappa-beta(NFkappaB), the phosphorylation of p38MAP kinase beta and Akt, as well as the inhibition of p38 MAP kinase alpha; all these effects but the activation of NFkappaB, were completely reversed by treatment with SnPP. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 121-124 18562309-0 2008 Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 78-81 18562309-2 2008 Because studies in cells other than cardiomyocytes revealed that AMP-activated protein kinase (AMPK) and Akt are affected by resveratrol, we hypothesized that resveratrol prevents cardiac myocyte hypertrophy via these two kinase systems. Resveratrol 125-136 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 18562309-2 2008 Because studies in cells other than cardiomyocytes revealed that AMP-activated protein kinase (AMPK) and Akt are affected by resveratrol, we hypothesized that resveratrol prevents cardiac myocyte hypertrophy via these two kinase systems. Resveratrol 159-170 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 18562309-5 2008 Our data also indicate that these effects of resveratrol are mediated via AMPK activation and Akt inhibition, and in the case of AMPK, is dependent on the presence of the AMPK kinase, LKB1. Resveratrol 45-56 AKT serine/threonine kinase 1 Rattus norvegicus 94-97 18562309-6 2008 Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription. Resveratrol 38-49 AKT serine/threonine kinase 1 Rattus norvegicus 126-129 17346750-5 2007 In insulin-deficient STZ-diabetic rats, resveratrol significantly lowered the plasma glucose 90 min after oral treatment, and the hypoglycemic effect was abolished by phosphatidyl-3-kinase (PI3K) inhibitors (LY294002 and wortmannin) which also inhibited resveratrol-induced Akt phosphorylation in soleus muscle of STZ-diabetic rats. Resveratrol 40-51 AKT serine/threonine kinase 1 Rattus norvegicus 274-277 17015251-11 2006 These results indicate that resveratrol generates cardioprotection by preconditioning the heart by HO-1-mediated mechanisms, which are regulated by p38MAP kinase and Akt survival signaling, but non-dependent on NFkappaB activation. Resveratrol 28-39 AKT serine/threonine kinase 1 Rattus norvegicus 166-169 15879002-1 2005 A recent study documented a role of adenosine A(3)-Akt-cAMP response element-binding protein (CREB) survival signaling in resveratrol preconditioning of the heart. Resveratrol 122-133 AKT serine/threonine kinase 1 Rattus norvegicus 51-54 15879002-0 2005 Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 106-109 15879002-2 2005 In this study, we demonstrate that resveratrol-mediated CREB activation can also occur through an Akt-independent pathway. Resveratrol 35-46 AKT serine/threonine kinase 1 Rattus norvegicus 98-101 15879002-6 2005 Resveratrol phosphorylated both Akt and CREB that was blocked by MRS-1191, which also abolished cardioprotective abilities of resveratrol. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 32-35 15879002-6 2005 Resveratrol phosphorylated both Akt and CREB that was blocked by MRS-1191, which also abolished cardioprotective abilities of resveratrol. Resveratrol 126-137 AKT serine/threonine kinase 1 Rattus norvegicus 32-35 15879002-11 2005 The results indicate that resveratrol preconditions the hearts through adenosine A(3) receptor signaling that triggers the phosphorylation of CREB through both Akt-dependent and -independent pathways, leading to cardioprotection. Resveratrol 26-37 AKT serine/threonine kinase 1 Rattus norvegicus 160-163 15849355-0 2005 Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 15882976-5 2005 Moreover, PC12 cells treated with resveratrol exhibited transient activation of Akt/protein kinase B and extracellular signal-regulated protein kinase 1/2 (ERK1/2). Resveratrol 34-45 AKT serine/threonine kinase 1 Rattus norvegicus 80-83 15882976-6 2005 LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects. Resveratrol 154-165 AKT serine/threonine kinase 1 Rattus norvegicus 113-116 34522086-0 2021 Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3beta Signaling Cascade. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 122-125 15345477-7 2005 Resveratrol induced expression of Bcl-2 and caused its phosphorylation along with phosphorylation of cAMP response element-binding protein (CREB), Akt, and Bad. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 147-150 15345477-10 2005 The results indicate that resveratrol preconditions the heart through activation of adenosine A(1) and A(3) receptors, the former transmitting a survival signal through PI3-kinase-Akt-Bcl-2 signaling pathway and the latter protecting the heart through a CREB-dependent Bcl-2 pathway in addition to an Akt-Bcl-2 pathway. Resveratrol 26-37 AKT serine/threonine kinase 1 Rattus norvegicus 180-183 15345477-10 2005 The results indicate that resveratrol preconditions the heart through activation of adenosine A(1) and A(3) receptors, the former transmitting a survival signal through PI3-kinase-Akt-Bcl-2 signaling pathway and the latter protecting the heart through a CREB-dependent Bcl-2 pathway in addition to an Akt-Bcl-2 pathway. Resveratrol 26-37 AKT serine/threonine kinase 1 Rattus norvegicus 301-304 12237323-0 2002 Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 46-49 34646331-8 2021 Results: Through network pharmacological analysis, this study found that resveratrol may regulate the TLR4 signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway, Osteoclast differentiation, Rheumatoid arthritis, etc. Resveratrol 73-84 AKT serine/threonine kinase 1 Rattus norvegicus 131-134 34616146-9 2021 Transcriptional analysis showed that the effects of resveratrol on the endometriosis model rats were manifested by alterations in the PPAR, insulin resistance, MAPK and PI3K/Akt signaling pathways. Resveratrol 52-63 AKT serine/threonine kinase 1 Rattus norvegicus 174-177 34522086-12 2021 Conclusion: Resveratrol can inhibit cardiomyocyte apoptosis, thus attenuating the CME-induced myocardial injury by triggering the PI3K/Akt/GSK-3beta cascade. Resveratrol 12-23 AKT serine/threonine kinase 1 Rattus norvegicus 135-138 35422955-0 2022 AKT/foxo3a signal pathway mediates the protective mechanism of resveratrol on renal interstitial fibrosis and oxidative stress in rats with unilateral ureteral obstruction. Resveratrol 63-74 AKT serine/threonine kinase 1 Rattus norvegicus 0-3 34107386-0 2021 Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 27-30 34107386-5 2021 Besides, resveratrol can activate PI3K/AKT signaling pathway. Resveratrol 9-20 AKT serine/threonine kinase 1 Rattus norvegicus 39-42 34107386-6 2021 PI3K siRNA can inhibit the PI3K/AKT signaling mediated by resveratrol. Resveratrol 58-69 AKT serine/threonine kinase 1 Rattus norvegicus 32-35 34107386-9 2021 In conclusion, our study shows that resveratrol can reduce ROS in cardiomyocytes by PI3K/AKT signaling pathway activation, and effectively inhibit the apoptosis of cardiomyocytes, thus having a direct protective effect on cardiomyocytes under SR. Resveratrol 36-47 AKT serine/threonine kinase 1 Rattus norvegicus 89-92 35422955-6 2022 CONCLUSION: AKT/foxo3a signaling pathway mediates the protective mechanism of RSV on RIF and oxidative stress in UUO rats, and RSV can improve RIF and oxidative stress in UUO rats by inhibiting AKT/foxo3a signaling pathway. Resveratrol 127-130 AKT serine/threonine kinase 1 Rattus norvegicus 12-15 35422955-1 2022 OBJECTIVE: To explore whether protein kinase B (serine/threonrine kinase, AKT)/forkhead box protein O3a (foxo3a) pathway mediates the protective mechanism of resveratrol (RSV) on renal interstitial fibrosis (RIF) and oxidative stress. Resveratrol 158-169 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 35422955-6 2022 CONCLUSION: AKT/foxo3a signaling pathway mediates the protective mechanism of RSV on RIF and oxidative stress in UUO rats, and RSV can improve RIF and oxidative stress in UUO rats by inhibiting AKT/foxo3a signaling pathway. Resveratrol 127-130 AKT serine/threonine kinase 1 Rattus norvegicus 194-197 35422955-6 2022 CONCLUSION: AKT/foxo3a signaling pathway mediates the protective mechanism of RSV on RIF and oxidative stress in UUO rats, and RSV can improve RIF and oxidative stress in UUO rats by inhibiting AKT/foxo3a signaling pathway. Resveratrol 78-81 AKT serine/threonine kinase 1 Rattus norvegicus 12-15 35422955-6 2022 CONCLUSION: AKT/foxo3a signaling pathway mediates the protective mechanism of RSV on RIF and oxidative stress in UUO rats, and RSV can improve RIF and oxidative stress in UUO rats by inhibiting AKT/foxo3a signaling pathway. Resveratrol 78-81 AKT serine/threonine kinase 1 Rattus norvegicus 194-197 33976931-0 2021 Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 65-68 33421145-0 2021 Antioxidant Sirt1/Akt axis expression in resveratrol pretreated adipose-derived stem cells increases regenerative capability in a rat model with cardiomyopathy induced by diabetes mellitus. Resveratrol 41-52 AKT serine/threonine kinase 1 Rattus norvegicus 18-21 33976931-1 2021 Objective: Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Resveratrol 49-60 AKT serine/threonine kinase 1 Rattus norvegicus 227-230 33125088-0 2020 Resveratrol contributes to the inhibition of liver fibrosis by inducing autophagy via the microRNA-20a-mediated activation of the PTEN/PI3K/AKT signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 140-143 33976931-1 2021 Objective: Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Resveratrol 62-65 AKT serine/threonine kinase 1 Rattus norvegicus 227-230 33125088-4 2020 The present study aimed to assess the mechanisms through which RSV induces autophagy and activates the miR-20a-mediated phosphatase and tensin homolog (PTEN)/PI3K/AKT signaling pathway in LF. Resveratrol 63-66 AKT serine/threonine kinase 1 Rattus norvegicus 163-166 33125088-12 2020 RSV reversed the inhibitory effects of miR-20a on PTEN expression, reducing miR-20a expression and promoting PTEN, PI3K and p-AKT protein expression, thus attenuating LF. Resveratrol 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 126-129 33125088-13 2020 On the whole, the present study demonstrates that RSV induces autophagy and activates the miR-20a-mediated PTEN/PI3K/AKT signaling pathway to attenuate LF. Resveratrol 50-53 AKT serine/threonine kinase 1 Rattus norvegicus 117-120 31872196-9 2020 Our data suggested that resveratrol protected cardiac cells from ERS by mobilizing intracellular Zn2+ and preventing mPTP opening through the ERK/GSK-3beta but not PI3K/AKT signaling pathway. Resveratrol 24-35 AKT serine/threonine kinase 1 Rattus norvegicus 169-172 31978799-6 2020 CONCLUSION: Resveratrol-preprocessed BMSCs can activate the PI3K/AKT signaling pathway in pancreatic cells and HUVECs through paracrine release of VEGFA; thus, achieving the therapeutic effect of resisting apoptosis of pancreatic cells and promoting regeneration of damaged blood vessels. Resveratrol 12-23 AKT serine/threonine kinase 1 Rattus norvegicus 65-68 31454852-6 2019 The anti-fibrotic effects of resveratrol correlated with decreased proliferation of TECs in the interstitium and tubules, resulting in suppressed activity of the proliferation-related signalling pathways, including that of the MAPK, PI3K/Akt, Wnt/beta-catenin, and JAK2/STAT3 pathways. Resveratrol 29-40 AKT serine/threonine kinase 1 Rattus norvegicus 238-241 30507263-0 2019 Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 117-120 31433112-0 2019 Resveratrol protects against cadmium chloride-induced hippocampal neurotoxicity by inhibiting ER stress and GAAD 153 and activating sirtuin 1/AMPK/Akt. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 147-150 31037738-9 2019 We found that ADSC precondition with resveratrol increases the survival marker p-Akt expression, leading to enhanced ADSC viability. Resveratrol 37-48 AKT serine/threonine kinase 1 Rattus norvegicus 81-84 32257906-0 2019 Resveratrol modulates the Akt/GSK-3beta signaling pathway in a middle cerebral artery occlusion animal model. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 26-29 32257906-6 2019 This study investigated whether resveratrol regulates Akt/glycogen synthase kinase-3beta (GSK-3beta) pathway in a middle cerebral artery occlusion (MCAO)-induced ischemic brain injury. Resveratrol 32-43 AKT serine/threonine kinase 1 Rattus norvegicus 54-57 32257906-14 2019 Thus, our finding suggests that resveratrol attenuates neuronal cell death in MCAO-induced cerebral ischemia and Akt/GSK-3beta signaling pathway contributes to the neuroprotective effect of resveratrol. Resveratrol 190-201 AKT serine/threonine kinase 1 Rattus norvegicus 113-116 31295526-0 2019 Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 78-81 31295526-1 2019 This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Resveratrol 38-49 AKT serine/threonine kinase 1 Rattus norvegicus 197-200 31295526-1 2019 This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Resveratrol 51-54 AKT serine/threonine kinase 1 Rattus norvegicus 197-200 31295526-6 2019 Compared with those in the model group, the number of dopaminergic neurons cells and the expression of PI3K-110alpha, p-Akt Ser473, and pro-caspase-3 in the Res 30 mg/kg group were significantly increased, and the Bax/Bcl-2 ratio and the level of activated caspase-3 was decreased. Resveratrol 157-160 AKT serine/threonine kinase 1 Rattus norvegicus 120-123 31295526-7 2019 The results indicate that Res ameliorates 6-OHDA-induced apoptosis and motor dysfunction via activating the PI3K/Akt signaling pathway, delaying the progression of Parkinson"s disease (PD) symptoms in this model. Resveratrol 26-29 AKT serine/threonine kinase 1 Rattus norvegicus 113-116 31481868-0 2019 Resveratrol Activates Autophagy via the AKT/mTOR Signaling Pathway to Improve Cognitive Dysfunction in Rats With Chronic Cerebral Hypoperfusion. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 40-43 31412263-0 2019 Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 31173195-8 2019 Wortmannin (a PI3K inhibitor) was used to investigate the involvement of the PI3k/Akt signalling pathway in the cardio-protective activity of resveratrol. Resveratrol 142-153 AKT serine/threonine kinase 1 Rattus norvegicus 82-85 30967498-7 2019 In addition, the resveratrol played an anti-senescence role in rat NP cells, which might affect the Akt-FoxO1-SIRT1 axis.Conclusion: SIRT1 ameliorated oxidative stress-induced senescence of rat NP cell which was regulated by Akt-FoxO1 pathway, and resveratrol exerted anti-senescence effects by affecting this signaling axis. Resveratrol 17-28 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 30967498-7 2019 In addition, the resveratrol played an anti-senescence role in rat NP cells, which might affect the Akt-FoxO1-SIRT1 axis.Conclusion: SIRT1 ameliorated oxidative stress-induced senescence of rat NP cell which was regulated by Akt-FoxO1 pathway, and resveratrol exerted anti-senescence effects by affecting this signaling axis. Resveratrol 17-28 AKT serine/threonine kinase 1 Rattus norvegicus 225-228 29875625-6 2018 In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. Resveratrol 37-48 AKT serine/threonine kinase 1 Rattus norvegicus 193-196 30867252-11 2019 Further analysis showed that IL-1beta significantly decreased activity of the PI3K/Akt pathway whereas resveratrol partly increased activity of the PI3K/Akt pathway in NP cells treated with IL-1beta. Resveratrol 103-114 AKT serine/threonine kinase 1 Rattus norvegicus 153-156 30867252-13 2019 In conclusion, resveratrol suppresses IL-1beta-mediated NP cell apoptosis through activating the PI3K/Akt pathway. Resveratrol 15-26 AKT serine/threonine kinase 1 Rattus norvegicus 102-105 30840305-0 2019 Resveratrol protects myocardial apoptosis induced by ischemia-reperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 133-136 30840305-17 2019 CONCLUSIONS: RSV protects cardiomyocyte apoptosis from ischemia-reperfusion injury through regulating phosphorylation levels of proteins relative to PI3K/Akt/e-NOS pathway. Resveratrol 13-16 AKT serine/threonine kinase 1 Rattus norvegicus 154-157 30374891-15 2019 When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased. Resveratrol 97-108 AKT serine/threonine kinase 1 Rattus norvegicus 293-296 30374891-16 2019 CONCLUSIONS: The findings in the present study suggest that the antidepressant effect of resveratrol treatment may act through activation of the Akt/GSK3beta signaling pathway and then regulation of proinflammatory cytokine expression and alteration of apoptosis. Resveratrol 89-100 AKT serine/threonine kinase 1 Rattus norvegicus 145-148 30156477-0 2018 Resveratrol attenuates brain damage in permanent focal cerebral ischemia via activation of PI3K/Akt signaling pathway in rats. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 96-99 30156477-2 2018 METHODS AND MATERIALS: To investigate whether phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway was involved in RSV anti-inflammatory and neuroprotective properties. Resveratrol 115-118 AKT serine/threonine kinase 1 Rattus norvegicus 76-79 29752339-0 2018 Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 109-112 29752339-10 2018 Additionally, RSV increased activity of the PI3K/Akt pathway compared with the control NP cells, but it was not affected by the addition of 3-MA. Resveratrol 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 49-52 29273676-0 2018 Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 132-135 29273676-9 2018 Further analysis showed that resveratrol suppressed reactive oxygen species (ROS) generation and increased the activity of the PI3K/Akt pathway under the high glucose condition. Resveratrol 29-40 AKT serine/threonine kinase 1 Rattus norvegicus 132-135 30867252-0 2019 Resveratrol inhibits IL-1beta-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 99-102 30881098-0 2019 Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1alpha pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 83-86 30478674-0 2019 Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3beta. Resveratrol 0-17 AKT serine/threonine kinase 1 Rattus norvegicus 134-137 30374891-0 2019 Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: involvement of the AKT/GSK3beta signaling pathway in hippocampus. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 129-132 29527953-0 2018 High glucose causes vascular dysfunction through Akt/eNOS pathway: reciprocal modulation by juglone and resveratrol. Resveratrol 104-115 AKT serine/threonine kinase 1 Rattus norvegicus 49-52 29851197-9 2018 CONCLUSION: Resveratrol reduced oxidative stress and inhibited apoptosis in granulosa cells by activating the PI3K/Akt/mTOR signaling pathway in a rat model of POI. Resveratrol 12-23 AKT serine/threonine kinase 1 Rattus norvegicus 115-118 30320189-0 2018 Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 71-74 30320189-4 2018 Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 123-126 30320189-10 2018 The results suggested that resveratrol significantly improved neurological function, reduced cerebral infarct volume, decreased neuronal damage, and markedly attenuated neuronal apoptosis; these effects were attenuated by the inhibition of PI3K/AKT with LY294002 and JAK2/STAT3 with AG490. Resveratrol 27-38 AKT serine/threonine kinase 1 Rattus norvegicus 245-248 30320189-11 2018 We also found that resveratrol significantly upregulated the expression of p-JAK2, p-STAT3, p-AKT, p-mTOR, and BCL-2 and downregulated expression of cleaved caspase-3 and BAX, which was partially reversed by LY294002 and AG490. Resveratrol 19-30 AKT serine/threonine kinase 1 Rattus norvegicus 94-97 30320189-12 2018 These results suggested that resveratrol provides a neuroprotective effect against cerebral ischemia/reperfusion injury, which is partially mediated by the activation of JAK2/STAT3 and PI3K/AKT/mTOR. Resveratrol 29-40 AKT serine/threonine kinase 1 Rattus norvegicus 190-193 30320189-13 2018 Resveratrol may indirectly upregulate the PI3K/AKT/mTOR pathway by activating JAK2/STAT3. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 47-50 29350822-0 2018 Resveratrol Suppresses Rotenone-induced Neurotoxicity Through Activation of SIRT1/Akt1 Signaling Pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 82-86 29350822-9 2018 Moreover, resveratrol reversed rotenone-induced decrease in SIRT1 expression and Akt1 phosphorylation (P < 0.05). Resveratrol 10-21 AKT serine/threonine kinase 1 Rattus norvegicus 81-85 29350822-10 2018 Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity. Resveratrol 133-144 AKT serine/threonine kinase 1 Rattus norvegicus 32-36 29350822-10 2018 Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity. Resveratrol 133-144 AKT serine/threonine kinase 1 Rattus norvegicus 201-205 29350822-11 2018 In summary, our study demonstrated that resveratrol reduced rotenone-induced oxidative damage, which was partly mediated through activation of the SIRT1/Akt1 signaling pathway. Resveratrol 40-51 AKT serine/threonine kinase 1 Rattus norvegicus 153-157 29360689-0 2018 Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 135-138 29360689-12 2018 Taken together, these findings indicate that resveratrol exerts neuroprotective effects on EBI after SAH by regulating autophagy and apoptosis mediated by the Akt/mTOR pathway. Resveratrol 45-56 AKT serine/threonine kinase 1 Rattus norvegicus 159-162 29360689-5 2018 In the present study, we examined the effect of resveratrol on EBI and their potential relationship with the Akt/mTOR pathway, autophagy, and apoptosis. Resveratrol 48-59 AKT serine/threonine kinase 1 Rattus norvegicus 109-112 29360689-10 2018 Western blot analysis showed that the expression of beclin-1, LC3-II, LC3-II/LC3-I, and Bcl-2 was increased in resveratrol-treated rats, whereas the expression of p-Akt, p-mTOR, p62, cleaved caspase-3, caspase-9, and Bcl-2-associated X protein was decreased. Resveratrol 111-122 AKT serine/threonine kinase 1 Rattus norvegicus 165-168 27667182-5 2016 We found that RSV was responsible for the up-regulation of VEGF-B mRNA and protein level, which caused the activation of Akt and the inhibition of GSK3beta. Resveratrol 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 121-124 29434742-0 2018 Resveratrol protects neuronal cells from isoflurane-induced inflammation and oxidative stress-associated death by attenuating apoptosis via Akt/p38 MAPK signaling. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 140-143 29434742-1 2018 The aim of the present study was to determine whether resveratrol protects neuronal cells from inflammation and isoflurane-induced oxidative stress-associated death via attenuating apoptosis via Akt/p38 mitogen-activated protein kinase (MAPK) signaling. Resveratrol 54-65 AKT serine/threonine kinase 1 Rattus norvegicus 195-198 29434742-5 2018 In addition, western blot analysis demonstrated that resveratrol treatment significantly attenuated isoflurane-induced decreases in the activated phosphorylated (p)-Akt/Akt ratio and increases in the p-p38/p38 MAPK protein ratio in PC12 cells. Resveratrol 53-64 AKT serine/threonine kinase 1 Rattus norvegicus 165-168 29434742-5 2018 In addition, western blot analysis demonstrated that resveratrol treatment significantly attenuated isoflurane-induced decreases in the activated phosphorylated (p)-Akt/Akt ratio and increases in the p-p38/p38 MAPK protein ratio in PC12 cells. Resveratrol 53-64 AKT serine/threonine kinase 1 Rattus norvegicus 169-172 29434742-6 2018 These findings indicated that resveratrol was able to protect neuronal cells from isoflurane-induced inflammation and oxidative stress-associated death by attenuating apoptosis via Akt/p38 MAPK signaling. Resveratrol 30-41 AKT serine/threonine kinase 1 Rattus norvegicus 181-184 29211809-0 2017 Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway. Resveratrol 83-94 AKT serine/threonine kinase 1 Rattus norvegicus 157-160 28361268-9 2017 It was also found that resveratrol could decline the increase of protein kinase A (PKA) and inhibit the activation of PI3K/Akt signaling pathway induced by Abeta25-35. Resveratrol 23-34 AKT serine/threonine kinase 1 Rattus norvegicus 123-126 28361268-10 2017 The results suggest that resveratrol alleviates Abeta25-35-induced dysfunction in hippocampal CA1 pyramidal neurons via recovery of the function of I A and I K(DR) by inhibiting the increase of PKA and the activation of PI3K/Akt signaling pathway. Resveratrol 25-36 AKT serine/threonine kinase 1 Rattus norvegicus 225-228 28678055-0 2017 Resveratrol Ameliorates Cardiac Dysfunction by Inhibiting Apoptosis via the PI3K/Akt/FoxO3a Pathway in a Rat Model of Diabetic Cardiomyopathy. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 81-84 28678055-9 2017 Together, these data indicate that RSV has therapeutic potential against DCM by inhibiting apoptosis via the PI3K/Akt/FoxO3a pathway. Resveratrol 35-38 AKT serine/threonine kinase 1 Rattus norvegicus 114-117 29067468-14 2017 In conclusion, resveratrol may improve overactive bladder by downregulating the protein expression of SCF, c-Kit and p-AKT in the bladder of rats with CP. Resveratrol 15-26 AKT serine/threonine kinase 1 Rattus norvegicus 119-122 27994500-12 2016 The in vitro assays showed that resveratrol inhibited the expression of HIF-1 alpha via suppressing the MAPK/ERK1 and PI3K/AKT pathways. Resveratrol 32-43 AKT serine/threonine kinase 1 Rattus norvegicus 123-126 29090409-0 2018 Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-beta1-42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 128-131 29090409-12 2018 More importantly, resveratrol stimulated the activation of HO-1, Nrf2, PI3K, and phosphorylated Akt. Resveratrol 18-29 AKT serine/threonine kinase 1 Rattus norvegicus 96-99 29090409-13 2018 Notably, the neuroprotective effects of resveratrol were eliminated by the HO-1 inhibitor zinc protoporphyrin IX (ZnPP), Nrf2 small interfering RNA (siRNA), and the PI3K/Akt inhibitor LY294002. Resveratrol 40-51 AKT serine/threonine kinase 1 Rattus norvegicus 170-173 29090409-14 2018 Taken together, the findings suggest that the cytoprotection of resveratrol against the cytotoxicity induced by Abeta1-42 in PC12 cells is through the upregulation of HO-1 expression via the activation of the PI3K/AKT/Nrf2 intracellular signaling pathway, which might provide novel insights for understanding the mechanism of the neuroprotective effect of resveratrol as an anti-AD drug. Resveratrol 64-75 AKT serine/threonine kinase 1 Rattus norvegicus 214-217 29277292-6 2018 In addition, resveratrol attenuated the overexpression of cyclin D1, cyclin E, cyclin dependent kinase 4 (Cdk4), Cdk2, phosphorylated retinoblastoma protein (pRb), Gialpha proteins and enhanced phosphorylation of ERK1/2 and AKT in VSMC from SHR. Resveratrol 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 224-227 29211809-6 2017 The results of the present study demonstrated that RSV activated klf5 phosphorylation by inhibiting PI3K/PKD1/Akt pathway, and then attenuated the interaction of klf5 with c-Myc, subsequently probably promoted the c-Myc binding to the promoter to repress Cav-1 expression. Resveratrol 51-54 AKT serine/threonine kinase 1 Rattus norvegicus 110-113 29931939-0 2017 [A study on anti-arrhythmia mechanisms of resveratrol on ischemia/reperfusion in rats by regulating PI3K/Akt signaling pathway]. Resveratrol 42-53 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 29931939-7 2017 CONCLUSIONS: Resveratrol could prevent the occurrence of reperfusion arrhythmias by increasing the content and ac-tivity of myocardial Cx43 through the PI3K/Akt signaling pathway. Resveratrol 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 157-160 28165488-7 2017 Furthermore, TGFbeta/Smad3-stimulated KLF5 production and SMC de-differentiation were blocked by resveratrol via its inhibition of the Akt-mTOR pathway. Resveratrol 97-108 AKT serine/threonine kinase 1 Rattus norvegicus 135-138 28165488-8 2017 Concordantly, resveratrol attenuated Akt phosphorylation in injured arteries. Resveratrol 14-25 AKT serine/threonine kinase 1 Rattus norvegicus 37-40 26283207-9 2015 Analysis of signaling pathways in this study demonstrated that RSV increased JNK phosphorylation but decreased Akt phosphorylation and increased NF-kappaB activation. Resveratrol 63-66 AKT serine/threonine kinase 1 Rattus norvegicus 111-114 27109835-0 2016 Neuroprotective effect of resveratrol against brain ischemia reperfusion injury in rats entails reduction of DJ-1 protein expression and activation of PI3K/Akt/GSK3b survival pathway. Resveratrol 26-37 AKT serine/threonine kinase 1 Rattus norvegicus 156-159 26801825-3 2016 The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring oxidative stress parameters and phosphorylation of AKT/mTOR pathway in the rat hippocampus and prefrontal cortex (PFC) exposed to the chronic unpredictable mild stress (CUMS). Resveratrol 98-109 AKT serine/threonine kinase 1 Rattus norvegicus 174-177 26801825-8 2016 In conclusion, our study showed that resveratrol exerted antidepressant-like effects in CUMS rats, which was mediated in part by its antioxidant action, up-regulation of phosphor-Akt and mTOR levels in the hippocampus and PFC. Resveratrol 37-48 AKT serine/threonine kinase 1 Rattus norvegicus 179-182 26824000-0 2016 Combined effect of 17beta-estradiol and resveratrol against apoptosis induced by interleukin-1beta in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway. Resveratrol 40-51 AKT serine/threonine kinase 1 Rattus norvegicus 138-141 26613251-0 2016 Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF-kappaB and the PI3K/Akt Signaling Pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 92-95 26613251-7 2016 Overall, we conclude that the antifibrotic effect of resveratrol is the result of blocking NF-kappaB activation and PI3K/Akt phosphorylation, which inhibits HSC activation to obstruct liver fibrosis. Resveratrol 53-64 AKT serine/threonine kinase 1 Rattus norvegicus 121-124 27551266-8 2016 Curcumin-resveratrol co-treatment decreased Bax/Bcl2 ratio, mitochondria to cytosolic translocation of cytochrome c and activated the survival protein Akt. Resveratrol 9-20 AKT serine/threonine kinase 1 Rattus norvegicus 151-154 25850408-6 2016 RESULTS: In endothelial cells, 0.1-10 mumol/L resveratrol suppressed IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB phosphorylation, as well as tumor necrosis factor-alpha and interleukin-6 production, and restored the insulin receptor substrate-1 (Irs-1)/Akt/endothelial NO synthase signaling pathway. Resveratrol 46-57 AKT serine/threonine kinase 1 Rattus norvegicus 261-264 26557094-6 2015 In parallel, resveratrol augmented the expression level and activity of SIRT1 and phosphorylation levels of Foxo3a and Akt while suppressed the increases in protein abundances of p53, Bax, MAFbx, and ubiquitin, enzymatic activities of caspase 3 and 20S proteasome, and apoptotic DNA fragmentation in the compressed muscle. Resveratrol 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 119-122 25471227-0 2015 Resveratrol protects PC12 cells from high glucose-induced neurotoxicity via PI3K/Akt/FoxO3a pathway. Resveratrol 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 81-84 25471227-3 2015 In this study, we aimed to investigate the effects of resveratrol on the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway in mediating high glucose (HG)-induced injuries in neuronal PC12 cells. Resveratrol 54-65 AKT serine/threonine kinase 1 Rattus norvegicus 126-129 25471227-8 2015 Furthermore, the protective effects of resveratrol were abolished by PI3K/Akt inhibitor LY294002. Resveratrol 39-50 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 25471227-9 2015 All these results demonstrate that resveratrol protected the PC12 cells from HG-induced oxidative stress and apoptosis via the activation of PI3K/Akt/FoxO3a signaling pathway. Resveratrol 35-46 AKT serine/threonine kinase 1 Rattus norvegicus 146-149 25394677-2 2015 Herein, we show that in rat cardiomyocytes, lower concentrations of resveratrol (0.1 and 1 muM) are efficient at selectively inhibiting important regulators involved in pathological LVH (such as nuclear factor of activated T cells (NFAT)) while not affecting pathways involved in physiological LVH (Akt and p70S6 kinase (p70S6K)). Resveratrol 68-79 AKT serine/threonine kinase 1 Rattus norvegicus 299-302 25394677-4 2015 Interestingly, in all of the experiments involving a low concentration of resveratrol (1 muM), the observed effects on Akt, p70S6K, and NFAT were independent from AMP-activated protein kinase (AMPK) activation while these effects at higher concentrations of resveratrol (50 muM) were potentiated by AMPK activation. Resveratrol 74-85 AKT serine/threonine kinase 1 Rattus norvegicus 119-122 25394677-4 2015 Interestingly, in all of the experiments involving a low concentration of resveratrol (1 muM), the observed effects on Akt, p70S6K, and NFAT were independent from AMP-activated protein kinase (AMPK) activation while these effects at higher concentrations of resveratrol (50 muM) were potentiated by AMPK activation. Resveratrol 258-269 AKT serine/threonine kinase 1 Rattus norvegicus 119-122