PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32809016-0 2020 Retraction: Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathway. Resveratrol 12-23 mechanistic target of rapamycin kinase Homo sapiens 121-125 33891090-0 2021 Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 29-33 33891090-12 2021 Resveratrol increased the phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin (mTOR) and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner, leading to autophagy. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 137-166 33891090-12 2021 Resveratrol increased the phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin (mTOR) and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner, leading to autophagy. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 168-172 33292283-0 2020 Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 77-81 33912959-9 2021 Furthermore, resveratrol promoted autophagy via the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, thereby protecting IEC-6 cells against radiation-induced damage. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 89-118 33912959-9 2021 Furthermore, resveratrol promoted autophagy via the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, thereby protecting IEC-6 cells against radiation-induced damage. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 120-124 33339133-9 2020 Resveratrol activated Akt by regulating Mammalian Target of Rapamycin (mTOR) Complex 2 (mTORC2) via phosphatase and tensin homolog (PTEN) and ribosomal protein S6 kinase beta-1 (S6K1). Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 40-69 33339133-9 2020 Resveratrol activated Akt by regulating Mammalian Target of Rapamycin (mTOR) Complex 2 (mTORC2) via phosphatase and tensin homolog (PTEN) and ribosomal protein S6 kinase beta-1 (S6K1). Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 71-75 33339133-10 2020 Moreover, resveratrol-mediated NK cell activation was more dependent on the mTOR pathway than the Akt pathway. Resveratrol 10-21 mechanistic target of rapamycin kinase Homo sapiens 76-80 33489476-2 2020 Although studies have individually shown that resveratrol can inhibit mTOR and that inhibiting mTOR leads to attenuated immune function, no studies to date have examined these two functions conjointly under one study. Resveratrol 46-57 mechanistic target of rapamycin kinase Homo sapiens 70-74 33489476-3 2020 Therefore, we hypothesize that resveratrol will decrease mTOR activation and expression as well as attenuate stimulated T cell activation and proliferation in peripheral blood mononuclear cells (PBMC). Resveratrol 31-42 mechanistic target of rapamycin kinase Homo sapiens 57-61 33489476-8 2020 RESULTS: Resveratrol treated stimulated PBMCs displayed a significant decrease in activated phosphorylation of mTOR at days 1, 3, and 5 (P < 0.0329). Resveratrol 9-20 mechanistic target of rapamycin kinase Homo sapiens 111-115 33489476-10 2020 CONCLUSION: Taken together, our data suggest that resveratrol can decrease the immune response of stimulated T-cells and inhibit the expression and activation of mTOR mediated cellular signalling under the same study setting. Resveratrol 50-61 mechanistic target of rapamycin kinase Homo sapiens 162-166 33293795-0 2020 Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 116-120 33081687-11 2021 On the other hand, resveratrol has an inhibitory effect on anti-apoptotic mediators such as nuclear factor kappa B (NFkappaB), cyclooxygenase-2 (COX-2), phosphatidylinositol 3-kinase (PI3K) and mTOR. Resveratrol 19-30 mechanistic target of rapamycin kinase Homo sapiens 194-198 32531316-0 2020 Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 98-102 32531316-3 2020 Resveratrol can also inhibit tumor growth by regulating the PI3K/AKT/mTOR signaling pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 69-73 28195449-8 2020 CONCLUSIONS: The mechanism of resveratrol in the inhibition of the proliferation of pathological scar fibroblasts may be related to its down-regulation in the expression of Akt and mTOR, which are the key molecules of mTOR signaling pathway. Resveratrol 30-41 mechanistic target of rapamycin kinase Homo sapiens 181-185 32696949-0 2020 Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 109-113 32477148-9 2020 Western blot results confirmed that resveratrol inhibited glutamate-induced apoptosis of hippocampal neurons partly by regulating the PI3K/AKT/mTOR pathway. Resveratrol 36-47 mechanistic target of rapamycin kinase Homo sapiens 143-147 32247449-6 2020 Mini rose displayed the highest antioxidant activity in FRAP and DPPH assays before in vitro digestion; its dialyzed and non-dialyzed fraction showed the highest activity in FRAP, correlated to pelargonidin 3,5-diglucoside, catechin, epicatechin galate, epicagocatechin galate, procyanidin A2, quercitin 3-glucoside and trans-resveratrol (r = 0.9). Resveratrol 320-337 mechanistic target of rapamycin kinase Homo sapiens 174-178 28195449-8 2020 CONCLUSIONS: The mechanism of resveratrol in the inhibition of the proliferation of pathological scar fibroblasts may be related to its down-regulation in the expression of Akt and mTOR, which are the key molecules of mTOR signaling pathway. Resveratrol 30-41 mechanistic target of rapamycin kinase Homo sapiens 218-222 30421395-0 2018 Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 104-108 31412263-13 2019 Further results indicated that PI3K/AKT pathway-mediated inhibition of the mammalian target of rapamycin (mTOR) pathway played a role in the activation of autophagy by resveratrol after CIH stimulation. Resveratrol 168-179 mechanistic target of rapamycin kinase Homo sapiens 75-104 31412263-13 2019 Further results indicated that PI3K/AKT pathway-mediated inhibition of the mammalian target of rapamycin (mTOR) pathway played a role in the activation of autophagy by resveratrol after CIH stimulation. Resveratrol 168-179 mechanistic target of rapamycin kinase Homo sapiens 106-110 31412263-14 2019 SIGNIFICANCE: In conclusion, resveratrol supplementation during CIH upregulates autophagy by targeting the PI3K/AKT/mTOR pathway, which appears to be beneficial for resisting cardiac hypertrophy. Resveratrol 29-40 mechanistic target of rapamycin kinase Homo sapiens 116-120 30959047-8 2019 We have further shown that mTOR regulators can affect ovarian functions without any changes in SIRT-1 accumulation and that the stimulatory effects of resveratrol on analyzed ovarian cell functions are opposite to the inhibitory effects of rapamycin and synthetic mTOR blockers. Resveratrol 151-162 mechanistic target of rapamycin kinase Homo sapiens 264-268 30066962-8 2019 Furthermore, inhibition of mechanistic/mammalian target of rapamycin (mTOR) with rapamycin or silencing mTOR enhanced resveratrol"s inhibitory effects on the basal and IGF-1-induced inhibition of PP2A-PTEN, activation of Akt-Erk1/2, and cell adhesion. Resveratrol 118-129 mechanistic target of rapamycin kinase Homo sapiens 27-68 30066962-8 2019 Furthermore, inhibition of mechanistic/mammalian target of rapamycin (mTOR) with rapamycin or silencing mTOR enhanced resveratrol"s inhibitory effects on the basal and IGF-1-induced inhibition of PP2A-PTEN, activation of Akt-Erk1/2, and cell adhesion. Resveratrol 118-129 mechanistic target of rapamycin kinase Homo sapiens 70-74 30066962-8 2019 Furthermore, inhibition of mechanistic/mammalian target of rapamycin (mTOR) with rapamycin or silencing mTOR enhanced resveratrol"s inhibitory effects on the basal and IGF-1-induced inhibition of PP2A-PTEN, activation of Akt-Erk1/2, and cell adhesion. Resveratrol 118-129 mechanistic target of rapamycin kinase Homo sapiens 104-108 30888659-6 2019 Resveratrol, rapamycin, metformin and aspirin, showing effectiveness in model organism life- and healthspan extension mainly target the master regulators of aging such as mTOR, FOXO and PGC1alpha, affecting autophagy, inflammation and oxidative stress. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 171-175 28195449-0 2020 Effects of resveratrol on the expression of molecules related to the mTOR signaling pathway in pathological scar fibroblasts. Resveratrol 11-22 mechanistic target of rapamycin kinase Homo sapiens 69-73 28195449-1 2020 BACKGROUND: We observed the effects of resveratrol on the expression of molecules involved in the mTOR signaling pathway in pathological scar fibroblasts, including PI3K, Akt and mTOR. Resveratrol 39-50 mechanistic target of rapamycin kinase Homo sapiens 98-102 28195449-1 2020 BACKGROUND: We observed the effects of resveratrol on the expression of molecules involved in the mTOR signaling pathway in pathological scar fibroblasts, including PI3K, Akt and mTOR. Resveratrol 39-50 mechanistic target of rapamycin kinase Homo sapiens 179-183 28195449-3 2020 After being treated with different concentrations of resveratrol, the expression of PI3K, Akt and mTOR mRNA and protein were detected by RT-PCR and Western Blot respectively. Resveratrol 53-64 mechanistic target of rapamycin kinase Homo sapiens 98-102 32111491-1 2020 Resveratrol modulates the transcription factor NF-kappaB, cytochrome P450 isoenzyme CYP1A1, expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated apoptosis, p53, mTOR and cyclins and various phospho-diesterases resulting in an increase in cytosolic cAMP levels. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 189-193 30979510-0 2019 Corrigendum to "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells" [Atherosclerosis 205 (July 2009) 126-134]. Resveratrol 16-27 mechanistic target of rapamycin kinase Homo sapiens 41-45 30528730-7 2019 A natural polyphenol resveratrol that was reported to have PDE4 inhibitory effects also showed tumor suppressive effects by inhibiting the mTOR-Myc axis. Resveratrol 21-32 mechanistic target of rapamycin kinase Homo sapiens 139-143 30421395-7 2018 Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 77-81 30421395-8 2018 Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Resveratrol 40-51 mechanistic target of rapamycin kinase Homo sapiens 127-131 29788929-9 2018 Moreover, we find that resveratrol increases both the levels of microtubule-associated protein 1 light chain 3-II and the number of autophagosomes, and further demonstrate that resveratrol-induced autophagy depends on the LKB1-AMPK-mTOR pathway. Resveratrol 23-34 mechanistic target of rapamycin kinase Homo sapiens 232-236 30464525-0 2018 Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 114-118 30464525-14 2018 Besides that, resveratrol treatment inhibited Akt/mTOR while p38-MAPK was activated in NSCLC cells in a dose-dependent manner. Resveratrol 14-25 mechanistic target of rapamycin kinase Homo sapiens 50-54 30464525-16 2018 Conclusion: Taken together, our findings suggest that resveratrol inhibited proliferation but induced apoptosis and autophagy via inhibiting Akt/mTOR and activating p38-MAPK pathway. Resveratrol 54-65 mechanistic target of rapamycin kinase Homo sapiens 145-149 29663499-0 2018 Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 134-138 29663499-4 2018 Exposure to resveratrol increased the expression and activation of AMPK and Caspase 3, and decreased the expression and activation of AMPK downstream kinase mTOR. Resveratrol 12-23 mechanistic target of rapamycin kinase Homo sapiens 157-161 29663499-5 2018 Moreover, AMPK inhibitor Compound C significantly abolished the effects of resveratrol on the activation of AMPK and Caspase 3 and the inhibition of mTOR. Resveratrol 75-86 mechanistic target of rapamycin kinase Homo sapiens 149-153 29704506-13 2018 In the mechanism study, RSV-miR-17 axis was found to activate PTEN/PI3K/AKT and mTOR pathways in LPS-treated cells. Resveratrol 24-27 mechanistic target of rapamycin kinase Homo sapiens 80-84 29704506-14 2018 CONCLUSION: RSV alleviated LPS-induced injury in human keratinocyte cell line HaCaT through activations of PTEN/PI3K/AKT and mTOR pathways, which were modulated by miR-17. Resveratrol 12-15 mechanistic target of rapamycin kinase Homo sapiens 125-129 29956767-0 2018 Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 140-144 29956767-10 2018 Resveratrol treatment further enhanced the activation of autophagy via the AMPK/mTOR pathway following SCI. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 80-84 29956767-12 2018 Together, these findings suggested that resveratrol promoted functional recovery and inhibited neuroinflammation through the activation of autophagy mediated by the AMPK/mTOR pathway following SCI. Resveratrol 40-51 mechanistic target of rapamycin kinase Homo sapiens 170-174 29164657-7 2018 Apart from this, resveratrol enhanced AMPK phosphorylation but reduced mTOR phosphorylation. Resveratrol 17-28 mechanistic target of rapamycin kinase Homo sapiens 71-75 29164657-9 2018 In conclusion, resveratrol may exert its cytoprotective role against oxidative injury by the activation of autophagy via AMPK/mTOR pathway. Resveratrol 15-26 mechanistic target of rapamycin kinase Homo sapiens 126-130 29731844-6 2018 These results suggested that downregulation of the mTOR signaling cascades is likely to be a crucial mediator in the impairment of viability and the induction of apoptosis resulting from combined therapy with resveratrol and rapamycin in MM1.S cells. Resveratrol 209-220 mechanistic target of rapamycin kinase Homo sapiens 51-55 29788929-9 2018 Moreover, we find that resveratrol increases both the levels of microtubule-associated protein 1 light chain 3-II and the number of autophagosomes, and further demonstrate that resveratrol-induced autophagy depends on the LKB1-AMPK-mTOR pathway. Resveratrol 177-188 mechanistic target of rapamycin kinase Homo sapiens 232-236 29788929-11 2018 CONCLUSIONS: These results suggest that resveratrol induced apoptotic cell death of HL-60 cells depends on the autophagy activated through both the LKB1-AMPK and PI3K/AKT-regulated mTOR signaling pathways. Resveratrol 40-51 mechanistic target of rapamycin kinase Homo sapiens 181-185 29780409-0 2018 Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury. Resveratrol 22-33 mechanistic target of rapamycin kinase Homo sapiens 61-65 29780409-4 2018 Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 113-117 29780409-5 2018 Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. Resveratrol 33-44 mechanistic target of rapamycin kinase Homo sapiens 96-100 29780409-6 2018 The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI. Resveratrol 38-49 mechanistic target of rapamycin kinase Homo sapiens 22-26 29154199-6 2018 Importantly, UVB treatment perturbs the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and LC3-II turnover in response to treatment with MTOR inhibitors (Torin 1 and pp242), as well as endoplasmic reticular stress (A23187 and tunicamycin), inositol pathway (L690,330) and autophagy inducers (resveratrol and STF62247). Resveratrol 324-335 mechanistic target of rapamycin kinase Homo sapiens 169-173 27225870-4 2017 In this study, we asked whether combination treatment with rapamycin and resveratrol could be effective in concurrently inhibiting mTOR and PI3K signaling and inducing cell death in bladder cancer cells. Resveratrol 73-84 mechanistic target of rapamycin kinase Homo sapiens 131-135 28197628-0 2017 Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 123-127 29115429-0 2018 Resveratrol-mediated apoptosis in renal cell carcinoma via the p53/AMP-activated protein kinase/mammalian target of rapamycin autophagy signaling pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 96-125 29115429-10 2018 In conclusion, resveratrol suppressed RCC viability and migration, and promoted RCC apoptosis via the p53/AMPK/mTOR-induced autophagy signaling pathway. Resveratrol 15-26 mechanistic target of rapamycin kinase Homo sapiens 111-115 28024794-3 2017 The aim of the present study was to investigate the effects of resveratrol treatment on the expression of the genes involved in insulin signalling cascade, such as Forkhead box protein O1 (FoxO1), 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and mammalian target of rapamycin (mTOR). Resveratrol 63-74 mechanistic target of rapamycin kinase Homo sapiens 255-284 28024794-3 2017 The aim of the present study was to investigate the effects of resveratrol treatment on the expression of the genes involved in insulin signalling cascade, such as Forkhead box protein O1 (FoxO1), 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and mammalian target of rapamycin (mTOR). Resveratrol 63-74 mechanistic target of rapamycin kinase Homo sapiens 286-290 28024794-7 2017 RESULTS: Resveratrol increased the expression of PDPK1, mTOR and FoxO1. Resveratrol 9-20 mechanistic target of rapamycin kinase Homo sapiens 56-60 27225870-5 2017 In combination with rapamycin, resveratrol was able to block rapamycin-induced Akt activation, while maintaining mTOR pathway inhibition. Resveratrol 31-42 mechanistic target of rapamycin kinase Homo sapiens 113-117 26924638-7 2016 Some agents that affect the mTOR signaling system, or that inhibit the synthesis of the proconvulsant cytokine as well as those derived from plants (resveratrol) also seem effective in this regard. Resveratrol 149-160 mechanistic target of rapamycin kinase Homo sapiens 28-32 27992581-7 2016 Inhibition of autophagy by 3-methyladenine shortens the transient phase, while inhibition of mTOR by rapamycin or resveratrol prolongs it. Resveratrol 114-125 mechanistic target of rapamycin kinase Homo sapiens 93-97 25917875-0 2016 Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 105-109 25917875-5 2016 Furthermore, RSV treatment also decreases ER calcium storage and store operated calcium entry (SOCE), which induces endoplasmic reticulum (ER) stress, thereby, activating AMPK and inhibiting the AKT/mTOR pathway. Resveratrol 13-16 mechanistic target of rapamycin kinase Homo sapiens 199-203 27211906-7 2016 Using a wound healing assay we show that inhibition of the mTOR pathway using rapamycin, rapalogues, resveratrol and NVP BEZ-235 induces a cytostatic and not cytotoxic response up to 18 h in these cell lines. Resveratrol 101-112 mechanistic target of rapamycin kinase Homo sapiens 59-63 26460589-0 2016 Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 135-139 26460589-6 2016 Resveratrol decreased the phosphorylation of Akt and mTOR but did not affect the phosphorylations of JNK or ERK1/2. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 53-57 26460589-7 2016 These results demonstrated that resveratrol could increase the anti-proliferative activity of bestatin through downregulating P-gp expression via suppressing the PI3K/Akt/mTOR signaling pathway. Resveratrol 32-43 mechanistic target of rapamycin kinase Homo sapiens 171-175 26902888-0 2016 Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 53-57 26902888-3 2016 Here, we demonstrate that resveratrol induces autophagy by directly inhibiting the mTOR-ULK1 pathway. Resveratrol 26-37 mechanistic target of rapamycin kinase Homo sapiens 83-87 26902888-4 2016 We found that inhibition of mTOR activity and presence of ULK1 are required for autophagy induction by resveratrol. Resveratrol 103-114 mechanistic target of rapamycin kinase Homo sapiens 28-32 26902888-5 2016 In line with this mTOR dependency, we found that resveratrol suppresses the viability of MCF7 cells but not of SW620 cells, which are mTOR inhibitor sensitive and insensitive cancer cells, respectively. Resveratrol 49-60 mechanistic target of rapamycin kinase Homo sapiens 18-22 26902888-5 2016 In line with this mTOR dependency, we found that resveratrol suppresses the viability of MCF7 cells but not of SW620 cells, which are mTOR inhibitor sensitive and insensitive cancer cells, respectively. Resveratrol 49-60 mechanistic target of rapamycin kinase Homo sapiens 134-138 26902888-7 2016 For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. Resveratrol 31-42 mechanistic target of rapamycin kinase Homo sapiens 46-50 26902888-7 2016 For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. Resveratrol 31-42 mechanistic target of rapamycin kinase Homo sapiens 113-117 26902888-7 2016 For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. Resveratrol 83-94 mechanistic target of rapamycin kinase Homo sapiens 46-50 26902888-7 2016 For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. Resveratrol 83-94 mechanistic target of rapamycin kinase Homo sapiens 113-117 26902888-8 2016 We found that resveratrol inhibits mTOR by docking onto the ATP-binding pocket of mTOR (i.e., it competes with ATP). Resveratrol 14-25 mechanistic target of rapamycin kinase Homo sapiens 35-39 26902888-8 2016 We found that resveratrol inhibits mTOR by docking onto the ATP-binding pocket of mTOR (i.e., it competes with ATP). Resveratrol 14-25 mechanistic target of rapamycin kinase Homo sapiens 82-86 26902888-9 2016 We propose mTOR as a novel direct target of resveratrol, and inhibition of mTOR is necessary for autophagy induction. Resveratrol 44-55 mechanistic target of rapamycin kinase Homo sapiens 11-15 26446654-6 2015 RESULTS: In ARPE-19 cells, resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation. Resveratrol 27-38 mechanistic target of rapamycin kinase Homo sapiens 136-140 26633463-3 2015 Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-kappaB) and immune function. Resveratrol 66-77 mechanistic target of rapamycin kinase Homo sapiens 213-244 26633463-3 2015 Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-kappaB) and immune function. Resveratrol 66-77 mechanistic target of rapamycin kinase Homo sapiens 246-250 26378398-10 2015 Furthermore, resveratrol potently inhibited inflammatory factors-mediated protein kinase B/mammalian target of rapamycin signaling in neurons. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 91-120 24932295-0 2014 Resveratrol inhibits the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in the human chronic myeloid leukemia K562 cell line. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 73-102 25448084-9 2014 Resveratrol also alleviated the PI3K/Akt/mTOR signaling by down-regulation of Akt phosphorylation and up-regulation of PTEN expression. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 41-45 26074695-6 2015 The expressions of hypoxia inducible factor (HIF)-1alpha, mammalian target of rapamycin (mTOR), and signal transducer and activator of transcription 3 were significantly decreased in the intestinal tissues of mice treated with resveratrol. Resveratrol 227-238 mechanistic target of rapamycin kinase Homo sapiens 58-87 25909713-6 2015 Such a glycolysis-associated MTOR signal cascade was validated in human HBV-related HCC tissues and shown to mediate the inhibitory effect of a model of combined resveratrol and silymarin product on tumor growth. Resveratrol 162-173 mechanistic target of rapamycin kinase Homo sapiens 29-33 25866375-7 2015 Gene expression profiles in granulosa cells, as evaluated by next-generation sequencing technology, revealed that resveratrol enhanced the expression of EIF2-related genes but downregulated the expression of mammalian target of rapamycin (mTOR)-, inflammation-, and cholesterol homeostasis-related genes in granulosa cells. Resveratrol 114-125 mechanistic target of rapamycin kinase Homo sapiens 208-237 25866375-7 2015 Gene expression profiles in granulosa cells, as evaluated by next-generation sequencing technology, revealed that resveratrol enhanced the expression of EIF2-related genes but downregulated the expression of mammalian target of rapamycin (mTOR)-, inflammation-, and cholesterol homeostasis-related genes in granulosa cells. Resveratrol 114-125 mechanistic target of rapamycin kinase Homo sapiens 239-243 24932295-2 2014 The present study was conducted to investigate the effect of resveratrol on the activation of the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling cascade in K562 cells. Resveratrol 61-72 mechanistic target of rapamycin kinase Homo sapiens 190-194 24932295-4 2014 In addition, resveratrol attenuated the phosphorylation of PI3K, Akt and mTOR in the K562 cells. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 73-77 24932295-5 2014 Furthermore, the selected inhibitors of PI3K (LY294002), Akt (SH-6) and mTOR (rapamycin) enhanced the effects of resveratrol in K562 cells. Resveratrol 113-124 mechanistic target of rapamycin kinase Homo sapiens 72-76 24932295-8 2014 These results suggested that the downregulation of the PI3K/Akt/mTOR signaling cascades may be a crucial mediator in the inhibition of proliferation and induction of apoptosis by resveratrol in K562 cells. Resveratrol 179-190 mechanistic target of rapamycin kinase Homo sapiens 64-68 24932295-2 2014 The present study was conducted to investigate the effect of resveratrol on the activation of the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling cascade in K562 cells. Resveratrol 61-72 mechanistic target of rapamycin kinase Homo sapiens 159-188 24534773-0 2014 Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 76-80 24534773-7 2014 Resveratrol supplementation effectively counteracts TNF-alpha induced muscle protein loss and reverses declining expression of Akt, mTOR, p70S6K, 4E-BP1and FoxO1, but exerts no influence of FoxO3a expression. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 132-136 24534773-8 2014 Our study demonstrates that resveratrol can reverse the muscle cell atrophy caused by TNF-alpha through regulation of the Akt/mTOR/FoxO1 signaling pathways, followed by inhibition of the atrophy-related ubiquitin ligase. Resveratrol 28-39 mechanistic target of rapamycin kinase Homo sapiens 126-130 24060150-0 2013 mTOR: more targets of resveratrol? Resveratrol 22-33 mechanistic target of rapamycin kinase Homo sapiens 0-4 24464048-10 2014 Furthermore, both OSU-CG5 and resveratrol induced dose-dependent energy restriction in the cells: they suppressed glucose uptake and Akt phosphorylation, decreased the levels of p-mTOR and p-p70S6K, increased the levels of ER stress response proteins GRP78 and GADD153, and increased the level of beta-TrCP, which led to the downregulation of cyclin D1 and Sp1. Resveratrol 30-41 mechanistic target of rapamycin kinase Homo sapiens 180-184 24579778-0 2014 Resveratrol triggers protective autophagy through the ceramide/Akt/mTOR pathway in melanoma B16 cells. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 67-71 24331535-8 2013 Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 71-75 24331535-10 2013 CONCLUSION: Our findings have suggested that resveratrol induces cell cycle arrest, apoptosis, and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways. Resveratrol 45-56 mechanistic target of rapamycin kinase Homo sapiens 147-151 24060150-5 2013 Recent studies suggest that modulation of the mTOR signalling pathway could play an important role in mediating the beneficial effects of RSV. Resveratrol 138-141 mechanistic target of rapamycin kinase Homo sapiens 46-50 24060150-6 2013 Therefore, this review summarises the current findings regarding RSV and its inhibition/activation of the proteins in the mTOR pathway, and thereby propose the proteins of the mTOR cascade to be primary targets for RSV. Resveratrol 65-68 mechanistic target of rapamycin kinase Homo sapiens 122-126 24060150-6 2013 Therefore, this review summarises the current findings regarding RSV and its inhibition/activation of the proteins in the mTOR pathway, and thereby propose the proteins of the mTOR cascade to be primary targets for RSV. Resveratrol 65-68 mechanistic target of rapamycin kinase Homo sapiens 176-180 24060150-6 2013 Therefore, this review summarises the current findings regarding RSV and its inhibition/activation of the proteins in the mTOR pathway, and thereby propose the proteins of the mTOR cascade to be primary targets for RSV. Resveratrol 215-218 mechanistic target of rapamycin kinase Homo sapiens 122-126 24060150-6 2013 Therefore, this review summarises the current findings regarding RSV and its inhibition/activation of the proteins in the mTOR pathway, and thereby propose the proteins of the mTOR cascade to be primary targets for RSV. Resveratrol 215-218 mechanistic target of rapamycin kinase Homo sapiens 176-180 24060150-7 2013 RSV affects many different targets related to mTOR, and it is not clear which is most relevant. Resveratrol 0-3 mechanistic target of rapamycin kinase Homo sapiens 46-50 24060150-8 2013 However, most frequently, RSV is found to inhibit the activity of the mTOR pathway proteins, and to activate AMPK and LKB1, which can suppress mTOR signalling. Resveratrol 26-29 mechanistic target of rapamycin kinase Homo sapiens 70-74 24060150-8 2013 However, most frequently, RSV is found to inhibit the activity of the mTOR pathway proteins, and to activate AMPK and LKB1, which can suppress mTOR signalling. Resveratrol 26-29 mechanistic target of rapamycin kinase Homo sapiens 143-147 24060150-9 2013 Thus, it appears that RSV plays a role in modulation of proteins of the mTOR pathway although more research is still needed to fully understand the interaction. Resveratrol 22-25 mechanistic target of rapamycin kinase Homo sapiens 72-76 24489988-2 2013 Resveratrol can promote transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) activation, increase the expression level of SIRT-1, which is a sirtuin family protein, and reduce mTOR pathway signaling. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 195-199 23541682-3 2013 Mechanistically, resveratrol-induced autophagy in the ESCC cells is AMPK/mTOR pathway independent. Resveratrol 17-28 mechanistic target of rapamycin kinase Homo sapiens 73-77 23680031-0 2013 Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells. Resveratrol 33-44 mechanistic target of rapamycin kinase Homo sapiens 72-76 23274061-6 2013 The activities of AMP-activated protein kinase and silent information regulator-1 were enhanced in hearts treated with resveratrol, whereas Akt activity and manganese superoxide dismutase expression were unchanged, and the activities of mammalian target of rapamycin and p70 S6 kinase were suppressed. Resveratrol 119-130 mechanistic target of rapamycin kinase Homo sapiens 237-266 24331535-0 2013 Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 107-111 23272906-0 2013 Targeting mTOR: evaluating the therapeutic potential of resveratrol for cancer treatment. Resveratrol 56-67 mechanistic target of rapamycin kinase Homo sapiens 10-14 23272906-2 2013 Over the past few years, numerous studies have suggested that suppressing the activity of mammalian target of rapamycin (mTOR), a critical regulator of cell metabolism, growth, and proliferation, may provide a key mechanism underlying the anticarcinogenic properties of resveratrol. Resveratrol 270-281 mechanistic target of rapamycin kinase Homo sapiens 90-119 23272906-2 2013 Over the past few years, numerous studies have suggested that suppressing the activity of mammalian target of rapamycin (mTOR), a critical regulator of cell metabolism, growth, and proliferation, may provide a key mechanism underlying the anticarcinogenic properties of resveratrol. Resveratrol 270-281 mechanistic target of rapamycin kinase Homo sapiens 121-125 23272906-3 2013 It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment. Resveratrol 23-34 mechanistic target of rapamycin kinase Homo sapiens 115-119 23272906-4 2013 In the current review, we discuss recent findings on the molecular mechanisms regulating mTOR signaling and the therapeutic potential of resveratrol for cancer treatment by targeting mTOR. Resveratrol 137-148 mechanistic target of rapamycin kinase Homo sapiens 183-187 23680031-12 2013 In conclusion, we demonstrate that resveratrol-induced A549 cell death was mediated by the process of autophagic cell death via Ca(2+)/AMPK-mTOR signaling pathway. Resveratrol 35-46 mechanistic target of rapamycin kinase Homo sapiens 140-144 23211629-0 2013 Resveratrol pre-treatment reduces early inflammatory responses induced by status epilepticus via mTOR signaling. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 97-101 23211629-5 2013 Futhermore, resveratrol significantly inhibited the activation of nuclear factor-kappa B and the production of proinflammatory molecules via mTOR pathway. Resveratrol 12-23 mechanistic target of rapamycin kinase Homo sapiens 141-145 23211629-6 2013 Additionally, we also proved that the inhibition of mTOR signal by resveratrol was mostly attributed to AMP-activated kinase (AMPK) activation. Resveratrol 67-78 mechanistic target of rapamycin kinase Homo sapiens 52-56 23211629-7 2013 Altogether, our results suggest that resveratrol suppresses inflammatory responses induced by seizures partially via AMPK/mTOR pathway. Resveratrol 37-48 mechanistic target of rapamycin kinase Homo sapiens 122-126 22574221-0 2012 Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 100-129 22530672-0 2012 Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 102-106 22530672-7 2012 CONCLUSIONS: Our findings demonstrate for the first time that resveratrol can enhance TMZ-mediated antitumor effects in GBM in vitro and in vivo, via ROS-dependent AMPK-TSC-mTOR signaling pathway. Resveratrol 62-73 mechanistic target of rapamycin kinase Homo sapiens 173-177 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Resveratrol 106-117 mechanistic target of rapamycin kinase Homo sapiens 330-334 22363816-0 2012 Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 52-81 22574221-4 2012 We observed that resveratrol down-regulated PKM2 expression by inhibiting mTOR signaling and suppressed cancer metabolism, adjudged by decreased glucose uptake, lactate production (aerobic glycolysis) and reduced anabolism (macromolecule synthesis) in various cancer cell lines. Resveratrol 17-28 mechanistic target of rapamycin kinase Homo sapiens 74-78 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 96-107 mechanistic target of rapamycin kinase Homo sapiens 18-47 21966552-0 2011 Resveratrol inhibits mTOR signaling by targeting DEPTOR. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 21-25 21966552-2 2011 Recent studies suggest that suppressing the signaling pathway mediated by mTOR, a well-known energy sensor that integrates various hormonal, nutrient and environmental signals to regulate cell growth, metabolism and survival, could play an important role in mediating the beneficial effect of RSV. Resveratrol 293-296 mechanistic target of rapamycin kinase Homo sapiens 74-78 21966552-3 2011 The underlying mechanisms by which RSV inhibits mTOR signaling remain elusive, but our recent studies show that RSV inhibits amino acid-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1- and AMPK-independent mechanism. Resveratrol 35-38 mechanistic target of rapamycin kinase Homo sapiens 48-52 21966552-3 2011 The underlying mechanisms by which RSV inhibits mTOR signaling remain elusive, but our recent studies show that RSV inhibits amino acid-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1- and AMPK-independent mechanism. Resveratrol 112-115 mechanistic target of rapamycin kinase Homo sapiens 147-151 21966552-4 2011 RSV treatment has no effect on the expression levels of mTOR, raptor and DEPTOR, but greatly promotes the interaction between mTOR and its inhibitor DEPTOR. Resveratrol 0-3 mechanistic target of rapamycin kinase Homo sapiens 126-130 21966552-5 2011 Our results reveal a novel mechanism by which RSV inhibits mTOR signaling and its function. Resveratrol 46-49 mechanistic target of rapamycin kinase Homo sapiens 59-63 21168265-0 2011 Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 52-56 21168265-8 2011 Thus, the resveratrol-rapamycin combination may have therapeutic value in treating breast cancer and perhaps other processes where mTOR is activated. Resveratrol 10-21 mechanistic target of rapamycin kinase Homo sapiens 131-135 22242130-6 2011 Given the role of the mammalian Target of Rapamycin (mTOR) in regulating protein synthesis, we examined the effect of resveratrol on mTOR signaling. Resveratrol 118-129 mechanistic target of rapamycin kinase Homo sapiens 133-137 22069489-11 2011 Resveratrol also attenuated phosphorylation of mammalian target of rapamycin (mTOR) and S6 ribosomal protein (S6RP) while ameliorating inflammation. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 47-76 22069489-11 2011 Resveratrol also attenuated phosphorylation of mammalian target of rapamycin (mTOR) and S6 ribosomal protein (S6RP) while ameliorating inflammation. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 78-82 21179458-4 2010 METHODOLOGY/PRINCIPAL FINDINGS: Resveratrol inhibited the phosphorylation of PI3K, AKT and mTOR. Resveratrol 32-43 mechanistic target of rapamycin kinase Homo sapiens 91-95 20812900-8 2010 Besides, some natural products, such as epigallocatechin gallate (EGCG), caffeine, curcumin and resveratrol, have been found to inhibit mTOR as well. Resveratrol 96-107 mechanistic target of rapamycin kinase Homo sapiens 136-140 20458181-1 2010 Resveratrol (RSV) is an attractive candidate for cancer therapy via its ability to intervene at different levels in the AMPK/mTOR pathway. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 125-129 20458181-1 2010 Resveratrol (RSV) is an attractive candidate for cancer therapy via its ability to intervene at different levels in the AMPK/mTOR pathway. Resveratrol 13-16 mechanistic target of rapamycin kinase Homo sapiens 125-129 20458181-2 2010 Indeed, RSV is unique in its capacity to inhibit both mTOR and S6 kinase and to activate AMPK. Resveratrol 8-11 mechanistic target of rapamycin kinase Homo sapiens 54-58 20458181-4 2010 Here we discuss how Resveratrol can mediate ACD in CML cells and the possibility of utilizing the AMPK/mTOR and JNK/p62 pathways via Resveratrol to combat CML and other hematopoietic malignancies. Resveratrol 133-144 mechanistic target of rapamycin kinase Homo sapiens 103-107 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 96-107 mechanistic target of rapamycin kinase Homo sapiens 49-53 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 96-107 mechanistic target of rapamycin kinase Homo sapiens 137-141 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 96-107 mechanistic target of rapamycin kinase Homo sapiens 137-141 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 281-292 mechanistic target of rapamycin kinase Homo sapiens 18-47 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 281-292 mechanistic target of rapamycin kinase Homo sapiens 49-53 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 281-292 mechanistic target of rapamycin kinase Homo sapiens 137-141 19959541-7 2010 The activation of mammalian target of rapamycin (mTOR) was differentially regulated by low-dose resveratrol, i.e. the phosphorylation of mTOR at serine 2448 was inhibited, whereas the phosphorylation of mTOR at serine 2481 was increased, which was attenuated with a higher dose of resveratrol. Resveratrol 281-292 mechanistic target of rapamycin kinase Homo sapiens 137-141 19108833-7 2009 Resveratrol blocked the oxLDL-induced phosphorylation and activation of the PI3K/Akt/mTOR/p70S6K pathway and strongly inhibited both the DNA synthesis and proliferation of SMC. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 85-89 20103647-5 2010 RSV also stimulated AMPK, thereby inhibiting the mTOR pathway. Resveratrol 0-3 mechanistic target of rapamycin kinase Homo sapiens 49-53 20103647-6 2010 AMPK knockdown or mTOR overexpression impaired RSV-induced autophagy but not JNK activation. Resveratrol 47-50 mechanistic target of rapamycin kinase Homo sapiens 18-22 19108833-0 2009 Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 25-29 20080969-8 2010 Furthermore, resveratrol inhibited the AMPK target mTOR (mammalian target of rapamycin) to trigger autophagy and lysosomal degradation of Abeta. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 51-55 20080969-8 2010 Furthermore, resveratrol inhibited the AMPK target mTOR (mammalian target of rapamycin) to trigger autophagy and lysosomal degradation of Abeta. Resveratrol 13-24 mechanistic target of rapamycin kinase Homo sapiens 57-86 19471118-0 2009 At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Resveratrol 37-48 mechanistic target of rapamycin kinase Homo sapiens 31-35 19471118-4 2009 We discuss whether concentrations of resveratrol that inhibit mTOR (target of rapamycin) and suppress cellular senescence are clinically achievable and whether partial inhibition of mTOR by resveratrol might be sufficient to affect organismal aging. Resveratrol 37-48 mechanistic target of rapamycin kinase Homo sapiens 62-66 17825886-10 2007 Moreover, resveratrol reduces the levels of phosphorylated Akt and mTOR, two signals that increase glucose uptake and the rate limiting steps in glycolysis. Resveratrol 10-21 mechanistic target of rapamycin kinase Homo sapiens 67-71 19827268-0 2009 Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. Resveratrol 0-11 mechanistic target of rapamycin kinase Homo sapiens 35-39 19827268-3 2009 In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol 38-49 mechanistic target of rapamycin kinase Homo sapiens 109-138 19827268-3 2009 In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol 38-49 mechanistic target of rapamycin kinase Homo sapiens 140-144 19827268-6 2009 Resveratrol reduced phosphorylation of ribosomal protein S6 and the mTOR inhibitor rapamycin further enhanced resveratrol-induced cell death. Resveratrol 110-121 mechanistic target of rapamycin kinase Homo sapiens 68-72 19827268-7 2009 These results suggest that the downregulation of PI3K/Akt/mTOR signaling pathways may be an important mediator in resveratrol-induced apoptosis in glioma cells. Resveratrol 114-125 mechanistic target of rapamycin kinase Homo sapiens 58-62 34791915-7 2021 CONCLUSION: The present study concludes that the combination of curcumin and resveratrol significantly sensitized the EOC cells to cisplatin treatment, thereby inhibiting chemoresistance in ovarian cancer cells by significant inhibition of the PI3K/AKT/mTOR pathway. Resveratrol 78-89 mechanistic target of rapamycin kinase Homo sapiens 254-258 34935193-9 2022 RES also inhibits the PI3K/Akt/mTOR pathway to induce apoptosis. Resveratrol 0-3 mechanistic target of rapamycin kinase Homo sapiens 31-35 35178649-6 2022 In addition, the levels of phosphorylated mTOR were low after resveratrol treatment. Resveratrol 62-73 mechanistic target of rapamycin kinase Homo sapiens 42-46 34832850-3 2021 We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Resveratrol 32-43 mechanistic target of rapamycin kinase Homo sapiens 173-177 34512368-3 2021 In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53. Resveratrol 113-124 mechanistic target of rapamycin kinase Homo sapiens 310-314 34439500-5 2021 In addition, RES, OXYRES, and their acetylated derivatives suppressed UVB-induced matrix metalloproteinase (MMP)-1 expression via inhibition of mitogen-activated protein kinases (MAPKs) and Akt/mTOR signaling pathways. Resveratrol 13-16 mechanistic target of rapamycin kinase Homo sapiens 194-198 35466048-0 2022 Erratum to "Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes" (Int. Resveratrol 12-23 mechanistic target of rapamycin kinase Homo sapiens 88-92