PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33894429-10	2021	Computational studies showed that H-bond formation between the nitrogen atom in pyrazolo[4,3-D] pyrimidine moiety with Gln817 and creating a hydrophobic cavity result in the stability of the alkyl group in the PDE5A active site.	Nitrogen	63-71	phosphodiesterase 5A	Homo sapiens	210-215	
30767749-9	2019	CONCLUSION: In silico docking studies revealed that nitrogen-containing tetrahydro-pyridonaphthyridine and dihydro-pyridoquinazoline tricyclic lead scaffolds have emerged as novel PDE5A inhibitors for antihypertensive activity.	Nitrogen	52-60	phosphodiesterase 5A	Homo sapiens	180-185	
23117589-2	2012	Some compounds were as active as tadalafil in inhibiting PDE5 and of better selectivity profile particularly versus PDE11A, the nature of the terminal ring and its nitrogen substituent are the main determinants of selectivity.	Nitrogen	164-172	phosphodiesterase 5A	Homo sapiens	57-61	
32199305-2	2020	Compounds that have the 6R, 12aR configuration and terminal carboxylic acid group at the side chain arising from the piperazinedione nitrogen were potent PDE5 inhibitors, with compound 11 having almost equal potency to tadalafil and superior selectivity over PDE11, the most common off-target for tadalafil.	Nitrogen	133-141	phosphodiesterase 5A	Homo sapiens	154-158