PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15024013-0 2004 The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. Nitrogen 12-13 solute carrier family 6 member 3 Homo sapiens 77-97 19532984-1 2009 A series of 2beta-carbomethoxy-3beta-phenyl tropanes with conformationally constrained nitrogen substituents were synthesized as potential selective dopamine transporter ligands. Nitrogen 87-95 solute carrier family 6 member 3 Homo sapiens 149-169 17869101-0 2007 High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors. Nitrogen 80-88 solute carrier family 6 member 3 Homo sapiens 5-25 16905323-5 2006 These results indicate that the dopamine transporter can tolerate some variability in proximity of the benzhydryl ether to the basic nitrogen atom of the tropane without loss in potency. Nitrogen 133-141 solute carrier family 6 member 3 Homo sapiens 32-52 15024013-1 2004 The present study addressed the role of N-linked glycosylation of the human dopamine transporter (DAT) in its function with the help of mutants, in which canonical N-glycosylation sites have been removed (N181Q, N181Q,N188Q, and N181Q,N188Q,N205Q), expressed in human embryonic kidney-293 cells. Nitrogen 40-41 solute carrier family 6 member 3 Homo sapiens 76-96 15024013-1 2004 The present study addressed the role of N-linked glycosylation of the human dopamine transporter (DAT) in its function with the help of mutants, in which canonical N-glycosylation sites have been removed (N181Q, N181Q,N188Q, and N181Q,N188Q,N205Q), expressed in human embryonic kidney-293 cells. Nitrogen 40-41 solute carrier family 6 member 3 Homo sapiens 98-101 15024013-1 2004 The present study addressed the role of N-linked glycosylation of the human dopamine transporter (DAT) in its function with the help of mutants, in which canonical N-glycosylation sites have been removed (N181Q, N181Q,N188Q, and N181Q,N188Q,N205Q), expressed in human embryonic kidney-293 cells. Nitrogen 164-165 solute carrier family 6 member 3 Homo sapiens 76-96 15024013-1 2004 The present study addressed the role of N-linked glycosylation of the human dopamine transporter (DAT) in its function with the help of mutants, in which canonical N-glycosylation sites have been removed (N181Q, N181Q,N188Q, and N181Q,N188Q,N205Q), expressed in human embryonic kidney-293 cells. Nitrogen 164-165 solute carrier family 6 member 3 Homo sapiens 98-101 15024013-3 2004 Prevention of N-glycosylation reduced both surface and intracellular DAT. Nitrogen 14-15 solute carrier family 6 member 3 Homo sapiens 69-72 15024013-6 2004 Non-glycosylated DAT did not transport dopamine as efficiently as wild-type DAT as judged from the sharp reduction in uptake V(max), and prevention of N-glycosylation enhanced the potency of cocaine-like drugs in inhibiting dopamine uptake into intact cells without changing their affinity for DAT when measured in membrane preparations prepared from these cells. Nitrogen 0-1 solute carrier family 6 member 3 Homo sapiens 17-20 10406650-1 1999 In order to further explore the importance of cocaine"s bridge nitrogen atom in binding to the dopamine transporter (DAT), we have synthesized the previously known racemic 8-oxa-norcocaines 3-6 in which the nitrogen atom has been replaced by oxygen. Nitrogen 63-71 solute carrier family 6 member 3 Homo sapiens 95-115 11277529-4 2001 The inactivity of the 8-oxygenated analogues seems to point out that, unlike cocaine and its analogues, interactions of benztropine ligands with DAT may be strongly governed by the nitrogen atom. Nitrogen 181-189 solute carrier family 6 member 3 Homo sapiens 145-148 20575852-9 2000 We present evidence that the widespread assumption that dopamine transporter blockers require an amine nitrogen in their structure is incorrect as non-amines are effective blockers of transporters. Nitrogen 103-111 solute carrier family 6 member 3 Homo sapiens 56-76 10479296-5 1999 Congeners in which the amide nitrogen atom was attached to the aralkyl moiety of the GBR molecule showed moderate affinity (K(i) = 51-61 nM) and selectivity for the dopamine transporter (DAT) site. Nitrogen 29-37 solute carrier family 6 member 3 Homo sapiens 165-185 10479296-5 1999 Congeners in which the amide nitrogen atom was attached to the aralkyl moiety of the GBR molecule showed moderate affinity (K(i) = 51-61 nM) and selectivity for the dopamine transporter (DAT) site. Nitrogen 29-37 solute carrier family 6 member 3 Homo sapiens 187-190 10406650-1 1999 In order to further explore the importance of cocaine"s bridge nitrogen atom in binding to the dopamine transporter (DAT), we have synthesized the previously known racemic 8-oxa-norcocaines 3-6 in which the nitrogen atom has been replaced by oxygen. Nitrogen 63-71 solute carrier family 6 member 3 Homo sapiens 117-120 10406650-1 1999 In order to further explore the importance of cocaine"s bridge nitrogen atom in binding to the dopamine transporter (DAT), we have synthesized the previously known racemic 8-oxa-norcocaines 3-6 in which the nitrogen atom has been replaced by oxygen. Nitrogen 207-215 solute carrier family 6 member 3 Homo sapiens 95-115 10406650-1 1999 In order to further explore the importance of cocaine"s bridge nitrogen atom in binding to the dopamine transporter (DAT), we have synthesized the previously known racemic 8-oxa-norcocaines 3-6 in which the nitrogen atom has been replaced by oxygen. Nitrogen 207-215 solute carrier family 6 member 3 Homo sapiens 117-120 205926-4 1978 A new view was constructed which suggests that the nitrogens of the DAT compounds were positioned better than those of the model compounds with regard to their binding sites. Nitrogen 51-60 solute carrier family 6 member 3 Homo sapiens 68-71 9703474-0 1998 Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter. Nitrogen 125-126 solute carrier family 6 member 3 Homo sapiens 213-233 2806548-6 1989 Complete N-linked deglycosylation of the neuronal dopamine transporter with the endoglycosidase, glycopeptidase-F, increased the electrophoretic mobility of the 62 kDa polypeptide to apparent Mr 48,000. Nitrogen 9-10 solute carrier family 6 member 3 Homo sapiens 50-70 28691317-2 2017 The 6FDA-DAT1-OH polyimide is thermally stable up to 440 C, shows excellent solubility in polar solvents, and has moderately high Brunauer-Teller-Emmett (BET) surface area of 160 m2 g-1 , as determined by nitrogen adsorption at -196 C. Hydroxyl functionalization applied to the rigid 3D triptycene-based diamine building block results in a polyimide that exhibits moderate pure-gas CO2 permeability of 70 Barrer combined with high CO2 /CH4 selectivity of 50. Nitrogen 206-214 solute carrier family 6 member 3 Homo sapiens 9-13 31661268-0 2020 Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability. Nitrogen 165-173 solute carrier family 6 member 3 Homo sapiens 114-134 29945932-0 2018 Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects. Nitrogen 33-34 solute carrier family 6 member 3 Homo sapiens 0-20 28442581-9 2017 The present results indicate that behavioral antagonist effects of the N-substituted BZT analogs are specific for abused drugs acting at the DAT and further suggest that sigmaR antagonism contributes to those actions. Nitrogen 71-72 solute carrier family 6 member 3 Homo sapiens 141-144