PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27847452-5 2012 CCl4 caused elevated levels of urea and creatinine while it decreased levels of total protein and albumin in plasma. Creatinine 40-50 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 22314953-8 2010 Also, CCL4 produced significant increase in serum blood urea nitrogen (BUN) and creatinine compared with normal rats. Creatinine 80-90 C-C motif chemokine ligand 4 Rattus norvegicus 6-10 9034934-4 1996 In CCl4-treated cirrhotic rats, the osteoid volume decreased while the urinary calcium/creatinine ratio increased. Creatinine 87-97 C-C motif chemokine ligand 4 Rattus norvegicus 3-7 34964416-7 2022 RESULTS: The application of CCl4 led to tubular necrosis, inflammation, vascular congestion, and increased Serum BUN and creatinine values. Creatinine 121-131 C-C motif chemokine ligand 4 Rattus norvegicus 28-32 35197735-5 2022 In renal samples of rats treated with CCl4, the antioxidant enzymes (POD, SOD, CAT), PH level, protein level, and glutathione contents were significantly (p < 0.05) declined whereas renal biochemicals (H2O2, TBARS, and nitrite), specific gravity, level of urea, urobilinogen, serum BUN and creatinine were markedly (p < 0.05) increased relative to control group. Creatinine 290-300 C-C motif chemokine ligand 4 Rattus norvegicus 38-42 6499094-0 1984 Elimination of creatinine following intravenous administration to chronically CCl4-treated rats. Creatinine 15-25 C-C motif chemokine ligand 4 Rattus norvegicus 78-82 33184842-5 2021 CCl4 induced considerable increases (p < .05) in the levels of serum ALT, AST, urea and creatinine, total lipid, and triglycerides coupled with significant reductions (p < .05) in serum antioxidant enzymes and some liver histopathological deformations compared to the negative control (group 1). Creatinine 88-98 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 33103102-8 2020 Results: Compared to the control animals, CCl4 administration caused kidney damage as evidenced by significant (P < 0.05) increase in the evaluated indices (urea, creatinine, Na+ and K+). Creatinine 163-173 C-C motif chemokine ligand 4 Rattus norvegicus 42-46 33824114-7 2020 CCl4 administration to the rats resulted to acute kidney injury with significantly increased Urea, Creatinine, K+ and MDA levels and decreased SOD activity (p<0.05, p<0.01 or p<0.001). Creatinine 99-109 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 32657163-4 2022 Administration of CCl4 resulted in a marked increase in hepatic (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase) and renal (blood urea nitrogen and creatinine) markers. Creatinine 176-186 C-C motif chemokine ligand 4 Rattus norvegicus 18-22 32349632-6 2021 MDA, serum TNF-alpha, AST, ALT, urea, and creatinine levels (p < 0.05) were significantly higher, and SOD activity and GSH level were significantly (p < 0.05) lower in the CCl4 group than in the control group. Creatinine 42-52 C-C motif chemokine ligand 4 Rattus norvegicus 172-176 32349632-7 2021 Treatment with chrysin in the chrysin + CCl4 group decreased MDA, AST, ALT, creatinine, and TNF-alpha levels (p < 0.05), and increased SOD activity, GSH levels (p < 0.05), and serum TNF-alpha levels (p < 0.05). Creatinine 76-86 C-C motif chemokine ligand 4 Rattus norvegicus 40-44 31949468-9 2019 The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde. Creatinine 309-319 C-C motif chemokine ligand 4 Rattus norvegicus 17-21 31222653-6 2019 The results revealed that the two actinomycete extracts S19 and G30 could significantly (p < 0.01) lower the elevated levels of serum creatinine, urea, and uric acid caused by the CCl4 administration. Creatinine 134-144 C-C motif chemokine ligand 4 Rattus norvegicus 180-184 30994004-7 2019 CvEO (100 mg/kg) caused significant reductions in CCl4-elevated levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, total cholesterol, triglycerides, low-density lipoprotein, urea, and creatinine and increased the level of high-density lipoprotein compared with the untreated group. Creatinine 262-272 C-C motif chemokine ligand 4 Rattus norvegicus 50-54 30676168-4 2019 CCl4 showed an increase of serum hepatic and renal markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine. Creatinine 135-145 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 30342848-8 2018 RESULTS: CCl4 caused a significant elevation of liver enzymes, lactic acid dehydrogenase, blood glucose, uric acid, blood urea and serum creatinine as compared to the control group. Creatinine 137-147 C-C motif chemokine ligand 4 Rattus norvegicus 9-13 30377595-9 2018 Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). Creatinine 30-40 C-C motif chemokine ligand 4 Rattus norvegicus 9-13 30377595-9 2018 Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). Creatinine 56-66 C-C motif chemokine ligand 4 Rattus norvegicus 9-13 29796221-4 2018 Results: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P<=0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman"s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. Creatinine 60-70 C-C motif chemokine ligand 4 Rattus norvegicus 16-20 29459508-7 2018 Plasma levels of creatinine and urea increased significantly in CCl4 control, while creatinine clearance was reduced significantly in the same group. Creatinine 17-27 C-C motif chemokine ligand 4 Rattus norvegicus 64-68 28778164-20 2017 Treatment of rats with CCl4 markedly (P < 0.01) increased the count of urinary red blood cells and leucocytes, concentration of urea, creatinine and urobilinogen and specific gravity whereas creatinine clearance was reduced. Creatinine 137-147 C-C motif chemokine ligand 4 Rattus norvegicus 23-27 28778164-20 2017 Treatment of rats with CCl4 markedly (P < 0.01) increased the count of urinary red blood cells and leucocytes, concentration of urea, creatinine and urobilinogen and specific gravity whereas creatinine clearance was reduced. Creatinine 194-204 C-C motif chemokine ligand 4 Rattus norvegicus 23-27 28778164-21 2017 Serum level of total protein, albumin, globulin, nitrite, creatinine and blood urea nitrogen (BUN) was significantly increased (P < 0.01) by CCl4 treatment. Creatinine 58-68 C-C motif chemokine ligand 4 Rattus norvegicus 144-148 28653915-5 2017 The administration of CCl4 and AAP caused significant (p<0.05) elevation in liver enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and other biochemical parameters, bilirubin, glucose, triglyceride and kidney function markers: urea and creatinine. Creatinine 321-331 C-C motif chemokine ligand 4 Rattus norvegicus 22-26 27530158-15 2016 MBM administration significantly alleviated the toxic effect of CCl4 in rat and decreased the elevated level of RBCs, pus and epithelial cells, specific gravity, creatinine, urobilinogen, urea and albumin while increased the pH and urinary protein. Creatinine 162-172 C-C motif chemokine ligand 4 Rattus norvegicus 64-68 27486379-7 2015 In CCl4 treated rats the results showed significant (p<0.05) increases in serum Na+, K+, Cl(-), urea and creatinine. Creatinine 108-118 C-C motif chemokine ligand 4 Rattus norvegicus 3-7 25933946-3 2015 RESULTS: Administration of CCl4 significantly (p<0.001) increased the levels of renal function test such as creatinine and blood urea nitrogen (BUN). Creatinine 111-121 C-C motif chemokine ligand 4 Rattus norvegicus 27-31 24867503-7 2014 Given at the above doses conferred significant protection against the hepatotoxic actions of CCl4 in rats, reducing serum markers like SGOT, SGPT, ALP, creatinine and urea levels back to near normal (p<0.05) compared to untreated rats. Creatinine 152-162 C-C motif chemokine ligand 4 Rattus norvegicus 93-97