PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16081678-5 2005 PGE(2) and EP1/EP3 agonist sulprostone increased neurotrophin-4 secretion and mRNA levels without altering its mRNA stability. sulprostone 27-38 prostaglandin E receptor 3 Homo sapiens 15-18 14562138-9 2003 Sulprostone, a selective EP3 receptor agonist, induced weak contractions in HCC tissue strips but augmented forskolin-induced cAMP synthesis in HCC SMC. sulprostone 0-11 prostaglandin E receptor 3 Homo sapiens 25-28 9779823-8 1998 Sulprostone, an EP3/EP1 agonist, has no effect on the expression of these three genes. sulprostone 0-11 prostaglandin E receptor 3 Homo sapiens 16-19 11447018-6 2001 Treatment with the EP1, EP2, EP3, and EP4 agonist PGE2 (1 microM) elevated R twofold and significantly increased tissue cAMP content, whereas the EP2 and EP4 agonist deoxy-PGE1 (1 microM) or the EP1 and EP3 agonist sulprostone (1 microM) had no effect. sulprostone 215-226 prostaglandin E receptor 3 Homo sapiens 29-32 10466584-10 1999 Sulprostone, an EP1/EP3 agonist, showed stimulatory effect on ICAM-1 expression elicited by IFN-gamma. sulprostone 0-11 prostaglandin E receptor 3 Homo sapiens 20-23 9530435-7 1997 Sulprostone (EP3 > EP1) did not stimulate adenylyl cyclase activity per se, but inhibited forskolin-stimulated adenylyl cyclase in a pertussis toxin (PT) sensitive way. sulprostone 0-11 prostaglandin E receptor 3 Homo sapiens 13-16 9786498-7 1998 Cumulative concentrations (1-1000 nM) of EP-receptor agonists like prostaglandin E2, nocloprost, and sulprostone (EP1 and EP3 selective) inhibited evoked [3H]ACh release in a concentration dependent manner with IC50 values between 4- 14 nM and maximal inhibition of about 70%. sulprostone 101-112 prostaglandin E receptor 3 Homo sapiens 122-125 9154343-8 1997 Isoforms EP3I and EP3II showed concentration-dependent inhibition of forskolin-stimulated adenylyl cyclase in CHO-K1 cells by the EP3 receptor agonist, sulprostone. sulprostone 152-163 prostaglandin E receptor 3 Homo sapiens 9-13 9154343-8 1997 Isoforms EP3I and EP3II showed concentration-dependent inhibition of forskolin-stimulated adenylyl cyclase in CHO-K1 cells by the EP3 receptor agonist, sulprostone. sulprostone 152-163 prostaglandin E receptor 3 Homo sapiens 18-23 9154343-9 1997 The IC50 calculated for sulprostone inhibition was 0.2 nM for EP3I and 0.15 nM for EP3II. sulprostone 24-35 prostaglandin E receptor 3 Homo sapiens 62-66 9154343-9 1997 The IC50 calculated for sulprostone inhibition was 0.2 nM for EP3I and 0.15 nM for EP3II. sulprostone 24-35 prostaglandin E receptor 3 Homo sapiens 83-88 9154343-18 1997 Pertussis toxin reversed sulprostone-mediated inhibition of cyclic AMP formation in EP3I and EP3II and abolished constitutive activity of EP3III, EP3IV and T-359 so that the level of forskolin-stimulated cyclic AMP produced was the same in all cells and similar to that obtained in mock-transfected cells. sulprostone 25-36 prostaglandin E receptor 3 Homo sapiens 84-88 9154343-18 1997 Pertussis toxin reversed sulprostone-mediated inhibition of cyclic AMP formation in EP3I and EP3II and abolished constitutive activity of EP3III, EP3IV and T-359 so that the level of forskolin-stimulated cyclic AMP produced was the same in all cells and similar to that obtained in mock-transfected cells. sulprostone 25-36 prostaglandin E receptor 3 Homo sapiens 93-98 9531979-7 1998 In contrast, activation of EP3 receptors by sulprostone, which is virtually devoid of agonist activity at EP2 or EP4 receptors, inhibited bromodeoxyuridine uptake in indomethacin-treated cells up to 30%. sulprostone 44-55 prostaglandin E receptor 3 Homo sapiens 27-30 8974845-10 1995 The EP2 agonist 11-deoxy-16, 16-dimethyl PGE2 at 10(-4) M inhibited cell contraction but the EP3 agonist sulprostone had no effect. sulprostone 105-116 prostaglandin E receptor 3 Homo sapiens 93-96 9031929-8 1996 CONCLUSION: Since firstly, PGE2 acts through EP1, EP2 and EP3 specific receptors, whereas the action of sulprostone is only mediated by EP1 and EP3, and secondly EP2 receptor is coupled with cAMP production, we conclude that cAMP is involved in mediating the action of PGE2 upon GAG synthesis by human cultured cervical fibroblasts. sulprostone 104-115 prostaglandin E receptor 3 Homo sapiens 144-147 8567030-4 1995 EP3 R expression was demonstrated by inhibition of [3H]PGE2 binding with the EP1/EP3 agonist sulprostone [50% inhibitory concentration (IC50 = 3.3 +/- 0.6 nM)] and the EP3/EP2 agonist M&B 28767 (IC50 = 2.1 +/- 0.3 nM), but not with the EP1 antagonist SC-19220. sulprostone 93-104 prostaglandin E receptor 3 Homo sapiens 0-3 8567030-4 1995 EP3 R expression was demonstrated by inhibition of [3H]PGE2 binding with the EP1/EP3 agonist sulprostone [50% inhibitory concentration (IC50 = 3.3 +/- 0.6 nM)] and the EP3/EP2 agonist M&B 28767 (IC50 = 2.1 +/- 0.3 nM), but not with the EP1 antagonist SC-19220. sulprostone 93-104 prostaglandin E receptor 3 Homo sapiens 81-84 8567030-4 1995 EP3 R expression was demonstrated by inhibition of [3H]PGE2 binding with the EP1/EP3 agonist sulprostone [50% inhibitory concentration (IC50 = 3.3 +/- 0.6 nM)] and the EP3/EP2 agonist M&B 28767 (IC50 = 2.1 +/- 0.3 nM), but not with the EP1 antagonist SC-19220. sulprostone 93-104 prostaglandin E receptor 3 Homo sapiens 81-84 7606349-7 1995 Similarly, the EP1-receptor agonist, 17-phenyl PGE2 (10 microM), and the EP3/EP1-receptor agonist, sulprostone (10 microM), also inhibited O2- generation, causing 32.2 +/- 7.0% and 15.3 +/- 3.4% inhibition respectively. sulprostone 99-110 prostaglandin E receptor 3 Homo sapiens 73-89 7480806-3 1995 On the other hand, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, and sulprostone, an agonist for the PGE2 receptor EP1/EP3 subtypes, had no effect. sulprostone 96-107 prostaglandin E receptor 3 Homo sapiens 146-149 7606349-12 1995 By contrast, even in the presence of IBMX (0.25 mM), sulprostone and 17-phenyl PGE2 were only effective at the highest concentration (10 microM), and gave EECs of > 700 and 486 respectively, suggesting that EP1 or EP3 receptors are not involved.6. sulprostone 53-64 prostaglandin E receptor 3 Homo sapiens 217-220 7834185-2 1994 In 13 of 15 experiments, prostaglandin E2 (PGE2) and sulprostone (a prostanoid EP1/EP3-receptor agonist) contracted isolated rings of human pulmonary artery at low concentrations (> or = 5 and > or = 0.5 nM respectively). sulprostone 53-64 prostaglandin E receptor 3 Homo sapiens 83-86 35450969-1 2022 BACKGROUND: Prostaglandin E2 (PGE2) increases pulmonary vascular permeability by activation of the PGE2 receptor 3 (EP3) which may explain adverse pulmonary effects of the EP1/EP3 receptor agonist sulprostone in patients. sulprostone 197-208 prostaglandin E receptor 3 Homo sapiens 116-119 32205366-9 2020 The uterotonic effects of the EP3/1 agonist sulprostone were more pronounced than the EP1 agonist ONO-D1-004, corresponding to abundant EP3 receptor expression in all samples. sulprostone 44-55 prostaglandin E receptor 3 Homo sapiens 30-33 32488496-6 2020 RESULTS: In vitro studies showed that sulprostone (an EP3 agonist) enhanced the proliferation and migration of cervical cancer cells, whereas silencing of EP3 inhibited their proliferation and migration. sulprostone 38-49 prostaglandin E receptor 3 Homo sapiens 54-57 29700097-6 2018 In vitro, we demonstrated that sulprostone (an EP1/EP3 agonist) inhibited the secretion of beta-hCG and progesterone in JEG-3 cells and the secretion of beta-hCG in HTR-8/SVneo cells while it induced the expression of plasminogen activator inhibitor type 1 in JEG-3 cells. sulprostone 31-42 prostaglandin E receptor 3 Homo sapiens 51-54 26228833-0 2015 The EP3 Agonist Sulprostone Enhances Platelet Adhesion But Not Thrombus Formation Under Flow Conditions. sulprostone 16-27 prostaglandin E receptor 3 Homo sapiens 4-7 26228833-6 2015 The EP3 agonist sulprostone caused an increase in the adhesion of washed platelets to fibrinogen as well as to collagen under low shear stress, an effect that was blocked by the EP3 antagonist L-798106. sulprostone 16-27 prostaglandin E receptor 3 Homo sapiens 4-7 26228833-6 2015 The EP3 agonist sulprostone caused an increase in the adhesion of washed platelets to fibrinogen as well as to collagen under low shear stress, an effect that was blocked by the EP3 antagonist L-798106. sulprostone 16-27 prostaglandin E receptor 3 Homo sapiens 178-181 21323896-7 2011 KEY RESULTS: PGE(2) induced contractions of IMA (E(max) = 1.43 +- 0.20 g; pEC(50) = 7.50 +- 0.10); contractions were also observed with the EP(3) receptor agonists, sulprostone, 17-phenyl-PGE(2) , misoprostol or ONO-AE-248. sulprostone 165-176 prostaglandin E receptor 3 Homo sapiens 140-145 23338277-6 2013 Treatment with PGE2 and the E prostanoid 3 (EP3) receptor agonist, sulprostone, resulted in the time-dependent increase in FBP1 protein expression; sulprostone increased the viability of the liver cancer cells. sulprostone 67-78 prostaglandin E receptor 3 Homo sapiens 44-47 20431854-0 2010 The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood. sulprostone 16-27 prostaglandin E receptor 3 Homo sapiens 4-7 18097066-8 2008 Conversely, the promitogenic effects of mid-range concentrations of PGE2 were mimicked by the EP3-selective agent, sulprostone, by cAMP reduction, and lost upon inhibition of Gi-mediated signaling with pertussis toxin. sulprostone 115-126 prostaglandin E receptor 3 Homo sapiens 94-97