PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28847709-4 2018 Recently, some flavonoids were shown to inhibit poly (ADP-ribose) polymerases (PARPs) and cyclic ADP-ribose (cADP) synthases (CD38 and CD157), elevate intracellular nicotinamide adenine dinucleotide+ (NAD+) levels and activate NAD+ dependent sirtuin -mediated signaling pathways. Flavonoids 15-25 CD38 molecule Homo sapiens 126-130 29178427-8 2018 When CD38-generated cADPR was restrained by 8-Br-cADPR or kuromanin, a flavonoid known to inhibit CD38 enzymatic activity, RSV-induced type I/III IFNs and ISGs were markedly reduced. Flavonoids 71-80 CD38 molecule Homo sapiens 5-9 29178427-8 2018 When CD38-generated cADPR was restrained by 8-Br-cADPR or kuromanin, a flavonoid known to inhibit CD38 enzymatic activity, RSV-induced type I/III IFNs and ISGs were markedly reduced. Flavonoids 71-80 CD38 molecule Homo sapiens 98-102 21641214-0 2011 Flavonoids as inhibitors of human CD38. Flavonoids 0-10 CD38 molecule Homo sapiens 34-38 21641214-4 2011 We report that human CD38 is inhibited at low micromolar concentrations by flavonoids such as luteolinidin, kuromanin and luteolin (IC(50) <10 muM). Flavonoids 75-85 CD38 molecule Homo sapiens 21-25 20951593-9 2010 A selection of representative flavonoid inhibitors indicated that although they also inhibit the homologous human CD38, a selectivity in favor of SmNACE could be reached. Flavonoids 30-39 CD38 molecule Homo sapiens 114-118 24990614-6 2015 Consistently, inhibition of the enzymatic activities of CD38 using the flavonoid kuromanin blocks CLL chemotaxis, adhesion and in vivo homing. Flavonoids 71-80 CD38 molecule Homo sapiens 56-60