PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23573138-0	2013	Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).	Flavonoids	64-74	solute carrier family 22 member 8	Homo sapiens	129-136	
21244849-3	2011	Accumulation of flavonoid conjugates was studied in human embryonic kidney 293H cells overexpressing OAT1 or OAT3.	Flavonoids	16-25	solute carrier family 22 member 8	Homo sapiens	109-113	
17920288-0	2007	Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	31-41	solute carrier family 22 member 8	Homo sapiens	96-101	
17920288-1	2007	The present study aimed to investigate the interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	74-84	solute carrier family 22 member 8	Homo sapiens	139-144	
17920288-2	2007	Five flavonoids (morin, silybin, naringin, naringenin and quercetin) were selected and their interaction characteristics with hOAT1 and hOAT3 were examined in MDCK cells overexpressing hOAT1 or hOAT3.	Flavonoids	5-15	solute carrier family 22 member 8	Homo sapiens	136-141	
32547398-0	2020	Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids.	Flavonoids	118-128	solute carrier family 22 member 8	Homo sapiens	60-64	
32547398-4	2020	In the present study, OAT3-mediated uptake of enalaprilat was first characterized, and the inhibition of OAT3 transport activity was then examined for a number of flavonoid and drug molecules with diverse structures.	Flavonoids	163-172	solute carrier family 22 member 8	Homo sapiens	105-109	
32547398-5	2020	A varying degree of inhibition potency was demonstrated for flavonoids, with IC50 values ranging from 0.03 to 22.6 microM against OAT3 transport activity.	Flavonoids	60-70	solute carrier family 22 member 8	Homo sapiens	130-134	
32547398-8	2020	For the polar center, hydroxyl groups present in flavonoids could act as either hydrogen bond donors or acceptors and the number and position of hydroxyl groups were critical drivers for inhibition potency, while carboxyl groups present in some drugs could form ionic bridges with OAT3.	Flavonoids	49-59	solute carrier family 22 member 8	Homo sapiens	281-285	
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	80-89	solute carrier family 22 member 8	Homo sapiens	33-37	
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	80-89	solute carrier family 22 member 8	Homo sapiens	154-158	
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	116-125	solute carrier family 22 member 8	Homo sapiens	154-158