PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23330926-2	2013	The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4"-, C-3", C-6 and C-8- position when there is a single or no hydroxy group on the B-ring.	Flavonoids	19-29	complement C4A (Rodgers blood group)	Homo sapiens	128-131	
22542668-7	2012	Analysis of structure-activity data revealed that flavonoids containing two hydroxyl groups in ring B and a carbonyl group at C-4 in combination with a double bond between C-2 and C-3 produced a much stronger inhibition, whereas substitution of a hydroxyl group at C-3 was associated with a less inhibitory effect.	Flavonoids	50-60	complement C4A (Rodgers blood group)	Homo sapiens	126-129	
31132359-13	2019	Also, methoxyl groups at C-4" may also be a favorable flavonoid structural characteristic for COX-2 mRNA inhibiton.	Flavonoids	54-63	complement C4A (Rodgers blood group)	Homo sapiens	25-28	
21413806-2	2011	We systematically studied the glucuronidation of 13 flavonoids (7 flavones and 6 flavonols, with hydroxyl groups at C-3, C-4", C-5, and/or C-7 positions in flavonoid structure) at a substrate concentration of 10 muM by 8 recombinant human UGT isoforms mainly responsible for the metabolism of flavonoids, UGTs 1A1, 1A3, 1A6, 1A7, 1A8, 1A9, 1A10, and 2B7.	Flavonoids	52-62	complement C4A (Rodgers blood group)	Homo sapiens	121-124	
6182778-4	1982	The inhibitory effect of flavonoids on human platelet function was diminished by saturation of the C-2, C-3 double bond, lack of the C-4 carbonyl, glycosylation at C-3 and a high number of hydroxyl substituents.	Flavonoids	25-35	complement C4A (Rodgers blood group)	Homo sapiens	133-136	
32149508-1	2020	Procyanidin B3 is a natural flavonoid composed of two catechins connected via a C4alpha-C8" bond.	Flavonoids	28-37	complement C4A (Rodgers blood group)	Homo sapiens	80-87	
32149508-2	2020	The couplings of catechin derivatives, promoted by Lewis acids, have been widely applied to the syntheses of procyanidin B3 and related flavonoids because the reactions construct the C4alpha-C8" bond in a highly stereo- and regioselective manner.	Flavonoids	136-146	complement C4A (Rodgers blood group)	Homo sapiens	183-190	
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C4A (Rodgers blood group)	Homo sapiens	121-124	
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C4A (Rodgers blood group)	Homo sapiens	170-173	
29318154-7	2017	Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property.	Flavonoids	114-124	complement C4A (Rodgers blood group)	Homo sapiens	36-39	
27397410-3	2016	The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.	Flavonoids	189-199	complement C4A (Rodgers blood group)	Homo sapiens	237-240