PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8798634-8 1996 An AT minor groove-binding drug, distamycin A, disrupted the TBP.TFIIA.DNA complex and restored the EGR1.DNA complex. stallimycin 33-45 TATA-box binding protein Homo sapiens 61-64 10524202-2 1999 Distamycin A inhibits transcription both in vitro and in vivo and can displace from DNA the transcription activator TATA binding protein promoter binding factor (TPBF). stallimycin 0-12 TATA-box binding protein Homo sapiens 116-136 7516181-3 1994 Our results demonstrate that reversible MGBs (DAPI, distamycin A, Hoechst 33258, and netropsin) are effective inhibitors of the formation of DNA/TBP complex and that distamycin A is the most potent (0.16 microM inhibits TBP complex formation by 50%). stallimycin 52-64 TATA-box binding protein Homo sapiens 145-148 7784168-0 1995 Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription. stallimycin 0-12 TATA-box binding protein Homo sapiens 38-41 7516181-3 1994 Our results demonstrate that reversible MGBs (DAPI, distamycin A, Hoechst 33258, and netropsin) are effective inhibitors of the formation of DNA/TBP complex and that distamycin A is the most potent (0.16 microM inhibits TBP complex formation by 50%). stallimycin 166-178 TATA-box binding protein Homo sapiens 145-148 7516181-3 1994 Our results demonstrate that reversible MGBs (DAPI, distamycin A, Hoechst 33258, and netropsin) are effective inhibitors of the formation of DNA/TBP complex and that distamycin A is the most potent (0.16 microM inhibits TBP complex formation by 50%). stallimycin 166-178 TATA-box binding protein Homo sapiens 220-223 7516181-4 1994 CC-1065, a drug that covalently binds to DNA in the minor groove, is even more active than distamycin A (0.00085 microM inhibits TBP complex formation by 50%). stallimycin 91-103 TATA-box binding protein Homo sapiens 129-132 7516181-7 1994 In the presence of TFIIA, a factor that enhances TBP association with DNA, greater drug concentrations (distamycin A and CC-1065, respectively) are needed to disrupt a preformed complex of DNA/TBP/TFIIA. stallimycin 104-116 TATA-box binding protein Homo sapiens 49-52 7516181-7 1994 In the presence of TFIIA, a factor that enhances TBP association with DNA, greater drug concentrations (distamycin A and CC-1065, respectively) are needed to disrupt a preformed complex of DNA/TBP/TFIIA. stallimycin 104-116 TATA-box binding protein Homo sapiens 193-196