PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19221147-6 2009 Finally, we show that a brief incubation of isolated PGCs with 10(-5)M lindane resulted in a marked decrease of the basal and kit-ligand-induced phosphorylation level of the AKT kinase, known to be crucial for PGC survival. Hexachlorocyclohexane 71-78 thymoma viral proto-oncogene 1 Mus musculus 174-177 19221147-7 2009 Taken together these results demonstrate that embryo exposure to lindane during early stages of gametogenesis can severely impair the number of germ cells in the fetal gonads; the compound appears to affect PGC survival through a direct proapoptotic action likely resulting from its adverse effect on AKT activity in such cells. Hexachlorocyclohexane 65-72 thymoma viral proto-oncogene 1 Mus musculus 301-304