PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1708174-1	1991	Rats treated with diets containing 20 ppm of alpha- or gamma-hexachlorocyclohexane (HCH) for 15 or 30 days showed increased levels of liver cytochrome P-450 followed by increased production of both thiobarbituric acid reactants by liver homogenates and microsomes and superoxide anion production by liver microsomes.	Hexachlorocyclohexane	84-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-156	
2483843-0	1989	Lindane mediated induction of cytochrome P-450 mRNA in rat liver: studies with a nonradioactive cDNA probe.	Hexachlorocyclohexane	0-7	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	30-46	
2483843-1	1989	Effect of lindane on the induction of cytochrome P-450 mRNA in rat liver was studied using a biotinylated cDNA probe.	Hexachlorocyclohexane	10-17	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	38-54	
2469257-4	1988	Lindane (60 mg/kg) administered orally to rats increased liver cytochrome P-450 content and superoxide radical (O2-.)	Hexachlorocyclohexane	0-7	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	63-79	
2469257-12	1988	Lindane administration results in time-dependent oxidative stress in liver which involves an early component (4-6 h) related to the reductive metabolism of lindane, and a late component (24 h) associated with the induction of cytochrome P-450; the biochemical changes correlated with the observed morphological lesions.	Hexachlorocyclohexane	0-7	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	226-242	
2429406-2	1986	doses of lindane (20, 40, 60 and 80 mg/kg) to rats produced a progressive increase in the liver microsomal content of cytochrome P-450 and in the rate of superoxide anion generation, as measured by adrenochrome formation.	Hexachlorocyclohexane	9-16	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-134	
2471492-0	1988	Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes.	Hexachlorocyclohexane	61-88	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	41-57	
2471492-1	1988	The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied.	Hexachlorocyclohexane	14-41	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	144-160	
2471492-1	1988	The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied.	Hexachlorocyclohexane	43-46	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	144-160	
16837770-5	2006	On the other hand, ovariectomy, administration of ICI182780, a specific estrogen antagonist, or administration of lindane, which is a widely used pesticide with anti-estrogenic effects, induced these adult male-specific CYP mRNAs in adult female SD rats.	Hexachlorocyclohexane	114-121	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	220-223	
2578765-6	1985	These results indicate that lindane interacts readily with heme and heme proteins, including cytochrome P-450, in the absence of oxygen to undergo multiple chloride eliminations forming chlorobenzene and benzene as end products.	Hexachlorocyclohexane	28-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109	
11684361-0	2001	Ovariectomy modulates the response of some cytochrome P450 isozymes to lindane in the rat.	Hexachlorocyclohexane	71-78	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	43-58	
11684361-2	2001	lindane, administered in corn oil by gavage, on cytochrome P450 (CYP) phenotype was investigated in the liver of ovariectomized (ovx), sham operated (sham-ope) and nonovariectomized (n/ovx) adult Wistar rats.	Hexachlorocyclohexane	0-7	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-63	
11684361-2	2001	lindane, administered in corn oil by gavage, on cytochrome P450 (CYP) phenotype was investigated in the liver of ovariectomized (ovx), sham operated (sham-ope) and nonovariectomized (n/ovx) adult Wistar rats.	Hexachlorocyclohexane	0-7	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	65-68	
11684361-13	2001	These results, overall, indicate that ovariectomy significantly affects, both qualitatively and quantitatively, CYP expression following induction by lindane and support the anti-estrogenic effect of lindane in rats.	Hexachlorocyclohexane	150-157	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-115	
11684361-13	2001	These results, overall, indicate that ovariectomy significantly affects, both qualitatively and quantitatively, CYP expression following induction by lindane and support the anti-estrogenic effect of lindane in rats.	Hexachlorocyclohexane	200-207	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-115	
11684361-14	2001	The pathophysiological and toxicological relevance of liver CYP induction by lindane and possibly other organochlorine xenobiotics in females with a lack or deficiency of estrogen supply remains to be investigated.	Hexachlorocyclohexane	77-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-63