PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25745770-15 2014 The aim of the study was to investigate genistein as a potential inhibitor of CTGF and TGFbeta1, beta2 and beta3 isoforms expression and a potential regulator of p53. Genistein 40-49 transforming growth factor beta 1 Homo sapiens 87-95 24243709-5 2015 Simultaneously, treatment with genistein suppressed epithelial-mesenchymal transition (EMT) induced by TGF-beta. Genistein 31-40 transforming growth factor beta 1 Homo sapiens 103-111 22884073-0 2012 The effects of genistein on transforming growth factor-beta1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro. Genistein 15-24 transforming growth factor beta 1 Homo sapiens 28-60 22884073-7 2012 RESULTS: Genistein can inhibit effectively TGF-b1-induced invasion and metastasis in Panc-1 by Transwell assay, which is through regulating the mRNA and protein expression of uPA and MMP2, but not MMP9 by RT-PCR/Western blotting, and is positively correlated with the concentration of genistein. Genistein 9-18 transforming growth factor beta 1 Homo sapiens 43-49 22884073-7 2012 RESULTS: Genistein can inhibit effectively TGF-b1-induced invasion and metastasis in Panc-1 by Transwell assay, which is through regulating the mRNA and protein expression of uPA and MMP2, but not MMP9 by RT-PCR/Western blotting, and is positively correlated with the concentration of genistein. Genistein 285-294 transforming growth factor beta 1 Homo sapiens 43-49 14605006-11 2004 Adipogenic differentiation and maturation, on the other hand, were reduced by genistein (and 17beta-estradiol) via an ER-dependent mechanism involving autocrine or paracrine TGFbeta1 signaling. Genistein 78-87 transforming growth factor beta 1 Homo sapiens 174-182 21865730-6 2011 Pre-treatment of the cells with the general tyrosine kinase inhibitor Genistein blocked the TGFbeta-induced early RhoA activation. Genistein 70-79 transforming growth factor beta 1 Homo sapiens 92-99 19119629-0 2008 [Effects of genistein on expression of TGF-beta1 and intracellular free Ca2+ concentration in fibroblasts derived from human hypertrophic scar]. Genistein 12-21 transforming growth factor beta 1 Homo sapiens 39-48 19119629-1 2008 OBJECTIVE: To observe the effects of Genistein on TGF-beta1 expression and the intracellular free Ca2+ concentration in human hypertrophic scar fibroblasts, and to discuss the mechanism of the anti-fibrosis effect. Genistein 37-46 transforming growth factor beta 1 Homo sapiens 50-59 16772519-0 2006 Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor beta-mediated activation of mitogen-activated protein kinase-activated protein kinase 2-27-kDa heat shock protein pathway. Genistein 0-9 transforming growth factor beta 1 Homo sapiens 112-143 16772519-2 2006 We have shown that genistein blocks prostate cancer (PCa) cell invasion, that p38 mitogen-activated protein (MAP) kinase regulates activation of matrix metalloproteinase type 2 (MMP-2) and cell invasion, and that genistein prevents transforming growth factor beta (TGFbeta) from activating p38 MAP kinase. Genistein 213-222 transforming growth factor beta 1 Homo sapiens 232-263 16772519-2 2006 We have shown that genistein blocks prostate cancer (PCa) cell invasion, that p38 mitogen-activated protein (MAP) kinase regulates activation of matrix metalloproteinase type 2 (MMP-2) and cell invasion, and that genistein prevents transforming growth factor beta (TGFbeta) from activating p38 MAP kinase. Genistein 213-222 transforming growth factor beta 1 Homo sapiens 265-272 16772519-6 2006 Genistein inhibited TGFbeta-mediated phosphorylation of MAPKAPK2 and HSP27. Genistein 0-9 transforming growth factor beta 1 Homo sapiens 20-27 15833883-5 2005 We now show that genistein inhibits matrix metalloproteinase type 2 (MMP-2) activity in six of seven prostate cell lines tested, blocks MMP-2 induction by TGF-beta, and inhibits cell invasion. Genistein 17-26 transforming growth factor beta 1 Homo sapiens 155-163 15833883-8 2005 Genistein exerted similar effects and was found to block activation of p38 MAPK by TGF-beta. Genistein 0-9 transforming growth factor beta 1 Homo sapiens 83-91 19119629-6 2008 RESULTS: Genistein inhibited the expression of TGF-beta1 in hypertrophic scar fibroblasts on a concentration-dependent manner. Genistein 9-18 transforming growth factor beta 1 Homo sapiens 47-56 19119629-8 2008 CONCLUSIONS: Genistein can reduce the expression of TGF-beta1 and block the accumulation of intracellular free calcium induced by growth factors. Genistein 13-22 transforming growth factor beta 1 Homo sapiens 52-61 11516623-5 2001 Smad2 was phosphorylated upon TGF-beta1 treatment, both in the absence and presence of genistein. Genistein 87-96 transforming growth factor beta 1 Homo sapiens 30-39 11506805-2 2001 For genistein (5,7,4"-trihydroxyisoflavone) (GEN), the major isoflavone in soy, reported mechanisms for these biological activities are numerous and include regulation of estrogen-mediated events, inhibition of tyrosine kinase and DNA topoisomerase activities, synthesis and release of TGF beta, and modulation of apoptosis. Genistein 4-13 transforming growth factor beta 1 Homo sapiens 286-294 11506805-2 2001 For genistein (5,7,4"-trihydroxyisoflavone) (GEN), the major isoflavone in soy, reported mechanisms for these biological activities are numerous and include regulation of estrogen-mediated events, inhibition of tyrosine kinase and DNA topoisomerase activities, synthesis and release of TGF beta, and modulation of apoptosis. Genistein 15-43 transforming growth factor beta 1 Homo sapiens 286-294 11506805-2 2001 For genistein (5,7,4"-trihydroxyisoflavone) (GEN), the major isoflavone in soy, reported mechanisms for these biological activities are numerous and include regulation of estrogen-mediated events, inhibition of tyrosine kinase and DNA topoisomerase activities, synthesis and release of TGF beta, and modulation of apoptosis. Genistein 45-48 transforming growth factor beta 1 Homo sapiens 286-294 11356157-4 2001 Analysis of the conditioned medium of human mammary epithelial cells exposed to genistein plus EGF showed increased levels of TGFbeta relative to those in the medium of cells exposed to EGF or genistein alone. Genistein 80-89 transforming growth factor beta 1 Homo sapiens 126-133 11678207-3 2001 The tyrosine kinase inhibitor genistein and AP-1 inhibitor curcumin significantly blocked TGF-beta induction of VEGF expression while SP-1 and MKK1 inhibitors did not. Genistein 30-39 transforming growth factor beta 1 Homo sapiens 90-98 9490005-5 1998 The tyrosine kinase inhibitor genistein abolished these TGF-beta1 and growth factor responses. Genistein 30-39 transforming growth factor beta 1 Homo sapiens 56-65 12094620-8 2001 In contrast, transforming growth factor-beta 1 production in ovarian cancer cells incubated with genistein or daidzein was significantly greater, i.e., by approximately 30%, than in the control group (P < 0.05). Genistein 97-106 transforming growth factor beta 1 Homo sapiens 13-46 9703891-2 1998 The addition of genistein results in a dose-dependent increase in TGF-beta 1 mRNA expression in normal human mammary epithelial cells (HMEC) but not in tumor-derived MCF-7 cells. Genistein 16-25 transforming growth factor beta 1 Homo sapiens 66-76 9703891-4 1998 The increased expression of TGF-beta 1 may contribute to the growth inhibitory as well as apoptotic effects of genistein on HMEC. Genistein 111-120 transforming growth factor beta 1 Homo sapiens 28-38 11778268-8 2000 Furthermore, genistein inhibited angiogenesis as shown by decreased vessel density and decreased production and release of VEGF and TGF-beta 1. Genistein 13-22 transforming growth factor beta 1 Homo sapiens 132-142 10953303-5 2000 Genistein also inhibits the expression of ER-downstream genes including pS2 and TGF-beta in these ER+ lines and this inhibition is also dependent on the presence of estrogen. Genistein 0-9 transforming growth factor beta 1 Homo sapiens 80-88 9813154-4 1998 In addition, the general tyrosine kinase inhibitor genistein completely blocked this TGF-beta1 effect. Genistein 51-60 transforming growth factor beta 1 Homo sapiens 85-94 34207527-7 2021 Additionally discussed is the protective role of phytoestrogen EDCs in counteracting androgen-induced sebocyte maturation through attenuation of PPARy transcriptional activity (i.e., resveratrol) and restoration of estrogen-regulated TGF-B expression in skin cells (i.e., genistein). Genistein 272-281 transforming growth factor beta 1 Homo sapiens 234-239 30707970-11 2019 Genistein treatment reduced TGF-beta1-induced PAI-1 production in normal human bronchial epithelial cells. Genistein 0-9 transforming growth factor beta 1 Homo sapiens 28-37