PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10820165-11 2000 Interestingly, thrombin-induced DNA synthesis and MCP-1 gene expression were completely blocked by genistein, a specific tyrosine kinase inhibitor, but not by its inactive analogue daidzein, demonstrating a central role for tyrosine kinase activation in the thrombin effects on hPTC. Genistein 99-108 coagulation factor II, thrombin Homo sapiens 15-23 12051756-4 2002 In addition, the tyrosine kinase inhibitor genistein, PKC inhibitor calphostin C, and Na(+)/H(+)exchanger antagonist MIA also partly inhibited thrombin-induced acidification rate responses. Genistein 43-52 coagulation factor II, thrombin Homo sapiens 143-151 10948069-11 2000 In addition, the protein tyrosine kinase inhibitor genistein reduced thrombin-induced endothelial permeability without affecting activation of RhoA by thrombin. Genistein 51-60 coagulation factor II, thrombin Homo sapiens 69-77 11775869-7 2000 Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs. Genistein 62-71 coagulation factor II, thrombin Homo sapiens 147-155 10820165-11 2000 Interestingly, thrombin-induced DNA synthesis and MCP-1 gene expression were completely blocked by genistein, a specific tyrosine kinase inhibitor, but not by its inactive analogue daidzein, demonstrating a central role for tyrosine kinase activation in the thrombin effects on hPTC. Genistein 99-108 coagulation factor II, thrombin Homo sapiens 258-266 10498846-20 1999 The phytoestrogens genistein, daidzein, apigenin and genistein-glucoside (genistin) produced inhibitory effects against thrombin similar to those seen with trans-resveratrol. Genistein 19-28 coagulation factor II, thrombin Homo sapiens 120-128 10440258-9 1999 Both genistein and herbimycin (tyrosine kinase inhibitors) suppressed the effect of thrombin on the 86Rb uptake response. Genistein 5-14 coagulation factor II, thrombin Homo sapiens 84-92 9784029-8 1998 The tyrosine kinase inhibitor erbstatin (30 microM) did not significantly alter the thrombin effect, whereas genistein at 10 microM caused a significant inhibition of contractile responses to both thrombin and PGF2alpha. Genistein 109-118 coagulation factor II, thrombin Homo sapiens 197-205 9831706-7 1998 The protein tyrosine kinase inhibitors genistein and herbimycin A, but not the inactive analogue daidzein, inhibited to a large extent the increase in permeability induced by thrombin. Genistein 39-48 coagulation factor II, thrombin Homo sapiens 175-183 9831706-8 1998 Genistein and BAPTA-AM inhibited the thrombin-induced permeability in an additive way, causing together an almost complete prevention of the thrombin-induced increase in permeability. Genistein 0-9 coagulation factor II, thrombin Homo sapiens 37-45 9831706-8 1998 Genistein and BAPTA-AM inhibited the thrombin-induced permeability in an additive way, causing together an almost complete prevention of the thrombin-induced increase in permeability. Genistein 0-9 coagulation factor II, thrombin Homo sapiens 141-149 9741823-8 1998 Pertussis toxin and genistein (inhibiting tyrosine kinase) significantly reduced the thrombin induction of both t-PA and PAI-1 (PTX: 142 +/- 23% and 146 +/- 19%, respectively, genistein: 156 +/- 42% and 76 +/- 24%, respectively). Genistein 20-29 coagulation factor II, thrombin Homo sapiens 85-93 9437201-5 1997 Stimulation through the second receptor/substrate depends on a genistein-sensitive step, is independent of an intracellular Ca2+ flux, and is initiated by a thrombin-activated receptor that does not depend on interaction with anion-binding exosite I, as previously indicated by the relative activity of Thrombin Quick I in stimulating platelet aggregation and thromboxane production. Genistein 63-72 coagulation factor II, thrombin Homo sapiens 157-165 9437201-5 1997 Stimulation through the second receptor/substrate depends on a genistein-sensitive step, is independent of an intracellular Ca2+ flux, and is initiated by a thrombin-activated receptor that does not depend on interaction with anion-binding exosite I, as previously indicated by the relative activity of Thrombin Quick I in stimulating platelet aggregation and thromboxane production. Genistein 63-72 coagulation factor II, thrombin Homo sapiens 303-311 8615807-4 1996 Genistein, but not the less active analogue daidzein, dose-dependently attenuated PGI2 release in response to thrombin and histamine (IC50 approx. Genistein 0-9 coagulation factor II, thrombin Homo sapiens 110-118 8663010-8 1996 The late diacylglycerol generation induced by thrombin stimulation was significantly reduced by the genistein treatment. Genistein 100-109 coagulation factor II, thrombin Homo sapiens 46-54 8615807-8 1996 At concentrations that abolished PGI2 release, genistein blocked thrombin- or histamine-evoked tyrosine phosphorylation of a 42 kDa protein. Genistein 47-56 coagulation factor II, thrombin Homo sapiens 65-73 7884545-7 1995 Genistein, an isoflavonoid derived from soy products, has been shown to inhibit thrombin formation and platelet activation in vitro in addition to its antigrowth factor activity. Genistein 0-9 coagulation factor II, thrombin Homo sapiens 80-88 7949170-13 1994 Because genistein also inhibited PAI-1 induction by thrombin and IL-4, it is likely that genistein does not act on a TNF alpha-receptor-coupled protein kinase but on the signal transduction pathway enhancing PAI-1 transcription. Genistein 8-17 coagulation factor II, thrombin Homo sapiens 52-60 7878644-0 1994 The tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate, inhibit the release of (3H)arachidonate from human platelets stimulated by thrombin or collagen. Genistein 32-41 coagulation factor II, thrombin Homo sapiens 152-160 8422913-0 1993 The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry in human platelets. Genistein 65-74 coagulation factor II, thrombin Homo sapiens 82-90 7526916-4 1994 PLD was activated in response to 0.3 U/ml thrombin, and this activation was reduced by several of the PTK inhibitors, especially genistein, methyl 2,5-dihydroxycinnamate (MDHC), ST271, and the tyrphostins A25 and A47. Genistein 129-138 coagulation factor II, thrombin Homo sapiens 42-50 8394081-1 1993 Genistein attenuates thrombin-induced Ca2+ mobilization in human platelets by affecting polyphosphoinositide turnover. Genistein 0-9 coagulation factor II, thrombin Homo sapiens 21-29 8394081-7 1993 Thrombin stimulation of genistein-pretreated cells intensified this tendency, i.e. a further increase in the amount of PI(4)P and a decrease in the amount of PI(4,5)P2 in an inversely proportional manner. Genistein 24-33 coagulation factor II, thrombin Homo sapiens 0-8 8422913-3 1993 Here we have investigated the effects of two tyrosine kinase inhibitors, methyl 2,5-dihydroxycinnamate and genistein, on thrombin-evoked protein tyrosine phosphorylation and Ca2+ signal generation in fura-2-loaded human platelets. Genistein 107-116 coagulation factor II, thrombin Homo sapiens 121-129 2017148-3 1991 Although thrombin induced an increase in the platelet phosphotyrosine content, genistein at 100 micrograms/ml only slightly attenuated thrombin-induced protein tyrosine phosphorylation. Genistein 79-88 coagulation factor II, thrombin Homo sapiens 135-143 1511739-0 1992 Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein. Genistein 106-115 coagulation factor II, thrombin Homo sapiens 0-8 1511739-2 1992 Preincubation of platelets with 50 microM of ST638 or 25 micrograms/ml of genistein completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. Genistein 74-83 coagulation factor II, thrombin Homo sapiens 157-165 1511739-5 1992 Increase of the intracellular Ca2+ concentration induced by thrombin was also inhibited by higher concentrations of genistein. Genistein 116-125 coagulation factor II, thrombin Homo sapiens 60-68 23254196-2 2013 Here, we report that genistein at physiologically relevant concentrations (0.1-10 muM) significantly inhibited thrombin-induced increase in endothelial monolayer permeability. Genistein 21-30 coagulation factor II, thrombin Homo sapiens 111-119 23254196-3 2013 Genistein also reduced the formation of stress fibers by thrombin and suppressed thrombin-induced phosphorylation of myosin light chain (MLC) on Ser(19)/Thr(18) in endothelial cells (ECs). Genistein 0-9 coagulation factor II, thrombin Homo sapiens 57-65 23254196-3 2013 Genistein also reduced the formation of stress fibers by thrombin and suppressed thrombin-induced phosphorylation of myosin light chain (MLC) on Ser(19)/Thr(18) in endothelial cells (ECs). Genistein 0-9 coagulation factor II, thrombin Homo sapiens 81-89 23254196-8 2013 Inhibition of PKA significantly attenuated the effect of genistein on thrombin-induced EC permeability, MLC phosphorylation, and RhoA membrane translocation in ECs. Genistein 57-66 coagulation factor II, thrombin Homo sapiens 70-78 23254196-9 2013 Furthermore, thrombin diminished cAMP production in ECs, which were prevented by treatment with genistein. Genistein 96-105 coagulation factor II, thrombin Homo sapiens 13-21 23254196-10 2013 These findings demonstrated that genistein improves thrombin-induced endothelial barrier dysfunction in ECs through PKA-mediated suppression of RhoA signaling. Genistein 33-42 coagulation factor II, thrombin Homo sapiens 52-60