PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10024519-5	1999	This effect was reproduced by T4-agarose (100 nM) and blocked by CGP 41251, genistein, PD 98059 and geldanamycin, inhibitors of protein kinase C (PKC), protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK) kinase and Raf-1 respectively.	Genistein	76-85	fibroblast growth factor receptor 4	Homo sapiens	152-175	
27525851-3	2016	Furthermore, the hypoxia-induced increase in GluR2 expression on the cell surface was partially blocked by the protein tyrosine kinase membrane-permeable inhibitor genistein.	Genistein	164-173	fibroblast growth factor receptor 4	Homo sapiens	111-134	
21570948-0	2011	Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.	Genistein	0-9	fibroblast growth factor receptor 4	Homo sapiens	106-129	
21570948-3	2011	We found that hKir2.1 current was reversibly inhibited by the broad spectrum PTK inhibitor genistein and the highly selective EGFR (epidermal growth factor receptor) kinase inhibitor AG556 in a concentration-dependent manner.	Genistein	91-100	fibroblast growth factor receptor 4	Homo sapiens	77-80	
11775830-4	2000	Genistein, the specific PTK inhibitor, was used to evaluate the inhibitory role in activation of MAPKs by IL-1 beta.	Genistein	0-9	fibroblast growth factor receptor 4	Homo sapiens	24-27	
10024519-5	1999	This effect was reproduced by T4-agarose (100 nM) and blocked by CGP 41251, genistein, PD 98059 and geldanamycin, inhibitors of protein kinase C (PKC), protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK) kinase and Raf-1 respectively.	Genistein	76-85	fibroblast growth factor receptor 4	Homo sapiens	177-180	
1851473-0	1991	Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells.	Genistein	0-9	fibroblast growth factor receptor 4	Homo sapiens	23-46	
9605111-6	1998	In further studies evaluating key associated intracellular signal transduction mechanisms, the protein tyrosine kinase (PTK) inhibitors herbimycin and genistein markedly decreased basal and lipoprotein-induced PDGF mRNA expression.	Genistein	151-160	fibroblast growth factor receptor 4	Homo sapiens	95-118	
9605111-6	1998	In further studies evaluating key associated intracellular signal transduction mechanisms, the protein tyrosine kinase (PTK) inhibitors herbimycin and genistein markedly decreased basal and lipoprotein-induced PDGF mRNA expression.	Genistein	151-160	fibroblast growth factor receptor 4	Homo sapiens	120-123	
7523496-4	1994	In the presence of genistein, a specific inhibitor of protein tyrosine kinase, the enhanced level of tyrosine phosphorylation was blocked, indicating that CD7 may induce signaling via activation of tyrosine kinases.	Genistein	19-28	fibroblast growth factor receptor 4	Homo sapiens	54-77	
1851473-1	1991	In this study, genistein, a selective protein tyrosine kinase (PTK) inhibitor, inhibited peripheral blood mononuclear cell (PBMC) proliferation and interleukin-2 production from cultures that were stimulated with phytohemagglutinin (PHA), phorbol 12-myristate 13-acetate (PMA) plus A23187, or PHA plus PMA, and genistein effectively blocked the PHA plus IL-2-induced PBMC proliferation.	Genistein	15-24	fibroblast growth factor receptor 4	Homo sapiens	63-66	
9531578-12	1998	Protein tyrosine kinase and protein kinase C are involved in signal transduction leading to VEGF production, as shown by the inhibitory effects of genistein and GF 109203X.	Genistein	147-156	fibroblast growth factor receptor 4	Homo sapiens	0-23	
7523496-10	1994	The mechanism by which cross-linking of CD7 or CD16 on NK cells induced adhesion to FN appeared to involve both protein tyrosine kinase and protein kinase C, because this adhesion was blocked in the presence of either genistein or a protein kinase C inhibitor, staurosporin.	Genistein	218-227	fibroblast growth factor receptor 4	Homo sapiens	112-135	
1851473-1	1991	In this study, genistein, a selective protein tyrosine kinase (PTK) inhibitor, inhibited peripheral blood mononuclear cell (PBMC) proliferation and interleukin-2 production from cultures that were stimulated with phytohemagglutinin (PHA), phorbol 12-myristate 13-acetate (PMA) plus A23187, or PHA plus PMA, and genistein effectively blocked the PHA plus IL-2-induced PBMC proliferation.	Genistein	15-24	fibroblast growth factor receptor 4	Homo sapiens	38-61