PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29761425-7 2018 In vitro phosphorylated-nuclear factor kappa-light-chain-enhancer of activated B cells and interleukin-6 were obviously reduced in the genistein treatment group compared with the LPS group in RAW 264.7 murine macrophage cells. Genistein 135-144 interleukin 6 Mus musculus 91-104 34242900-8 2021 Furthermore, MET in combination with genistein reduced the expression of TNF-alpha, IL-1beta, MCP-1, and IL-6 and increased the expression of IL-10 in comparison with genistein and MET groups alone. Genistein 37-46 interleukin 6 Mus musculus 105-109 34242900-8 2021 Furthermore, MET in combination with genistein reduced the expression of TNF-alpha, IL-1beta, MCP-1, and IL-6 and increased the expression of IL-10 in comparison with genistein and MET groups alone. Genistein 167-176 interleukin 6 Mus musculus 105-109 34168482-11 2021 In BV2 cells exposed to isoflurane, genistein treatment decreased IL-1beta, TNF-alpha, IL-6 and IL-8 mRNA expressions, promoted M2 and suppressed M1 microglia polarization. Genistein 36-45 interleukin 6 Mus musculus 87-91 30734460-5 2019 Significantly increased TNF-alpha, IL-6, IL-8 expressions during DOX-induced inflammatory responses were down regulated by genistein treatment. Genistein 123-132 interleukin 6 Mus musculus 35-39 30743203-5 2019 It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors,including interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha (TNF-alpha), chemokine ligand 2 (CCL2), IL-17 and IL-23. Genistein 18-27 interleukin 6 Mus musculus 234-238 29747742-7 2018 RESULTS: The results showed that genistein exerted inhibitory effects on LPS-induced expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6). Genistein 33-42 interleukin 6 Mus musculus 232-245 29747742-7 2018 RESULTS: The results showed that genistein exerted inhibitory effects on LPS-induced expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6). Genistein 33-42 interleukin 6 Mus musculus 247-251 29736382-6 2018 Genistein also decreased the expression of TNF-alpha and IL-6 (1.04 and 1.3 mg/day) compared with the endometriosis group, reaching level comparable to that of the control group (p > 0.05). Genistein 0-9 interleukin 6 Mus musculus 57-61 23820591-6 2013 The recombinant RTB-induced production of NO, TNF-alpha and IL-6 was inhibited in the macrophages treated with the pharmacological inhibitors genistein, LY294002, staurosporine, AG490, SB203580 and BAY 11-7082, indicating the possible involvement of protein tyrosine kinases, PI3K, PKC, JAK2, p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB in the above processes. Genistein 142-151 interleukin 6 Mus musculus 60-64 25382637-0 2015 C/EBPbeta promotes angiogenesis through secretion of IL-6, which is inhibited by genistein, in EGFRvIII-positive glioblastoma. Genistein 81-90 interleukin 6 Mus musculus 53-57 25382637-6 2015 In contrast, genistein-mediated upregulation of CHOP impeded C/EBPbeta interaction with the IL-6 promoter, thus disturbing the angiogenic microenvironment. Genistein 13-22 interleukin 6 Mus musculus 92-96 24659138-6 2014 The induction of the inflammatory cytokines TGF-beta1, IL-1beta,TNF-alpha, and IL-6 by IR were in turn inhibited in the serum and BALF of the genistein-pretreated mice (P < 0.05). Genistein 142-151 interleukin 6 Mus musculus 79-83 17141199-5 2007 This effect was probably due to the inhibition of PTPs, resulting in increased tyrosine phosphorylation, since genistein, an inhibitor of protein tyrosine kinases further potentiated ISO-induced IL-6 production and could partially reverse the inhibitory effect of PAO. Genistein 111-120 interleukin 6 Mus musculus 195-199 19716438-6 2009 Interleukin-6 (IL-6) was significantly increased in genistein-treated animals 4h after irradiation. Genistein 52-61 interleukin 6 Mus musculus 0-13 19716438-6 2009 Interleukin-6 (IL-6) was significantly increased in genistein-treated animals 4h after irradiation. Genistein 52-61 interleukin 6 Mus musculus 15-19 19716438-7 2009 Because G-CSF and IL-6 are important hematopoietic factors, these results support our hypothesis that the previously observed radioprotective efficacy by genistein may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and IL-6. Genistein 154-163 interleukin 6 Mus musculus 18-22 19716438-7 2009 Because G-CSF and IL-6 are important hematopoietic factors, these results support our hypothesis that the previously observed radioprotective efficacy by genistein may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and IL-6. Genistein 154-163 interleukin 6 Mus musculus 261-265 18052238-5 2007 Results showed that all of the isoflavone powders and genistein standard were effective in inhibiting LPS-induced inflammation, lowering leukocyte number in mice blood and reducing production of IL-1beta, IL-6, NO, and PGE2 in both peritoneal exudate cell supernatant and peritoneal exudate fluid. Genistein 54-63 interleukin 6 Mus musculus 205-209 11201166-8 2001 On the other hand, the expression of cell surface IL-1RI is inhibited by tyrosine kinase inhibitors, herbimycin and genistein, resulting in reduction of the kinase activity of IRAK (IL-1 receptor associated kinase) and IL-1-induced IL-6 production from the fibroblasts. Genistein 116-125 interleukin 6 Mus musculus 232-236 9331108-8 1997 The IL-6 responses of mice pretreated with 100 microg/kg genistein were decreased by more than 40%. Genistein 57-66 interleukin 6 Mus musculus 4-8 27784235-9 2016 RESULTS: Genistein suppressed the expressions of IL-1beta, IL-6 and TNF-alpha in the serum. Genistein 9-18 interleukin 6 Mus musculus 59-63 12873716-2 2003 Interleukin-6 production was decreased 40% to 60% in osteoblastic cells treated with genistein from either day 8-16 or day 12-16, at dietarily achievable concentrations (10(-10) to 10(-8) M) (P<0.05). Genistein 85-94 interleukin 6 Mus musculus 0-13 12873716-6 2003 The addition of ICI-182,780, an estrogen receptor blocker, reduced the inhibitory effect of genistein on IL-6 production by 30-50%. Genistein 92-101 interleukin 6 Mus musculus 105-109 12873716-7 2003 In summary, these findings suggest that the beneficial skeletal effects of genistein, at dietarily achievable levels, appear to be mediated, at least in part, by interleukin-6 and osteoprotegerin, and estrogen receptors play important roles in the inhibition of interleukin-6 synthesis by genistein in osteoblastic MC3T3-E1 cells. Genistein 75-84 interleukin 6 Mus musculus 162-175 12873716-7 2003 In summary, these findings suggest that the beneficial skeletal effects of genistein, at dietarily achievable levels, appear to be mediated, at least in part, by interleukin-6 and osteoprotegerin, and estrogen receptors play important roles in the inhibition of interleukin-6 synthesis by genistein in osteoblastic MC3T3-E1 cells. Genistein 75-84 interleukin 6 Mus musculus 262-275 9106265-3 1997 This study examined the effects of two potent protein tyrosine kinase inhibitors, genistein and tyrphostin A25, on lipopolysaccharide (LPS)-induced production of TNF alpha, IL-1 alpha, and IL-6 in mouse primary mixed glia, microglia- or astrocyte-enriched cultures. Genistein 82-91 interleukin 6 Mus musculus 189-193 7868057-10 1994 Addition of calphostin C, a specific protein kinase C (PKC) inhibitor or genistein and herbimycin A, specific tyrosine kinase (TK) inhibitors to the culture also decreased colony numbers formed with IL-6 and TPA. Genistein 73-82 interleukin 6 Mus musculus 199-203