PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18671941-4 2008 However, inhibition of K(ATP) currents by IGF-I was abolished by the tyrosine kinase inhibitor genistein or the phosphoinositide 3-kinase inhibitors, LY 294002 and wortmannin. Genistein 95-104 insulin-like growth factor 1 Rattus norvegicus 42-47 15880694-12 2005 The effect of IGF-I on the death of wild-type cells was observed in the presence of genistein or vanadate. Genistein 84-93 insulin-like growth factor 1 Rattus norvegicus 14-19 17024419-4 2007 Co-incubation of insulin or IGF-1 with genistein (25 microM), an inhibitor of the tyrosine kinase receptor, reduced the proliferation of lactotrophs elicited by the hormone and the growth factor. Genistein 39-48 insulin-like growth factor 1 Rattus norvegicus 28-33 16133120-6 2005 Co-incubation of IGF-1 (30 ng/ml) with genistein (25 microM) or BIM (0.5 or 2 microM), lowered of tyrosine kinase receptor or of PKC respectively, inhibited the induced IGF-1 lactotrophs proliferation. Genistein 39-48 insulin-like growth factor 1 Rattus norvegicus 17-22 16133120-6 2005 Co-incubation of IGF-1 (30 ng/ml) with genistein (25 microM) or BIM (0.5 or 2 microM), lowered of tyrosine kinase receptor or of PKC respectively, inhibited the induced IGF-1 lactotrophs proliferation. Genistein 39-48 insulin-like growth factor 1 Rattus norvegicus 169-174 14660553-10 2004 Genistein treatment largely decreased the IGF-1-induced changes in both Ca(2+)(i) and IP(3). Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 42-47 15668985-7 2005 These effects of IGF-1 were abolished by cycloheximide or genistein. Genistein 58-67 insulin-like growth factor 1 Rattus norvegicus 17-22 12840208-1 2003 We examined the ability of polyphenols from tomatoes and soy (genistein, quercetin, kaempferol, biochanin A, daidzein and rutin) to modulate insulin-like growth factor-I (IGF-I)-induced in vitro proliferation and apoptotic resistance in the AT6.3 rat prostate cancer cell line. Genistein 62-71 insulin-like growth factor 1 Rattus norvegicus 141-169 12840208-6 2003 Genistein, quercetin, kaempferol and biochanin A, but not daidzein and rutin, counteracted the antiapoptotic effects of IGF-I. Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 120-125 9490004-2 1998 Genistein, whether added during preincubation or with IGF-1 at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, autophosphorylation of the beta-subunit of IGF-1 receptor and inhibition of ERK. Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 54-59 11548882-4 2001 This hypertrophic effect of IGF-1 was blocked by genistein (tyrosine kinase inhibitor), PD98059 (MEK inhibitor). Genistein 49-58 insulin-like growth factor 1 Rattus norvegicus 28-33 11256230-8 2000 A tyrosine kinase inhibitor (genistein), a MAPK inhibitor (PD-098059) and a P13 kinase inhibitor (wortmannin) could also suppress the antiapoptotic effects of IGF-I. Genistein 29-38 insulin-like growth factor 1 Rattus norvegicus 159-164 11281731-4 2000 IGF1-induced activation of p44/p42 MAP kinase was blocked by preincubation with the PKC inhibitors, bisindolylmaleimide and Go6976, as well as the tyrosine kinase inhibitor, genistein. Genistein 174-183 insulin-like growth factor 1 Rattus norvegicus 0-4 10875243-8 2000 Genistein abolished both the cAMP-dependent increase in tyrosine phosphorylation of the 125-kDa protein and the enhanced DNA synthesis induced by IGF-I in a similar concentration-dependent manner. Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 146-151 9560443-4 1998 Cell exposure to the alpha1-adrenoceptor agonist phenylephrine (PE, 20 microM) and IGF-1 (60 ng/ml) for 72 h both induced a significant increase of cell size indicating myocyte hypertrophy, which could be separately blocked by the protein kinase C inhibitor staurosporine (20 nM) and the tyrosine kinase inhibitor genistein (15 microM). Genistein 314-323 insulin-like growth factor 1 Rattus norvegicus 83-88 9582514-5 1998 Both the IGF-I-induced protein phosphorylation and [3H]thymidine incorporation were abolished in the presence of the tyrosine kinase inhibitor, genistein. Genistein 144-153 insulin-like growth factor 1 Rattus norvegicus 9-14 9490004-2 1998 Genistein, whether added during preincubation or with IGF-1 at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, autophosphorylation of the beta-subunit of IGF-1 receptor and inhibition of ERK. Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 116-121 9490004-2 1998 Genistein, whether added during preincubation or with IGF-1 at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, autophosphorylation of the beta-subunit of IGF-1 receptor and inhibition of ERK. Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 116-121 8526802-10 1995 Pretreatment with the tyrosine kinase inhibitor genistein (20 micrograms/ml) significantly inhibited EGF- and IGF-I-induced tyrosine phosphorylation in permeabilized RDP 4-1 cells, and the tyrosine phosphatase inhibitor orthovanadate (1 mM) significantly prolonged the duration of the mitogen-stimulated tyrosine phosphorylation in both intact or permeabilized cells. Genistein 48-57 insulin-like growth factor 1 Rattus norvegicus 110-115 9332449-5 1997 IGF-1 effect was mediated by the classical tyrosine kinase signalling process, since IGF-1 action on PG synthesis was abolished by genistein and tyrphostin A9, two well known tyrosine kinase inhibitors. Genistein 131-140 insulin-like growth factor 1 Rattus norvegicus 0-5 9332449-5 1997 IGF-1 effect was mediated by the classical tyrosine kinase signalling process, since IGF-1 action on PG synthesis was abolished by genistein and tyrphostin A9, two well known tyrosine kinase inhibitors. Genistein 131-140 insulin-like growth factor 1 Rattus norvegicus 85-90 9207239-7 1997 The tyrosine kinase inhibitor, genistein, and the PKC inhibitor peptide, 19-36, decreased IGF-1 induced phosphorylation of alpha1 subunit to 15% in young and middle-age fibers but failed to inhibit phosphorylation in old fibers. Genistein 31-40 insulin-like growth factor 1 Rattus norvegicus 90-95 7679900-4 1993 Genistein inhibited DNA synthesis induced by BAY K8644 and by IGF-I. Genistein 0-9 insulin-like growth factor 1 Rattus norvegicus 62-67 8562311-6 1995 The inhibitory effects of either insulin or IGF-I on insulin release are abolished by 10(-4) M GEN but not by daidzein indicating an involvement of tyrosine kinase in the inhibitory effect of both insulin and IGF-I on insulin release. Genistein 95-98 insulin-like growth factor 1 Rattus norvegicus 44-49 8562311-6 1995 The inhibitory effects of either insulin or IGF-I on insulin release are abolished by 10(-4) M GEN but not by daidzein indicating an involvement of tyrosine kinase in the inhibitory effect of both insulin and IGF-I on insulin release. Genistein 95-98 insulin-like growth factor 1 Rattus norvegicus 209-214 7679900-6 1993 These data demonstrate that the signal transduction pathway induced by BAY K8644 or IGF-I may possibly involve genistein-sensitive process at the downstream step of Ca2+ entry. Genistein 111-120 insulin-like growth factor 1 Rattus norvegicus 84-89 34612711-8 2021 Additionally, the perfused PI3K/Akt agonist insulin-like growth factor 1 (30 muM) also abolished ANP secretion induced by genistein and inhibited expression of HIF-1alpha. Genistein 122-131 insulin-like growth factor 1 Rattus norvegicus 44-72 21855913-3 2011 In the current experiments we determined the effects of genistein and 17alpha-estradiol on the modulation of dietary fat induced prostate 5alpha-reductase-2 and insulin-like growth factor-1 gene expression, and prostate growth. Genistein 56-65 insulin-like growth factor 1 Rattus norvegicus 138-189 21855913-7 2011 RESULTS: Two-week exposure to a high fat diet significantly increased prostate insulin-like growth factor-1 mRNA without significant changes in plasma insulin-like growth factor-1, which was blocked by genistein and 17alpha-estradiol. Genistein 202-211 insulin-like growth factor 1 Rattus norvegicus 79-107 21855913-7 2011 RESULTS: Two-week exposure to a high fat diet significantly increased prostate insulin-like growth factor-1 mRNA without significant changes in plasma insulin-like growth factor-1, which was blocked by genistein and 17alpha-estradiol. Genistein 202-211 insulin-like growth factor 1 Rattus norvegicus 151-179 21855913-11 2011 CONCLUSIONS: Results indicate that genistein and 17alpha-estradiol can inhibit dietary fat induced changes in prostate 5alpha-reductase-2 and insulin-like growth factor-1 gene expression, and prostate growth in the rat. Genistein 35-44 insulin-like growth factor 1 Rattus norvegicus 119-170 31144391-1 2019 The objective of this study was to assess the effects of genistein (GEN) on expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 (IGFBP-1) in young and aged rat ovary. Genistein 57-66 insulin-like growth factor 1 Rattus norvegicus 90-118 31144391-1 2019 The objective of this study was to assess the effects of genistein (GEN) on expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 (IGFBP-1) in young and aged rat ovary. Genistein 57-66 insulin-like growth factor 1 Rattus norvegicus 120-125 31144391-1 2019 The objective of this study was to assess the effects of genistein (GEN) on expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 (IGFBP-1) in young and aged rat ovary. Genistein 68-71 insulin-like growth factor 1 Rattus norvegicus 90-118 31144391-1 2019 The objective of this study was to assess the effects of genistein (GEN) on expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 (IGFBP-1) in young and aged rat ovary. Genistein 68-71 insulin-like growth factor 1 Rattus norvegicus 120-125 29085576-6 2017 Also according to results ovariectomized groups that were treated with genistein/exercise or both of them showed significant difference in expression of microRNA-132, BDNF, and IGF-1 in the hippocampus (P<0.05) and decreased latency in MWM (P<0.05) compared with the OVX group but combination treatment was more effective in the OVX.G.E group in comparison with OVX.E and OVX.G groups. Genistein 71-80 insulin-like growth factor 1 Rattus norvegicus 177-182 29085576-7 2017 CONCLUSION: Overall our results emphasized that combination treatment with genistein and exercise could improve microRNA-132, BDNF, and IGF-1 expression in the hippocampus as well as the spatial memory of ovariectomized rats. Genistein 75-84 insulin-like growth factor 1 Rattus norvegicus 136-141