PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20726235-0 2010 [Inhibition of genistein on the proliferation of RWPE-1 cells induced by testosterone under the control of insulin-like growth factor-1]. Genistein 15-24 insulin like growth factor 1 Homo sapiens 107-136 22098108-0 2012 Inhibition of IGF-1 signaling by genistein: modulation of E-cadherin expression and downregulation of beta-catenin signaling in hormone refractory PC-3 prostate cancer cells. Genistein 33-42 insulin like growth factor 1 Homo sapiens 14-19 22098108-3 2012 We investigated whether genistein downregulated the IGF-1/IGF-1R signaling pathway and inhibited cell growth in hormone refractory PC-3 prostate cancer cells. Genistein 24-33 insulin like growth factor 1 Homo sapiens 52-57 22098108-4 2012 Genistein treatment caused a significant inhibition of IGF-1-stimulated cell growth. Genistein 0-9 insulin like growth factor 1 Homo sapiens 55-60 22098108-6 2012 In IGF-1-treated cells, genistein effectively inhibited the phosphorylation of IGF-1R and the phosphorylation of its downstream targets, such as Src, Akt, and glycogen synthase kinase-3beta (GSk-3beta). Genistein 24-33 insulin like growth factor 1 Homo sapiens 3-8 22098108-8 2012 However, genistein treatment greatly attenuated IGF-1-induced beta-catenin signaling that correlated with increasing the levels of E-cadherin and decreasing cyclin D1 levels in PC-3 cells. Genistein 9-18 insulin like growth factor 1 Homo sapiens 48-53 22098108-10 2012 These results showed that genistein effectively inhibited cell growth in IGF-1-stimulated PC-3 cells, possibly by inhibiting downstream of IGF-1R activation. Genistein 26-35 insulin like growth factor 1 Homo sapiens 73-78 18796517-14 2008 Genistein also significantly reduced pyridinoline, as well as serum carboxy-terminal cross-linking telopeptide and soluble receptor activator of NF-kappaB ligand while increasing bone-specific alkaline phosphatase, IGF-I, and osteoprotegerin levels. Genistein 0-9 insulin like growth factor 1 Homo sapiens 215-220 19373614-8 2009 Treatment with insulin-like growth factor I (IGF-I) elevated levels of total and phosphorylated AKT and suppressed the effects of genistein. Genistein 130-139 insulin like growth factor 1 Homo sapiens 15-43 19373614-8 2009 Treatment with insulin-like growth factor I (IGF-I) elevated levels of total and phosphorylated AKT and suppressed the effects of genistein. Genistein 130-139 insulin like growth factor 1 Homo sapiens 45-50 19429436-6 2009 Whereas the expression of proliferation related genes (PCNA; Ki67; IGF-1; IGF-1R), analyzed by real-time-qPCR and Western blot, were significantly down-regulated in juvenile animals exposed to genistein. Genistein 193-202 insulin like growth factor 1 Homo sapiens 67-72 14551225-5 2004 However, genistein, a nonspecific tyrosine kinase inhibitor that does not inhibit JAK2 and STAT5 phosphorylation, significantly suppressed the GH-induced IGF-I gene expression. Genistein 9-18 insulin like growth factor 1 Homo sapiens 154-159 18492705-0 2008 A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells. Genistein 23-32 insulin like growth factor 1 Homo sapiens 69-97 15533642-16 2005 Examples are: genistein and EGCG, which effect signaling through the IGF-1/AKT pathway and resveratrol and limonen, which do so through the RAS pathway. Genistein 14-23 insulin like growth factor 1 Homo sapiens 69-74 18424208-3 2008 Therefore, the present in vitro-study was undertaken to determine, whether genistein and daidzein affect the mRNA expression of growth factor receptors (IGF-I receptor and EGF receptor) and their related growth factors in porcine skeletal muscle cell cultures. Genistein 75-84 insulin like growth factor 1 Homo sapiens 153-158 16379552-0 2005 Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. Genistein 0-9 insulin like growth factor 1 Homo sapiens 19-47 16379552-0 2005 Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. Genistein 158-167 insulin like growth factor 1 Homo sapiens 19-47 15126563-2 2004 In this study, we hypothesize that low concentration of genistein mimics the action of 17beta-estradiol in stimulation of MCF-7 cell growth by enhancement of IGF-I signaling pathway. Genistein 56-65 insulin like growth factor 1 Homo sapiens 158-163 15126563-7 2004 Our results also showed that genistein induction of IGF-IR and IRS-1 expression resulted in enhanced tyrosine phosphorylation of IGF-IR and IRS-1 on IGF-I stimulation. Genistein 29-38 insulin like growth factor 1 Homo sapiens 52-57 10898549-7 2000 Genistein, a tyrosine kinase inhibitor, which by itself had no effect on NE metabolism, abolished the induction effect of IGF-1 on TH and MHPG/NE ratio. Genistein 0-9 insulin like growth factor 1 Homo sapiens 122-127 12050579-4 2002 Genistein almost completely inhibited growth-promoting activity in amniotic fluid P = 0.002), and growth was partially inhibited by antibodies against epidermal growth factor (EGF) (P = 0.047), insulin-like growth factor-1 (IGF-1, P = 0.047), or fibroblast growth factor (FGF, P = 0.014). Genistein 0-9 insulin like growth factor 1 Homo sapiens 224-229 10990445-4 1998 Genistein, an inhibitor of tyrosine kinase blocked IGF-I- but not fluoride-stimulated Na(d) alanine transport. Genistein 0-9 insulin like growth factor 1 Homo sapiens 51-56 10362694-3 1999 This stimulatory effect of IGF-I was prevented by the tyrosine kinase inhibitor genistein (5 microM) and by the specific phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin (100 nM) and LY-294002 (25 microM). Genistein 80-89 insulin like growth factor 1 Homo sapiens 27-32 7775599-8 1995 The tyrosine kinase inhibitor genistein blocked the survival effect of IGF-1, but not that of TPA and ATA. Genistein 30-39 insulin like growth factor 1 Homo sapiens 71-76 26971408-13 2016 In conclusion, injecting gilts with 440 mg/day of genistein in late gestation increased IGF1 concentrations in gilts and carcass fat in neonatal piglets, but had minimal effect on muscle development of piglets at birth and on the performance of lactating sows and their litters. Genistein 50-59 insulin like growth factor 1 Homo sapiens 88-92 33432829-3 2022 Compared with a casein-based placebo, 18 mo, of consumption of 19.2 g/day of whole soy protein isolate containing 24 mg genistein-reduced circulating testosterone and SHBG, but not free testosterone, and did not affect serum concentrations of estradiol, VEGF, IGF-1, IGFBP-3, IGF-1/IGFBP-3 ratio, soluble Fas, Fas-ligand, and sFas/Fas-ligand ratio. Genistein 120-129 insulin like growth factor 1 Homo sapiens 260-265 33432829-3 2022 Compared with a casein-based placebo, 18 mo, of consumption of 19.2 g/day of whole soy protein isolate containing 24 mg genistein-reduced circulating testosterone and SHBG, but not free testosterone, and did not affect serum concentrations of estradiol, VEGF, IGF-1, IGFBP-3, IGF-1/IGFBP-3 ratio, soluble Fas, Fas-ligand, and sFas/Fas-ligand ratio. Genistein 120-129 insulin like growth factor 1 Homo sapiens 276-281 7513035-9 1994 Genistein, a tyrosine kinase inhibitor, resulted in a profound suppression of the IGF-I-induced release of NO. Genistein 0-9 insulin like growth factor 1 Homo sapiens 82-87