PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30901677-7	2019	Moreover, Genistein treatment down-regulated production of caspase-1 and IL-1beta and increased intracellular cAMP level, which were similar to the treatment for INT-777, a semi-synthetic TGR5 agonist, in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells and U937 cells.	Genistein	10-19	interleukin 1 beta	Homo sapiens	73-81	
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	Genistein	14-23	interleukin 1 beta	Homo sapiens	76-84	
24934473-2	2015	Genistein modified PES/PVP membranes reveal significant reduction of the reactive oxygen species and also considerable suppression of interleukin-1beta and tumor necrosis factor-alpha levels in whole blood, but to a lesser extent ininterleukin-6.	Genistein	0-9	interleukin 1 beta	Homo sapiens	134-183	
25447760-3	2014	150 kGy gamma-irradiated genistein did not exert cytotoxicity in macrophages, and inhibited inducible nitric oxide synthase-mediated nitric oxide production and pro-inflammatory cytokines level, such as tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta, in lipopolysaccharide (LPS)-induced macrophages.	Genistein	25-34	interleukin 1 beta	Homo sapiens	250-267	
25319548-10	2014	Genistein significantly decreased IL-6 and IL-1beta mRNA levels, as well as IL-6 production in PMA/A23187-induced mast cells activation.	Genistein	0-9	interleukin 1 beta	Homo sapiens	43-51	
31137797-2	2019	This compound has anti-inflammatory, anti-oxidative, and anti-cancer effects; however, the mechanism underlying the effects of genistein on IL-1beta-stimulated human osteoarthritis (OA) chondrocytes remains unknown.	Genistein	127-136	interleukin 1 beta	Homo sapiens	140-148	
31137797-3	2019	Our objectives in this study were to explore the anti-inflammatory effects of genistein on IL-1beta-stimulated human OA chondrocytes and to investigate the potential mechanisms which underlie them.	Genistein	78-87	interleukin 1 beta	Homo sapiens	91-99	
31137797-4	2019	Our results from an in-vitro model of osteoarthritis indicate that genistein inhibits the IL-1beta-induced expression of the catabolic factors nitric oxide synthase 2 (NOS2), cyclooxygenase 2 (COX-2), and matrix metalloproteinases (MMPs).	Genistein	67-76	interleukin 1 beta	Homo sapiens	90-98	
24669186-8	2014	RESULTS: Genistein decreased the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner.	Genistein	9-18	interleukin 1 beta	Homo sapiens	46-54	
22521737-5	2012	In contrast, genistein, an estrogen receptor ligand, postpones the activation of MAPKs induced by IL-1beta.	Genistein	13-22	interleukin 1 beta	Homo sapiens	98-106	
21792602-6	2012	Genistein had an inhibitory role on cell number and (3)H-TdR incorporation of RA-FLS stimulated with IL-1beta, TNF-alpha and EGF; genistein arrested the cell cycle at G(1) restriction point; genistein decreased colony numbers under anchorage-independent condition stimulated by EGF in serum condition.	Genistein	0-9	interleukin 1 beta	Homo sapiens	101-109	
21792602-7	2012	IL-1beta or TNF-alpha increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes; EGF stimulated expression of MMP-9 but not of MMP-2; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1beta or TNF-alpha; rMMP-9, rMMP-2, or their inhibitors had no effect on the (3)H-TdR incorporation of synovial cells.	Genistein	143-152	interleukin 1 beta	Homo sapiens	0-8	
21792602-7	2012	IL-1beta or TNF-alpha increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes; EGF stimulated expression of MMP-9 but not of MMP-2; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1beta or TNF-alpha; rMMP-9, rMMP-2, or their inhibitors had no effect on the (3)H-TdR incorporation of synovial cells.	Genistein	143-152	interleukin 1 beta	Homo sapiens	211-219	
21792602-11	2012	Genistein inhibited IL-1beta, TNF-alpha or EGF-induced proliferation and MMP-9 expression in fibroblast-like synoviocytes of rheumatoid arthritis; the proliferation of RA-FLS was mediated by Erk1/2 but not JNK activation, while JNK activation was involved in the signal transduction pathway leading to MMP-9 expression in rheumatoid synoviocytes.	Genistein	0-9	interleukin 1 beta	Homo sapiens	20-28	
21657246-10	2011	Of particular importance is that the genistein-modified blend membranes (PA:PVP/G) showed greater suppression of the concentrations of all three cytokines (TNF-alpha, IL-1beta, and IL-6) in comparison with those of the PA/G membranes, signifying the role of PVP in the enhanced anti-inflammatory properties of these genistein-modified membranes.	Genistein	37-46	interleukin 1 beta	Homo sapiens	167-175	
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Genistein	28-37	interleukin 1 beta	Homo sapiens	132-140	
18202522-8	2007	The IL-1beta-stimulated uPA mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrolidinedithiocarbamate, and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	Genistein	156-165	interleukin 1 beta	Homo sapiens	4-12	
12714616-17	2003	Genistein (50 microM) and dexamethasone (1 microM) also partially blocked (by 26% and 28%, respectively) the effect of IL-1beta.	Genistein	0-9	interleukin 1 beta	Homo sapiens	119-127	
11996950-9	2002	Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects.	Genistein	56-65	interleukin 1 beta	Homo sapiens	153-161	
11076808-5	2000	Neutralizing antibodies to epidermal growth factor (EGF) and transforming growth factor-alpha or inhibition of the EGF receptor by tyrphostin AG-1478 or genistein inhibited IL-1beta-induced alveolar epithelial repair, indicating that IL-1beta enhances in vitro alveolar epithelial repair by an EGF- or transforming growth factor-alpha-dependent mechanism.	Genistein	153-162	interleukin 1 beta	Homo sapiens	173-181	
11775830-4	2000	Genistein, the specific PTK inhibitor, was used to evaluate the inhibitory role in activation of MAPKs by IL-1 beta.	Genistein	0-9	interleukin 1 beta	Homo sapiens	106-115	
10942208-9	2000	This increase of DNA-protein complex formation induced by IL-1beta was blocked by herbimycin A and another tyrosine kinase inhibitor, genistein.	Genistein	134-143	interleukin 1 beta	Homo sapiens	58-66	
9551901-8	1998	In dendritic cells generated from mononuclear progenitors, the protein tyrosine kinase inhibitor genistein was able to block tyrosine phosphorylation as well as production of IL-1beta mRNA transcripts.	Genistein	97-106	interleukin 1 beta	Homo sapiens	175-183	
10688620-4	2000	Genistein also blocks the effect of IL-1beta, indicating involvement of tyrosine phosphorylation in the process.	Genistein	0-9	interleukin 1 beta	Homo sapiens	36-44	
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Genistein	113-122	interleukin 1 beta	Homo sapiens	0-9	
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Genistein	113-122	interleukin 1 beta	Homo sapiens	318-327	
10068525-10	1999	RESULTS: TLCK, genistein, and LLnL each inhibited IL-1beta-induced C3 production in a dose-dependent fashion.	Genistein	15-24	interleukin 1 beta	Homo sapiens	50-58	
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Genistein	32-41	interleukin 1 beta	Homo sapiens	132-140	
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	Genistein	52-61	interleukin 1 beta	Homo sapiens	87-96	
8967514-7	1996	Pretreatment of cells with genistein (0.37 microM), a specific tyrosine kinase inhibitor, attenuated the proliferative effect of IL-1 beta and PDGF-BB.	Genistein	27-36	interleukin 1 beta	Homo sapiens	129-138	
8967514-10	1996	In contrast, genistein pretreatment (0.37 microM) prevented formation of inositol 1,4,5-trisphosphate (IP3), as induced by IL-1 beta and/or PDGF-BB.	Genistein	13-22	interleukin 1 beta	Homo sapiens	123-132	
8587246-8	1995	Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression.	Genistein	168-177	interleukin 1 beta	Homo sapiens	96-105	
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Genistein	114-123	interleukin 1 beta	Homo sapiens	87-96	
8089188-9	1994	When adhering monocytes are treated with the tyrosine kinase inhibitors genistein or herbimycin, both phosphorylation of pp76 and induction of IL-1 beta message are blocked in a dose-dependent fashion.	Genistein	72-81	interleukin 1 beta	Homo sapiens	143-152	
7875467-8	1995	However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by > 95%).	Genistein	132-141	interleukin 1 beta	Homo sapiens	30-39	
7861699-10	1994	The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity.	Genistein	67-76	interleukin 1 beta	Homo sapiens	165-169	
11854837-4	1995	Genistein, an inhibitor of tyrosine phosphorylation completely inhibited the ability of IL-1beta to induce the COX II message.	Genistein	0-9	interleukin 1 beta	Homo sapiens	88-96	
7541794-5	1995	The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.	Genistein	31-40	interleukin 1 beta	Homo sapiens	129-138	
8089188-10	1994	Similarly, treatment with genistein or herbimycin can block tyrosine phosphorylation of pp76 and IL-1 beta message induction mediated by ligation of beta 1 integrin with antibodies.	Genistein	26-35	interleukin 1 beta	Homo sapiens	97-106	
8340234-9	1993	Two tyrosine kinase inhibitors, genistein and dihydroxycinnamate, both inhibited SEB-induced IL-1 beta mRNA in monocytes.	Genistein	32-41	interleukin 1 beta	Homo sapiens	93-102	
8454038-2	1993	Genistein, a specific tyrosine kinase inhibitor, inhibited PMA induced IL-1 beta protein and mRNA levels in THP-1 cells.	Genistein	0-9	interleukin 1 beta	Homo sapiens	71-80	
1639516-3	1992	In contrast, the secretion of IL-1 beta was blocked by a cyclic AMP- and cyclic GMP-dependent kinase inhibitor (HA1004) as well as by H7 and genistein.	Genistein	141-150	interleukin 1 beta	Homo sapiens	30-39