PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30911044-6 2019 However, pre-treatment of PBMCs with physiologically-relevant concentrations of genistein (p = 0.0023) and equol (p = 0.006) decreases interleukin (IL)-12/IL-18-induced interferon-gamma (IFN-gamma) production versus controls. Genistein 80-89 interferon gamma Homo sapiens 169-185 33908440-7 2021 Furthermore, genistein inhibited the phosphorylation of ERK and STAT3 to downregulate the expression of cytokines and chemokines, and feedback downregulate phospho-p38 in TNF-alpha/IFN-gamma-induced HaCaT cells. Genistein 13-22 interferon gamma Homo sapiens 181-190 30911044-6 2019 However, pre-treatment of PBMCs with physiologically-relevant concentrations of genistein (p = 0.0023) and equol (p = 0.006) decreases interleukin (IL)-12/IL-18-induced interferon-gamma (IFN-gamma) production versus controls. Genistein 80-89 interferon gamma Homo sapiens 187-196 21672594-5 2011 We therefore tested whether GEN would prevent apoptosis in cultured motoneurons following exposure to pro-inflammatory cytokines released from IFN-gamma activated microglia. Genistein 28-31 interferon gamma Homo sapiens 143-152 15844596-10 2005 Furthermore, Genistein abrogated the transient increased roles and partly reversed the longterm inhibitory functions by IFN-gamma (P < 0.05) . Genistein 13-22 interferon gamma Homo sapiens 120-129 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. Genistein 114-123 interferon gamma Homo sapiens 66-82 10048787-10 1999 However, responses to fMLP and IFN-gamma were both depressed by pertussis toxin, and the IFN-gamma responses were, in addition, inhibited by the tyrosine kinase inhibitor genistein. Genistein 171-180 interferon gamma Homo sapiens 89-98 9687151-9 1998 The turnover time of the nuclear protein lasted for only 4 h although the suppressive effect of IFNgamma on Tg gene transcription lasted for 48 h. The effect of IFNgamma was lost when the thyrocytes were co-treated with genistein, a specific tyrosine kinase inhibitor. Genistein 220-229 interferon gamma Homo sapiens 96-104 9687151-9 1998 The turnover time of the nuclear protein lasted for only 4 h although the suppressive effect of IFNgamma on Tg gene transcription lasted for 48 h. The effect of IFNgamma was lost when the thyrocytes were co-treated with genistein, a specific tyrosine kinase inhibitor. Genistein 220-229 interferon gamma Homo sapiens 161-169 8980289-6 1997 Each competitive inhibitor of PTK, genistein or tyrphostin, substantially increased the C3 production by IFNgamma at lower concentrations, although each agent had little effect on TNFalpha-associated production of C3 at the same concentrations. Genistein 35-44 interferon gamma Homo sapiens 105-113 8764139-8 1996 We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets. Genistein 52-61 interferon gamma Homo sapiens 102-111 15611648-3 2004 Here we demonstrate that the soy isoflavone genistein, a tyrosine kinase inhibitor, rapidly decreased IL-10 secretion followed by upregulation of IFNgamma and inhibition of cell proliferation with pre-dominantly G2 arrest. Genistein 44-53 interferon gamma Homo sapiens 146-154 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. Genistein 255-264 interferon gamma Homo sapiens 175-184 11751911-4 2002 Tyrosine kinase inhibitors (genistein or herbimycin), Src family inhibitor (PP2), or a phosphatidylinositol-phospholipase C inhibitor (U73122) attenuated the IFN-gamma-induced ICAM-1 expression. Genistein 28-37 interferon gamma Homo sapiens 158-167 10419647-7 1999 With Genistein, an inhibitor of tyrosine kinase, the IFN-gamma-induced IP-10 mRNA expression was also found to be diminished. Genistein 5-14 interferon gamma Homo sapiens 53-62 10353535-10 1999 Three specific tyrosine protein kinase (TPK) inhibitors, herbimycin A, tyrphostin, and genistein, significantly inhibited IFN-gamma-induced EC apoptosis in a dose-dependent fashion (p < .05). Genistein 87-96 interferon gamma Homo sapiens 122-131 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 46-55 interferon gamma Homo sapiens 121-130 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 235-244 interferon gamma Homo sapiens 121-130 8823363-9 1996 As expected, staurosporine and genistein inhibited, whereas okadaic acid augmented, the induction of K17 by IFN gamma. Genistein 31-40 interferon gamma Homo sapiens 108-117 8568231-10 1996 However, the promotive effect of IL-7 on IFN-gamma and IL-4 gene expression could be blocked by genistein and cyclosporin A. Genistein 96-105 interferon gamma Homo sapiens 41-50 8861714-7 1995 The tyrosine kinase inhibitors, genistein (10(-7) - 10(-4) M) and herbimycin A (5.2 x 10(-9) - 1.74 x 10(-6) M), produced a powerful concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma. Genistein 32-41 interferon gamma Homo sapiens 237-246 7643015-8 1995 In contrast, IL-12 induction of IFN-gamma cytoplasmic mRNA appears to only partially depend on activation of protein kinase C. Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive. Genistein 181-190 interferon gamma Homo sapiens 32-41 7521164-6 1994 Genistein also modulates the expression of ICAM-1 on endothelial cells by potentiating the upregulating effect of TNF and IFN-gamma. Genistein 0-9 interferon gamma Homo sapiens 122-131 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Genistein 0-9 interferon gamma Homo sapiens 33-42 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Genistein 0-9 interferon gamma Homo sapiens 115-124 7588238-8 1995 The tyrosine protein kinase inhibitor, genistein, inhibited the production of inositol phosphates and the elevation of [Ca2+]i induced by IFN gamma, but had no effect on ATP, suggesting that tyrosine protein kinase is involved in the signaling transduction of IFN gamma. Genistein 39-48 interferon gamma Homo sapiens 138-147 7588238-8 1995 The tyrosine protein kinase inhibitor, genistein, inhibited the production of inositol phosphates and the elevation of [Ca2+]i induced by IFN gamma, but had no effect on ATP, suggesting that tyrosine protein kinase is involved in the signaling transduction of IFN gamma. Genistein 39-48 interferon gamma Homo sapiens 260-269 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. Genistein 62-71 interferon gamma Homo sapiens 105-114 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. Genistein 62-71 interferon gamma Homo sapiens 155-164 1469778-4 1992 Being consistent with this, IFN-gamma induced increased tyrosine phosphorylation and this was inhibited by genistein. Genistein 107-116 interferon gamma Homo sapiens 28-37