PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21713398-0 2011 Mechanism of attenuation of pro-inflammatory Ang II-induced NF-kappaB activation by genistein in the kidneys of male rats during aging. Genistein 84-93 angiotensinogen Rattus norvegicus 45-51 26164719-6 2015 Additionally, genistein (50 muM) attenuated angiotensin II-induced cell proliferation. Genistein 14-23 angiotensinogen Rattus norvegicus 44-58 21713398-7 2011 The results of the analysis showed that Ang II and AT1 expression increased during aging and that these increases were blunted by treatment with genistein. Genistein 145-154 angiotensinogen Rattus norvegicus 40-46 21713398-8 2011 Furthermore, we investigated the inhibitory effects of genistein on the Ang II-induced redox imbalance in aged rat kidneys. Genistein 55-64 angiotensinogen Rattus norvegicus 72-78 21713398-10 2011 We also determined genistein attenuated Ang II-induced NF-kappaB activation through its anti-oxidant activity in YPEN-1 cells. Genistein 19-28 angiotensinogen Rattus norvegicus 40-46 21713398-11 2011 Taken together, our present results show that genistein has potent anti-inflammatory effect resulting in the attenuation of the Ang II-induced NF-kappaB activation during aging. Genistein 46-55 angiotensinogen Rattus norvegicus 128-134 21713398-13 2011 Based on these data, genistein may be an anti-Ang II agent that may be used in anti-inflammatory therapies. Genistein 21-30 angiotensinogen Rattus norvegicus 46-52 17303665-6 2007 AngII-MCP-1 induction was inhibited by the tyrosine kinase inhibitor genistein, suggesting a MAPK signaling mechanism. Genistein 69-78 angiotensinogen Rattus norvegicus 0-5 17667142-2 2007 We hypothesized that genistein would improve vascular reactivity involving changes in endothelial nitric oxide synthase (NOS) expression and its regulatory proteins (caveolin and calmodulin), angiotensin II receptor, and/or oxidative status in OVX spontaneously hypertensive rats (SHRs). Genistein 21-30 angiotensinogen Rattus norvegicus 192-206 16989733-6 2006 AII-induced PLCgamma1 activation required both tyrosine kinase and PI3Kgamma since genistein and tyrphostin B48 (inhibitors of tyrosine kinase), LY294002 and wortmannin (inhibitors of PI3K) and anti-PI3Kgamma antibody abolished AII-induced stimulation of InsPs accumulation. Genistein 83-92 angiotensinogen Rattus norvegicus 0-3 12121887-4 2002 ANG II-induced contraction of the rat LES and IAS SMC was inhibited by genistein, PD-98059 [a specific inhibitor of MAPK kinases (MEK 1/2)], herbimycin A (a pp60(c-src) inhibitor), and antibodies to pp60(c-src) and p(120) ras GTPase-activating protein (p(120) rasGAP). Genistein 71-80 angiotensinogen Rattus norvegicus 0-6 15569307-7 2004 The stimulatory effect of both Ang II on Pax-2 gene expression was blocked by PD123319 (AT2R inhibitor), AG 490 (specific Janus kinase 2 (JAK2) inhibitor) and genistein (tyrosine kinase inhibitor), but not by losartan (AT1R inhibitor). Genistein 159-168 angiotensinogen Rattus norvegicus 31-37 15750262-5 2004 Treatment with genistein also remarkably reduced the Ang II-induced superoxide by the reduction of nitroblue tetrazolium, inhibited nitrotyrosine formation, and attenuated endothelin-1 production by ELISA via the stimulation of Ang II. Genistein 15-24 angiotensinogen Rattus norvegicus 53-59 15750262-5 2004 Treatment with genistein also remarkably reduced the Ang II-induced superoxide by the reduction of nitroblue tetrazolium, inhibited nitrotyrosine formation, and attenuated endothelin-1 production by ELISA via the stimulation of Ang II. Genistein 15-24 angiotensinogen Rattus norvegicus 228-234 12323389-4 2002 The renal artery contractions were attenuated by the 2-day low-dose genistein treatment as follows: angiotensin II (46%), noradrenaline (42%) KCl (36%), and endothelin-1 (34%). Genistein 68-77 angiotensinogen Rattus norvegicus 100-114 12323389-5 2002 Only the angiotensin II-induced contractions were reduced by the 2-week treatment with estradiol-17beta (38%) and with the low-dose of genistein (31%). Genistein 135-144 angiotensinogen Rattus norvegicus 9-23 11841996-4 2002 ANG II-induced contraction of rat IAS smooth muscle and SMC was attenuated by tyrosine kinase inhibitors genistein and tyrphostin, protein kinase C (PKC) inhibitor H-7, Ca(2+) channel blocker nicardipine, Rho kinase inhibitor Y-27632 or p(44/42) mitogen-activating protein kinase (MAPK(44/42)) inhibitor PD-98059. Genistein 105-114 angiotensinogen Rattus norvegicus 0-6 12079690-3 2002 A tyrosine kinase inhibitor genistein (10 microM) reduced the angiotensin II- and endothelin-1-induced aortic contraction, while 10 microM of daidzein (an inactive analogue of genistein) did not. Genistein 28-37 angiotensinogen Rattus norvegicus 62-76 11881120-3 2001 Genistein partially inhibited Ang II- and Ang I-induced contractions. Genistein 0-9 angiotensinogen Rattus norvegicus 30-36 11117383-0 2000 Effect of genistein on cardiovascular responses to angiotensin II in conscious unrestrained rats. Genistein 10-19 angiotensinogen Rattus norvegicus 51-65 10406834-7 1999 Chelating of intracellular Ca(2+) with BAPTA-AM, inhibition of tyrosine kinase with genistein, and inhibition of mitogen-activated protein kinase kinase with PD98059 completely abolished the effect of Ang II. Genistein 84-93 angiotensinogen Rattus norvegicus 201-207 11040245-9 2000 The Ang II-induced increase in ERK1/2 activity was inhibited by protein kinase C inhibitors Ro-31-8220 (1 micromol/L) and Go-6976 (300 nmol/L) and tyrosine kinase inhibitors genistein (1 micromol/L, general) and herbimycin A (1 micromol/L, c-Src family). Genistein 174-183 angiotensinogen Rattus norvegicus 4-10 10642276-4 2000 Ang II subtype 1 receptor activation by Ang II (1 micromol/L) induced a transient increase in Ca(2+)(i) that was partially attenuated by genistein, a tyrosine kinase inhibitor. Genistein 137-146 angiotensinogen Rattus norvegicus 0-6 10642276-4 2000 Ang II subtype 1 receptor activation by Ang II (1 micromol/L) induced a transient increase in Ca(2+)(i) that was partially attenuated by genistein, a tyrosine kinase inhibitor. Genistein 137-146 angiotensinogen Rattus norvegicus 40-46 10533984-10 1999 Both Gen (n = 7) and TB-48 (n = 3) inhibited AP 125I-Ang II internalization (80+/-7% inhibition; p<0.025 vs. control). Genistein 5-8 angiotensinogen Rattus norvegicus 53-59 10533984-13 1999 Incubating MSC with Gen (n = 5) or herbimycin A [150 ng/ml] (n = 4) also inhibited MSC 125I-Ang II internalization (82+/-11% inhibition; p<0.005 vs. control). Genistein 20-23 angiotensinogen Rattus norvegicus 92-98 9821807-0 1998 Effects of genistein and staurosporine on angiotensin II-induced DNA synthesis, protein synthesis and mitogen-activated protein kinase activation in vascular smooth muscle cells. Genistein 11-20 angiotensinogen Rattus norvegicus 42-56 10330055-6 1999 The inhibition of HCO-3 absorption by ANG II was reduced by >50% in the presence of the tyrosine kinase inhibitors genistein (7 microM) or herbimycin A (1 microM). Genistein 118-127 angiotensinogen Rattus norvegicus 38-44 10209301-5 1999 A protein tyrosine kinase inhibitor, genistein, completely blocked both Ang II- and PMA-induced PAI-1 mRNA expression. Genistein 37-46 angiotensinogen Rattus norvegicus 72-78 10209301-7 1999 Both bisindorylmaleimide I and genistein suppressed the Ang II plus TGF-beta1-induced PAI-1 mRNA upregulation to the basal level, while downregulation of PKC attenuated the synergistic upregulation of PAI-1 mRNA expression to the level comparable to TGF-beta1 alone. Genistein 31-40 angiotensinogen Rattus norvegicus 56-62 10077431-8 1999 It appears that genistein inhibits angiotensin II-induced DNA synthesis partly by inhibiting PDGF-A gene expression. Genistein 16-25 angiotensinogen Rattus norvegicus 35-49 9797345-8 1998 The tyrosine kinase inhibitor genistein and the mitogen-activated protein kinase kinase inhibitor PD098059 inhibited Ang II-induced MCP-1 gene expression, consistent with a mitogen-activated protein kinase-dependent signaling mechanism. Genistein 30-39 angiotensinogen Rattus norvegicus 117-123 9821807-3 1998 The tyrosine kinase inhibitor genistein caused an inhibition of the angiotensin II-induced DNA synthesis but not of the agent-induced protein synthesis. Genistein 30-39 angiotensinogen Rattus norvegicus 68-82 9821807-6 1998 Angiotensin II stimulated mitogen-activated protein (MAP) kinases and the angiotensin II-induced MAP kinase activation was inhibited by genistein but not by staurosporine. Genistein 136-145 angiotensinogen Rattus norvegicus 0-14 9821807-6 1998 Angiotensin II stimulated mitogen-activated protein (MAP) kinases and the angiotensin II-induced MAP kinase activation was inhibited by genistein but not by staurosporine. Genistein 136-145 angiotensinogen Rattus norvegicus 74-88 9677408-10 1998 The tyrosine kinase inhibitor, genistein, had no effect on the peak response to Ang II stimulation, but significantly inhibited IP3 production after 30 s, a time period which temporally correlated with PLC-gamma tyrosine phosphorylation in response to Ang II. Genistein 31-40 angiotensinogen Rattus norvegicus 252-258 9683930-8 1998 The effect of AII on the increase in thrombin receptor mRNA expression was enhanced by the protein kinase C inhibitor Ro 31-8220, but was unaffected by prolonged incubation with phorbol myristate acetate or the tyrosine kinase inhibitors genistein and erbstatin A. Genistein 238-247 angiotensinogen Rattus norvegicus 14-17 9116917-5 1997 Genistein, an inhibitor of protein tyrosine kinases, significantly suppressed the Ang II-induced AA metabolite release. Genistein 0-9 angiotensinogen Rattus norvegicus 82-88 9439636-6 1998 The Ang II effect can be blocked by treatment with either the Ang II type 1 receptor-selective antagonist CI-996 or the tyrosine kinase inhibitor genistein. Genistein 146-155 angiotensinogen Rattus norvegicus 4-10 9440699-5 1998 The tyrosine kinase inhibitors, genistein and CP-188,556, blocked Ang II-mediated ERK1/2 activation in rat VSMCs (rVSMCs). Genistein 32-41 angiotensinogen Rattus norvegicus 66-72 9188505-3 1997 Pretreatment with tyrosine kinase inhibitors, genistein and herbimycin A, or a putative phosphatidylinositol 3-kinase inhibitor, wortmannin, completely blocked ANG II-induced Ras activation, whereas neither of them had an effect on ANG II-induced MAP kinase activation. Genistein 46-55 angiotensinogen Rattus norvegicus 160-166 8831515-10 1996 Stretch-induced changes in levels of Ang II receptors were inhibited by genistein but not by H-7, staurosporin, and protein kinase C depletion or by BAPTA-AM. Genistein 72-81 angiotensinogen Rattus norvegicus 37-43 8999881-9 1997 Both calcium- and Ang II-dependent activation of p70(S6K) were attenuated by the tyrosine kinase inhibitor genistein, and activation of p70(S6K) was higher in GN4 than WB cells, correlating with the increased expression and activation of CADTK/PYK-2 in GN4 cells. Genistein 107-116 angiotensinogen Rattus norvegicus 18-24 8678916-8 1996 Genistein and tyrphostin, protein tyrosine kinase inhibitors, significantly suppressed the Ang II-induced Ca2+ influx. Genistein 0-9 angiotensinogen Rattus norvegicus 91-97 8662912-5 1996 The calmodulin inhibitor, calmidazolium, and the tyrosine kinase inhibitor, genistein, completely blocked MAPK activation by Ang II as well as by the Ca2+ ionophore A23187. Genistein 76-85 angiotensinogen Rattus norvegicus 125-131 8662912-6 1996 Ang II caused a rapid increase in the binding of GTP to p21(ras), and this was inhibited by genistein, TMB-8, and calmidazolium but not by pertussis toxin or GF109203X. Genistein 92-101 angiotensinogen Rattus norvegicus 0-6 8948516-2 1996 Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0.1-10 microM) or angiotensin II (1-100 nM). Genistein 0-9 angiotensinogen Rattus norvegicus 106-120 8948516-6 1996 Subsequent addition of genistein counteracted the effect of thapsigargin on noradrenaline- and angiotensin II-induced contraction. Genistein 23-32 angiotensinogen Rattus norvegicus 95-109 8678916-9 1996 Genistein and tyrphostin also suppressed the Ang II-induced formation of choline. Genistein 0-9 angiotensinogen Rattus norvegicus 45-51 8713501-12 1996 Preincubation with genistein, abolished the usual 10-fold increase in Cl- channel activity observed with AngII. Genistein 19-28 angiotensinogen Rattus norvegicus 105-110 7565768-11 1995 In contrast, genistein, in concentrations sufficient to inhibit Ca(2+)-dependent tyrosine phosphorylation, prevented Ang II and thapsigargin-induced JNK activation. Genistein 13-22 angiotensinogen Rattus norvegicus 117-123 7476882-8 1995 Treatment of quiescent aortic SMC with genistein and herbimycin A abolished the stimulatory effect of AII on overall protein tyrosine phosphorylation. Genistein 39-48 angiotensinogen Rattus norvegicus 102-105 7476882-11 1995 In parallel to their selective action on tyrosine phosphorylation, both genistein and herbimycin A completely inhibited AII-stimulated protein synthesis in a dose-dependent manner. Genistein 72-81 angiotensinogen Rattus norvegicus 120-123 7842390-1 1994 In a porcine coronary artery helical strip preparation, the tyrosine kinase inhibitors genistein and tyrphostin (AG82) attenuated the contractile actions of angiotensin II, arginine vasopressin, epidermal growth factor--urogastrone, noradrenaline, and prostaglandin F2 alpha, under conditions where contractions due to acetylcholine and KCl were not affected. Genistein 87-96 angiotensinogen Rattus norvegicus 157-171 7842390-2 1994 Both genistein and tyrphostin also caused a selective inhibition of angiotensin II action in rat aorta helical strips, without affecting KCl-mediated contractions. Genistein 5-14 angiotensinogen Rattus norvegicus 68-82 7842390-5 1994 Angiotensin II caused an elevation of phosphotyrosyl protein (antiphosphotyrosine Western blot) in the porcine coronary artery, which was reversed by genistein. Genistein 150-159 angiotensinogen Rattus norvegicus 0-14 7842390-7 1994 Our data (i) document the selective inhibition by genistein and tyrphostin of the contractile action of some, but by no means all, G-protein-linked vascular agonists in porcine and rat arterial preparations, (ii) establish the presence of sarcoma virus related tyrosine kinase activity in the porcine coronary artery, and (iii) demonstrate angiotensin II mediated increases in phosphotyrosyl protein content in porcine coronary artery tissue. Genistein 50-59 angiotensinogen Rattus norvegicus 340-354 33557258-6 2021 Genistein reduced circulating angiotensin-converting enzyme activity and angiotensin II concentrations in L-NAME rats. Genistein 0-9 angiotensinogen Rattus norvegicus 73-87 35062067-9 2022 Genistein reduced serum angiotensin converting enzyme (ACE) activity and plasma angiotensin II (Ang II) in 2K1C rats. Genistein 0-9 angiotensinogen Rattus norvegicus 80-94 30452971-0 2019 Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARgamma-NF-kappaB signaling pathway in rat vascular smooth muscle cells. Genistein 0-9 angiotensinogen Rattus norvegicus 19-25