PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11106000-2 2000 Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistein 15-24 interleukin 6 Homo sapiens 91-95 12094620-7 2001 In addition, interleukin-6 synthesis by these two cell lines was inhibited by genistein or daidzein; production was decreased by approximately 20% compared with the control group (P < 0.05). Genistein 78-87 interleukin 6 Homo sapiens 13-26 10880263-6 2000 Blocking protein tyrosine kinase (PTK) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha, IL-1beta and OSM. Genistein 69-78 interleukin 6 Homo sapiens 156-160 7693792-3 1993 Genistein, a tyrosine kinase inhibitor inhibited the interleukin 6 stimulated synthesis of acute phase proteins suggesting that a tyrosine kinase event participates in the signal transduction pathway. Genistein 0-9 interleukin 6 Homo sapiens 53-66 10920220-6 2000 The protein kinase C inhibitor, H7, and the serine/threonine kinase inhibitor, genistein, abolished the particle-induced increase in IL-6 release at a concentration of 100 microM for each compound. Genistein 79-88 interleukin 6 Homo sapiens 133-137 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. Genistein 157-166 interleukin 6 Homo sapiens 5-9 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. Genistein 168-171 interleukin 6 Homo sapiens 5-9 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 46-55 interleukin 6 Homo sapiens 112-116 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 235-244 interleukin 6 Homo sapiens 112-116 7595543-3 1995 Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879. Genistein 127-136 interleukin 6 Homo sapiens 69-82 7539384-9 1995 IL-3 induced IL-6 secretion in these cells, which was augmented by a protein kinase-C (PKC) inhibitor, H7, and reduced by a tyrosine kinase inhibitor, genistein. Genistein 151-160 interleukin 6 Homo sapiens 13-17 7515809-3 1994 Herbimycin A and genistein, inhibitors of tyrosine kinases, markedly attenuated LPS-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) protein and mRNA production. Genistein 17-26 interleukin 6 Homo sapiens 136-149 7515809-3 1994 Herbimycin A and genistein, inhibitors of tyrosine kinases, markedly attenuated LPS-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) protein and mRNA production. Genistein 17-26 interleukin 6 Homo sapiens 151-155 8258685-8 1993 In addition to cytokine mRNA levels, LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein. Genistein 169-178 interleukin 6 Homo sapiens 49-53 8258685-8 1993 In addition to cytokine mRNA levels, LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein. Genistein 169-178 interleukin 6 Homo sapiens 76-80 8258686-4 1993 Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7) or the tyrosine kinase inhibitor, genistein. Genistein 258-267 interleukin 6 Homo sapiens 44-48 8370693-6 1993 The addition of genistein to rIL-1- and rTNF-alpha-stimulated trophoblasts inhibited rIL-1-induced and rTNF-alpha induced hCG production but maintained rIL-1- and rTNF-alpha-induced IL-6 production. Genistein 16-25 interleukin 6 Homo sapiens 182-186 32440504-7 2020 Furthermore, GEN inhibited IL-6-induced vascular endothelial cell migration and tube formation in vitro. Genistein 13-16 interleukin 6 Homo sapiens 27-31 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. Genistein 85-94 interleukin 6 Homo sapiens 148-152 31610186-4 2019 Among the 17 flavonoids tested, only apigenin (flavones), luteolin (flavones), daidzein (isoflavones) and genistein (isoflavones) reduced LPS-induced release of inflammatory cytokines/chemokines interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 in BEAS-2B cells. Genistein 106-115 interleukin 6 Homo sapiens 195-213 32440504-0 2020 Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. Genistein 0-9 interleukin 6 Homo sapiens 82-86 32440504-8 2020 Conclusion: GEN inhibits IL-6-induced VEGF expression and angiogenesis partially through the Janus kinase 2 (JAK2)/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA. Genistein 12-15 interleukin 6 Homo sapiens 25-29 32440504-6 2020 Results: GEN dose-dependently inhibited the expression and secretion of interleukin (IL)-6 and VEGF, as well as the nucleus translocation of Signal transducer and activator of transcription 3 (STAT3) in MH7A. Genistein 9-12 interleukin 6 Homo sapiens 72-90 25626894-9 2015 The present findings suggest that GEN protects HCY-induced endothelial cell inflammatory injury may through reducing the release of ROS, inhibiting NF-kB activation, down-regulating the expression of cytokine IL-6 and adhesion molecules ICAM-1, avoiding inflammatory cells and platelet adhesion, accordingly, leading to a balance of endothelial cell proliferation and apoptosis. Genistein 34-37 interleukin 6 Homo sapiens 209-213 30743203-8 2019 The inhibitory effect of genistein on the expression of IL-6, IL-23 and TNF-alpha was weakened after Stat3 siRNA in HaCaT cells. Genistein 25-34 interleukin 6 Homo sapiens 56-60 30324111-14 2018 Regarding inflammatory cytokines, genistein and L-carnitine had less effect on TNF-alpha than on IL-6. Genistein 34-43 interleukin 6 Homo sapiens 97-101 29693152-0 2018 Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors. Genistein 0-9 interleukin 6 Homo sapiens 72-75 28923363-4 2018 In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage. Genistein 43-52 interleukin 6 Homo sapiens 173-177 29901960-1 2016 Objective: The present study aimed to investigate the anti-inflammatory effect of phytoestrogen genistein (Ge) on the secretion of interleukin 6 (IL6) under lipopolysaccharide (LPS) stimulated conditions in human endometrial epithelial cell line RL95-2. Genistein 96-105 interleukin 6 Homo sapiens 131-144 29901960-1 2016 Objective: The present study aimed to investigate the anti-inflammatory effect of phytoestrogen genistein (Ge) on the secretion of interleukin 6 (IL6) under lipopolysaccharide (LPS) stimulated conditions in human endometrial epithelial cell line RL95-2. Genistein 96-105 interleukin 6 Homo sapiens 146-149 25447760-3 2014 150 kGy gamma-irradiated genistein did not exert cytotoxicity in macrophages, and inhibited inducible nitric oxide synthase-mediated nitric oxide production and pro-inflammatory cytokines level, such as tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta, in lipopolysaccharide (LPS)-induced macrophages. Genistein 25-34 interleukin 6 Homo sapiens 232-245 22284780-11 2012 Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6. Genistein 52-61 interleukin 6 Homo sapiens 236-240 25319548-10 2014 Genistein significantly decreased IL-6 and IL-1beta mRNA levels, as well as IL-6 production in PMA/A23187-induced mast cells activation. Genistein 0-9 interleukin 6 Homo sapiens 34-38 24669186-8 2014 RESULTS: Genistein decreased the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner. Genistein 9-18 interleukin 6 Homo sapiens 56-60 21657246-10 2011 Of particular importance is that the genistein-modified blend membranes (PA:PVP/G) showed greater suppression of the concentrations of all three cytokines (TNF-alpha, IL-1beta, and IL-6) in comparison with those of the PA/G membranes, signifying the role of PVP in the enhanced anti-inflammatory properties of these genistein-modified membranes. Genistein 37-46 interleukin 6 Homo sapiens 181-185 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. Genistein 194-203 interleukin 6 Homo sapiens 0-4 17581928-6 2007 In addition, genistein and herbimycin A completely blocked the IL-6-induced increases in alpha-MG uptake and the protein expression level of SGLTs. Genistein 13-22 interleukin 6 Homo sapiens 63-67 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Genistein 58-67 interleukin 6 Homo sapiens 146-159 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Genistein 58-67 interleukin 6 Homo sapiens 161-164 12761896-7 2003 Genistein, but not raloxifene, also mimicked E(2) action in the hFOB/ERbeta6 cells increasing PR gene expression and inhibiting IL-6 production. Genistein 0-9 interleukin 6 Homo sapiens 128-132 21320636-6 2011 The results showed that the NASH model rats reproduced typical pathogenetic and histopathological features of NASH in human, and genistein administration improved liver function, slowed down NASH progression, decreased the levels of TBARS, TNF-alpha and IL-6 in serum and liver, as well as inhibited IkappaB-alpha phosphorylation, nuclear translocation of NF-kappaB p65 subunit, and activation of c-Jun N-terminal kinase (JNK). Genistein 129-138 interleukin 6 Homo sapiens 254-258 20184800-10 2010 AG-1478 dual effects on IL-6 secretion induced by BK alone or BK plus EGF were also observed in cells treated with genistein, a tyrosine kinase inhibitor, and AG-825, an ErbB-2 inhibitor. Genistein 115-124 interleukin 6 Homo sapiens 24-28 19434061-7 2009 Endogenous and TNF-alpha-induced expressions of IL-6, IL-8, p38, p65 and C/EBP-beta were also downregulated by genistein, showing its anti-inflammatory properties. Genistein 111-120 interleukin 6 Homo sapiens 48-52 17404287-2 2007 We previously demonstrated that genistein suppresses TNF-alpha-induced NF-kappaB-dependent IL-6 gene expression in cancer cells by interfering with the mitogen- and stress-activated protein kinase 1 activation pathway. Genistein 32-41 interleukin 6 Homo sapiens 91-95 17404287-5 2007 More particularly, we observe that genistein inhibits IL-6 gene expression by modulating the transcription factor NF-kappaB. Genistein 35-44 interleukin 6 Homo sapiens 54-58 17404287-9 2007 Moreover, analysis of IL-6 mRNA levels in bone marrow-derived p53 null vs wild-type dendritic cells confirms a role for p53 in the reduction of NF-kappaB-dependent gene expression, mediated by genistein. Genistein 193-202 interleukin 6 Homo sapiens 22-26 16491457-4 2006 Coumestrol, daidzein and genistein stimulate the expression of the ERE-dependent reporter in MVLN cells and repress the activity of the IL-6 promoter in U2OS cells in a dose-dependent manner. Genistein 25-34 interleukin 6 Homo sapiens 136-140 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. Genistein 255-264 interleukin 6 Homo sapiens 167-171 12349949-7 2002 Genistein, a tyrosine kinase inhibitor, and H-7, a protein kinase C inhibitor, also inhibited IL-6 secretion but not MIF secretion in both LPS- and H2O2-stimulated fibroblasts. Genistein 0-9 interleukin 6 Homo sapiens 94-98 11369659-9 2001 Actinomycin D and genistein blocked IL-6 production, whereas staurosporine did not, suggesting that CD44-dependent IL-6 production requires gene transcription and tyrosine kinase activity. Genistein 18-27 interleukin 6 Homo sapiens 36-40 11369659-9 2001 Actinomycin D and genistein blocked IL-6 production, whereas staurosporine did not, suggesting that CD44-dependent IL-6 production requires gene transcription and tyrosine kinase activity. Genistein 18-27 interleukin 6 Homo sapiens 115-119