PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30969810-6 2019 Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect. Genistein 36-45 cystic fibrosis transmembrane conductance regulator Mus musculus 55-59 30969810-6 2019 Interestingly, the CFTR potentiator genistein enhanced CFTR-mediated iodide efflux from CHO cells expressing either human or mouse F508del-CFTR, whereas it only potentiated human F508del-CFTR Cl- channels in cell-free membrane patches, suggesting that its action on mouse F508del-CFTR is indirect. Genistein 36-45 cystic fibrosis transmembrane conductance regulator Mus musculus 55-59 25674010-3 2015 Genistein, a naturally occurring phytoestrogen, is known to stimulate CFTR function in vitro. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 70-74 30981209-9 2019 Notably, genistein protected gliadin-sensitive mice from intestinal CFTR malfunction and gliadin-induced inflammation as it prevented gliadin-induced IFN-gamma production by celiac peripheral-blood-mononuclear-cells (PBMC) cultured ex-vivo in the presence of P31-43-challenged Caco-2 cells. Genistein 9-18 cystic fibrosis transmembrane conductance regulator Mus musculus 68-72 30282922-2 2018 Genistein has been shown to increase the open probability of the most common cystic fibrosis (CF) disease-associated mutation, F508-CFTR. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 133-137 22833409-4 2013 Our whole-cell patch-clamp recordings from testicular mouse sperm now reveal a Cl(-) selective component to membrane current that is ATP-dependent, stimulated by cAMP, cGMP, and genistein (a CFTR agonist, at low concentrations), and inhibited by DPC and CFTR(inh) -172, two well-known CFTR antagonists. Genistein 178-187 cystic fibrosis transmembrane conductance regulator Mus musculus 191-195 22833409-4 2013 Our whole-cell patch-clamp recordings from testicular mouse sperm now reveal a Cl(-) selective component to membrane current that is ATP-dependent, stimulated by cAMP, cGMP, and genistein (a CFTR agonist, at low concentrations), and inhibited by DPC and CFTR(inh) -172, two well-known CFTR antagonists. Genistein 178-187 cystic fibrosis transmembrane conductance regulator Mus musculus 254-258 22833409-4 2013 Our whole-cell patch-clamp recordings from testicular mouse sperm now reveal a Cl(-) selective component to membrane current that is ATP-dependent, stimulated by cAMP, cGMP, and genistein (a CFTR agonist, at low concentrations), and inhibited by DPC and CFTR(inh) -172, two well-known CFTR antagonists. Genistein 178-187 cystic fibrosis transmembrane conductance regulator Mus musculus 254-258 21093426-2 2011 We recently found that genistein stimulates murine duodenal HCO(3)(-) secretion through cystic fibrosis transmembrane conductance regulator (CFTR). Genistein 23-32 cystic fibrosis transmembrane conductance regulator Mus musculus 88-139 21093426-2 2011 We recently found that genistein stimulates murine duodenal HCO(3)(-) secretion through cystic fibrosis transmembrane conductance regulator (CFTR). Genistein 23-32 cystic fibrosis transmembrane conductance regulator Mus musculus 141-145 19788494-0 2009 Differential activation of the HCO(3)(-) conductance through the cystic fibrosis transmembrane conductance regulator anion channel by genistein and forskolin in murine duodenum. Genistein 134-143 cystic fibrosis transmembrane conductance regulator Mus musculus 65-116 21865731-4 2011 The forskolin-stimulated (10 muM) I(sc) was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 muM) and CFTR(inh)-172 (100 muM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl(-) secretion. Genistein 220-229 cystic fibrosis transmembrane conductance regulator Mus musculus 75-79 21865731-4 2011 The forskolin-stimulated (10 muM) I(sc) was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 muM) and CFTR(inh)-172 (100 muM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl(-) secretion. Genistein 220-229 cystic fibrosis transmembrane conductance regulator Mus musculus 137-141 21865731-4 2011 The forskolin-stimulated (10 muM) I(sc) was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 muM) and CFTR(inh)-172 (100 muM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl(-) secretion. Genistein 220-229 cystic fibrosis transmembrane conductance regulator Mus musculus 137-141 19788494-5 2009 KEY RESULTS: Genistein markedly stimulated duodenal HCO(3)(-) secretion and I(sc) in a dose-dependent manner in CFTR wild-type mice, but not in CFTR null mice. Genistein 13-22 cystic fibrosis transmembrane conductance regulator Mus musculus 112-116 19788494-6 2009 CFTR(inh)-172, a highly specific CFTR inhibitor, inhibited genistein-stimulated duodenal HCO(3)(-) secretion and I(sc) in wild-type mice. Genistein 59-68 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 19788494-6 2009 CFTR(inh)-172, a highly specific CFTR inhibitor, inhibited genistein-stimulated duodenal HCO(3)(-) secretion and I(sc) in wild-type mice. Genistein 59-68 cystic fibrosis transmembrane conductance regulator Mus musculus 33-37 19788494-8 2009 Further data showed that CFTR HCO(3)(-)/Cl(-) conductance ratio was 1.05 after genistein stimulation, whereas after forskolin stimulation, the CFTR HCO(3)(-)/Cl(-) conductance ratio was 0.27. Genistein 79-88 cystic fibrosis transmembrane conductance regulator Mus musculus 25-29 17766192-7 2008 The CFTR activator genistein (50 microM) significantly potentiated the secretory response of Cftr(+/+) mice whereas its vehicle, ethanol, had no effect. Genistein 19-28 cystic fibrosis transmembrane conductance regulator Mus musculus 4-8 17766192-7 2008 The CFTR activator genistein (50 microM) significantly potentiated the secretory response of Cftr(+/+) mice whereas its vehicle, ethanol, had no effect. Genistein 19-28 cystic fibrosis transmembrane conductance regulator Mus musculus 93-97 15155835-7 2004 Capsaicin may act as a partial agonist of genistein because the maximally enhanced wild-type CFTR currents with genistein are partially inhibited by capsaicin. Genistein 42-51 cystic fibrosis transmembrane conductance regulator Mus musculus 93-97 17588945-10 2007 On the other hand, a CFTR activator (genistein; 5-10 microM) promoted hyperpolarization in mouse sperm incubated under conditions that do not support capacitation. Genistein 37-46 cystic fibrosis transmembrane conductance regulator Mus musculus 21-25 17056801-1 2006 Genistein, a naturally occurring isoflavone, augments in vitro epithelial anion transport via activation of the cystic fibrosis transmembrane conductance regulator chloride channel. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 112-163 15306545-6 2004 Glibenclamide, a blocker of CFTR, eliminated the genistein-stimulated increase of I(sc) and reduced the forskolin-activated I(sc). Genistein 49-58 cystic fibrosis transmembrane conductance regulator Mus musculus 28-32 15155835-3 2004 In whole-cell experiments, capsaicin potentiates cAMP-stimulated wild-type CFTR currents expressed in NIH 3T3 cells or Chinese hamster ovary cells in a dose-dependent manner with a maximal response approximately 60% of that with genistein and an apparent Kd of 48.4 +/- 6.8 microM. Genistein 229-238 cystic fibrosis transmembrane conductance regulator Mus musculus 75-79 15155835-7 2004 Capsaicin may act as a partial agonist of genistein because the maximally enhanced wild-type CFTR currents with genistein are partially inhibited by capsaicin. Genistein 112-121 cystic fibrosis transmembrane conductance regulator Mus musculus 93-97 15155835-10 2004 Both capsaicin and genistein potentiate the cAMP-stimulated G551D-CFTR, DeltaF508-CFTR, and 8SA mutant channel currents. Genistein 19-28 cystic fibrosis transmembrane conductance regulator Mus musculus 66-70 15155835-10 2004 Both capsaicin and genistein potentiate the cAMP-stimulated G551D-CFTR, DeltaF508-CFTR, and 8SA mutant channel currents. Genistein 19-28 cystic fibrosis transmembrane conductance regulator Mus musculus 82-86 15155835-12 2004 In conclusion, capsaicin is a partial agonist of genistein in activation of the CFTR chloride channel. Genistein 49-58 cystic fibrosis transmembrane conductance regulator Mus musculus 80-84 12556293-1 2003 In cell culture systems, genistein, a soy-derived isoflavone with chemopreventive and estrogenic effects, enhances cAMP-dependent activation of the most common cystic fibrosis-causing mutation, deltaF508-CFTR, by as much as 20-fold. Genistein 25-34 cystic fibrosis transmembrane conductance regulator Mus musculus 204-208 10766914-2 2000 The isoflavone genistein may either stimulate or inhibit cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. Genistein 15-24 cystic fibrosis transmembrane conductance regulator Mus musculus 57-108 10913005-0 2000 Genistein activates CFTR-mediated Cl(-) secretion in the murine trachea and colon. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 20-24 10913005-1 2000 The action of the isoflavone genistein on the cystic fibrosis transmembrane conductance regulator (CFTR) has been studied in many cell systems but not in intact murine tissues. Genistein 29-38 cystic fibrosis transmembrane conductance regulator Mus musculus 46-97 10913005-1 2000 The action of the isoflavone genistein on the cystic fibrosis transmembrane conductance regulator (CFTR) has been studied in many cell systems but not in intact murine tissues. Genistein 29-38 cystic fibrosis transmembrane conductance regulator Mus musculus 99-103 10913005-8 2000 We conclude that genistein activates CFTR-mediated Cl(-) secretion in the murine trachea and distal colon. Genistein 17-26 cystic fibrosis transmembrane conductance regulator Mus musculus 37-41 10766914-2 2000 The isoflavone genistein may either stimulate or inhibit cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. Genistein 15-24 cystic fibrosis transmembrane conductance regulator Mus musculus 110-114 10766914-7 2000 Single-channel analysis of channel block suggested that genistein (100 microM) may inhibit CFTR by two mechanisms: first, it may slow the rate of channel opening and second, it may block open channels. Genistein 56-65 cystic fibrosis transmembrane conductance regulator Mus musculus 91-95 10766914-9 2000 Acidification of the intracellular solution relieved channel block, suggesting that the anionic form of genistein may inhibit CFTR. Genistein 104-113 cystic fibrosis transmembrane conductance regulator Mus musculus 126-130 7537452-0 1995 cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein. Genistein 81-90 cystic fibrosis transmembrane conductance regulator Mus musculus 31-35 9482713-3 1998 Possible molecular mechanisms for genistein"s action include inhibition of tyrosine kinases, inhibition of serine/threonine protein phosphatases, or direct binding of genistein to CFTR. Genistein 34-43 cystic fibrosis transmembrane conductance regulator Mus musculus 180-184 9482713-5 1998 Genistein (50 microM) did not open phosphorylated CFTR channels by itself, but increased the ATP- induced CFTR channel current by approximately twofold. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 106-110 9482713-11 1998 Closed time analysis showed that 50 microM genistein caused a prolonged closed state with a time constant of 2.410 +/- 0.035 s. We thus conclude that (a) the effects of genistein are likely caused by a direct binding of the drug to the CFTR protein, and (b) at least two binding sites are required to explain the effects of genistein: a high affinity site that decreases the closing rate and a low affinity site that reduces the opening rate. Genistein 43-52 cystic fibrosis transmembrane conductance regulator Mus musculus 236-240 9482713-11 1998 Closed time analysis showed that 50 microM genistein caused a prolonged closed state with a time constant of 2.410 +/- 0.035 s. We thus conclude that (a) the effects of genistein are likely caused by a direct binding of the drug to the CFTR protein, and (b) at least two binding sites are required to explain the effects of genistein: a high affinity site that decreases the closing rate and a low affinity site that reduces the opening rate. Genistein 169-178 cystic fibrosis transmembrane conductance regulator Mus musculus 236-240 8770006-0 1996 CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases. Genistein 36-45 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 8770006-4 1996 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). Genistein 27-36 cystic fibrosis transmembrane conductance regulator Mus musculus 81-132 8770006-4 1996 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). Genistein 27-36 cystic fibrosis transmembrane conductance regulator Mus musculus 134-138 8770006-4 1996 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). Genistein 27-36 cystic fibrosis transmembrane conductance regulator Mus musculus 242-246 8770006-4 1996 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). Genistein 27-36 cystic fibrosis transmembrane conductance regulator Mus musculus 242-246 8770006-6 1996 As measured by 125I efflux, genistein and calyculin A stimulate the CFTR to approximately 50% of the maximal activity with forskolin. Genistein 28-37 cystic fibrosis transmembrane conductance regulator Mus musculus 68-72 8770006-7 1996 Neither agonist increases CFTR activity at saturating forskolin concentrations, but genistein and calyculin A have an additive effect on CFTR activity. Genistein 84-93 cystic fibrosis transmembrane conductance regulator Mus musculus 137-141 8770006-10 1996 Proteolytic digestion of in vivo phosphorylated CFTR suggests that the CFTR is phosphorylated on the same sites during stimulation with genistein and forskolin but on different sites stimulation with calyculin A. Genistein 136-145 cystic fibrosis transmembrane conductance regulator Mus musculus 48-52 8770006-10 1996 Proteolytic digestion of in vivo phosphorylated CFTR suggests that the CFTR is phosphorylated on the same sites during stimulation with genistein and forskolin but on different sites stimulation with calyculin A. Genistein 136-145 cystic fibrosis transmembrane conductance regulator Mus musculus 71-75 8770006-11 1996 The data suggest that genistein and calyculin A inhibit different PPase activities, allowing CFTR phosphorylation and partial stimulation, by a basal PKA activity. Genistein 22-31 cystic fibrosis transmembrane conductance regulator Mus musculus 93-97 9852348-8 1998 Thus, it is concluded that genistein alone activates CFTR by a protein tyrosine kinase-independent and protein phosphatase-independent mechanism from the extracellular side, but not from the intracellular side. Genistein 27-36 cystic fibrosis transmembrane conductance regulator Mus musculus 53-57 9316420-5 1997 Genistein increased the forskolin-induced macroscopic currents of wt-CFTR and delta F508-CFTR by 3- and 19-fold, respectively. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 69-73 9316420-5 1997 Genistein increased the forskolin-induced macroscopic currents of wt-CFTR and delta F508-CFTR by 3- and 19-fold, respectively. Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 89-93 9316420-7 1997 In single-channel studies, at maximal adenosine 3",5"-cyclic monophosphate (cAMP) stimulation, genistein increased the Po of wt-CFTR by prolonging the open time, but, at submaximal cAMP stimulation, the Po was increased by prolonging the open time and shortening the closed time. Genistein 95-104 cystic fibrosis transmembrane conductance regulator Mus musculus 128-132 9316420-8 1997 In excised patches with CFTR channels preactivated in the cell-attached mode, genistein increased ATP-dependent wt- and delta F508-CFTR current about twofold by prolonging the open time. Genistein 78-87 cystic fibrosis transmembrane conductance regulator Mus musculus 24-28 9316420-8 1997 In excised patches with CFTR channels preactivated in the cell-attached mode, genistein increased ATP-dependent wt- and delta F508-CFTR current about twofold by prolonging the open time. Genistein 78-87 cystic fibrosis transmembrane conductance regulator Mus musculus 131-135 7537452-1 1995 Genistein, a protein tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) in transfected NIH-3T3 fibroblasts that express the CFTR (3T3-CFTR). Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 62-113 7537452-1 1995 Genistein, a protein tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) in transfected NIH-3T3 fibroblasts that express the CFTR (3T3-CFTR). Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 115-119 7537452-1 1995 Genistein, a protein tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) in transfected NIH-3T3 fibroblasts that express the CFTR (3T3-CFTR). Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 173-177 7537452-1 1995 Genistein, a protein tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) in transfected NIH-3T3 fibroblasts that express the CFTR (3T3-CFTR). Genistein 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 179-187 7537452-3 1995 Both forskolin and genistein stimulated 125I efflux and activated a 9-10 pS anion channel in 3T3-CFTR cells but failed to activate 125I efflux in mock-transfected NIH-3T3 cells. Genistein 19-28 cystic fibrosis transmembrane conductance regulator Mus musculus 93-101