PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1610348-5 1992 When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling. Sulfur-35 155-158 interleukin 1 alpha Homo sapiens 5-15 9795242-8 1998 Disaccharide analysis of the [35S]GAG chains showed that IL-1alpha preferentially inhibited sulphation of the 6-sulphated isomer and that l-NIO reversed this effect. Sulfur-35 30-33 interleukin 1 alpha Homo sapiens 57-66 10334506-2 1999 Esculetin (EST) significantly suppressed the proteoglycan depletion and the release of pulse-labeled [35S]proteoglycan from the matrix layer of rabbit chondrocytes treated with recombinant human interleukin-1alpha. Sulfur-35 102-105 interleukin 1 alpha Homo sapiens 195-213 9795242-1 1998 Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production. Sulfur-35 108-111 interleukin 1 alpha Homo sapiens 54-72 9795242-1 1998 Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production. Sulfur-35 108-111 interleukin 1 alpha Homo sapiens 74-83 9795242-2 1998 Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent. Sulfur-35 20-23 interleukin 1 alpha Homo sapiens 45-54 1373107-7 1992 Pretreatment of endothelial cells with IL-1 increased their adhesion to fibronectin and vitronectin and increased the expression of vitronectin receptor and fibronectin receptor as detected by immunofluorescence flow cytometry, quantitative antibody binding, and immunoprecipitation of [35S]methionine-labeled cell extracts. Sulfur-35 287-290 interleukin 1 alpha Homo sapiens 39-43 1312061-4 1992 [35S]-labelled single-stranded RNA probes were prepared by transcribing human cDNA fragments of the TNF-alpha and IL-1 alpha genes subcloned into appropriate vectors. Sulfur-35 1-4 interleukin 1 alpha Homo sapiens 114-124 2203800-2 1990 [35S]Methionine incorporation into IL-1 induced, immunoprecipitable HLA-DR molecules demonstrated de novo synthesis of both light and heavy chains of the HLA-DR molecules. Sulfur-35 1-4 interleukin 1 alpha Homo sapiens 35-39 2053589-3 1991 Subsequent in situ hybridization using 35S-labeled synthetic oligonucleotide probes complementary to human IL-1 alpha and IL-1 beta mRNA showed IL-1 transcripts in macrophages predominantly but not in T cells or B cells. Sulfur-35 39-42 interleukin 1 alpha Homo sapiens 107-117 2053589-3 1991 Subsequent in situ hybridization using 35S-labeled synthetic oligonucleotide probes complementary to human IL-1 alpha and IL-1 beta mRNA showed IL-1 transcripts in macrophages predominantly but not in T cells or B cells. Sulfur-35 39-42 interleukin 1 alpha Homo sapiens 107-111 2230430-3 1990 As a result, IL-1 suppressed dose-dependently the secretion of both 35S and 3H into the supernatant of the medium containing free human or porcine chondrocytes. Sulfur-35 68-71 interleukin 1 alpha Homo sapiens 13-17 2783391-9 1989 Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor. Sulfur-35 177-180 interleukin 1 alpha Homo sapiens 280-290 2157662-4 1990 Using an [35S]methionine-labeled preparation, specific binding of IL-1 to PMNs was demonstrated. Sulfur-35 10-13 interleukin 1 alpha Homo sapiens 66-70 2804117-3 1989 In the presence of IL-1, both 35S-proteoglycan monomers and aggregates were lost, suggesting that IL-1 increases the susceptibility of aggregates to loss from the cartilage matrix. Sulfur-35 30-33 interleukin 1 alpha Homo sapiens 19-23 2804117-3 1989 In the presence of IL-1, both 35S-proteoglycan monomers and aggregates were lost, suggesting that IL-1 increases the susceptibility of aggregates to loss from the cartilage matrix. Sulfur-35 30-33 interleukin 1 alpha Homo sapiens 98-102 2801306-5 1989 IL-1 also resulted in a dose-related decrease in the ability of cartilage to synthesize new proteoglycan as measured by 35S incorporation. Sulfur-35 120-123 interleukin 1 alpha Homo sapiens 0-4 2783391-9 1989 Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor. Sulfur-35 177-180 interleukin 1 alpha Homo sapiens 111-115 2783391-9 1989 Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor. Sulfur-35 177-180 interleukin 1 alpha Homo sapiens 242-252 3058540-12 1988 Measurable increases in uptake of [35S]sulfate into GAG occurred with IL-1, baFGF, TGF-beta, h-EGF, IGF-1, bbFGF, NGF, and Forskolin. Sulfur-35 35-38 interleukin 1 alpha Homo sapiens 70-74 2516411-5 1989 IL-1 stimulation of enhanced COX synthesis was time and dose dependent; as little as 0.03 units/ml of IL-1 produced significant stimulation of [35S]-labeled COX synthesis. Sulfur-35 144-147 interleukin 1 alpha Homo sapiens 0-4 2516411-5 1989 IL-1 stimulation of enhanced COX synthesis was time and dose dependent; as little as 0.03 units/ml of IL-1 produced significant stimulation of [35S]-labeled COX synthesis. Sulfur-35 144-147 interleukin 1 alpha Homo sapiens 102-106 3490846-2 1986 Incorporation of [35S]sulfate into glycosaminoglycan was strikingly diminished by the addition of IL-1 in a dose- and time- dependent manner. Sulfur-35 18-21 interleukin 1 alpha Homo sapiens 98-102