PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24551237-7 2014 Similarly, hydroxycinnamic acids and derivatives (chlorogenic, cinnamic, and ferulic acids) combined with leucine/HMB increased FAO (300-1300%, p<0.01), AMPK activity (50-150%, p<0.01), and Sirt1 activity (~70%, p<0.001). Coumaric Acids 11-32 sirtuin 1 Homo sapiens 196-201 24551237-9 2014 Thus, the six-carbon ring structure bound to a carboxylic group seems to be a necessary element for leucine/HMB synergy with other stilbenes and hydroxycinnamic acids to stimulate AMPK/Sirt1 dependent FAO; these effects occur at concentrations that produce no independent effects and are readily achievable via oral administration. Coumaric Acids 145-166 sirtuin 1 Homo sapiens 185-190