PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10099868-14 1998 These results suggest that the greater secretion of TSH in pregnant rats is in part due to an increase of spontaneous release of TRH by MBH and a decrease of plasma thyroid hormones. Thyrotropin 52-55 thyrotropin releasing hormone Rattus norvegicus 129-132 14530520-6 2003 In conclusion, TRH and leptin rapidly decreased pituitary NB and it is first proposed that the reduction of the inhibitory tonus of NB on TSH release will ultimately contribute to the amplification of TSH secretion elicited by TSH secretagogues. Thyrotropin 138-141 thyrotropin releasing hormone Rattus norvegicus 15-18 14530520-6 2003 In conclusion, TRH and leptin rapidly decreased pituitary NB and it is first proposed that the reduction of the inhibitory tonus of NB on TSH release will ultimately contribute to the amplification of TSH secretion elicited by TSH secretagogues. Thyrotropin 201-204 thyrotropin releasing hormone Rattus norvegicus 15-18 14530520-6 2003 In conclusion, TRH and leptin rapidly decreased pituitary NB and it is first proposed that the reduction of the inhibitory tonus of NB on TSH release will ultimately contribute to the amplification of TSH secretion elicited by TSH secretagogues. Thyrotropin 201-204 thyrotropin releasing hormone Rattus norvegicus 15-18 11179600-7 2001 Topical application of TRH and M-TRH induced an increase in TSH serum concentration from 0.32 +/- 0.09 ng/ml to 32.6 +/- 5.0 and 22.9 +/- 7.6 ng/ml, respectively, after 30 min. Thyrotropin 60-63 thyrotropin releasing hormone Rattus norvegicus 23-26 11179600-7 2001 Topical application of TRH and M-TRH induced an increase in TSH serum concentration from 0.32 +/- 0.09 ng/ml to 32.6 +/- 5.0 and 22.9 +/- 7.6 ng/ml, respectively, after 30 min. Thyrotropin 60-63 thyrotropin releasing hormone Rattus norvegicus 33-36 11179600-8 2001 The addition of terpene and ethanol in combination with TRH or M-TRH, increased the TSH release to 43.0 +/- 3.8 and 48.4 +/- 4.0 ng/ml, respectively. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 56-59 11179600-8 2001 The addition of terpene and ethanol in combination with TRH or M-TRH, increased the TSH release to 43.0 +/- 3.8 and 48.4 +/- 4.0 ng/ml, respectively. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 65-68 10568704-7 1999 Both strains of rats responded to intravenous TRH by releasing TSH into their blood in a dose-responsive fashion. Thyrotropin 63-66 thyrotropin releasing hormone Rattus norvegicus 46-49 10568704-10 1999 The effective dose 50 (ED50) of TRH (that dose causing release of half maximal TSH concentrations) was 61 ng in F344 rats and 78 ng in SD rats. Thyrotropin 79-82 thyrotropin releasing hormone Rattus norvegicus 32-35 10394027-12 1999 RESULTS: The results indicate that enteral TRH (125 and 500 microg) produced the same TSH response as intravenous TRH. Thyrotropin 86-89 thyrotropin releasing hormone Rattus norvegicus 43-46 8940336-11 1996 Essentially all TRH-responsive cells stained for either PRL or TSH. Thyrotropin 63-66 thyrotropin releasing hormone Rattus norvegicus 16-19 9421422-1 1998 TRH, an amidated tripeptide secreted by certain hypothalamic neurons, is a principal regulator of TSH secretion and thyroid hormone release. Thyrotropin 98-101 thyrotropin releasing hormone Rattus norvegicus 0-3 9396064-1 1997 Thyrotropin-releasing hormone (TRH) from the hypothalamus is the major regulator of TSH synthesis and secretion. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 0-29 9396064-1 1997 Thyrotropin-releasing hormone (TRH) from the hypothalamus is the major regulator of TSH synthesis and secretion. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 31-34 9551251-6 1997 The spontaneous and TRH-induced release of TSH in vitro from rat APs, and pituitary TSH content were increased by T3, or T3 plus P as compared with the animals injected with vehicle, or P alone. Thyrotropin 43-46 thyrotropin releasing hormone Rattus norvegicus 20-23 9551251-6 1997 The spontaneous and TRH-induced release of TSH in vitro from rat APs, and pituitary TSH content were increased by T3, or T3 plus P as compared with the animals injected with vehicle, or P alone. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 20-23 9551251-8 1997 Application of T3 in vitro prevented the release of TSH in response to TRH. Thyrotropin 52-55 thyrotropin releasing hormone Rattus norvegicus 71-74 7501234-7 1995 These data indicate that at high concentration, TRH-Gly interacts directly with TRH-R to activate signal transduction pathway, and that release of prolactin and TSH induced by TRH-Gly in vitro may be due, at least in part, to the direct effect of TRH-Gly on the TRH-R. Thyrotropin 161-164 thyrotropin releasing hormone Rattus norvegicus 48-51 8618941-4 1996 As expected, in euthyroid rats NB decreased basal and TRH-stimulated TSH release, but only at the highest concentration tested (10(-7) M). Thyrotropin 69-72 thyrotropin releasing hormone Rattus norvegicus 54-57 8618941-9 1996 Surprisingly, pituitaries from hypothyroid rats showed a paradoxical increased release of TSH in response to the lowest concentration of NB (10(-11) M), which decreased with increasing concentrations and was not distinguishable from control release in the presence of TRH at the highest concentration of NB (10(-7) M). Thyrotropin 90-93 thyrotropin releasing hormone Rattus norvegicus 268-271 8618941-16 1996 This downregulation of receptors in some manner reverses the inhibitory action of NB on basal and TRH-stimulated TSH release. Thyrotropin 113-116 thyrotropin releasing hormone Rattus norvegicus 98-101 7581975-7 1995 In contrast, DEA significantly potentiates the TSH response to TRH and the DHP nifedipine reverses that potentiation. Thyrotropin 47-50 thyrotropin releasing hormone Rattus norvegicus 63-66 7501234-7 1995 These data indicate that at high concentration, TRH-Gly interacts directly with TRH-R to activate signal transduction pathway, and that release of prolactin and TSH induced by TRH-Gly in vitro may be due, at least in part, to the direct effect of TRH-Gly on the TRH-R. Thyrotropin 161-164 thyrotropin releasing hormone Rattus norvegicus 80-83 7617131-10 1995 These above results indicated that the increase in plasma PRL and TSH levels is associated with a rise in hypophysial portal plasma dopamine and TRH following injection of both progesterone and estradiol benzoate. Thyrotropin 66-69 thyrotropin releasing hormone Rattus norvegicus 145-148 7479297-5 1995 TNF-alpha did not affect the concanavalin A and lentil lectin binding of TSH accumulated in the medium during the 4-day culture, but significantly decreased the lentil lectin binding of TSH released in response to acute TRH stimulation. Thyrotropin 186-189 thyrotropin releasing hormone Rattus norvegicus 220-223 7621893-0 1995 Triiodo-L-thyronine enhances TRH-induced TSH release from perifused rat pituitaries and intracellular Ca2+ levels from dispersed pituitary cells. Thyrotropin 41-44 thyrotropin releasing hormone Rattus norvegicus 29-32 7920881-0 1993 TSH secretory responses to prolonged infusion of TRH in hypothyroid rats. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 49-52 7934981-3 1994 Exposure of the pituitary cells to TRH (0.1 mumol/L) for 2 hours stimulated TSH secretion by 176%. Thyrotropin 76-79 thyrotropin releasing hormone Rattus norvegicus 35-38 7827627-10 1994 TSH concentration in the culture medium was increased by TRH treatment on 6, 12 and 24 h after the treatment on day 2, on 12 h and 24 h on day 3, and 24 h on day 6. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 57-60 7970152-1 1994 Prepro-TRH-(160-169) (Ps4), one of the predicted connecting peptides of pro-TRH, potentiates TRH-induced TSH release in vivo and in vitro. Thyrotropin 105-108 thyrotropin releasing hormone Rattus norvegicus 7-10 7970152-1 1994 Prepro-TRH-(160-169) (Ps4), one of the predicted connecting peptides of pro-TRH, potentiates TRH-induced TSH release in vivo and in vitro. Thyrotropin 105-108 thyrotropin releasing hormone Rattus norvegicus 3-10 7970152-1 1994 Prepro-TRH-(160-169) (Ps4), one of the predicted connecting peptides of pro-TRH, potentiates TRH-induced TSH release in vivo and in vitro. Thyrotropin 105-108 thyrotropin releasing hormone Rattus norvegicus 76-79 7920881-3 1993 Infusion of a constant concentration of TRH induced a peak in the plasma TSH concentration within 5-15 min which declined to the baseline within 1 h. The refractory period lasted 20-40 min after stopping the continuous TRH infusion. Thyrotropin 73-76 thyrotropin releasing hormone Rattus norvegicus 40-43 7920881-4 1993 A second burst of TSH secretion was induced by increasing the TRH concentration during the refractory period while TRH was being continuously infused. Thyrotropin 18-21 thyrotropin releasing hormone Rattus norvegicus 62-65 7920881-4 1993 A second burst of TSH secretion was induced by increasing the TRH concentration during the refractory period while TRH was being continuously infused. Thyrotropin 18-21 thyrotropin releasing hormone Rattus norvegicus 115-118 7920881-5 1993 These data indicate that in hypothyroid rats TSH secretion rapidly becomes refractory to continuous exposure to the same concentration of TRH but is stimulated by a higher TRH concentration. Thyrotropin 45-48 thyrotropin releasing hormone Rattus norvegicus 138-141 7920881-5 1993 These data indicate that in hypothyroid rats TSH secretion rapidly becomes refractory to continuous exposure to the same concentration of TRH but is stimulated by a higher TRH concentration. Thyrotropin 45-48 thyrotropin releasing hormone Rattus norvegicus 172-175 1680265-0 1991 The role of somatostatin and/or dopamine in basal and TRH-stimulated TSH release in food-restricted rats. Thyrotropin 69-72 thyrotropin releasing hormone Rattus norvegicus 54-57 8367024-8 1993 The prompt parallel rate of rise of plasma TSH in Sham and PVN groups following thyroidectomy indicates that a primary physiologic action of TRH in the thyrotroph is to control the set-point for thyroid hormone negative feedback on TSH secretion. Thyrotropin 43-46 thyrotropin releasing hormone Rattus norvegicus 141-144 8406344-6 1993 Plasma TRH and TSH level responses to cold as well as plasma TSH level response to TRH were enhanced with treatment of antisera to these peptides. Thyrotropin 61-64 thyrotropin releasing hormone Rattus norvegicus 83-86 8479613-7 1993 In another experiment, EGF 10(-8) M or TRH 10(-8) M significantly elevated TSH secretion (p < 0.01). Thyrotropin 75-78 thyrotropin releasing hormone Rattus norvegicus 39-42 8479613-9 1993 In the in vivo studies, the intravenous administration of EGF 10(-5) M or TRH 10(-5) M both induced significant elevation of TSH release at 10 min after the injection (p < 0.02 for EGF and p < 0.01 for TRH). Thyrotropin 125-128 thyrotropin releasing hormone Rattus norvegicus 74-77 1446603-7 1992 This alpha 2-adrenergic agonist caused a significant (P < 0.01) 12.7-fold rise in plasma TSH levels in normal rabbit serum-treated animals, which was completely abolished by TRH-AS pretreatment, indicating that clonidine stimulates TSH secretion via activation of hypothalamic TRH release. Thyrotropin 92-95 thyrotropin releasing hormone Rattus norvegicus 177-180 1446603-7 1992 This alpha 2-adrenergic agonist caused a significant (P < 0.01) 12.7-fold rise in plasma TSH levels in normal rabbit serum-treated animals, which was completely abolished by TRH-AS pretreatment, indicating that clonidine stimulates TSH secretion via activation of hypothalamic TRH release. Thyrotropin 92-95 thyrotropin releasing hormone Rattus norvegicus 280-283 1446603-7 1992 This alpha 2-adrenergic agonist caused a significant (P < 0.01) 12.7-fold rise in plasma TSH levels in normal rabbit serum-treated animals, which was completely abolished by TRH-AS pretreatment, indicating that clonidine stimulates TSH secretion via activation of hypothalamic TRH release. Thyrotropin 235-238 thyrotropin releasing hormone Rattus norvegicus 177-180 1446603-8 1992 When TRH-AS was slowly infused into hypothyroid rats that were sampled frequently for the detection of TSH pulsatility, it caused a significant (60.3%; P < 0.01) decrease in mean TSH levels, with TSH titers approaching euthyroid concentrations 1 h after the infusion of TRH-AS. Thyrotropin 103-106 thyrotropin releasing hormone Rattus norvegicus 5-8 1446603-8 1992 When TRH-AS was slowly infused into hypothyroid rats that were sampled frequently for the detection of TSH pulsatility, it caused a significant (60.3%; P < 0.01) decrease in mean TSH levels, with TSH titers approaching euthyroid concentrations 1 h after the infusion of TRH-AS. Thyrotropin 182-185 thyrotropin releasing hormone Rattus norvegicus 5-8 1446603-8 1992 When TRH-AS was slowly infused into hypothyroid rats that were sampled frequently for the detection of TSH pulsatility, it caused a significant (60.3%; P < 0.01) decrease in mean TSH levels, with TSH titers approaching euthyroid concentrations 1 h after the infusion of TRH-AS. Thyrotropin 182-185 thyrotropin releasing hormone Rattus norvegicus 5-8 1664499-1 1991 The stimulation of TSH secretion by TRH involves the phosphatidylinositol second messenger pathway via activation of phospholipase C. This effect is mediated by a GTP-binding protein and leads to a mobilization of intracellular Ca2+ stores and an activation of protein kinase C. However, TRH stimulation also results in an influx of extracellular Ca2+. Thyrotropin 19-22 thyrotropin releasing hormone Rattus norvegicus 36-39 1664499-1 1991 The stimulation of TSH secretion by TRH involves the phosphatidylinositol second messenger pathway via activation of phospholipase C. This effect is mediated by a GTP-binding protein and leads to a mobilization of intracellular Ca2+ stores and an activation of protein kinase C. However, TRH stimulation also results in an influx of extracellular Ca2+. Thyrotropin 19-22 thyrotropin releasing hormone Rattus norvegicus 288-291 1589596-2 1992 We hypothesized that the inappropriately high TSH secretion in SHR may be the result of an impaired thyroid hormone negative feedback regulation of hypothalamic thyrotropin-releasing hormone (TRH) and/or pituitary TSH production. Thyrotropin 46-49 thyrotropin releasing hormone Rattus norvegicus 161-190 1589596-2 1992 We hypothesized that the inappropriately high TSH secretion in SHR may be the result of an impaired thyroid hormone negative feedback regulation of hypothalamic thyrotropin-releasing hormone (TRH) and/or pituitary TSH production. Thyrotropin 46-49 thyrotropin releasing hormone Rattus norvegicus 192-195 1589596-15 1992 Since the overproduction of hypothalamic TRH and hypophysial TSH should lead to an increased thyroid hormone biosynthesis other defects in the hypothalamus-pituitary-thyroid-axis may contribute to the abnormal regulation of TSH secretion in SHR rats. Thyrotropin 224-227 thyrotropin releasing hormone Rattus norvegicus 41-44 1316588-0 1992 Okadaic acid inhibits the release of TSH in response to TRH and K+ from rat anterior pituitaries. Thyrotropin 37-40 thyrotropin releasing hormone Rattus norvegicus 56-59 1572595-5 1992 An injection of 250 ng of TRH increased plasma concentrations of TSH in all groups, but this increase was more pronounced in fasted rats injected with pimozide during 3 consecutive days. Thyrotropin 65-68 thyrotropin releasing hormone Rattus norvegicus 26-29 1376959-5 1992 These results point towards a facilitatory role of HA on TSH secretion both at the hypothalamic level where it may interfere with TRH synthesis, as well as at the pituitary level where it may modify TSH response to TRH. Thyrotropin 57-60 thyrotropin releasing hormone Rattus norvegicus 130-133 1376959-5 1992 These results point towards a facilitatory role of HA on TSH secretion both at the hypothalamic level where it may interfere with TRH synthesis, as well as at the pituitary level where it may modify TSH response to TRH. Thyrotropin 57-60 thyrotropin releasing hormone Rattus norvegicus 215-218 1530781-10 1992 In conclusion, STZ-induced diabetes in the rat is associated with reduced hypothalamic secretion of TRH, which, in turn, may be responsible for the reduced plasma TSH and thyroid hormone levels. Thyrotropin 163-166 thyrotropin releasing hormone Rattus norvegicus 100-103 1738433-4 1992 Furthermore, in vitro pre-treatment of anterior pituitaries with triiodothyronine (T3) produced a dose-dependent decrease in both TSH secretion and the formation of [3H]IP in response to TRH. Thyrotropin 130-133 thyrotropin releasing hormone Rattus norvegicus 187-190 1738433-5 1992 These results indicate that thyroid hormones regulate TRH receptor-linked inositol phospholipid hydrolysis in the rat anterior pituitary, suggesting that negative feedback action of thyroid hormone occurs at post receptor event in the rat anterior pituitary, which may, to a certain extent, be responsible for the underlying mechanism of T3 inhibition of TSH secretion. Thyrotropin 355-358 thyrotropin releasing hormone Rattus norvegicus 54-57 1680265-3 1991 Restricted feeding by 50% or 75% was associated with a decrease in the pituitary and circulating levels of TSH and GH in both untreated and TRH-treated groups (p less than 0.001), the changes being proportional to the feeding level. Thyrotropin 107-110 thyrotropin releasing hormone Rattus norvegicus 140-143 2128932-6 1990 Ir-pro-TRH concentrations in the hypothalamus decreased significantly after T4 and T3 injection and tended to decrease after TRH and TSH injection, but not significantly. Thyrotropin 133-136 thyrotropin releasing hormone Rattus norvegicus 7-10 1907564-7 1991 In the hypophysectomized rats, ir-pro-TRH concentrations in the hypothalamus decreased significantly after T4 or T3 injection and tended to decrease after TRH or TSH injection. Thyrotropin 162-165 thyrotropin releasing hormone Rattus norvegicus 34-41 1936193-3 1991 The TRH-induced TSH release elicited by pituitary fragments from the old rats was decreased in comparison to that found in young animals. Thyrotropin 16-19 thyrotropin releasing hormone Rattus norvegicus 4-7 1936193-4 1991 Addition of T3 to the superfusion medium did not alter basal TSH release but significantly decreased the TSH secretory response to TRH in the young rats. Thyrotropin 105-108 thyrotropin releasing hormone Rattus norvegicus 131-134 1936193-6 1991 Our results suggest that aging induces not only a TSH hyporesponsiveness to TRH stimulation but also a decrease of this responsiveness to the inhibitory effect of T3 which could be related to a decreased TSH synthesis and to an age-related impairment of T3 action on the thyrotrophs. Thyrotropin 50-53 thyrotropin releasing hormone Rattus norvegicus 76-79 19215378-20 1990 The inhibition of TSH secretion may result from the inhibition of thyrotropin-releasing hormone release from more caudal periventricular structures of the hypothalamus. Thyrotropin 18-21 thyrotropin releasing hormone Rattus norvegicus 66-95 1980023-10 1990 As expected however, plasma TSH and T3 levels were increased at 20 min and 2 h, respectively, following TRH infusions. Thyrotropin 28-31 thyrotropin releasing hormone Rattus norvegicus 104-107 1706271-0 1990 Involvement of dihydropyridine-sensitive calcium channels in the GABAA potentiation of TRH-induced TSH release. Thyrotropin 99-102 thyrotropin releasing hormone Rattus norvegicus 87-90 1706271-2 1990 At nanomolar concentrations the two agonists induced potentiation of the TRH-induced TSH release. Thyrotropin 85-88 thyrotropin releasing hormone Rattus norvegicus 73-76 1706271-4 1990 The isoguvacine potentiation of the TSH response to TRH failed to occur when cobalt (Co2+) was added to the perifused medium. Thyrotropin 36-39 thyrotropin releasing hormone Rattus norvegicus 52-55 2178251-9 1990 To induce a significant release of TSH several hundred times more of 4(5)-I-Im-TRH and over 1000 times more of 2,4(5)-I2-Im-TRH were needed as compared to TRH. Thyrotropin 35-38 thyrotropin releasing hormone Rattus norvegicus 79-82 2517858-15 1989 These data suggest that the release of TSH from APs in response to TRH is decreased by aging in female but not in male rats. Thyrotropin 39-42 thyrotropin releasing hormone Rattus norvegicus 67-70 1695481-4 1990 Furthermore, thyrotropin-releasing hormone (TRH)-induced TSH release was decreased about 30% and the intracellular TSH content was also reduced 45% in diabetic rat thyrotrophs compared with controls. Thyrotropin 57-60 thyrotropin releasing hormone Rattus norvegicus 13-42 1695481-4 1990 Furthermore, thyrotropin-releasing hormone (TRH)-induced TSH release was decreased about 30% and the intracellular TSH content was also reduced 45% in diabetic rat thyrotrophs compared with controls. Thyrotropin 57-60 thyrotropin releasing hormone Rattus norvegicus 44-47 1695481-8 1990 Preincubation of thyrotrophs with 10, 100, or 1000 nM of T4 for 48 h decreased basal TSH release by 27%, 45%, and 48%, respectively, and reduced TRH-induced TSH release by 46%, 48%, and 55%; 100 nM T4 also reduced TRH-induced TSH release from diabetic thyrotrophs. Thyrotropin 157-160 thyrotropin releasing hormone Rattus norvegicus 145-148 1695481-8 1990 Preincubation of thyrotrophs with 10, 100, or 1000 nM of T4 for 48 h decreased basal TSH release by 27%, 45%, and 48%, respectively, and reduced TRH-induced TSH release by 46%, 48%, and 55%; 100 nM T4 also reduced TRH-induced TSH release from diabetic thyrotrophs. Thyrotropin 157-160 thyrotropin releasing hormone Rattus norvegicus 145-148 2514392-3 1989 Anterior pituitary in the presence of TRH showed heterogeneous components of [3H]glucosamine-labeled TSH with 6 different isoelectric points (components I-VI). Thyrotropin 101-104 thyrotropin releasing hormone Rattus norvegicus 38-41 2507289-9 1989 TRH administration in vivo normalized the Concanavalin-A binding pattern of secreted TSH glycopeptides in the PVN lesioned group but had no significant effect in the sham lesioned group. Thyrotropin 85-88 thyrotropin releasing hormone Rattus norvegicus 0-3 2474048-7 1989 At an extracellular Ca2+ concentration of less than 500 nmol/l, TRH-induced TSH release was observed only after treatment with 1,25-(OH)2D3 (P less than 0.01). Thyrotropin 76-79 thyrotropin releasing hormone Rattus norvegicus 64-67 2474048-8 1989 As the extracellular Ca2+ concentration was increased, greater increments of TRH-induced TSH release were observed following pretreatment with 1,25-(OH)2D3 (P less than 0.01). Thyrotropin 89-92 thyrotropin releasing hormone Rattus norvegicus 77-80 2502597-3 1989 TRH (1 nmol/l)-induced TSH release over 1 h was enhanced by 70% (P less than 0.01) following exposure to 10 nmol 1,25-(OH)2D3/l for 24 h. Pretreatment with T3 (1 pmol/l-1 mumol/l) for 24 h caused a dose-dependent inhibition of TRH-induced TSH release. Thyrotropin 23-26 thyrotropin releasing hormone Rattus norvegicus 0-3 2502597-3 1989 TRH (1 nmol/l)-induced TSH release over 1 h was enhanced by 70% (P less than 0.01) following exposure to 10 nmol 1,25-(OH)2D3/l for 24 h. Pretreatment with T3 (1 pmol/l-1 mumol/l) for 24 h caused a dose-dependent inhibition of TRH-induced TSH release. Thyrotropin 239-242 thyrotropin releasing hormone Rattus norvegicus 0-3 2502597-4 1989 Net TRH-induced TSH release was inhibited by 85% at T3 concentrations of 3 nmol/l or greater. Thyrotropin 16-19 thyrotropin releasing hormone Rattus norvegicus 4-7 2502597-5 1989 Co-incubation with 1,25-(OH)2D3 resulted in enhanced TRH-induced TSH release at all T3 concentrations tested (P less than 0.001). Thyrotropin 65-68 thyrotropin releasing hormone Rattus norvegicus 53-56 2502597-6 1989 The increment of TRH-induced TSH release resulting from 1,25-(OH)2D3 pretreatment was equivalent in the presence or absence of maximal inhibitory T3 concentrations. Thyrotropin 29-32 thyrotropin releasing hormone Rattus norvegicus 17-20 2502597-7 1989 At 1 nmol T3/l, there was a two- to threefold relative increase in 1,25-(OH)2D3-enhanced TRH-induced TSH release. Thyrotropin 101-104 thyrotropin releasing hormone Rattus norvegicus 89-92 2502597-8 1989 Incubation with cortisol (100 pmol/l-100 nmol/l) had no effect on basal or TRH-induced TSH release, nor did it alter 1,25-(OH)2D3-enhanced TRH-induced TSH release when added 24 h before, or at the time of addition of 1,25-(OH)2D3. Thyrotropin 151-154 thyrotropin releasing hormone Rattus norvegicus 139-142 2498473-3 1989 Iron-deficient anemic rats had lower basal TSH values and blunted TSH responses to intravenous TRH injection at three different doses (10, 25 and 50 ng TRH/100 g body wt). Thyrotropin 66-69 thyrotropin releasing hormone Rattus norvegicus 95-98 2705461-10 1989 When TRH (500 ng/kg body weight, IV) was given, the increment in serum TSH at 10 minutes was significantly lower in the PB group (PB, 53 +/- 26 microU/ml vs. control, 131 +/- 18 microU/ml, p less than .05). Thyrotropin 71-74 thyrotropin releasing hormone Rattus norvegicus 5-8 3753950-3 1986 The intracellular concentration of TSH after the TRH test showed a slight decreasing tendency after a 24 h incubation with increasing amounts of 1,25(OH)2D3. Thyrotropin 35-38 thyrotropin releasing hormone Rattus norvegicus 49-52 2501768-4 1989 Highly significant positive correlations between whole blood TRH-Gly-IR levels and the corresponding serum TSH values (p less than 0.01), whole blood TRH-IR versus serum TSH (p less than 0.01) and whole blood TRH-Gly-IR versus whole blood TRH-IR (p less than 0.01) are consistent with cosecretion of TRH and TRH precursor peptides into the circulation. Thyrotropin 107-110 thyrotropin releasing hormone Rattus norvegicus 61-64 3362301-3 1988 Naloxone administration produced a significant increase in the basal concentration of TSH response to TRH (5 micrograms i.v.) Thyrotropin 86-89 thyrotropin releasing hormone Rattus norvegicus 102-105 3410280-0 1988 The effect of indomethacin, ibuprofen and paracetamol on the TRH induced TSH secretion in the rat. Thyrotropin 73-76 thyrotropin releasing hormone Rattus norvegicus 61-64 3127251-2 1987 TSH secretion from the rat anterior pituitaries progressively increased in the presence of TRH in doses between 0.2-20 ng/ml. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 91-94 3127251-3 1987 In contrast, administration of TRH in a dose of 200 ng/ml decreased TSH secretion as compared to TRH in a dose of 20 ng/ml. Thyrotropin 68-71 thyrotropin releasing hormone Rattus norvegicus 31-34 3127251-6 1987 These data indicate that in vitro refractoriness of TSH response to TRH did not depend on the significant change in TRH disappearance rate. Thyrotropin 52-55 thyrotropin releasing hormone Rattus norvegicus 68-71 3113918-4 1987 1 X 10(-9) M 1,25-(OH)2D3 increased TRH (10(-9) M)-induced TSH release by 20% (P less than 0.05) but 10(-7) M and 10(-6) M 25-hydroxyvitamin D3 (25-OH D3) had no effect. Thyrotropin 59-62 thyrotropin releasing hormone Rattus norvegicus 36-39 3113918-5 1987 The effect of 1,25-(OH)2D3 on TRH (10(-9) M)-induced TSH release was evident within 8 h and was maximal by 16 h. There was no effect on basal TSH release, TSH accumulation in the medium in the preceding 24 h nor on cell-associated TSH. Thyrotropin 53-56 thyrotropin releasing hormone Rattus norvegicus 30-33 3116883-10 1987 Older pituitaries (19- to 21-day) apparently can release an amount of TSH in the presence of TRH that is greater than their own spontaneous TSH secretion. Thyrotropin 70-73 thyrotropin releasing hormone Rattus norvegicus 93-96 3114404-1 1987 The effects of a physiological replacement dose of thyroxine (T4) on the response of plasma TSH to TRH in hypothyroid rats were studied. Thyrotropin 92-95 thyrotropin releasing hormone Rattus norvegicus 99-102 3114404-7 1987 The plasma concentration of TSH 10 min after injection of TRH increased to 167 +/- 14% of the mean basal value (P less than 0.001). Thyrotropin 28-31 thyrotropin releasing hormone Rattus norvegicus 58-61 3114404-8 1987 The injection of T4 significantly (P less than 0.005) reduced the TSH response to TRH in both IOP-treated (118 +/- 15%) and vehicle-treated (108 +/- 15%) rats compared with untreated controls. Thyrotropin 66-69 thyrotropin releasing hormone Rattus norvegicus 82-85 2427524-3 1986 Hypothalamic hormones such as thyrotropin-releasing hormone (TRH) and dopamine have profound effects on TSH secretion and may also modulate TSH synthesis. Thyrotropin 104-107 thyrotropin releasing hormone Rattus norvegicus 30-59 2427524-3 1986 Hypothalamic hormones such as thyrotropin-releasing hormone (TRH) and dopamine have profound effects on TSH secretion and may also modulate TSH synthesis. Thyrotropin 104-107 thyrotropin releasing hormone Rattus norvegicus 61-64 2427524-3 1986 Hypothalamic hormones such as thyrotropin-releasing hormone (TRH) and dopamine have profound effects on TSH secretion and may also modulate TSH synthesis. Thyrotropin 140-143 thyrotropin releasing hormone Rattus norvegicus 30-59 2427524-3 1986 Hypothalamic hormones such as thyrotropin-releasing hormone (TRH) and dopamine have profound effects on TSH secretion and may also modulate TSH synthesis. Thyrotropin 140-143 thyrotropin releasing hormone Rattus norvegicus 61-64 3005459-4 1986 Pretreatment with TRH (20 nmol/l) for 8 h reduced subsequent TSH release: basal release fell to 64% of the control value (1.01 +/- 0.10 micrograms/l pretreated, 1.58 +/- 0.16 control) and release in response to TRH (100 nmol/l) to 69% of the control (2.7 +/- 0.19 micrograms/l vs 3.98 +/- 0.22); K+ response was reduced to 86% of the control (3.77 +/- 0.21 micrograms/l vs 4.39 +/- 0.20), significantly less than the other reductions. Thyrotropin 61-64 thyrotropin releasing hormone Rattus norvegicus 18-21 3005459-7 1986 After 6-h pretreatment with dbcAMP, subsequent TSH responses were augmented: basal release was 130% of the control, response to TRH (100 nmol/l) was 137% and to K+ it was 132% of the control, with a parallel upward shift of the TRH dose-response curve but no change in cellular TSH content. Thyrotropin 47-50 thyrotropin releasing hormone Rattus norvegicus 128-131 3005459-7 1986 After 6-h pretreatment with dbcAMP, subsequent TSH responses were augmented: basal release was 130% of the control, response to TRH (100 nmol/l) was 137% and to K+ it was 132% of the control, with a parallel upward shift of the TRH dose-response curve but no change in cellular TSH content. Thyrotropin 47-50 thyrotropin releasing hormone Rattus norvegicus 228-231 3080358-9 1986 The plasma TSH response to TRH was inhibited by histidine or HA and enhanced by FA. Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 27-30 3127831-2 1988 Pretreatment with iopanoic acid blocked the ability of T4 but not of T3 to suppress TRH-induced TSH secretion 2 hr after administration of the respective thyroid hormone. Thyrotropin 96-99 thyrotropin releasing hormone Rattus norvegicus 84-87 3127831-5 1988 Our data support the concept that although equivalent physiologic doses of T4 or T3 inhibit basal or TRH-induced TSH secretion equally rapidly, TSH inhibition produced by T4 is probably dependent on its rapid conversion to T3, either within the pituitary or peripherally. Thyrotropin 113-116 thyrotropin releasing hormone Rattus norvegicus 101-104 2836225-5 1988 These data imply that the reduction in the blood TRH level may contribute in part to the decrease in the blood TSH level after food deprivation, but the origin of the blood TRH has remained to be determined. Thyrotropin 111-114 thyrotropin releasing hormone Rattus norvegicus 49-52 3103364-3 1987 A similar order of potency in increasing plasma TSH (Analogue I greater than TRH greater than Analogue II) was found in vivo, as shown by dose-response curves. Thyrotropin 48-51 thyrotropin releasing hormone Rattus norvegicus 77-80 3103364-4 1987 After a 4-day pre-treatment with TRH (2 X 100 micrograms/day) a similar TSH response to TRH and Analogue I (500 nmol/kg body weight) was observed. Thyrotropin 72-75 thyrotropin releasing hormone Rattus norvegicus 33-36 3101338-0 1987 The pituitary TSH response to TRH is inversely related to the plasma TSH concentration and directly related to the pituitary TSH content during hypothyroidism in the rat. Thyrotropin 14-17 thyrotropin releasing hormone Rattus norvegicus 30-33 3101338-0 1987 The pituitary TSH response to TRH is inversely related to the plasma TSH concentration and directly related to the pituitary TSH content during hypothyroidism in the rat. Thyrotropin 69-72 thyrotropin releasing hormone Rattus norvegicus 30-33 3101338-4 1987 After 7 or 14 days of severe hypothyroidism (nonreplaced THYREX rats) the pituitary TSH secretory response to TRH (250 ng/100 g body weight, iv) was found to be decreased when compared to that of euthyroid rats. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 110-113 3101341-0 1987 The effect of 1,25-dihydroxy-cholecalciferol on the TRH induced TSH release in rats. Thyrotropin 64-67 thyrotropin releasing hormone Rattus norvegicus 52-55 3101341-1 1987 The effect of 1,25-dihydroxy-vitamin D3 (1,25-(OH)2-D3) on the TRH induced TSH release was investigated. Thyrotropin 75-78 thyrotropin releasing hormone Rattus norvegicus 63-66 3492364-8 1986 The plasma TSH response to TRH was also enhanced by PG A1 and A2. Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 27-30 3023014-1 1986 The perifusion technique was used to investigate the action of diazepam (DZ), a benzodiazepine molecule known to compete for TRH receptor binding in rat pituitary, on TRH-induced TSH and GH release. Thyrotropin 179-182 thyrotropin releasing hormone Rattus norvegicus 167-170 3023014-3 1986 The dynamic patterns of TSH and GH release in response to TRH were characterized by a rapid increase in hormone release, declining slowly over the next 20 min. Thyrotropin 24-27 thyrotropin releasing hormone Rattus norvegicus 58-61 3023014-5 1986 Addition of increasing doses of DZ suppressed the stimulatory effect of TRH in a dose-related manner, with an ID50 of 3 nM for both TSH and GH. Thyrotropin 132-135 thyrotropin releasing hormone Rattus norvegicus 72-75 3096145-3 1986 In hypophysectomized rats, TRH infusion led to the appearance of substantial amounts of biologically active serum TSH and prevented the hypothyroidism that occurred in the control group. Thyrotropin 114-117 thyrotropin releasing hormone Rattus norvegicus 27-30 3096145-6 1986 TRH infusion depleted only 63% of the TSH content of sellar thyrotrophs. Thyrotropin 38-41 thyrotropin releasing hormone Rattus norvegicus 0-3 3097230-5 1986 These results suggest that TRH exerts a direct effect on the pretranslational events involved in TSH synthesis and further that the adenylate cyclase system may be involved in the regulation of synthesis. Thyrotropin 97-100 thyrotropin releasing hormone Rattus norvegicus 27-30 3087736-1 1986 To investigate whether TRH regulates TSH production through a pre- or posttranslational mechanism, we determined the pituitary levels of mRNAs for alpha-subunit and TSH beta in male Sprague-Dawley rats given TRH in the presence or absence of thyroid hormones, with or without hypothalamic influence. Thyrotropin 37-40 thyrotropin releasing hormone Rattus norvegicus 23-26 3087736-3 1986 Infusion of TRH, achieved by osmotic minipumps that were implanted sc, increased serum TSH for 3 days. Thyrotropin 87-90 thyrotropin releasing hormone Rattus norvegicus 12-15 3087736-9 1986 These pituitaries responded to TRH infusion by releasing TSH. Thyrotropin 57-60 thyrotropin releasing hormone Rattus norvegicus 31-34 3087736-14 1986 Although a translational regulation cannot be completely excluded, the present data, in conjunction with previous findings, support the hypothesis that TRH regulates TSH production primarily by stimulating both posttranslational carbohydrate processing and secretion of this hormone. Thyrotropin 166-169 thyrotropin releasing hormone Rattus norvegicus 152-155 3084213-1 1986 The regulation of TSH biological activity by thyroid hormone and TRH was studied by comparison of pituitary and in vitro secreted TSH from normal and thyroidectomized rats that were alternatively treated with TRH either in vivo or in vitro. Thyrotropin 18-21 thyrotropin releasing hormone Rattus norvegicus 65-68 3084213-5 1986 TRH, both in vivo and in vitro, when compared to the corresponding untreated groups, produced a significant increase in bioactive TSH in media from both normal (TRH in vivo, 131%; TRH in vitro, 139%) and thyroidectomized samples after TRH in vivo (158%). Thyrotropin 130-133 thyrotropin releasing hormone Rattus norvegicus 0-3 3084213-5 1986 TRH, both in vivo and in vitro, when compared to the corresponding untreated groups, produced a significant increase in bioactive TSH in media from both normal (TRH in vivo, 131%; TRH in vitro, 139%) and thyroidectomized samples after TRH in vivo (158%). Thyrotropin 130-133 thyrotropin releasing hormone Rattus norvegicus 161-164 3084213-5 1986 TRH, both in vivo and in vitro, when compared to the corresponding untreated groups, produced a significant increase in bioactive TSH in media from both normal (TRH in vivo, 131%; TRH in vitro, 139%) and thyroidectomized samples after TRH in vivo (158%). Thyrotropin 130-133 thyrotropin releasing hormone Rattus norvegicus 161-164 3084213-5 1986 TRH, both in vivo and in vitro, when compared to the corresponding untreated groups, produced a significant increase in bioactive TSH in media from both normal (TRH in vivo, 131%; TRH in vitro, 139%) and thyroidectomized samples after TRH in vivo (158%). Thyrotropin 130-133 thyrotropin releasing hormone Rattus norvegicus 161-164 3084213-6 1986 The TRH effect in the pituitary showed a significant increase in TSH bioactivity from normal samples treated with TRH in vivo (137%), whereas in thyroidectomized pituitary samples with TRH in vitro, TSH bioactivity was decreased (69%). Thyrotropin 65-68 thyrotropin releasing hormone Rattus norvegicus 4-7 3084213-6 1986 The TRH effect in the pituitary showed a significant increase in TSH bioactivity from normal samples treated with TRH in vivo (137%), whereas in thyroidectomized pituitary samples with TRH in vitro, TSH bioactivity was decreased (69%). Thyrotropin 65-68 thyrotropin releasing hormone Rattus norvegicus 114-117 3084213-6 1986 The TRH effect in the pituitary showed a significant increase in TSH bioactivity from normal samples treated with TRH in vivo (137%), whereas in thyroidectomized pituitary samples with TRH in vitro, TSH bioactivity was decreased (69%). Thyrotropin 65-68 thyrotropin releasing hormone Rattus norvegicus 114-117 3084213-6 1986 The TRH effect in the pituitary showed a significant increase in TSH bioactivity from normal samples treated with TRH in vivo (137%), whereas in thyroidectomized pituitary samples with TRH in vitro, TSH bioactivity was decreased (69%). Thyrotropin 199-202 thyrotropin releasing hormone Rattus norvegicus 4-7 3084213-7 1986 These results indicate that thyroid hormone deficiency and TRH differentially regulate TSH bioactivity. Thyrotropin 87-90 thyrotropin releasing hormone Rattus norvegicus 59-62 3086478-1 1986 We have investigated the effect of TRH on the accumulation of glycosylated TSH in the rat anterior pituitary gland. Thyrotropin 75-78 thyrotropin releasing hormone Rattus norvegicus 35-38 3086478-5 1986 Although the release of [3H]glucosamine-labelled and unlabelled TSH into media was stimulated by the addition of TRH in a time- and dose-dependent manner, TRH administration did not alter the amounts of labelled or unlabelled TSH in the anterior pituitary lobes. Thyrotropin 64-67 thyrotropin releasing hormone Rattus norvegicus 113-116 3086478-8 1986 The present data provide evidence that TRH significantly changes the heterogeneity of glycosylated TSH in the anterior pituitary without altering the amount of the glycosylated form. Thyrotropin 99-102 thyrotropin releasing hormone Rattus norvegicus 39-42 3926471-6 1985 The change in the plasma TSH concentration (delta plasma TSH) was significantly greater 15, 30, and 45 min after iv bolus injection of TRH in food-deprived rats than in control rats. Thyrotropin 25-28 thyrotropin releasing hormone Rattus norvegicus 135-138 3005895-5 1986 Blockade of CNS EPI synthesis resulted in inhibition of basal and cold and thyrotropin-releasing hormone induced TSH release, suppression of serum T4, and increased corticosterone release. Thyrotropin 113-116 thyrotropin releasing hormone Rattus norvegicus 75-104 3926471-6 1985 The change in the plasma TSH concentration (delta plasma TSH) was significantly greater 15, 30, and 45 min after iv bolus injection of TRH in food-deprived rats than in control rats. Thyrotropin 57-60 thyrotropin releasing hormone Rattus norvegicus 135-138 6329654-5 1984 In contrast, exogenous TRH caused a 9-fold increase in plasma TSH levels during suckling without further increasing the PRL response. Thyrotropin 62-65 thyrotropin releasing hormone Rattus norvegicus 23-26 2990855-7 1985 In contrast, TRH (and the Ca+2 channel ionophore A23187) released twice as much TSH from the hypothyroid cells as in the euthyroid cultures. Thyrotropin 80-83 thyrotropin releasing hormone Rattus norvegicus 13-16 2990855-9 1985 In contrast, TRH-induced TSH release was enhanced (P less than 0.001) in the euthyroid cultures. Thyrotropin 25-28 thyrotropin releasing hormone Rattus norvegicus 13-16 3926927-5 1985 Injection of anti-TRH serum, but not control non-immune or anti-bovine serum albumin, significantly decreased the basal release of TSH but did not abolish the prolactin response to suckling. Thyrotropin 131-134 thyrotropin releasing hormone Rattus norvegicus 18-21 3926927-6 1985 These results show that TRH is the principal mediator of the neural control of TSH release in the rat, but is not crucial for the release of prolactin in response to either hypothalamic stimulation or suckling. Thyrotropin 79-82 thyrotropin releasing hormone Rattus norvegicus 24-27 6436423-7 1984 Addition of TRH increased incorporation of [14C]alanine into TSH in each of the components to a greater extent than that of [3H]glucosamine. Thyrotropin 61-64 thyrotropin releasing hormone Rattus norvegicus 12-15 6436423-8 1984 In addition, new components with pI 7.2, 6.5 and 6.2, each component corresponding to each unlabelled TSH component, were demonstrated in the presence of TRH. Thyrotropin 102-105 thyrotropin releasing hormone Rattus norvegicus 154-157 3926927-3 1985 Injection of sheep anti-TRH serum blocked the rise in plasma TSH concentration in response to stimulation of either brain area, but did not block the increase in plasma prolactin concentration. Thyrotropin 61-64 thyrotropin releasing hormone Rattus norvegicus 24-27 3927182-0 1985 Comparison of the ability of thyroxine and triiodothyronine to suppress TRH-induced TSH secretion by perfused rat anterior pituitary fragments. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 72-75 3927182-3 1985 A similar temporal course of inhibition of TRH-induced TSH secretion was produced by both iodothyronines, suggesting but not proving that T4 may inhibit the TSH secretion by a direct effect not dependent on its prior intra- or extrapituitary conversion to T3. Thyrotropin 55-58 thyrotropin releasing hormone Rattus norvegicus 43-46 3925674-3 1985 TRH-treated sham-operated animals showed significantly reduced serum and pituitary TSH levels and increased serum T3 levels at most of the times studied (1, 6, 10, 18 and 34 days of oral TRH or DW administration), and a transient elevation in serum T4 between day 1 and 6. Thyrotropin 83-86 thyrotropin releasing hormone Rattus norvegicus 0-3 3925674-5 1985 TSH response to iv TRH administration on the 10th day of oral TRH administration was reduced in controls chronically treated with oral TRH as compared to non-treated controls, and was increased in thyroidectomized-L-T4-treated animals on chronic TRH vs the same group on oral DW. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 19-22 3925674-5 1985 TSH response to iv TRH administration on the 10th day of oral TRH administration was reduced in controls chronically treated with oral TRH as compared to non-treated controls, and was increased in thyroidectomized-L-T4-treated animals on chronic TRH vs the same group on oral DW. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 62-65 3925674-5 1985 TSH response to iv TRH administration on the 10th day of oral TRH administration was reduced in controls chronically treated with oral TRH as compared to non-treated controls, and was increased in thyroidectomized-L-T4-treated animals on chronic TRH vs the same group on oral DW. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 62-65 3925674-5 1985 TSH response to iv TRH administration on the 10th day of oral TRH administration was reduced in controls chronically treated with oral TRH as compared to non-treated controls, and was increased in thyroidectomized-L-T4-treated animals on chronic TRH vs the same group on oral DW. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 62-65 6432670-6 1984 The plasma TSH response to TRH was also significantly inhibited. Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 27-30 6432605-12 1984 Simultaneous administration of 10(-6) M DA with 10(-8) M TRH prevented the release of TSH and PRL. Thyrotropin 86-89 thyrotropin releasing hormone Rattus norvegicus 57-60 6428117-1 1984 Using dispersed and primarily cultured cells of rat pituitary glands, thyrotrophin (TSH) release by TSH-releasing hormone (TRH) and an analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L- prolinamide (DN-1417) which is more potent than TRH on central nervous system behavioural paradigms, was examined under conditions of static incubation and superfusion. Thyrotropin 70-82 thyrotropin releasing hormone Rattus norvegicus 100-121 6428117-1 1984 Using dispersed and primarily cultured cells of rat pituitary glands, thyrotrophin (TSH) release by TSH-releasing hormone (TRH) and an analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L- prolinamide (DN-1417) which is more potent than TRH on central nervous system behavioural paradigms, was examined under conditions of static incubation and superfusion. Thyrotropin 70-82 thyrotropin releasing hormone Rattus norvegicus 123-126 6428117-1 1984 Using dispersed and primarily cultured cells of rat pituitary glands, thyrotrophin (TSH) release by TSH-releasing hormone (TRH) and an analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L- prolinamide (DN-1417) which is more potent than TRH on central nervous system behavioural paradigms, was examined under conditions of static incubation and superfusion. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 100-121 6428117-1 1984 Using dispersed and primarily cultured cells of rat pituitary glands, thyrotrophin (TSH) release by TSH-releasing hormone (TRH) and an analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L- prolinamide (DN-1417) which is more potent than TRH on central nervous system behavioural paradigms, was examined under conditions of static incubation and superfusion. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 123-126 6428117-6 1984 In the superfusion study, a biphasic profile of TSH release was observed during a continuous exposure (100 min) to maximal doses of either the analogue or TRH. Thyrotropin 48-51 thyrotropin releasing hormone Rattus norvegicus 155-158 6432565-4 1984 Finally, under the above dose of infused apomorphine, the effect of TRH on the increase of TSH level was depressed at the 30th min as compared to that 0 and 120th min of infusion. Thyrotropin 91-94 thyrotropin releasing hormone Rattus norvegicus 68-71 6423373-2 1984 TRH (10(-9) and 10(-8)M) consistently stimulated the release of TSH and PRL, but not GH, in pituitary cell cultures of euthyroid male rats. Thyrotropin 64-67 thyrotropin releasing hormone Rattus norvegicus 0-3 6430687-2 1984 Release of TSH in response to continuous exposure to TRH exhibited a biphasic pattern; the first phase was characterized by a rapid, transient and high-rate release (phase I) and the second phase by a chronic and low-rate release (phase II). Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 53-56 6430687-9 1984 The decreased phase I release in response to TRH was observed with the cells which were previously stimulated by high K+ instead of TRH, suggesting that the decrease in the response of phase I reflects the depletion of a releasable pool of TSH rather than homologous desensitization of thyrotrophs with TRH. Thyrotropin 240-243 thyrotropin releasing hormone Rattus norvegicus 45-48 6423373-3 1984 Basal and TRH-stimulated TSH secretion were significantly increased in cells from thyroidectomized rats cultured in medium supplemented with hypothyroid serum, and a dose-related stimulation of GH release by 10(-9)-10(-8) M TRH was observed. Thyrotropin 25-28 thyrotropin releasing hormone Rattus norvegicus 10-13 6423373-3 1984 Basal and TRH-stimulated TSH secretion were significantly increased in cells from thyroidectomized rats cultured in medium supplemented with hypothyroid serum, and a dose-related stimulation of GH release by 10(-9)-10(-8) M TRH was observed. Thyrotropin 25-28 thyrotropin releasing hormone Rattus norvegicus 224-227 6423373-4 1984 The minimum duration of hypothyroidism required to demonstrate the onset of this GH stimulatory effect of TRH was 4 weeks, a period significantly longer than that required to cause intracellular GH depletion, decreased basal secretion of GH, elevated serum TSH, or increased basal secretion of TSH by cultured cells. Thyrotropin 257-260 thyrotropin releasing hormone Rattus norvegicus 106-109 6423373-4 1984 The minimum duration of hypothyroidism required to demonstrate the onset of this GH stimulatory effect of TRH was 4 weeks, a period significantly longer than that required to cause intracellular GH depletion, decreased basal secretion of GH, elevated serum TSH, or increased basal secretion of TSH by cultured cells. Thyrotropin 294-297 thyrotropin releasing hormone Rattus norvegicus 106-109 6710532-5 1984 When a single dose of nitrofen was administered to euthyroid female rats, a trend toward reduction (p = 0.058) in the release of TSH after a thyrotropin-releasing hormone (TRH) challenge was observed 4 and 5 hr after exposure. Thyrotropin 129-132 thyrotropin releasing hormone Rattus norvegicus 141-170 6425038-8 1984 The plasma TSH response to TRH was also significantly enhanced by PG I2. Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 27-30 6439618-5 1984 An increase in the dose of TRH (112 pmol), administered to euthyroid tissue, resulted in increased TSH and PRL response, but no decline in response to sequential stimuli was observed. Thyrotropin 99-102 thyrotropin releasing hormone Rattus norvegicus 27-30 6201427-8 1984 The plasma TSH response to TRH was inhibited by SP, but enhanced by angiotensin II. Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 27-30 6439618-6 1984 Three consecutive stimuli by TRH (28 pmol) of hypothyroid tissue resulted in a consistent decline in TSH response. Thyrotropin 101-104 thyrotropin releasing hormone Rattus norvegicus 29-32 6785072-3 1981 TRH, high K+, and Ba2+ resulted in a 2-fold or greater stimulation of TSH release. Thyrotropin 70-73 thyrotropin releasing hormone Rattus norvegicus 0-3 6415989-3 1983 The serum TSH levels in Neo-TRH rats were significantly lower than those in controls on days 4 (male group only), 10 and 21 (only 10 micrograms/kg group). Thyrotropin 10-13 thyrotropin releasing hormone Rattus norvegicus 28-31 6415989-6 1983 However, the response of serum TSH to exogenous TRH (10 micrograms/kg/ip) was blunted in Neo-TRH rats on days 10, 21 and 90. Thyrotropin 31-34 thyrotropin releasing hormone Rattus norvegicus 48-51 6415989-6 1983 However, the response of serum TSH to exogenous TRH (10 micrograms/kg/ip) was blunted in Neo-TRH rats on days 10, 21 and 90. Thyrotropin 31-34 thyrotropin releasing hormone Rattus norvegicus 93-96 6412238-6 1983 Treatment with a high dosage (2 micrograms) of TRH induced a sixfold rise in plasma TSH during both phases of gestation. Thyrotropin 84-87 thyrotropin releasing hormone Rattus norvegicus 47-50 6304605-3 1983 In order to study the role of thyroid releasing hormone (TRH) in the control of thyroid stimulating hormone (TSH) secretion during the neonatal period, we measured the binding of [3H]-TRH to pituitary homogenate of rats at various stages of development. Thyrotropin 80-107 thyrotropin releasing hormone Rattus norvegicus 57-60 6304605-3 1983 In order to study the role of thyroid releasing hormone (TRH) in the control of thyroid stimulating hormone (TSH) secretion during the neonatal period, we measured the binding of [3H]-TRH to pituitary homogenate of rats at various stages of development. Thyrotropin 109-112 thyrotropin releasing hormone Rattus norvegicus 57-60 6304605-3 1983 In order to study the role of thyroid releasing hormone (TRH) in the control of thyroid stimulating hormone (TSH) secretion during the neonatal period, we measured the binding of [3H]-TRH to pituitary homogenate of rats at various stages of development. Thyrotropin 109-112 thyrotropin releasing hormone Rattus norvegicus 184-187 6304605-8 1983 These studies thus indicate that TRH binding sites are present during the neonatal period in the rat and suggest that TRH may be an important modulator of TSH secretion during this period in the rat and that these effects are mediated by postreceptor mechanisms. Thyrotropin 155-158 thyrotropin releasing hormone Rattus norvegicus 33-36 6304605-8 1983 These studies thus indicate that TRH binding sites are present during the neonatal period in the rat and suggest that TRH may be an important modulator of TSH secretion during this period in the rat and that these effects are mediated by postreceptor mechanisms. Thyrotropin 155-158 thyrotropin releasing hormone Rattus norvegicus 118-121 6132345-6 1983 The inclusion of somatostatin-14 (3 X 10(-9) M) in the perfusate inhibited TRH-stimulated TSH release. Thyrotropin 90-93 thyrotropin releasing hormone Rattus norvegicus 75-78 6804214-7 1982 On the other hand, TRH induced the release of TSH and PRL from the first day of life and no sex difference was observed. Thyrotropin 46-49 thyrotropin releasing hormone Rattus norvegicus 19-22 6415151-3 1983 TSH response to TRH administered intravenously did not differ between old and young rats. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 16-19 6408930-4 1983 In cells from euthyroid animals, TRH induced TSH secretion only in the eutopic cells but induced PRL secretion in both eutopic and heterotopic cells. Thyrotropin 45-48 thyrotropin releasing hormone Rattus norvegicus 33-36 6408930-5 1983 Hypothyroidism increased TRH-induced TSH secretion and content in the cell lysate in both eutopic and heterotopic cells but increased TRH-induced PRL secretion only in the eutopic cells. Thyrotropin 37-40 thyrotropin releasing hormone Rattus norvegicus 25-28 6403887-0 1983 Factors involved in the attenuation of the TSH response to a second injection of TRH in the rat. Thyrotropin 43-46 thyrotropin releasing hormone Rattus norvegicus 81-84 6222895-7 1982 The plasma TSH response to TRH was decreased, but not significantly. Thyrotropin 11-14 thyrotropin releasing hormone Rattus norvegicus 27-30 6785072-6 1981 Perifusion with 3.5 x 10(-5) M cycloheximide or 10(-6) M actinomycin D 1 h before and during T3 administration led to greater TSH release with TRH than in the presence of T3 alone. Thyrotropin 126-129 thyrotropin releasing hormone Rattus norvegicus 143-146 6781874-2 1981 Subcutaneous administration of 1 ng/g BW TRH caused a greater rise in plasma TSH in the hypothyroid pups than in their mothers. Thyrotropin 77-80 thyrotropin releasing hormone Rattus norvegicus 41-44 7212062-17 1981 It was concluded that 1) the plasma T4 exerts a negative feedback on basal TSH secretion in addition to that due to plasma T3 and 2) small amounts of T4 replacement enhance the TSH response to exogenous TRH in short-term hypothyroid rats. Thyrotropin 75-78 thyrotropin releasing hormone Rattus norvegicus 203-206 7212062-17 1981 It was concluded that 1) the plasma T4 exerts a negative feedback on basal TSH secretion in addition to that due to plasma T3 and 2) small amounts of T4 replacement enhance the TSH response to exogenous TRH in short-term hypothyroid rats. Thyrotropin 177-180 thyrotropin releasing hormone Rattus norvegicus 203-206 6787114-6 1981 In this study, the radioimmunoassay showed that TSH content rose dramatically in the hypothyroid animals treated with PTU for 77 days and thyroxine for 2 days before death (from 8.5--64.1 mU/mg wet wt); however, the rise in TRH content was minimal (5.8--9.8 pg/mg wet wt). Thyrotropin 48-51 thyrotropin releasing hormone Rattus norvegicus 224-227 410310-1 1977 Daily administration of estradiol benzoate (10 microgram/100 g body wt) to intact male rats led to a twofold increase of the plasma TSH (thyroid-stimulating hormone) response to thyrotropin-releasing hormone (TRH) after 4 and 7 days of treatment whereas the basal plasma TSH level was not affected. Thyrotropin 132-135 thyrotropin releasing hormone Rattus norvegicus 178-207 6777284-4 1980 Basal and TRH-stimulated TSH release was markedly greater in the rats radiothyroidectomized within 12 h of birth than for the other 3 groups, probably reflecting greater thyroid damage at a critical time in development. Thyrotropin 25-28 thyrotropin releasing hormone Rattus norvegicus 10-13 6775240-8 1980 It is known that TRH not only stimulates TSH secretion but will stimulate prolactin secretion as well. Thyrotropin 41-44 thyrotropin releasing hormone Rattus norvegicus 17-20 120164-5 1979 These findings suggest that TRH stimulates the thyrotroph and accelerates synchronously the secretion as well as the synthesis of TSH. Thyrotropin 130-133 thyrotropin releasing hormone Rattus norvegicus 28-31 115671-1 1979 We have studied the effect of two inhibitors of prostaglandin synthesis on the basal and TRH-stimulated plasma TSH levels in the rat. Thyrotropin 111-114 thyrotropin releasing hormone Rattus norvegicus 89-92 115671-9 1979 The increased sensitivity of plasma TSH response to exogenous TRH in the indomethacin group is presumably due to higher pituitary TSH content than in the controls. Thyrotropin 36-39 thyrotropin releasing hormone Rattus norvegicus 62-65 108290-5 1979 Similarly, acute TRH-AS administration to the pregnant rat fed LID-PTU markedly decreased the serum TSH concentration in the mother, but not in the fetus, 60 min after TRH-AS administration. Thyrotropin 100-103 thyrotropin releasing hormone Rattus norvegicus 17-20 108290-6 1979 Chronic TRH-AS administration to neonatal rats whose nursing mothers were fed LID-PTU was in-effective in decreasing the elevated serum TSH in the neonate through day 8 of life, whereas a slight but significant decrease in serum TSH was observed on day 10. Thyrotropin 136-139 thyrotropin releasing hormone Rattus norvegicus 8-11 108290-6 1979 Chronic TRH-AS administration to neonatal rats whose nursing mothers were fed LID-PTU was in-effective in decreasing the elevated serum TSH in the neonate through day 8 of life, whereas a slight but significant decrease in serum TSH was observed on day 10. Thyrotropin 229-232 thyrotropin releasing hormone Rattus norvegicus 8-11 107181-8 1979 3) Both placental extract and synthetic TRH stimulated TSH release from rat pituitaries in vitro. Thyrotropin 55-58 thyrotropin releasing hormone Rattus norvegicus 40-43 117392-6 1979 Serum TSH responded to TRH after the stress as well. Thyrotropin 6-9 thyrotropin releasing hormone Rattus norvegicus 23-26 106341-4 1979 TRH injection to protein-deficient dams caused a marked reduction in pituitary TSH concentration, suggesting that the elevated plasma TSH seen in uninjected dams might be due to decreased metabolic clearance rather than to hypersecretion by the pituitary. Thyrotropin 79-82 thyrotropin releasing hormone Rattus norvegicus 0-3 106341-4 1979 TRH injection to protein-deficient dams caused a marked reduction in pituitary TSH concentration, suggesting that the elevated plasma TSH seen in uninjected dams might be due to decreased metabolic clearance rather than to hypersecretion by the pituitary. Thyrotropin 134-137 thyrotropin releasing hormone Rattus norvegicus 0-3 109291-3 1978 Similarly, the increased plasma TSH level following PTU treatment was significantly suppressed after iv injection of antiserum to TRH. Thyrotropin 32-35 thyrotropin releasing hormone Rattus norvegicus 130-133 107021-4 1978 When TSH was administered simultaneously with T4 to Hx rats, hypothalamic TRH content was restored to normal. Thyrotropin 5-8 thyrotropin releasing hormone Rattus norvegicus 74-77 98684-2 1978 Five days starvation resulted in a significant decrease in serum TSH and a slightly enhanced serum TSH response to exogenous TRH, suggesting that the pituitary retains its sensitivity to TRH. Thyrotropin 99-102 thyrotropin releasing hormone Rattus norvegicus 125-128 99299-13 1978 The above morphological results are contradictory a plausible view that TRH acts only upon the thyrotrophs to release TSH. Thyrotropin 118-121 thyrotropin releasing hormone Rattus norvegicus 72-75 6455047-8 1981 Therefore, 1) decreased TSH release in TX rats treated with T3 was induced by the block of TRH release from the AHN and ME as compared with the TX group, and 2) elevated serum TSH levels in 4 degrees C cold stress might be induced by the release of TRH from the PMD and PV. Thyrotropin 24-27 thyrotropin releasing hormone Rattus norvegicus 91-94 6455047-8 1981 Therefore, 1) decreased TSH release in TX rats treated with T3 was induced by the block of TRH release from the AHN and ME as compared with the TX group, and 2) elevated serum TSH levels in 4 degrees C cold stress might be induced by the release of TRH from the PMD and PV. Thyrotropin 176-179 thyrotropin releasing hormone Rattus norvegicus 249-252 6780312-4 1981 The administration of synthetic TRH during the neonatal period induced a significant increase of serum TSH in the newborn; however, TSH release by the pituitary gland increased progressively from days 3-10. Thyrotropin 103-106 thyrotropin releasing hormone Rattus norvegicus 32-35 6780312-4 1981 The administration of synthetic TRH during the neonatal period induced a significant increase of serum TSH in the newborn; however, TSH release by the pituitary gland increased progressively from days 3-10. Thyrotropin 132-135 thyrotropin releasing hormone Rattus norvegicus 32-35 6780312-7 1981 It is concluded that neonatal pituitary-thyroid function in the rat is not physiologically dependent upon TRH secretion, although synthetic TRH is able to stimulate the secretion of TSH at birth. Thyrotropin 182-185 thyrotropin releasing hormone Rattus norvegicus 140-143 6770280-3 1980 Basal and TRH-stimulated thyroid-stimulating hormone (TSH) levels were higher in the hypothyroids, and the developmental patterns of basal TSH secretion and TSH reserve were parallel in the two groups, with maximal TSH secretion occurring at 30 days. Thyrotropin 54-57 thyrotropin releasing hormone Rattus norvegicus 10-13 6992487-5 1980 The effect of TRH on TSH biosynthesis is presented as a biological application of this procedure. Thyrotropin 21-24 thyrotropin releasing hormone Rattus norvegicus 14-17 6769064-5 1980 In addition, TRH (0.1--10 mg/kg IP) or beta-Ala TRH treatment (1.0--10 mg/kg IP) for 9 days significantly reduced serum TSH levels in rats. Thyrotropin 120-123 thyrotropin releasing hormone Rattus norvegicus 13-16 6769064-5 1980 In addition, TRH (0.1--10 mg/kg IP) or beta-Ala TRH treatment (1.0--10 mg/kg IP) for 9 days significantly reduced serum TSH levels in rats. Thyrotropin 120-123 thyrotropin releasing hormone Rattus norvegicus 48-51 6774943-1 1980 The roles of prolactin and thyrotrophin (TSH) in the regulation of glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) activities in rat mammary glands were investigated by the administration of thyroid hormone-releasing hormone (TRH), bromocriptine, prolactin, TSH and triiodo-1-thyronine (T(3)). Thyrotropin 41-44 thyrotropin releasing hormone Rattus norvegicus 230-263 6774943-1 1980 The roles of prolactin and thyrotrophin (TSH) in the regulation of glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) activities in rat mammary glands were investigated by the administration of thyroid hormone-releasing hormone (TRH), bromocriptine, prolactin, TSH and triiodo-1-thyronine (T(3)). Thyrotropin 41-44 thyrotropin releasing hormone Rattus norvegicus 265-268 114467-5 1979 TSH secretion was markedly increased by 500 pg TRH, whether or not plasma preincubation was employed. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 47-50 109291-0 1978 Effect of active and passive immunization with TRH on plasma TSH response to propylthiouracil. Thyrotropin 61-64 thyrotropin releasing hormone Rattus norvegicus 47-50 80734-2 1978 Serum TSH and triiodothyronine (T3) responses to cold exposure (4 +/- 1 C) were abolished by administration of anti-TRH serum. Thyrotropin 6-9 thyrotropin releasing hormone Rattus norvegicus 116-119 80734-4 1978 These observations provide evidence that TRH is involved in the mechanism of enhanced TSH secretion from the pituitary following thyroidectomy and cold exposure. Thyrotropin 86-89 thyrotropin releasing hormone Rattus norvegicus 41-44 418309-2 1978 Mean (+/- SE) peak TSH responses to TRH were 168 +/- 64 microU/ml during 3,3"T2 administration and 168 +/- 65 muU/ml during 3,3"T2 administration. Thyrotropin 19-22 thyrotropin releasing hormone Rattus norvegicus 36-39 418309-5 1978 for 5 days had a mean TSH response to TRH stimulation of 0.051 +/- 0.003 mU/ml, whereas rats to whom saline or 3,3"T2 (50 microgram b.i.d.) Thyrotropin 22-25 thyrotropin releasing hormone Rattus norvegicus 38-41 418309-6 1978 had been given for the same time interval had mean TRH-induced TSH responses of 1.127 +/- 0.179 mU/ml and 1.324 +/- 0.286 mU/ml, respectively. Thyrotropin 63-66 thyrotropin releasing hormone Rattus norvegicus 51-54 413840-9 1978 These studies demonstrate that TRH is required for TSH secretion in the normal, cold-exposed and proestrus rat and contributes, at least in part, to TSH secretion in the hypothyroid rat, but is not required for Prl secretion in these states. Thyrotropin 51-54 thyrotropin releasing hormone Rattus norvegicus 31-34 413840-9 1978 These studies demonstrate that TRH is required for TSH secretion in the normal, cold-exposed and proestrus rat and contributes, at least in part, to TSH secretion in the hypothyroid rat, but is not required for Prl secretion in these states. Thyrotropin 149-152 thyrotropin releasing hormone Rattus norvegicus 31-34 414907-5 1977 In thyroidectomized rats the hypothalamic TRH levels were slightly reduced in spite of the marked increase of plasma TSH levels and decrease of pituitary TSH levels. Thyrotropin 117-120 thyrotropin releasing hormone Rattus norvegicus 42-45 410310-1 1977 Daily administration of estradiol benzoate (10 microgram/100 g body wt) to intact male rats led to a twofold increase of the plasma TSH (thyroid-stimulating hormone) response to thyrotropin-releasing hormone (TRH) after 4 and 7 days of treatment whereas the basal plasma TSH level was not affected. Thyrotropin 132-135 thyrotropin releasing hormone Rattus norvegicus 209-212 188629-12 1977 On the basis of these results, it is assumed that the central noradrenergic system has a stimulatory effect on the release of TRH from the hypothalamus, reflected in our experiments by the changes of serum TSH levels. Thyrotropin 206-209 thyrotropin releasing hormone Rattus norvegicus 126-129 192538-4 1977 Contrary to findings with LHRH and LH, repeated injections of a small dose (10 ng) of TRH in the afternoon of proestrus abolished PRL and TSH responses to subsequent injection of the neurohormone. Thyrotropin 139-142 thyrotropin releasing hormone Rattus norvegicus 87-90 12985-0 1977 Comparison of adiphenine and TRH effects on TSH release by rat pituitary in vitro. Thyrotropin 44-47 thyrotropin releasing hormone Rattus norvegicus 29-32 12985-2 1977 The comparative study showed that adiphenine and TRH were able to increase TSH release in a dose-dependent manner, had similar time courses of action for equipotent stimulating concentrations and produced similar aspects of stimulated TSH cells. Thyrotropin 75-78 thyrotropin releasing hormone Rattus norvegicus 49-52 416857-3 1977 Results indicate that TRH administered to lactating rats induces release of TSH from the pituitary of suckling pups. Thyrotropin 76-79 thyrotropin releasing hormone Rattus norvegicus 22-25 181934-0 1976 Augmented secretion of TSH in response to TRH after pre-treatment with dexamethasone for six days in rats. Thyrotropin 23-26 thyrotropin releasing hormone Rattus norvegicus 42-45 819250-6 1976 In males, thyrotropin-releasing hormone (TRH) induced a significant elevation in serum TSH at all ages tested, but was less effective in increasing serum TSH on day 25 than on days 15 or 40 or in 3-4-month-old rats. Thyrotropin 87-90 thyrotropin releasing hormone Rattus norvegicus 10-39 819250-6 1976 In males, thyrotropin-releasing hormone (TRH) induced a significant elevation in serum TSH at all ages tested, but was less effective in increasing serum TSH on day 25 than on days 15 or 40 or in 3-4-month-old rats. Thyrotropin 87-90 thyrotropin releasing hormone Rattus norvegicus 41-44 819251-2 1976 In euthyroid control rats, intravenous injection of TRH (200 ng/100 g BW) resulted in a significant increase in both plasma GH and TSH. Thyrotropin 131-134 thyrotropin releasing hormone Rattus norvegicus 52-55 819251-5 1976 These results suggest that altered thyroid status influences GH release as well as TSH secretion induced by TRH in rats. Thyrotropin 83-86 thyrotropin releasing hormone Rattus norvegicus 108-111 819252-4 1976 PRL release was greater in response to a maximally effective dose of pSME than the release elicited by a maximal dose of TRH, and pSME administered together with a greater than mazimally effective dose of TRH caused additional PRL but not TSH secretion. Thyrotropin 239-242 thyrotropin releasing hormone Rattus norvegicus 205-208 819252-10 1976 TSH-releasing activity eluted from the charcoal with methanol was considerably greater than that expected on the basis of the recovery of [3H]TRH, suggesting the presence in the crude extract of a TSH-release inhibitor or of a TSH-releasing factor other than TRH. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 228-248 819252-10 1976 TSH-releasing activity eluted from the charcoal with methanol was considerably greater than that expected on the basis of the recovery of [3H]TRH, suggesting the presence in the crude extract of a TSH-release inhibitor or of a TSH-releasing factor other than TRH. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 260-263 29057835-9 2017 We found a high release of hypothalamic TRH, which along with reduced MBH PPII activity, increased TSH levels in Zn-deficient pups independently of changes in TH concentration. Thyrotropin 99-102 thyrotropin releasing hormone Rattus norvegicus 40-43 819248-1 1976 Passive immunization of rats with an antiserum to synthetic somatostatin caused a 250% elevation of basal serum TSH levels and a nearly 200% increase in TSH-response to TRH. Thyrotropin 153-156 thyrotropin releasing hormone Rattus norvegicus 169-172 811690-14 1975 If TRH secretion is responsible for cold-induced increases in plasma TSH concentrations, the increase in TRH secretion is of insufficient magnitude to alter periperal plasma TRH concentrations. Thyrotropin 69-72 thyrotropin releasing hormone Rattus norvegicus 3-6 810342-3 1975 TRH administration via both routes resulted in substantial release of TSH. Thyrotropin 70-73 thyrotropin releasing hormone Rattus norvegicus 0-3 810342-4 1975 Following intraventricular injection of TRH, there was a delay in reached maximal TSH concentration when compared with the faster elevation and faster decline in TSH concentrations which followed intravenous injection of the same dose of TRH. Thyrotropin 82-85 thyrotropin releasing hormone Rattus norvegicus 40-43 810342-10 1975 The data support the view that TRH is able to cross the medium eminence from CSF into hypophysial portal blood and that it is capable of stimulating the pituitary gland to release TSH. Thyrotropin 180-183 thyrotropin releasing hormone Rattus norvegicus 31-34 1183410-6 1975 These results suggest that most, if not all of the thyrotropin-releasing factor (TRF) necessary for normal TSH secretion in resting conditions or during the hypothyroid state, is produced and released in the median eminence-arcuate nucleus area, the adequate activity of which, in turn, depends on intact connections with the anterior hypothalamus. Thyrotropin 107-110 thyrotropin releasing hormone Rattus norvegicus 51-79 1183410-6 1975 These results suggest that most, if not all of the thyrotropin-releasing factor (TRF) necessary for normal TSH secretion in resting conditions or during the hypothyroid state, is produced and released in the median eminence-arcuate nucleus area, the adequate activity of which, in turn, depends on intact connections with the anterior hypothalamus. Thyrotropin 107-110 thyrotropin releasing hormone Rattus norvegicus 81-84 809721-1 1975 Intravenous injection of the synthetic tripeptide (PyroGlu-His-Pro-NH2:TRH) effected the prompt release of TSH and prolactin (PRL) from the pituitary of the goitrous rat. Thyrotropin 107-110 thyrotropin releasing hormone Rattus norvegicus 71-74 809721-2 1975 Plasma TSH and PRL levels increased 2-3-fold within 1 min after the injection of 0.4 and 2 mug TRH. Thyrotropin 7-10 thyrotropin releasing hormone Rattus norvegicus 95-98 809721-7 1975 Ingestion of large amounts of TRH (1,700 mug daily for 8 and 14 days) by the euthyroid rat resulted in a 2-3-fold elevation of the plasma TSH level. Thyrotropin 138-141 thyrotropin releasing hormone Rattus norvegicus 30-33 4203687-0 1973 Stimulation of TSH release and glucose oxidation in pituitaries from thyroidectomized rats by thyrotropin releasing factor (TRF). Thyrotropin 15-18 thyrotropin releasing hormone Rattus norvegicus 94-122 4203687-0 1973 Stimulation of TSH release and glucose oxidation in pituitaries from thyroidectomized rats by thyrotropin releasing factor (TRF). Thyrotropin 15-18 thyrotropin releasing hormone Rattus norvegicus 124-127 33743173-8 2021 TSH production was measured by RIA after time-dependent stimulation with TRH. Thyrotropin 0-3 thyrotropin releasing hormone Rattus norvegicus 73-76 33743173-14 2021 CONCLUSION: Our data indicate that the expression of Ca2+/CaMK in rat anterior pituitary are correlated to the role of CREB in the genetic regulation of TSH, and that TRH stimulation activates CaMKIV, which in turn phosphorylates CREB. Thyrotropin 153-156 thyrotropin releasing hormone Rattus norvegicus 167-170 165068-2 1975 Dexamethasone given 3 h before experiemtns significantly depressed both TRH- and cold-induced TSH responses at all dose levels. Thyrotropin 94-97 thyrotropin releasing hormone Rattus norvegicus 72-75 804399-4 1975 Pretreatment with either T3 (50 mug/100 g body wt ip) significantly suppressed both plasma GH and TSH responses to TRH. Thyrotropin 98-101 thyrotropin releasing hormone Rattus norvegicus 115-118 810186-9 1975 In all comparisons the males had higher serum TSH concentrations than females and usually had a greater response to TRH stimulation. Thyrotropin 46-49 thyrotropin releasing hormone Rattus norvegicus 116-119 809721-8 1975 In PTU (propylthiouracil)-treated rats ingesting approximately the same amount of TRH, a plasma TSH increase failed to occur. Thyrotropin 96-99 thyrotropin releasing hormone Rattus norvegicus 82-85 809721-9 1975 The oral ingestion of TRH for 22-27 days by goitrous, TSH-rebounded rats resulted in a significant dimunution in the circulating levels of TSH and PRL, and in ultrastructural manifestations suggestive of impaired release by the adenohypophysis. Thyrotropin 54-57 thyrotropin releasing hormone Rattus norvegicus 22-25 809721-9 1975 The oral ingestion of TRH for 22-27 days by goitrous, TSH-rebounded rats resulted in a significant dimunution in the circulating levels of TSH and PRL, and in ultrastructural manifestations suggestive of impaired release by the adenohypophysis. Thyrotropin 139-142 thyrotropin releasing hormone Rattus norvegicus 22-25 809721-10 1975 It is concluded that the acute administration of TRH causes the rapid release of TSH and PRL from the pituitary of the chronically hypothyroid rat. Thyrotropin 81-84 thyrotropin releasing hormone Rattus norvegicus 49-52 32114434-7 2020 We suggest that the sex difference in TSH secretion kinetics is driven not only at the level of paraventricular nucleus TRH neurons, but also by differences in post-secretory catabolism of TRH, with enhancement of TRH-degrading activity more sustained in male than female animals. Thyrotropin 38-41 thyrotropin releasing hormone Rattus norvegicus 120-123 32114434-7 2020 We suggest that the sex difference in TSH secretion kinetics is driven not only at the level of paraventricular nucleus TRH neurons, but also by differences in post-secretory catabolism of TRH, with enhancement of TRH-degrading activity more sustained in male than female animals. Thyrotropin 38-41 thyrotropin releasing hormone Rattus norvegicus 189-192 32114434-7 2020 We suggest that the sex difference in TSH secretion kinetics is driven not only at the level of paraventricular nucleus TRH neurons, but also by differences in post-secretory catabolism of TRH, with enhancement of TRH-degrading activity more sustained in male than female animals. Thyrotropin 38-41 thyrotropin releasing hormone Rattus norvegicus 189-192 15944919-1 2005 Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Thyrotropin 114-141 thyrotropin releasing hormone Rattus norvegicus 0-29 18063289-24 2008 Pituitary response to TRH-mediated TSH release was not diminished after 8-daily oral doses of PFOS. Thyrotropin 35-38 thyrotropin releasing hormone Rattus norvegicus 22-25 24498374-6 2014 The activation of TRH hypophysiotropic neurons by the thermode cooling of POA was indirectly assessed, in conditions in which thermoregulation was either fully operant (wakefulness) or not operant (REMS), by a radioimmunoassay determination of plasmatic levels of TSH. Thyrotropin 264-267 thyrotropin releasing hormone Rattus norvegicus 18-21 19179432-10 2009 We propose that an increase in circulating thyroid hormone up-regulates PPII activity in tanycytes and enhances degradation of extracellular TRH in the median eminence through glial-axonal associations, contributing to the feedback regulation of thyroid hormone on anterior pituitary TSH secretion. Thyrotropin 284-287 thyrotropin releasing hormone Rattus norvegicus 141-144 15944919-1 2005 Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Thyrotropin 114-141 thyrotropin releasing hormone Rattus norvegicus 31-34 15944919-1 2005 Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Thyrotropin 143-146 thyrotropin releasing hormone Rattus norvegicus 0-29 15944919-1 2005 Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Thyrotropin 143-146 thyrotropin releasing hormone Rattus norvegicus 31-34