PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10411124-8 1999 TSH or forskolin, in contrast, halved the activity of the full length chimera within 24 hours and significantly suppressed the TNF-alpha and IFN-gamma-induced increase (>50%; p < 0.02). Thyrotropin 0-3 tumor necrosis factor Rattus norvegicus 127-136 15637292-1 2005 We previously demonstrated that TNF-alpha-dependent activation of p65 nuclear factor kappaB in rat thyroid FRTL-5 cells requires TSH. Thyrotropin 129-132 tumor necrosis factor Rattus norvegicus 32-41 15637292-7 2005 Interestingly, it was found that PKAc formed a complex with IkappaBalpha and beta only in the presence of TSH, and this PKAc could be activated by TNF-alpha. Thyrotropin 106-109 tumor necrosis factor Rattus norvegicus 147-156 15637292-10 2005 These results demonstrate that TSH induces the formation of PKAc/IkappaB complex in FRTL-5 cells and that this PKAc bound with IkappaB plays a critical role in TNF-alpha-dependent activation of p65. Thyrotropin 31-34 tumor necrosis factor Rattus norvegicus 160-169 11237861-9 2001 Taken together, these observations indicate that the presence of TSH is crucial for the NF-kappaB-mediated actions of TNF-alpha on thyroid follicular cells. Thyrotropin 65-68 tumor necrosis factor Rattus norvegicus 118-127 10411124-5 1999 Moreover, TSH/forskolin decrease ICAM-1 RNA levels that are maximally induced by two cytokines: 100 ng/mL tumor necrosis factor-alpha (TNF-alpha) or 100 U/ml interferon-gamma (IFN-gamma). Thyrotropin 10-13 tumor necrosis factor Rattus norvegicus 135-144 10411124-15 1999 We thus show that TSH/cAMP can downregulate ICAM-1 gene expression and inhibit the activity of cytokines (TNF-alpha and IFN-gamma) to increase ICAM-1 gene expression in FRTL-5 thyroid cells. Thyrotropin 18-21 tumor necrosis factor Rattus norvegicus 106-115 9316456-6 1997 We conclude that TNF-alpha, through a sphingomyelinase-ceramide pathway, regulates TSH-induced H2O2 production at steps beyond the Ca2+ mobilization step in the PLC-Ca2+ signaling pathway coupled to TSH. Thyrotropin 83-86 tumor necrosis factor Rattus norvegicus 17-26 9846164-5 1998 TSH enhanced NIS mRNA expression in a dose-dependent manner, with induction evident at 0.1 mU/l, reaching a peak at 50 mU/l, an effect detected after 6 h of stimulation, but not in the first 2 h. Both TNF alpha and, to a lesser extent, IL-1 alpha inhibited basal and TSH-induced NIS expression. Thyrotropin 0-3 tumor necrosis factor Rattus norvegicus 201-210 9316456-0 1997 Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway. Thyrotropin 14-17 tumor necrosis factor Rattus norvegicus 58-67 9316456-3 1997 In the present study, we found that TNF-alpha inhibits TSH-induced H2O2 production, which is an inevitable process for iodide organification, and hence thyroid hormone synthesis, in FRTL-5 thyroid cells. Thyrotropin 55-58 tumor necrosis factor Rattus norvegicus 36-45 9316456-6 1997 We conclude that TNF-alpha, through a sphingomyelinase-ceramide pathway, regulates TSH-induced H2O2 production at steps beyond the Ca2+ mobilization step in the PLC-Ca2+ signaling pathway coupled to TSH. Thyrotropin 199-202 tumor necrosis factor Rattus norvegicus 17-26 7627812-5 1995 Basal and TSH-induced I-5"-deiodination were significantly inhibited by 100 ng/liter of IL-1 beta and IL-6, and the inhibitory effect of TNF-alpha was seen over 1 microgram/liter. Thyrotropin 10-13 tumor necrosis factor Rattus norvegicus 137-146 9142647-2 1997 TNF-alpha is only cytotoxic to aged (> 40 passages) FRTL-5 cells grown in TSH-containing medium, whereas TGF-beta induces programmed cell death (apoptosis) in epithelial cells but not in FRTL-5 cells, which otherwise retain many properties of normal thyroid follicular cells. Thyrotropin 77-80 tumor necrosis factor Rattus norvegicus 0-9 9142647-4 1997 One prominent effect of TNF-alpha (and TGF-beta 1) on FRTL-5 cell function is suppression of iodide uptake, which is markedly stimulated by TSH. Thyrotropin 140-143 tumor necrosis factor Rattus norvegicus 24-33 8612490-1 1996 The effects of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on basal and TRH-induced TSH release, and the effects of IL-1 beta on the uptake of [125I]T3 and [125I]T4 and on nuclear binding of [125I]T3 were examined. Thyrotropin 115-118 tumor necrosis factor Rattus norvegicus 79-88 8612490-5 1996 Exposure to IL-1 beta (1 pM-1 nM) or TNF alpha (100 pM) for 2-4 h resulted in a significant decline in TSH release, which was almost 50% (P < 0.05) for 1 nM IL-1 beta and 24% (P < 0.05) for 100 pM TNF alpha. Thyrotropin 103-106 tumor necrosis factor Rattus norvegicus 37-46 8612490-5 1996 Exposure to IL-1 beta (1 pM-1 nM) or TNF alpha (100 pM) for 2-4 h resulted in a significant decline in TSH release, which was almost 50% (P < 0.05) for 1 nM IL-1 beta and 24% (P < 0.05) for 100 pM TNF alpha. Thyrotropin 103-106 tumor necrosis factor Rattus norvegicus 203-212 8612490-7 1996 When the effects of IL-1 beta (1 pM-1 nM) and TNF alpha (100 pM) on TRH-induced TSH release were measured in short term experiments, the inhibitory effects had disappeared. Thyrotropin 80-83 tumor necrosis factor Rattus norvegicus 46-55 7479297-5 1995 TNF-alpha did not affect the concanavalin A and lentil lectin binding of TSH accumulated in the medium during the 4-day culture, but significantly decreased the lentil lectin binding of TSH released in response to acute TRH stimulation. Thyrotropin 186-189 tumor necrosis factor Rattus norvegicus 0-9 2474435-5 1989 TNF alpha had minimal effects on growth indices (slight increase in [3H]Tdr incorporation) and had no influence on I- uptake; it inhibited TSH stimulation of both growth and I- uptake. Thyrotropin 139-142 tumor necrosis factor Rattus norvegicus 0-9 8118227-6 1993 Inhibition of protein kinase A and protein kinase C by H7 or HA inhibited TSH-stimulated iodide transport, but did not block the TNF-alpha action, suggesting that the mechanism of TNF-alpha action on thyroid cells is independent of protein kinase A and C. Thyrotropin 74-77 tumor necrosis factor Rattus norvegicus 180-189 1322286-5 1992 TNF alpha markedly stimulated [3H]thymidine incorporation into DNA, inhibited TSH-stimulated 125I uptake per micrograms DNA, but dramatically decreased the total DNA content and cell number. Thyrotropin 78-81 tumor necrosis factor Rattus norvegicus 0-9 2551628-3 1989 The TSH-stimulated [125I]iodide uptake by FRTL-5 cells was inhibited by TNF in a dose-dependent manner. Thyrotropin 4-7 tumor necrosis factor Rattus norvegicus 72-75 2474435-11 1989 Stimulation of I- uptake by TSH was enhanced by IFN gamma, reduced by TNF alpha, and, when serum was present, increased to a degree that was greater than additive by the combined cytokines. Thyrotropin 28-31 tumor necrosis factor Rattus norvegicus 70-79 2474435-6 1989 When combined, IFN gamma and TNF alpha synergized in inhibiting TSH-stimulated growth. Thyrotropin 64-67 tumor necrosis factor Rattus norvegicus 29-38 2474435-14 1989 Simultaneous with inhibition of TSH-stimulated growth, both IFN gamma and TNF alpha enhanced cAMP accumulation. Thyrotropin 32-35 tumor necrosis factor Rattus norvegicus 74-83 2474435-7 1989 By itself TNF alpha inhibited stimulation of I- uptake by TSH, but augmented the enhancement seen with IFN gamma. Thyrotropin 58-61 tumor necrosis factor Rattus norvegicus 10-19 2500334-5 1989 The single injection of 200 micrograms TNF/kg significantly reduced (all P less than 0.05) serum TSH, T4, free T4, T3, and hypothalamic TRH compared to the corresponding hormone levels in saline-injected control rats. Thyrotropin 97-100 tumor necrosis factor Rattus norvegicus 39-42 2500334-11 1989 TNF treatment reduced the binding of pituitary TSH to Concanavalin-A, indicating that it alters the glycosylation of TSH. Thyrotropin 47-50 tumor necrosis factor Rattus norvegicus 0-3 29440225-9 2018 Based on Pearson correlation analysis, the levels of chemerin, TNF-alpha, ET-1, LDL-C, TC and triglyceride (TG) were positively correlated with TSH, but APN and NO levels were negatively correlated with TSH. Thyrotropin 144-147 tumor necrosis factor Rattus norvegicus 63-72