PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8886857-8 1996 IL-1 reduced the TPO content and inhibited the TSH-induced increase in TPO in a concentration-dependent manner. Thyrotropin 47-50 interleukin 1 beta Homo sapiens 0-4 15953673-4 2005 Moreover, IL-1beta and ceramides are demonstrated to inhibit the TSH-induced cAMP production via the implication of alphaGi subunit of the adenylyl cyclase system. Thyrotropin 65-68 interleukin 1 beta Homo sapiens 10-18 9112403-4 1997 TSH-stimulated cultured human thyroid cells exposed for 72 h to IL-1beta (0.0002-20 microg/liter = 1-105 IU/liter) exhibited a dose-dependent and reversible inhibition of thyroglobulin and cAMP release and a dose-dependent stimulation of cGMP and IL-6 release. Thyrotropin 0-3 interleukin 1 beta Homo sapiens 64-72 7623615-3 1995 Recombinant human (rh) IL-1 beta, at a dose of 10(-11) mol/l only, produced a very small increase in basal TSH secretion after 4h, but not 20h, exposure. Thyrotropin 107-110 interleukin 1 beta Homo sapiens 23-32 8754734-5 1996 In contrast, treatment of thyrocytes with either interleukin-1 beta (IL-1 beta) or interferon- gamma (IFN gamma) markedly increased Fas antigen expression on thyrocytes, and these effects were inhibited in the presence of TSH. Thyrotropin 222-225 interleukin 1 beta Homo sapiens 49-67 8754734-5 1996 In contrast, treatment of thyrocytes with either interleukin-1 beta (IL-1 beta) or interferon- gamma (IFN gamma) markedly increased Fas antigen expression on thyrocytes, and these effects were inhibited in the presence of TSH. Thyrotropin 222-225 interleukin 1 beta Homo sapiens 69-78 8754734-7 1996 When thyrocytes stimulated with either IL-1 beta or IFN gamma were treated with anti-Fas IgM mAb, the cells were committed to apoptosis, whereas this apoptotic process was significantly inhibited by the addition of TSH. Thyrotropin 215-218 interleukin 1 beta Homo sapiens 39-48 2167217-6 1990 IL-1 beta had no effect on basal TG release but modulates the TSH-stimulated TG secretion. Thyrotropin 62-65 interleukin 1 beta Homo sapiens 0-9 7835824-4 1994 IL-1 beta (10 U/ml) decreased basal and TSH-stimulated iodide uptake and organification after an incubation time of 45 min to 6 h without any influence on cAMP-formation. Thyrotropin 40-43 interleukin 1 beta Homo sapiens 0-9 7835824-5 1994 In addition, after 40 h of incubation IL-1 beta dose-dependently increased T3-secretion, followed by a decrease during simultaneous TSH-stimulation, whereas there was no effect on T4-secretion. Thyrotropin 132-135 interleukin 1 beta Homo sapiens 38-47 7578850-2 1994 IL-1 inhibits the function of cultured human thyroid cells too, and in this study human thyroid cell production of NO in response to the TSH-stimulated influence of IL-1 beta (10(5) U/l) and TNF-alpha (10(6) U/l), alone or in combination was measured. Thyrotropin 137-140 interleukin 1 beta Homo sapiens 0-4 7578850-2 1994 IL-1 inhibits the function of cultured human thyroid cells too, and in this study human thyroid cell production of NO in response to the TSH-stimulated influence of IL-1 beta (10(5) U/l) and TNF-alpha (10(6) U/l), alone or in combination was measured. Thyrotropin 137-140 interleukin 1 beta Homo sapiens 165-174 1425414-5 1992 During the infusion of 2.0 micrograms IL-1/day, the decrease in plasma free T4 levels was paralleled by a significant decline in plasma TSH values and an impaired TSH responsiveness to TRH administration on the second day of infusion. Thyrotropin 136-139 interleukin 1 beta Homo sapiens 38-42 1425414-5 1992 During the infusion of 2.0 micrograms IL-1/day, the decrease in plasma free T4 levels was paralleled by a significant decline in plasma TSH values and an impaired TSH responsiveness to TRH administration on the second day of infusion. Thyrotropin 163-166 interleukin 1 beta Homo sapiens 38-42 1425414-10 1992 Restriction of food consumption to the level observed in the 2.0 micrograms IL-1 experiment caused small decreases in T3, total and free T4, and TSH levels compared to those in ad libitum fed rats, but had no effects on T4 binding. Thyrotropin 145-148 interleukin 1 beta Homo sapiens 76-80 2167217-7 1990 At low dose (10(-5) to 10(-3) U/ml) IL-1 beta increased the TSH-stimulated TG secretion while higher doses (1-100 U/ml) of IL-1 beta had an inhibitory effect. Thyrotropin 60-63 interleukin 1 beta Homo sapiens 36-45 2167217-7 1990 At low dose (10(-5) to 10(-3) U/ml) IL-1 beta increased the TSH-stimulated TG secretion while higher doses (1-100 U/ml) of IL-1 beta had an inhibitory effect. Thyrotropin 60-63 interleukin 1 beta Homo sapiens 123-132 2167217-11 1990 This biphasic effect of IL-1 beta on TG synthesis is paralleled by a similar change in TSH-stimulated cAMP secretion. Thyrotropin 87-90 interleukin 1 beta Homo sapiens 24-33 3262503-0 1988 Human recombinant interleukin-1 beta decreases plasma thyroid hormone and thyroid stimulating hormone levels in rats. Thyrotropin 74-101 interleukin 1 beta Homo sapiens 18-36