PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31934554-1	2019	Background: Resistance to thyroid hormone beta (RTHbeta) is characterized by elevated thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), caused by thyroid hormone receptor beta gene (THRB) defects.	Thyrotropin	148-151	thyroid hormone receptor beta	Homo sapiens	200-204	
33959275-5	2021	Roxadustat has structural similarity with T3 and is a selective activating ligand for thyroid hormone receptor-beta possibly suppressing TSH release.	Thyrotropin	137-140	thyroid hormone receptor beta	Homo sapiens	86-115	
28527577-3	2017	Patients with mutations in THRB, exhibiting resistance within the hypothalamic-pituitary-thyroid axis with elevated TH and nonsuppressed thyroid-stimulating hormone (TSH) levels, were first described decades ago.	Thyrotropin	137-164	thyroid hormone receptor beta	Homo sapiens	27-31	
25905212-2	2000	Contrary to previous RIAs, ultrasensitive TSH assays allow a clear distinction between patients with suppressed and those with non-suppressed circulating TSH concentrations, i.e. between patients with primary hyperthyroidism (Graves" disease or toxic nodular goiter) and those with central hyperthyroidism (TSH-oma or pituitary resistance to thyroid hormone action, PRTH).	Thyrotropin	42-45	thyroid hormone receptor beta	Homo sapiens	366-370	
28527577-3	2017	Patients with mutations in THRB, exhibiting resistance within the hypothalamic-pituitary-thyroid axis with elevated TH and nonsuppressed thyroid-stimulating hormone (TSH) levels, were first described decades ago.	Thyrotropin	166-169	thyroid hormone receptor beta	Homo sapiens	27-31	
22919057-3	2012	Similar to RTH patients with mutations of two alleles of the THRB gene, the Thrb(PV/PV) mouse exhibits elevated thyroid hormones accompanied by highly nonsuppressible TSH.	Thyrotropin	167-170	thyroid hormone receptor beta	Homo sapiens	76-80	
23528896-2	2013	THRB mutations cause a disorder with central (hypothalamic-pituitary) resistance to thyroid hormone action with markedly elevated thyroid hormone and normal TSH levels.	Thyrotropin	157-160	thyroid hormone receptor beta	Homo sapiens	0-4	
25135573-2	2014	Patients with mutations in THRB present with resistance to thyroid hormone beta (RTHbeta), which is a disorder characterized by elevated levels of thyroid hormone, normal or elevated levels of TSH and goitre.	Thyrotropin	193-196	thyroid hormone receptor beta	Homo sapiens	27-31	
21367965-9	2011	Suggestive associations were detected for one FOXE1 (P=0.0028) and three THRB (P=0.0045) polymorphisms with TSH, and one SLC16A10 polymorphism (P=0.0110) with FT(4), but failed to reach the significant multiple-testing corrected P value (P<0.0022 and P<0.0033 respectively).	Thyrotropin	108-111	thyroid hormone receptor beta	Homo sapiens	73-77	
18844476-14	2008	Only THRB-in9-G/A was associated with higher serum TSH in a large population of Danish twins.	Thyrotropin	51-54	thyroid hormone receptor beta	Homo sapiens	5-9	
1306520-1	1992	Pituitary thyroid hormone resistance (PRTH) refers to a particular form of thyroid hormone refractoriness that is accompanied by peripheral hyperthyroidism, as only the TSH-secreting pituitary cells appear to be resistant to the effects of thyroid hormones.	Thyrotropin	169-172	thyroid hormone receptor beta	Homo sapiens	38-42	
1306520-2	1992	The presence of PRTH is suspected and diagnosed on the basis of the finding of high free thyroid hormone levels along with unsuppressed TSH, clinical signs and symptoms of hyperthyroidism and values of at least one of the parameters evaluating peripheral thyroid hormone action in the hyperthyroid range.	Thyrotropin	136-139	thyroid hormone receptor beta	Homo sapiens	16-20	
2189602-2	1990	Selective pituitary resistance to thyroid hormone (PRTH) is responsible for thyrotoxicosis due to inappropriate secretion of TSH.	Thyrotropin	125-128	thyroid hormone receptor beta	Homo sapiens	51-55	
2110573-13	1990	Without previous ablative therapy, serum TSH in patients with GRTH is usually normal or mildly elevated.	Thyrotropin	41-44	thyroid hormone receptor beta	Homo sapiens	62-66