PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12668683-6	2003	TSH induced the PDK1-dependent phosphorylation of S6K1 but did not induce Akt/protein kinase B phosphorylation.	Thyrotropin	0-3	ribosomal protein S6 kinase B1	Homo sapiens	50-54	
12668683-8	2003	Rapamycin inhibited the phosphorylation of S6K1 in the cells treated with either TSH or 8-bromo-cAMP.	Thyrotropin	81-84	ribosomal protein S6 kinase B1	Homo sapiens	43-47	
12668683-11	2003	These findings suggest an interaction between TSHR and PI3K, which is stimulated by TSH and cAMP and might involve the downstream S6K1 but not Akt/protein kinase B.	Thyrotropin	46-49	ribosomal protein S6 kinase B1	Homo sapiens	130-134	
20484410-3	2010	Here we show in PC Cl3 rat thyroid cells that TSH/cAMP, like insulin, activates the mammalian target of rapamycin (mTOR)-raptor complex (mTORC1) leading to phosphorylation of S6K1 and 4E-BP1.	Thyrotropin	46-49	ribosomal protein S6 kinase B1	Homo sapiens	175-190	
10702801-9	2000	Unlike the inhibitory effects of TSH on the proliferation of RasV12S35-expressing cells, TSH enhanced RasV12C40-stimulated proliferation by further increasing the activity of p70s6k, an important mediator of the mitogenic effects of TSH and RasV12C40.	Thyrotropin	89-92	ribosomal protein S6 kinase B1	Homo sapiens	175-181	
22419707-12	2012	TSH induced phosphorylation of protein kinase S6K1, whereas TSHR blocking antibodies inhibited the phosphorylation of the protein kinase S6K1.	Thyrotropin	0-3	ribosomal protein S6 kinase B1	Homo sapiens	46-50	
17804710-5	2007	We show that the in vivo proliferative response to chronic TSHR stimulation relies heavily on the activation of the mTOR/S6K1 axis, and that mTOR inhibition during goitrogenic stimulation abrogates the hyperplastic but not the hypertrophic thyrocyte responses to TSH, thus functionally uncoupling these two processes.	Thyrotropin	59-62	ribosomal protein S6 kinase B1	Homo sapiens	121-125