PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22843686-1	2012	Gram-negative bacteria harboring KPC-2, a class A beta-lactamase, are resistant to all beta-lactam antibiotics and pose a major public health threat.	beta-Lactams	50-61	KPC-2	Escherichia coli	33-38	
24033858-3	2013	To better understand the variability in beta-lactam MICs among KPC-producing Enterobacteriaceae, three isoforms of bla(KPC-2) gene were used to transform Escherichia coli W4573 and its deletion mutant of an efflux pump (AcrAB) to examine the effects on beta-lactam susceptibility.	beta-Lactams	253-264	KPC-2	Escherichia coli	119-124	
20662006-2	2010	Recent crystal structures of KPC-2 and other class A beta-lactamases suggest that Ambler position Trp105 may be of importance in binding beta-lactam compounds.	beta-Lactams	53-64	KPC-2	Escherichia coli	29-34	
20662006-11	2010	We conclude that interactions between Trp105 of KPC-2 and the beta-lactam are essential for hydrolysis of substrates.	beta-Lactams	62-73	KPC-2	Escherichia coli	48-53	
35019685-16	2022	The newly available beta-lactam combination agent ceftazidime-avibactam has been demonstrated good in vitro and in vivo activity against ESBL, AmpC, KPC-2, or OXA-48-like-producing isolates and has shown promise in treating carbapenem-resistant Enterobacterales infections.	beta-Lactams	20-31	KPC-2	Escherichia coli	149-154