PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29620269-6 2018 MLE-12 cells were divided into 2 groups: The control group was administered sterile PBS; the treatment group was administered 500 ng/ml LPS for 12 h. The mRNA expression of IL-6 in the treatment group was significantly upregulated compared with the control group (P<0.05). Lead 84-87 interleukin 6 Mus musculus 173-177 28264025-10 2017 Serum MCP-1 levels were elevated in the anti-TNF group relative to the CTLA4 Ig and PBS groups, whereas IL-6 levels were higher in PBS controls than in the other two groups. Lead 131-134 interleukin 6 Mus musculus 104-108 25028260-7 2015 The expression of IL-1beta, IL-6, and GFAP was increased in Pb-exposed groups in comparison with the control group (p < 0.05). Lead 60-62 interleukin 6 Mus musculus 28-32 25028260-8 2015 The high expression of IL-1beta, IL-6, and GFAP in the hippocampus of pups may contribute to the neurotoxicity associated with maternal Pb exposure. Lead 136-138 interleukin 6 Mus musculus 33-37 22445968-6 2012 RESULTS: Compared with the control group, PBS-treated ALI group showed significantly higher protein levels, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and neutrophil count in the BALF and MPO content in the lung tissue, with also severe damage of lung histology. Lead 42-45 interleukin 6 Mus musculus 149-162 22445968-6 2012 RESULTS: Compared with the control group, PBS-treated ALI group showed significantly higher protein levels, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and neutrophil count in the BALF and MPO content in the lung tissue, with also severe damage of lung histology. Lead 42-45 interleukin 6 Mus musculus 164-168 21322097-5 2011 Two cytokines, interleukin-6 (IL-6) and transforming growth factor-beta1 (TGF-beta1), displayed significantly changed transcript levels in the presence of Pb. Lead 155-157 interleukin 6 Mus musculus 15-28 21322097-5 2011 Two cytokines, interleukin-6 (IL-6) and transforming growth factor-beta1 (TGF-beta1), displayed significantly changed transcript levels in the presence of Pb. Lead 155-157 interleukin 6 Mus musculus 30-34 21322097-8 2011 Pb also modulated IL-6, TGF-beta1, and IL-18 protein expression in select brain regions. Lead 0-2 interleukin 6 Mus musculus 18-22 19582164-8 2009 Tumors formed by Calu6/beta2 cells in SCID/NOD mice, inoculated subcutaneously or orthotopically, were significantly smaller following IL-12 vs PBS treatment due to inhibition of angiogenesis, and of IL-6 and VEGF-C production. Lead 144-147 interleukin 6 Mus musculus 200-204 19483311-6 2009 The increases in plasma concentrations of interleukin-6 suggest that the production of interleukin-6 by Pb administration is involved in the induction of MT in the liver. Lead 104-106 interleukin 6 Mus musculus 42-55 19483311-6 2009 The increases in plasma concentrations of interleukin-6 suggest that the production of interleukin-6 by Pb administration is involved in the induction of MT in the liver. Lead 104-106 interleukin 6 Mus musculus 87-100 17898286-8 2007 rmST2- versus PBS-injected mice exhibited increased bacterial load, PMN infiltrate, and higher corneal mRNA levels for IL-1beta, MIP-2, IL-6, IL-1R1, and Th1-type cytokine such as IFN-gamma. Lead 14-17 interleukin 6 Mus musculus 136-140 12096892-5 2002 With this mouse model, after infection, serum levels of interleukin (IL)-1beta and IL-6 were enhanced in Pb-exposed mice. Lead 105-107 interleukin 6 Mus musculus 83-87 12096892-7 2002 As a substitute for the infection, mice were injected with IL-1 and/or IL-6; Pb exacerbated sickness behavior only in mice injected peripherally with IL-1 and IL-6. Lead 77-79 interleukin 6 Mus musculus 71-75 12096892-7 2002 As a substitute for the infection, mice were injected with IL-1 and/or IL-6; Pb exacerbated sickness behavior only in mice injected peripherally with IL-1 and IL-6. Lead 77-79 interleukin 6 Mus musculus 159-163 9515939-3 1998 Thus, the effects of Pb on the regulation of interleukin-6 (IL-6), a proinflammatory cytokine that shows high correlation with symptoms of endotoxic shock, and the levels of corticosterone, a hormone produced to prepare the body to cope with stress, upon lipopolysaccharide (LPS; endotoxin) administration were investigated. Lead 21-23 interleukin 6 Mus musculus 45-58 9515939-3 1998 Thus, the effects of Pb on the regulation of interleukin-6 (IL-6), a proinflammatory cytokine that shows high correlation with symptoms of endotoxic shock, and the levels of corticosterone, a hormone produced to prepare the body to cope with stress, upon lipopolysaccharide (LPS; endotoxin) administration were investigated. Lead 21-23 interleukin 6 Mus musculus 60-64 9515939-4 1998 After intravenous administration of LPS, the kinetics of IL-6 gene expression by Northern blot analysis revealed a rapid increase of IL-6 mRNA, which peaked by 2 h in the spleens and 3 h in the brains of B6C3F1 female mice, with or without Pb exposure. Lead 240-242 interleukin 6 Mus musculus 57-61 9515939-4 1998 After intravenous administration of LPS, the kinetics of IL-6 gene expression by Northern blot analysis revealed a rapid increase of IL-6 mRNA, which peaked by 2 h in the spleens and 3 h in the brains of B6C3F1 female mice, with or without Pb exposure. Lead 240-242 interleukin 6 Mus musculus 133-137 9515939-5 1998 Peak production of IL-6 protein after LPS challenge was observed at 2 h in the spleens and 3 h in the sera regardless of Pb-treatment. Lead 121-123 interleukin 6 Mus musculus 19-23 9515939-6 1998 However, Pb-exposed mice showed an altered kinetic profile of IL-6 appearance in the brain, in that the levels of IL-6 in the brains peaked at 4 h rather than 3 h, the peak for the control mice. Lead 9-11 interleukin 6 Mus musculus 62-66 9515939-6 1998 However, Pb-exposed mice showed an altered kinetic profile of IL-6 appearance in the brain, in that the levels of IL-6 in the brains peaked at 4 h rather than 3 h, the peak for the control mice. Lead 9-11 interleukin 6 Mus musculus 114-118 9515939-7 1998 Moreover, at two time points, the amounts of IL-6 were found to be higher in the brains of Pb-treated mice. Lead 91-93 interleukin 6 Mus musculus 45-49 1294619-3 1992 The inhibition by Cd and Pb was dependent on both time of addition of the metal and IL-6 concentration. Lead 25-27 interleukin 6 Mus musculus 84-88 1294619-4 1992 Cd (10 microM) and Pb (50 microM) added at the same time as IL-6 were inhibitory but added 24h later had no effect. Lead 19-21 interleukin 6 Mus musculus 60-64 1294619-5 1992 Increasing the concentration of IL-6 overcame the inhibitory effect of Cd (10 microM) and Pb (50 microM). Lead 90-92 interleukin 6 Mus musculus 32-36 1294619-8 1992 The results suggest that there are at least two distinct metal sensitive events in B9 proliferation, i) IL-6 reversible inhibition by Cd and Pb ii) IL-6 independent inhibition by Co, Cu and Hg. Lead 141-143 interleukin 6 Mus musculus 104-108 34511967-8 2021 Compared to the antibiotic alone or PBS groups, the combination group had higher levels of IL-1alpha, IL-1beta and IFN-gamma and lower levels of IL-6, IL-10, TNF-alpha. Lead 36-39 interleukin 6 Mus musculus 145-149 34374265-13 2021 In vitro experiments, compared with PBS group, PGRN level was decreased (P<0.05), IL-6 level was increased (P<0.01), phosphorylation of p38 was activated in IL-13 treatment group. Lead 36-39 interleukin 6 Mus musculus 82-86 33884175-5 2021 GAS ameliorated Pb-induced inflammation in kidneys by reducing the TNF-alpha and IL-6 levels. Lead 16-18 interleukin 6 Mus musculus 81-85 32901495-6 2020 After 2 days, Il-1beta and Il-6 expression was upregulated in the TA of CTX-IBU and CTX-PL vs. PBS. Lead 95-98 interleukin 6 Mus musculus 27-31 32557032-9 2020 Interleukin (IL)-6 in BALF significantly increased after exposure to Pb (p < 0.05) accompanied by lung inflammatory infiltration. Lead 69-71 interleukin 6 Mus musculus 0-18 32557032-14 2020 IL-6 in the liver was significantly increased by PM2.5, Ni, V, and Pb after exposure (p < 0.05), accompanied by liver inflammatory infiltration. Lead 67-69 interleukin 6 Mus musculus 0-4