PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7377131-3	1980	The thrombin remaining after neutralization by AT-III cleaves a chromophore, p-nitroaniline, from the substrate, which can then te quantified in a spectrophotometer.	4-nitroaniline	77-91	coagulation factor II, thrombin	Homo sapiens	4-12	
3603422-1	1987	A chromogenic substrate, H-D-Phe-Pip-Arg-pNA (S-2238) is a highly specific substrate to thrombin and releases p-nitroaniline (pNA) by the action of thrombin.	4-nitroaniline	110-124	coagulation factor II, thrombin	Homo sapiens	88-96	
3603422-1	1987	A chromogenic substrate, H-D-Phe-Pip-Arg-pNA (S-2238) is a highly specific substrate to thrombin and releases p-nitroaniline (pNA) by the action of thrombin.	4-nitroaniline	110-124	coagulation factor II, thrombin	Homo sapiens	148-156	
11846431-2	2002	The reactions mainly consisted of formation of a h-TM and h-thrombin complex, activation of h-protein C by the complex and digestion of substrate by activated h-protein C. Linear time-dependent formation of p -nitroaniline from the substrate, S-2366, was observed up to 12 min during measurement of the activity of urinary h-TM (uh-TM) reference material by the standard method.	4-nitroaniline	207-222	coagulation factor II, thrombin	Homo sapiens	60-68	
7509511-1	1993	A method is described by which the time-course of thrombin generation in plasma can be obtained from a continuous optical density recording of p-nitroaniline (pNA) production in a 2:3 diluted plasma.	4-nitroaniline	143-157	coagulation factor II, thrombin	Homo sapiens	50-58	
7509511-1	1993	A method is described by which the time-course of thrombin generation in plasma can be obtained from a continuous optical density recording of p-nitroaniline (pNA) production in a 2:3 diluted plasma.	4-nitroaniline	159-162	coagulation factor II, thrombin	Homo sapiens	50-58	
497395-4	1979	The assays of factor Xa and thrombin, which measure the initial rate of p-nitroaniline release from S-2222 and S-2238, respectively, showed similar small amounts of factor Xa (4-34 ng/ml) and thrombin (12-76 ng/ml) in the activated and unactivated concentrates.	4-nitroaniline	72-86	coagulation factor II, thrombin	Homo sapiens	28-36	
436285-2	1979	The thrombin generated is allowed to split the chromogenic substrate Tol-Gly-Pro-Arg-pNA yielding p-nitroaniline.	4-nitroaniline	98-112	coagulation factor II, thrombin	Homo sapiens	4-12	
29411223-3	2018	In this assay, the activation of factor X leads to the formation of activated thrombin from prothrombin and the eventual hydrolyses of a thrombin chromogenic substrate which contains a p-nitroaniline leaving group.	4-nitroaniline	185-199	coagulation factor II, thrombin	Homo sapiens	78-86	
29411223-3	2018	In this assay, the activation of factor X leads to the formation of activated thrombin from prothrombin and the eventual hydrolyses of a thrombin chromogenic substrate which contains a p-nitroaniline leaving group.	4-nitroaniline	185-199	coagulation factor II, thrombin	Homo sapiens	95-103	
32814078-1	2020	Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for thrombin.	4-nitroaniline	117-131	coagulation factor II, thrombin	Homo sapiens	15-23