PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20732302-1 2010 Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). NADP 99-104 heme oxygenase 1 Homo sapiens 6-22 20732302-1 2010 Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). NADP 99-104 heme oxygenase 1 Homo sapiens 24-28 18487208-2 2008 Human heme oxygenase-1 (hHO-1) catalyzes the O2- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron. NADP 53-58 heme oxygenase 1 Homo sapiens 6-22 18487208-2 2008 Human heme oxygenase-1 (hHO-1) catalyzes the O2- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron. NADP 53-58 heme oxygenase 1 Homo sapiens 24-29 18275848-7 2008 HO-1 upregulation by SAM was causally related to a decrease in NADPH-mediated production of oxygen radicals. NADP 63-68 heme oxygenase 1 Homo sapiens 0-4 33845576-6 2021 Analysis of HO-1 activity using Escherichia coli lysates overexpressing hHO-1 found that a 6-fold increase in emission intensity at 383 nm was observed following incubation with NADPH. NADP 178-183 heme oxygenase 1 Homo sapiens 12-16 15911218-5 2005 Pre-treating endothelial cells with AZD3582 at concentrations that were effective at inducing HO-1 also reduced NADPH-dependent production of oxygen radicals. NADP 112-117 heme oxygenase 1 Homo sapiens 94-98 15911218-7 2005 When added exogenously to the cells at low micromolar concentrations, the HO-1 metabolite, bilirubin, virtually abolished NADPH-dependent oxidative stress. NADP 122-127 heme oxygenase 1 Homo sapiens 74-78 15525643-2 2005 The NADPH-dependent reaction, like that of wild-type hHO-1, yields exclusively biliverdin IXalpha. NADP 4-9 heme oxygenase 1 Homo sapiens 53-58 15516695-8 2005 Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group. NADP 153-158 heme oxygenase 1 Homo sapiens 25-29 15516695-0 2005 Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. NADP 15-20 heme oxygenase 1 Homo sapiens 48-94 15516695-2 2005 In this study, we investigated the effect of NADP(H) on the interaction of HO-1 with CPR by surface plasmon resonance. NADP 45-52 heme oxygenase 1 Homo sapiens 75-79 15516695-3 2005 We found that HO-1 associated with CPR more tightly in the presence of NADP(+) (K(D) = 0.5 microm) than in its absence (K(D) = 2.4 microm). NADP 71-78 heme oxygenase 1 Homo sapiens 14-18 15541371-6 2004 The HO-1 metabolite bilirubin, when added exogenously to the cells, virtually abolished NADPH-dependent oxidative stress. NADP 88-93 heme oxygenase 1 Homo sapiens 4-8 33845576-6 2021 Analysis of HO-1 activity using Escherichia coli lysates overexpressing hHO-1 found that a 6-fold increase in emission intensity at 383 nm was observed following incubation with NADPH. NADP 178-183 heme oxygenase 1 Homo sapiens 72-77 30934992-1 2019 The upregulation of heme oxygenase-1 (HO-1) by the carbon monoxide-releasing molecule (CORM)-2 may be mediated through the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases [Nox] and reactive oxygen species (ROS) generation, which could provide cytoprotection against various cellular injuries. NADP 137-180 heme oxygenase 1 Homo sapiens 20-36 31972252-6 2020 In high glucose-incubated vascular endothelial cells, NO donor attenuated oxidative stress and endothelial dysfunction via the inhibition of NADPH oxidase, where a heme oxygenase-1 (HO-1)-dependent mechanism was demonstrated for the antioxidant abilities of NO. NADP 141-146 heme oxygenase 1 Homo sapiens 164-180 31952230-7 2020 MVS-induced HO-1 expression was mediated via NADPH oxidase (Nox)-derived reactive oxygen species (ROS) generation. NADP 45-50 heme oxygenase 1 Homo sapiens 12-16 30883732-0 2019 Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+ binding. NADP 156-161 heme oxygenase 1 Homo sapiens 72-88 30883732-2 2019 Recently, we determined the complex structure of NADP+ -bound open-conformation stabilized CYPOR and heme-HMOX1, but the resolution was limited to 4.3 A. NADP 49-54 heme oxygenase 1 Homo sapiens 106-111 30883732-6 2019 As a result of this change, the FMN-binding domain of CYPOR approaches heme-bound HMOX1 upon NADP+ binding to enhance the electron-transfer efficiency from FMN to heme. NADP 93-98 heme oxygenase 1 Homo sapiens 82-87 30934992-1 2019 The upregulation of heme oxygenase-1 (HO-1) by the carbon monoxide-releasing molecule (CORM)-2 may be mediated through the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases [Nox] and reactive oxygen species (ROS) generation, which could provide cytoprotection against various cellular injuries. NADP 137-180 heme oxygenase 1 Homo sapiens 38-42 30934992-1 2019 The upregulation of heme oxygenase-1 (HO-1) by the carbon monoxide-releasing molecule (CORM)-2 may be mediated through the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases [Nox] and reactive oxygen species (ROS) generation, which could provide cytoprotection against various cellular injuries. NADP 182-187 heme oxygenase 1 Homo sapiens 20-36 30934992-1 2019 The upregulation of heme oxygenase-1 (HO-1) by the carbon monoxide-releasing molecule (CORM)-2 may be mediated through the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases [Nox] and reactive oxygen species (ROS) generation, which could provide cytoprotection against various cellular injuries. NADP 182-187 heme oxygenase 1 Homo sapiens 38-42 23729024-9 2013 The effectiveness of miltefosine for positive induction of ROS via NADPH correlated with a decrease in HO-1/ERK/Nrf-2-dependent parasite load. NADP 67-72 heme oxygenase 1 Homo sapiens 103-107 24024172-5 2013 Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1. NADP 77-82 heme oxygenase 1 Homo sapiens 289-304 23661026-6 2013 Further investigation showed that Smad7 regulated NADPH-mediated ROS production through activating Heme oxygenase-1 (HO-1). NADP 50-55 heme oxygenase 1 Homo sapiens 99-115 23661026-6 2013 Further investigation showed that Smad7 regulated NADPH-mediated ROS production through activating Heme oxygenase-1 (HO-1). NADP 50-55 heme oxygenase 1 Homo sapiens 117-121