PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8118686-1 1993 In view of the divergent literature concerning the long-term effects of ibotenic acid lesions of the nucleus basalis of Meynert (NBM) on the choline acetyltransferase (ChAT) activity in adult rat cerebral cortex, we have critically reassessed the issue of an eventual recovery of this enzymatic activity by sprouting of the residual acetylcholine (ACh) innervation. Ibotenic Acid 72-85 choline O-acetyltransferase Rattus norvegicus 141-166 8239290-4 1993 After one week, choline acetyltransferase activity in frontal cortex was decreased (26%, p < 0.005, n = 14) on the nBM ibotenate-lesion side relative to the contralateral side, while there were no differences following the nBM sham-lesion. Ibotenic Acid 122-131 choline O-acetyltransferase Rattus norvegicus 16-41 1322821-8 1992 Associated with the decreased choline acetyltransferase activity after 1 week was an enhanced phosphoinositide hydrolysis in response to norepinephrine, and after 2 weeks there were enhanced responses to norepinephrine and to ibotenate. Ibotenic Acid 226-235 choline O-acetyltransferase Rattus norvegicus 30-55 1281523-11 1992 Excitotoxins (ibotenic acid, quinolinic acid, N-methyl-D-aspartic acid) that produce the greatest impairments in memory were found to produce the greatest depletion of choline acetyltransferase in the amygdala. Ibotenic Acid 14-27 choline O-acetyltransferase Rattus norvegicus 168-193 1579212-5 1992 Unilateral ibotenate nucleus basalis lesioning decreased choline acetyltransferase activity in the cortex and produced a large nonspecific subcortical cell loss in young rats. Ibotenic Acid 11-20 choline O-acetyltransferase Rattus norvegicus 57-82 2574419-4 1989 As expected, choline acetyltransferase activity was decreased in the frontal cortex ipsilateral to the ibotenic acid infusion in unilaterally or bilaterally lesioned animals. Ibotenic Acid 103-116 choline O-acetyltransferase Rattus norvegicus 13-38 2175866-1 1990 Choline acetyltransferase activities were measured in various forebrain regions 3, 7, 14, 21 and 28 days after bilateral lesions of the pedunculopontine nucleus area with ibotenic acid. Ibotenic Acid 171-184 choline O-acetyltransferase Rattus norvegicus 0-25 1922778-3 1991 However, acquisition was significantly impaired in rats with ibotenic acid-induced lesions that reduced cortical choline acetyltransferase by 50%. Ibotenic Acid 61-74 choline O-acetyltransferase Rattus norvegicus 113-138 2765180-5 1989 Similar analyses in 6- and 15-month-old rats with ibotenic acid-induced lesions of the nucleus basalis magnocellularis (NBM) showed several alterations in sleep, memory, and cortical CAT activity comparable to those seen in the old rats. Ibotenic Acid 50-63 choline O-acetyltransferase Rattus norvegicus 183-186 2602504-1 1989 Bilateral ibotenic acid lesions of the nucleus basalis magnocellularis (NBM), which resulted in 30% depletion of cortical choline acetyltransferase, facilitated acquisition of shuttlebox two-way active avoidance learning in rats. Ibotenic Acid 10-23 choline O-acetyltransferase Rattus norvegicus 122-147 20504503-7 1989 After bilateral lesion with ibotenic acid at the level of nucleus basalis of Meynert, there was a significant decrease of about 50% in the high affinity uptake of choline and choline acetyltransferase activity in the frontoparietal cortex. Ibotenic Acid 28-41 choline O-acetyltransferase Rattus norvegicus 175-200 2792258-8 1989 In Experiment 3, neurochemical analysis of the hippocampus in rats with ibotenic acid-induced lesions demonstrated that choline acetyl-transferase levels were reduced to the same extent as in rats with comparable conventional lesions. Ibotenic Acid 72-85 choline O-acetyltransferase Rattus norvegicus 120-146 2501767-1 1989 Microinjection of ibotenic acid into medial septum of rats decreased choline acetyltransferase (CAT) and high-affinity choline uptake (HACU) activities in hippocampus and retarded the learning of a spatial memory task in the radial-arm maze. Ibotenic Acid 18-31 choline O-acetyltransferase Rattus norvegicus 69-94 3174805-2 1988 According to the literature, ibotenic acid-induced lesions of the nucleus basalis magnocellularis cause a significant decrease in choline acetyltransferase activity in frontal and parietal cortex, but had no effect on enzyme activity in the occipital cortex or cortical areas controlateral to the lesion. Ibotenic Acid 29-42 choline O-acetyltransferase Rattus norvegicus 130-155 3696497-4 1987 Choline acetyltransferase (ChAT) activity and [3H]hemicholinium-3 ([3H]HCh-3) binding are reduced in cortex ipsilateral to ibotenic acid lesions in the 12-month postlesion rat following an initial recovery to normal levels by about 3 months postlesion. Ibotenic Acid 123-136 choline O-acetyltransferase Rattus norvegicus 0-25 3335856-5 1988 There were also differences between the effect of kainic and ibotenic acid lesions on choline acetyltransferase activity in the capillaries of the ipsilateral side with respect to that of the contralateral one. Ibotenic Acid 61-74 choline O-acetyltransferase Rattus norvegicus 86-111 20501268-2 1988 Ibotenic acid lesions of the cortical cholinergic tract caused a small reduction in the content of high affinity binding sites for type A neurotoxin and a concomitant decrease in the activities of acetylcholinesterase and choline acetyltransferase. Ibotenic Acid 0-13 choline O-acetyltransferase Rattus norvegicus 222-247 3696497-4 1987 Choline acetyltransferase (ChAT) activity and [3H]hemicholinium-3 ([3H]HCh-3) binding are reduced in cortex ipsilateral to ibotenic acid lesions in the 12-month postlesion rat following an initial recovery to normal levels by about 3 months postlesion. Ibotenic Acid 123-136 choline O-acetyltransferase Rattus norvegicus 27-31 3954876-7 1986 The ibotenate-induced lesions significantly reduced the activity of choline acetyltransferase (CAT) in the anterior and the posterior neocortex. Ibotenic Acid 4-13 choline O-acetyltransferase Rattus norvegicus 68-93 3954876-7 1986 The ibotenate-induced lesions significantly reduced the activity of choline acetyltransferase (CAT) in the anterior and the posterior neocortex. Ibotenic Acid 4-13 choline O-acetyltransferase Rattus norvegicus 95-98 2936982-3 1985 Injections of 20 micrograms ibotenic acid, deposited over four injection sites in the head of the caudate-putamen, had by one week caused a 70-85% reduction in glutamate decarboxylase and choline acetyltransferase activity. Ibotenic Acid 28-41 choline O-acetyltransferase Rattus norvegicus 188-213 4094693-1 1985 Unilateral ibotenic acid lesions of the rat nucleus basalis magnocellularis produce approximately 60% depletion of choline acetyltransferase activity in ipsilateral frontal and frontoparietal neocortex. Ibotenic Acid 11-24 choline O-acetyltransferase Rattus norvegicus 115-140 6875049-9 1983 In contrast, ibotenate lesions of the caudal ventral globus pallidus and substantia innominata caused decreases in CAT activity in the frontal cortex of up to 65% without affecting enzyme activity in the hippocampal formation. Ibotenic Acid 13-22 choline O-acetyltransferase Rattus norvegicus 115-118 6704718-0 1984 Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in rats. Ibotenic Acid 69-82 choline O-acetyltransferase Rattus norvegicus 24-49 4000475-8 1985 The ibotenate lesions reduced the activity of choline acetyltransferase by about 40% in the anterior cortex and by 15% in the posterior cortex. Ibotenic Acid 4-13 choline O-acetyltransferase Rattus norvegicus 46-71 12183643-6 2002 Extrapolating these effects to a well defined rodent model of neurodegeneration, GLP-1 and exendin-4 greatly reduced ibotenic acid-induced depletion of choline acetyltransferase immunoreactivity in basal forebrain cholinergic neurons. Ibotenic Acid 117-130 choline O-acetyltransferase Rattus norvegicus 152-177 16819183-6 2006 These treatments also reduced the loss of choline acetyltransferase (ChAT) immunoreactivity in the MS induced by ibotenic acid. Ibotenic Acid 113-126 choline O-acetyltransferase Rattus norvegicus 42-67 10599934-2 1999 Rats received ibotenic acid lesions of cholinergic basal forebrain nuclei resulting in a 30% to 40% depletion of both cortical choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity. Ibotenic Acid 14-27 choline O-acetyltransferase Rattus norvegicus 127-152 9881861-6 1998 Ibotenate infusion into the nucleus basalis magnocellularis reduced levels of choline acetyltransferase activity in the cortex, as well as reduced numbers of choline acetyltransferase-immunoreactive and retrogradely (FluoroGold)-labelled cortically-projecting neurons in the nucleus basalis. Ibotenic Acid 0-9 choline O-acetyltransferase Rattus norvegicus 78-103