PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17683829-6 2007 We further tested whether the intraperitoneal injection of IL-1beta, known to aggravate the ibotenate-induced lesions, could modify the expression pattern of VIP-related genes. Ibotenic Acid 92-101 vasoactive intestinal peptide Homo sapiens 158-161 17683829-7 2007 Finally, we concluded using histological analysis that VIP[ala(11,22,28)], a synthetic VPAC(1) agonist completely reversed the aggravating effects of IL-1beta on ibotenate-induced lesions of the periventricular white matter. Ibotenic Acid 162-171 vasoactive intestinal peptide Homo sapiens 55-58 17683829-9 2007 All together, our results suggest that an activation of VIP/VPAC(1) signaling cascade in the vicinity of the injury site could circumvent the synergizing degenerative effects of ibotenate and pro-inflammatory cytokines. Ibotenic Acid 178-187 vasoactive intestinal peptide Homo sapiens 56-59