PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14748561-5	2004	The ibotenic acid doses required to induce WM cysts were lower in the wild-type mice (EC50 < 0.01 microg/animal) than in the t-PA-/- mice (EC50 = 2.5 microg/animal) (p < 0.01), indicating the existence of t-PA-dependent and t-PA-independent mechanisms.	Ibotenic Acid	4-17	plasminogen activator, tissue	Mus musculus	211-215	
17321054-2	2007	With both low (0.1 mug) and high (5 mug) ibotenic acid doses, tissue-plasminogen activator (t-PA) is involved in cyst formation.	Ibotenic Acid	41-54	plasminogen activator, tissue	Mus musculus	62-96	
17321054-5	2007	Intracerebral hrt-PA induced WM cystic lesions in t-PA(-/-) mice and had an additive effect when co-injected with high-dose ibotenic acid.	Ibotenic Acid	124-137	plasminogen activator, tissue	Mus musculus	16-20	
17321054-8	2007	Thus, the t-PA-dependent effect of low-dose ibotenic acid on cyst formation appeared independent from plasmin activity or inflammation.	Ibotenic Acid	44-57	plasminogen activator, tissue	Mus musculus	10-14	
17321054-9	2007	Conversely, a t-PA-dependent inflammatory process occurred with high-dose ibotenic acid.	Ibotenic Acid	74-87	plasminogen activator, tissue	Mus musculus	14-18	
15590153-4	2005	In mice injected the day of birth, postnatal (P) day 0, ibotenic acid induced neuronal migration disorders together with low local microglial activation in wild-type and t-PA-/- mice.	Ibotenic Acid	56-69	plasminogen activator, tissue	Mus musculus	170-174	
15590153-14	2005	t-PA-/- mice showed reduced lesion size under high doses (>5 microg) of ibotenic acid.	Ibotenic Acid	75-88	plasminogen activator, tissue	Mus musculus	0-4	
14748561-5	2004	The ibotenic acid doses required to induce WM cysts were lower in the wild-type mice (EC50 < 0.01 microg/animal) than in the t-PA-/- mice (EC50 = 2.5 microg/animal) (p < 0.01), indicating the existence of t-PA-dependent and t-PA-independent mechanisms.	Ibotenic Acid	4-17	plasminogen activator, tissue	Mus musculus	211-215