PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11861798-3	2002	Time- and concentration-dependent uptake of ACV and GCV was observed in hOAT1- and hOCT1-expressing cells.	Acyclovir	44-47	solute carrier family 22 member 6	Homo sapiens	72-77	
35508593-3	2022	METHODS: Physiologically based pharmacokinetic models were constructed for four OAT1/3 substrates in healthy individuals: acyclovir, meropenem, furosemide, and ciprofloxacin.	Acyclovir	122-131	solute carrier family 22 member 6	Homo sapiens	80-86	
23744435-0	2013	Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.	Acyclovir	49-58	solute carrier family 22 member 6	Homo sapiens	62-66	
23744435-7	2013	CONCLUSIONS: It indicates that acyclovir is a substrate for OAT1 and OAT3.	Acyclovir	31-40	solute carrier family 22 member 6	Homo sapiens	60-64	
23744435-8	2013	PCG inhibits the renal excretion of acyclovir by inhibiting renal transporters OAT1 and OAT3 in vivo and in vitro.	Acyclovir	36-45	solute carrier family 22 member 6	Homo sapiens	79-83	
22728397-0	2012	Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3.	Acyclovir	50-59	solute carrier family 22 member 6	Homo sapiens	81-85	
22728397-1	2012	The purpose is to investigate whether the targets of drug-drug interactions (DDIs) between JBP485 and acyclovir are OAT1 and OAT3 in kidney.	Acyclovir	102-111	solute carrier family 22 member 6	Homo sapiens	116-120	
31341258-0	2020	Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2.	Acyclovir	44-53	solute carrier family 22 member 6	Homo sapiens	68-74	
31341258-2	2020	Acyclovir is a substrate of organic anion transporter (OAT) 1/3 and multidrug resistance-associated protein (MRP) 2.	Acyclovir	0-9	solute carrier family 22 member 6	Homo sapiens	28-63	
31341258-10	2020	TER (5 mumol/L) significantly inhibited the uptake of acyclovir in hOAT1/3-HEK293 cells.	Acyclovir	54-63	solute carrier family 22 member 6	Homo sapiens	67-74	
22728397-4	2012	JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells.	Acyclovir	165-174	solute carrier family 22 member 6	Homo sapiens	24-28	
22728397-4	2012	JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells.	Acyclovir	165-174	solute carrier family 22 member 6	Homo sapiens	80-84	
22728397-4	2012	JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells.	Acyclovir	165-174	solute carrier family 22 member 6	Homo sapiens	199-204	
22728397-5	2012	These results suggest that JBP485 inhibits the renal excretion of acyclovir by inhibiting renal transporters OAT1 and OAT3 in vivo and in vitro.	Acyclovir	66-75	solute carrier family 22 member 6	Homo sapiens	109-113	
11861798-8	2002	In addition, probenecid weakly inhibited the hOAT1-mediated ACV uptake.	Acyclovir	60-63	solute carrier family 22 member 6	Homo sapiens	45-50	
11861798-9	2002	In conclusion, these results suggest that hOAT1 and hOCT1 mediate renal ACV and GCV transport, whereas hOAT1, hOAT2, hOAT3, and hOAT4 mediate renal AZT transport.	Acyclovir	72-75	solute carrier family 22 member 6	Homo sapiens	42-47	
11861798-6	2002	The Km values of ACV uptake by hOAT1 and hOCT1 were 342.3 and 151.2 microM, respectively, whereas those of GCV uptake by hOAT1 and hOCT1 were 895.5 and 516.2 microM, respectively.	Acyclovir	17-20	solute carrier family 22 member 6	Homo sapiens	31-36