PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20522547-5	2010	Frataxin interacts with Isu, iron, and the cysteine desulfurase Nfs1, which supplies sulfide, thus placing it at the center of mitochondrial FeS cluster biosynthesis.	Sulfides	85-92	NFS1 cysteine desulfurase	Homo sapiens	64-68	
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Sulfides	42-49	NFS1 cysteine desulfurase	Homo sapiens	62-66	
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfides	109-116	NFS1 cysteine desulfurase	Homo sapiens	101-105	
19722697-3	2009	This C-terminal domain contains a pair of redox active cysteines and demonstrates thioredoxin-like activity by both binding to and mediating persulfide bond cleavage of sulfur-loaded IscS, the sulfide donor for [2Fe-2S] cluster assembly on ISU-type scaffold proteins.	Sulfides	144-151	NFS1 cysteine desulfurase	Homo sapiens	183-187	
19146390-3	2009	This C-terminal domain contains a pair of redox active cysteines and demonstrates thioredoxin-like activity by mediating persulfide bond cleavage of sulfur-loaded NifS (an IscS-type protein), the sulfide donor for [2Fe-2S] cluster assembly on ISU-type scaffold proteins.	Sulfides	124-131	NFS1 cysteine desulfurase	Homo sapiens	163-167	
11343803-7	2001	To further probe the relevance of sulfide in the mobilization of iron, several enzymes, such as NifS, rhodanese, or sulfite reductase generating reduced forms of sulfur by different mechanisms, have been assayed for their ability to catalyze the release of iron from ferritin.	Sulfides	34-41	NFS1 cysteine desulfurase	Homo sapiens	96-100	
16431909-3	2006	In the absence of chaperones, the kinetics of Fe/S cluster formation on Isu1p were compatible with a chemical reconstitution pathway with Nfs1p functioning as a sulfide donor.	Sulfides	161-168	NFS1 cysteine desulfurase	Homo sapiens	138-143	
11123951-10	2000	NifS is a cysteine desulfurase, releasing sulfur or sulfide (depending on the reducing environment) from L-cysteine, in agreement with its proposed role as a sulfur donor to Fe-S clusters.	Sulfides	52-59	NFS1 cysteine desulfurase	Homo sapiens	0-4	
10891064-2	2000	The homodimeric IscS protein has been shown to be a cysteine desulfurase that catalyzes the reductive conversion of cysteine to alanine and sulfide.	Sulfides	140-147	NFS1 cysteine desulfurase	Homo sapiens	16-20