PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11301042-9	2001	The cell cycle inhibitory and apoptotic effects of BisA, therefore, appear to be PKC-independent in IEC-18 cells.	bistratene A	51-55	protein kinase C, alpha	Rattus norvegicus	81-84	
11301042-10	2001	On the other hand, BisA and PMA both promoted PKC-dependent activation of Erk 1 and 2 in this system.	bistratene A	19-23	protein kinase C, alpha	Rattus norvegicus	46-49	
11301042-11	2001	Thus, intestinal epithelial cells respond to BisA through activation of at least two signaling pathways: a PKC delta-dependent pathway, which leads to activation of mitogen-activated protein kinase and possibly cytostasis in the appropriate context, and a PKC-independent pathway, which induces both cell cycle arrest in G(0)/G(1) and G(2)/M and apoptosis through as yet unknown mechanisms.	bistratene A	45-49	protein kinase C, alpha	Rattus norvegicus	107-110