PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20404999-2	2010	Several IscS-interacting partners including IscU, a scaffold for Fe-S cluster assembly; TusA, the first member of a sulfur relay leading to sulfur incorporation into the wobble uridine of several tRNAs; ThiI, involved in tRNA modification and thiamine biosynthesis; and rhodanese RhdA are sulfur acceptors.	Thiamine	243-251	NFS1 cysteine desulfurase	Homo sapiens	8-12	
10781607-0	2000	The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD.	Thiamine	85-92	NFS1 cysteine desulfurase	Homo sapiens	4-8	
10781607-4	2000	In addition to lacking s(4)U, the iscS(-) strain requires thiamin and nicotinic acid for growth in minimal media.	Thiamine	58-65	NFS1 cysteine desulfurase	Homo sapiens	34-38	
10781607-5	2000	The thiamin requirement can be relieved by the addition of the thiamin precursor 5-hydroxyethyl-4-methylthiazole, indicating that iscS is required specifically for thiazole biosynthesis.	Thiamine	4-11	NFS1 cysteine desulfurase	Homo sapiens	130-134	
10781607-5	2000	The thiamin requirement can be relieved by the addition of the thiamin precursor 5-hydroxyethyl-4-methylthiazole, indicating that iscS is required specifically for thiazole biosynthesis.	Thiamine	63-70	NFS1 cysteine desulfurase	Homo sapiens	130-134	
10781607-7	2000	When the iscS(-) strain is switched from rich to minimal medium containing thiamin and nicotinate, growth is preceded by a considerable lag period relative to the parent strain.	Thiamine	75-82	NFS1 cysteine desulfurase	Homo sapiens	9-13	
10781607-14	2000	Thus, IscS plays a significant and specific role at the top of a potentially broad sulfur transfer cascade that is required for the biosynthesis of thiamin, NAD, Fe-S clusters, and thionucleosides.	Thiamine	148-155	NFS1 cysteine desulfurase	Homo sapiens	6-10